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公开(公告)号：US10751642B2
公开(公告)日：2020-08-25
申请号：US14359396
申请日：2012-12-07
Applicant: Waters Technologies Corporation
Inventor： Kurt D. Joudrey , Maruth Sok
Abstract: A liquid chromatography system includes a pumping system with a selector valve in fluidic communication with a pump inlet. The selector valve switches between a first position, in which the selector valve fluidically couples a solvent reservoir to the pump inlet, and a second position, in which the selector valve fluidically couples a pressurized source of liquefied carbon dioxide (for example) to the pump inlet. The liquid chromatography system can perform as a HPLC system (or as an UPLC system) when the selector valve is in the first position and as a CO2-based chromatography system when the selector valve is in the second position. The selector valve can have a third position in which both the fluidic pathway between the solvent reservoir and the pump inlet and the fluidic pathway between the pressurized source and the pump inlet are blocked. This shut-off position advantageously facilitates system maintenance.
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公开(公告)号：US10345276B2
公开(公告)日：2019-07-09
申请号：US15303321
申请日：2015-04-10
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Shreve , Kurt D. Joudrey
Abstract: A passive pre-heater assembly includes a thermally conductive heat-spreading block and a plurality of passive pre-heaters in thermally conductive communication with the heat-spreading block. The plurality of the pre-heaters exchanges heat with the thermally conductive heat-spreading block. Each pre-heater includes a thermally conductive base in thermal communication with the heat-spreading block, and a plurality of thermally conductive fins is in thermal communication with the thermally conductive base. The plurality of fins of each pre-heater exchanges heat convectively with ambient air and conductively with the thermally conductive base of that pre-heater. A given one of the passive pre-heaters further comprises a tube in thermally conductive contact with the thermally conductive base of the given passive pre-heater. The thermally conductive heat-spreading block exchanges heat with a fluid passing through the tube of the given passive pre-heater.
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公开(公告)号：US10386341B2
公开(公告)日：2019-08-20
申请号：US14898282
申请日：2014-06-16
Applicant: Waters Technologies Corporation
Inventor： Robert Dumas , Kurt D. Joudrey , Michael R. Jackson
IPC: G01N30/16 , F04B13/00 , F04B15/08 , F04B53/08 , F04B15/06 , F04B19/22 , F04B23/06 , F04B49/06 , F04B53/06 , F04B53/10 , F04B53/14 , F04B53/16 , G01N30/74 , G01N30/68 , G01N30/72 , G01N30/32 , G01N30/02
Abstract: Systems and methods for pumping carbon dioxide in a chromatography system include an actuator that receives and compresses carbon dioxide at or above room temperature at a given pressure to put the carbon dioxide in or near supercritical form. This actuator can be a pre-pump disposed on the intake side of a pumping system. Alternatively, this actuator can be a primary actuator in the pumping system. The actuator includes an intake chamber that receives the carbon dioxide and a movable plunger extending into and closely received by the intake chamber. The plunger has a diameter and stroke length adapted to compress the carbon dioxide received by the intake chamber in sufficient volume at the given pressure to put the carbon dioxide in or near supercritical form at or above room temperature. A metered amount of the carbon dioxide in or near supercritical form can then be pumped.
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公开(公告)号：US09441996B2
公开(公告)日：2016-09-13
申请号：US14511636
申请日：2014-10-10
Applicant: Waters Technologies Corporation
Inventor： Ryan Hill , Joshua A. Shreve , Robert Dumas , Sylvain Cormier , Edwin Denecke , Kenneth R. Plant , Kurt D. Joudrey
Abstract: The present disclosure relates to phase detection in multi-phase fluids where two fluid phases can be present in the fluid. Phase detection apparatus and methods are disclosed for determining the phase(s) (e.g., supercritical, liquid, and/or gas) of a fluid in a multi-phase fluid system, such as carbon dioxide based separation and chromatography system.
Abstract translation: 本公开涉及在流体中可以存在两个流体相的多相流体中的相位检测。 公开了用于确定多相流体系统中的流体（例如基于二氧化碳的分离和色谱系统）的相（例如超临界，液体和/或气体）的相位检测装置和方法。
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公开(公告)号：US11237137B2
公开(公告)日：2022-02-01
申请号：US15303328
申请日：2015-04-10
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Shreve , Kurt D. Joudrey
Abstract: A column-conditioning enclosure includes a column chamber adapted to hold one or more chromatography separation columns. A duct system provides an airflow path around the column chamber such that the one or more chromatography separation columns held within the column chamber are isolated from the airflow path. An air mover disposed in the airflow path generates a flow of air within the duct system. A heat exchanger system disposed in the airflow path near the air to exchange heat with the air as the air flows past the heat exchanger system. The air circulates through the duct system around the column chamber, convectively exchanging heat with the column chamber to produce a thermally conditioned environment for the one or more chromatography separation columns held within the column chamber.
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Patent Agency Ranking
公开(公告)号：US11105780B2
公开(公告)日：2021-08-31
申请号：US15309421
申请日：2014-05-07
Applicant: Waters Technologies Corporation
Inventor： Sylvain Cormier , Kurt D. Joudrey , Joshua A. Shreve
Abstract: The invention provides compression fittings and methods of assembling compression fittings. In exemplary embodiments, compression fittings are provided that include a fitting body, a ferrule and a tube. For example, the fitting body can be removably coupled to the ferrule when the tube is disposed therethrough.
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公开(公告)号：US10232287B2
公开(公告)日：2019-03-19
申请号：US14382900
申请日：2013-03-04
Applicant: Waters Technologies Corporation
Inventor： Kurt D. Joudrey , Steven D. Trudeau , Paul Keenan , Joseph A. Luongo , Daniel J. McCormick , Eugene Berthiaume
Abstract: An apparatus for use in a liquid chromatography system includes a chromatography port and a tubing assembly having a chromatography tube coupled at one end to the chromatography port. The end of the tube has an end face covered with a corrosion-resistant material, for example, gold. The corrosion-resistant nature of the material protects the end of the tube from corrosion or erosion, which improves the quality and reliability of a seal between the end face of the tube and a sealing surface of the port. Alternatively, or in addition to covering the end face of the tube with the corrosion-resistant material, a gasket covered with or made of the corrosion-resistant material can be disposed between the end face of the tube and the port. This gasket extends the reach of the tube to facilitate bottoming out the tube within the port.
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公开(公告)号：US20180313585A1
公开(公告)日：2018-11-01
申请号：US15565324
申请日：2016-04-07
Applicant: Waters Technologies Corporation
Inventor： Michael R. Jackson , Christopher Seith , Nathan Barrett , Kara O'Donnell , Neal B. Almeida , Wen Lu , James E. Usowicz , Maruth Sok , Kurt D. Joudrey , Joshua A. Shreve
CPC classification number: F25B25/005 , B01D15/40 , G01N30/30
Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling pump heads and providing balanced cooling and heat transfer between multiple pump heads. Multi-pump systems that are used to pump fluids that vary greatly in density with minor changes in temperature, such as the mobile phase of a C02-based chromatography system, require highly stable temperature conditions. In order to achieve a substantially equal average heat transfer between multiple pump heads and a coolant fluid, coolant fluid may be flowed through coolant passageways within the pump heads in a recursive and/or parallel coolant flow patterns. Such recursive and/or parallel coolant fluid flow patterns provide increased stability in temperature, compressibility, and density of the fluids passing through a multi-pump system.
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公开(公告)号：US20170038345A1
公开(公告)日：2017-02-09
申请号：US15303321
申请日：2015-04-10
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Shreve , Kurt D. Joudrey
CPC classification number: G01N30/30 , G01N1/44 , G01N2030/3007
Abstract: A passive pre-heater assembly includes a thermally conductive heat-spreading block and a plurality of passive pre-heaters in thermally conductive communication with the heat-spreading block. The plurality of the pre-heaters exchanges heat with the thermally conductive heat-spreading block. Each pre-heater includes a thermally conductive base in thermal communication with the heat-spreading block, and a plurality of thermally conductive fins is in thermal communication with the thermally conductive base. The plurality of fins of each pre-heater exchanges heat convectively with ambient air and conductively with the thermally conductive base of that pre-heater. A given one of the passive pre-heaters further comprises a tube in thermally conductive contact with the thermally conductive base of the given passive pre-heater. The thermally conductive heat-spreading block exchanges heat with a fluid passing through the tube of the given passive pre-heater.
Abstract translation: 无源预热器组件包括导热散热块和与热扩散块导热连通的多个无源预热器。 多个预热器与导热散热块交换热量。 每个预热器包括与热扩散块热连通的导热基座，并且多个导热翅片与导热基底热连通。 每个预热器的多个散热片与环境空气对流交换热量，并与该预热器的导热底座导电地交换。 被动预热器中的给定的一个还包括与给定的无源预热器的导热底座导热接触的管。 导热散热块与通过给定无源预热器的管的流体进行热交换。
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公开(公告)号：US20150101419A1
公开(公告)日：2015-04-16
申请号：US14511636
申请日：2014-10-10
Applicant: Waters Technologies Corporation
Inventor： Ryan Hill , Joshua A. Shreve , Robert Dumas , Sylvain Cormier , Edwin Denecke , Kenneth R. Plant , Kurt D. Joudrey
IPC: G01F1/74
Abstract: The present disclosure relates to phase detection in multi-phase fluids where two fluid phases can be present in the fluid. Phase detection apparatus and methods are disclosed for determining the phase(s) (e.g., supercritical, liquid, and/or gas) of a fluid in a multi-phase fluid system, such as carbon dioxide based separation and chromatography system.
Abstract translation: 本公开涉及在流体中可以存在两个流体相的多相流体中的相位检测。 公开了用于确定多相流体系统中的流体（例如基于二氧化碳的分离和色谱系统）的相（例如超临界，液体和/或气体）的相位检测装置和方法。
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