公开(公告)号：US20240226845A1

公开(公告)日：2024-07-11

申请号：US18407660

申请日：2024-01-09

Applicant: Waters Technologies Corporation

Inventor： Matthew Lauber ,  Nicole Lawrence ,  Daniel Walsh ,  Jessica Field

IPC: B01J20/10 ,  B01J20/28 ,  B01J20/30 ,  G01N21/33 ,  G01N30/02 ,  G01N30/88

CPC classification number: B01J20/103 ,  B01J20/28016 ,  B01J20/28045 ,  B01J20/3085 ,  G01N21/33 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/8827

Abstract: Provided herein are compositions, kits and methods that may be useful for improving the efficiency of solid phase extraction to separate oligonucleotides from a complex matrix. Particularly, the present technology relates to a sorbent material including porous particles, the surface of which is modified with a ligand that includes one or more bridging alkyl substituted amines and at least two siloxyl terminal groups.

公开(公告)号：US20220362741A1

公开(公告)日：2022-11-17

申请号：US17731952

申请日：2022-04-28

Applicant: Waters Technologies Corporation

Inventor： Nicole L. Lawrence ,  Darryl W. Brousmiche ,  Jessica Field ,  Daniel P. Walsh

IPC: B01J20/26 ,  B01D15/36 ,  B01J20/28 ,  B01J43/00

Abstract: In some aspects, the present disclosure pertains to chromatographic materials that comprise (a) a bulk material and (b) a zwitterionic polymer covalently linked to a surface of the bulk material, in which the zwitterionic polymer comprises one or more monomer residues that comprise an amide or urea moiety, a positively charged moiety, and a negatively charged moiety. Other aspects of the present disclosure pertain to chromatographic separation devices that comprise such chromatographic materials, to chromatographic methods that employ such chromatographic separation devices, and to kits that contain (i) such chromatographic materials and (ii) one or more chromatographic devices for containing such materials.