公开(公告)号：US10751642B2

公开(公告)日：2020-08-25

申请号：US14359396

申请日：2012-12-07

Applicant: Waters Technologies Corporation

Inventor： Kurt D. Joudrey ,  Maruth Sok

IPC: B01D15/14 ,  F04B49/22 ,  G01N30/20 ,  B01D15/40 ,  G01N30/32 ,  F16K11/02 ,  G01N30/02 ,  G01N30/34

Abstract: A liquid chromatography system includes a pumping system with a selector valve in fluidic communication with a pump inlet. The selector valve switches between a first position, in which the selector valve fluidically couples a solvent reservoir to the pump inlet, and a second position, in which the selector valve fluidically couples a pressurized source of liquefied carbon dioxide (for example) to the pump inlet. The liquid chromatography system can perform as a HPLC system (or as an UPLC system) when the selector valve is in the first position and as a CO2-based chromatography system when the selector valve is in the second position. The selector valve can have a third position in which both the fluidic pathway between the solvent reservoir and the pump inlet and the fluidic pathway between the pressurized source and the pump inlet are blocked. This shut-off position advantageously facilitates system maintenance.

公开(公告)号：US20180313585A1

公开(公告)日：2018-11-01

申请号：US15565324

申请日：2016-04-07

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Nathan Barrett ,  Kara O'Donnell ,  Neal B. Almeida ,  Wen Lu ,  James E. Usowicz ,  Maruth Sok ,  Kurt D. Joudrey ,  Joshua A. Shreve

IPC: F25B25/00 ,  B01D15/40 ,  B01D15/18 ,  G01N30/30

CPC classification number: F25B25/005 ,  B01D15/40 ,  G01N30/30

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling pump heads and providing balanced cooling and heat transfer between multiple pump heads. Multi-pump systems that are used to pump fluids that vary greatly in density with minor changes in temperature, such as the mobile phase of a C02-based chromatography system, require highly stable temperature conditions. In order to achieve a substantially equal average heat transfer between multiple pump heads and a coolant fluid, coolant fluid may be flowed through coolant passageways within the pump heads in a recursive and/or parallel coolant flow patterns. Such recursive and/or parallel coolant fluid flow patterns provide increased stability in temperature, compressibility, and density of the fluids passing through a multi-pump system.

公开(公告)号：US20140326664A1

公开(公告)日：2014-11-06

申请号：US14359396

申请日：2012-12-07

Applicant: Waters Technologies Corporation

Inventor： Kurt D. Joudrey ,  Maruth Sok

IPC: B01D15/14 ,  F16K11/02 ,  G01N30/02

Abstract: A liquid chromatography system includes a pumping system with a selector valve in fluidic communication with a pump inlet. The selector valve switches between a first position, in which the selector valve fluidically couples a solvent reservoir to the pump inlet, and a second position, in which the selector valve fluidically couples a pressurized source of liquefied carbon dioxide (for example) to the pump inlet. The liquid chromatography system can perform as a HPLC system (or as an UPLC system) when the selector valve is in the first position and as a CO2-based chromatography system when the selector valve is in the second position. The selector valve can have a third position in which both the fluidic pathway between the solvent reservoir and the pump inlet and the fluidic pathway between the pressurized source and the pump inlet are blocked. This shut-off position advantageously facilitates system maintenance.

Abstract translation: 液相色谱系统包括具有与泵入口流体连通的选择阀的泵送系统。 选择阀在其中选择阀将溶剂容器流体耦合到泵入口的第一位置和第二位置之间切换，在第二位置，选择阀将加压的液化二氧化碳源（例如）流体耦合到泵 进口。 当选择阀处于第一位置时，液相色谱系统可以作为HPLC系统（或作为UPLC系统）进行，并且当选择阀处于第二位置时可以作为基于CO 2的色谱系统。 选择阀可以具有第三位置，在该第三位置中，溶剂容器和泵入口之间的流体路径以及加压源和泵入口之间的流体路径均被阻挡。 该关闭位置有利于系统维护。

公开(公告)号：US10159913B2

公开(公告)日：2018-12-25

申请号：US15333876

申请日：2016-10-25

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette ,  Maruth Sok ,  Carlos Gomez ,  Joshua A. Shreve

IPC: B01D19/00 ,  B01D15/40 ,  G01N30/14 ,  G01N30/84

Abstract: Methods, systems and apparatus are provided for degassing a supersaturated solution. An example degasser is described having a continuous body of gas-permeable tubing to remove an amount of a gas from the supersaturated solution below the gas's saturation point in the supersaturated solution. The degasser can be connected to at least one of a fraction collector or a detector. The example degasser is sized and/or positioned to cause a change in pressure (ΔP) across the degasser to drive removal of a dissolved gas from a supersaturated solution passing through the degasser. As a result of the reduction of gas, efficiencies in system flow and fraction collection are achieved.

公开(公告)号：US20170136389A1

公开(公告)日：2017-05-18

申请号：US15333876

申请日：2016-10-25

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette ,  Maruth Sok ,  Carlos Gomez ,  Joshua A. Shreve

IPC: B01D19/00 ,  G01N30/14 ,  B01D15/40

CPC classification number: B01D15/40 ,  B01D19/0031 ,  G01N30/84 ,  G01N2030/8423

Abstract: Methods, systems and apparatus are provided for degassing a supersaturated solution. An example degasser is described having a continuous body of gas-permeable tubing to remove an amount of a gas from the supersaturated solution below the gas's saturation point in the supersaturated solution. The degasser can be connected to at least one of a fraction collector or a detector. The example degasser is sized and/or positioned to cause a change in pressure (ΔP) across the degasser to drive removal of a dissolved gas from a supersaturated solution passing through the degasser. As a result of the reduction of gas, efficiencies in system flow and fraction collection are achieved.