Select valve for liquid chromatography

    公开(公告)号:US10751642B2

    公开(公告)日:2020-08-25

    申请号:US14359396

    申请日:2012-12-07

    Abstract: A liquid chromatography system includes a pumping system with a selector valve in fluidic communication with a pump inlet. The selector valve switches between a first position, in which the selector valve fluidically couples a solvent reservoir to the pump inlet, and a second position, in which the selector valve fluidically couples a pressurized source of liquefied carbon dioxide (for example) to the pump inlet. The liquid chromatography system can perform as a HPLC system (or as an UPLC system) when the selector valve is in the first position and as a CO2-based chromatography system when the selector valve is in the second position. The selector valve can have a third position in which both the fluidic pathway between the solvent reservoir and the pump inlet and the fluidic pathway between the pressurized source and the pump inlet are blocked. This shut-off position advantageously facilitates system maintenance.

    Passive column pre-heater for use in chromatographic systems

    公开(公告)号:US10345276B2

    公开(公告)日:2019-07-09

    申请号:US15303321

    申请日:2015-04-10

    Abstract: A passive pre-heater assembly includes a thermally conductive heat-spreading block and a plurality of passive pre-heaters in thermally conductive communication with the heat-spreading block. The plurality of the pre-heaters exchanges heat with the thermally conductive heat-spreading block. Each pre-heater includes a thermally conductive base in thermal communication with the heat-spreading block, and a plurality of thermally conductive fins is in thermal communication with the thermally conductive base. The plurality of fins of each pre-heater exchanges heat convectively with ambient air and conductively with the thermally conductive base of that pre-heater. A given one of the passive pre-heaters further comprises a tube in thermally conductive contact with the thermally conductive base of the given passive pre-heater. The thermally conductive heat-spreading block exchanges heat with a fluid passing through the tube of the given passive pre-heater.

    Convectively controlled adiabatic column chamber for use in chromatographic systems

    公开(公告)号:US11237137B2

    公开(公告)日:2022-02-01

    申请号:US15303328

    申请日:2015-04-10

    Abstract: A column-conditioning enclosure includes a column chamber adapted to hold one or more chromatography separation columns. A duct system provides an airflow path around the column chamber such that the one or more chromatography separation columns held within the column chamber are isolated from the airflow path. An air mover disposed in the airflow path generates a flow of air within the duct system. A heat exchanger system disposed in the airflow path near the air to exchange heat with the air as the air flows past the heat exchanger system. The air circulates through the duct system around the column chamber, convectively exchanging heat with the column chamber to produce a thermally conditioned environment for the one or more chromatography separation columns held within the column chamber.

    Corrosion protection in tubing used chromatography

    公开(公告)号:US10232287B2

    公开(公告)日:2019-03-19

    申请号:US14382900

    申请日:2013-03-04

    Abstract: An apparatus for use in a liquid chromatography system includes a chromatography port and a tubing assembly having a chromatography tube coupled at one end to the chromatography port. The end of the tube has an end face covered with a corrosion-resistant material, for example, gold. The corrosion-resistant nature of the material protects the end of the tube from corrosion or erosion, which improves the quality and reliability of a seal between the end face of the tube and a sealing surface of the port. Alternatively, or in addition to covering the end face of the tube with the corrosion-resistant material, a gasket covered with or made of the corrosion-resistant material can be disposed between the end face of the tube and the port. This gasket extends the reach of the tube to facilitate bottoming out the tube within the port.

    PASSIVE COLUMN PRE-HEATER FOR USE IN CHROMATOGRAPHIC SYSTEMS
    9.
    发明申请
    PASSIVE COLUMN PRE-HEATER FOR USE IN CHROMATOGRAPHIC SYSTEMS 审中-公开
    被动色谱柱预热器用于色谱系统

    公开(公告)号:US20170038345A1

    公开(公告)日:2017-02-09

    申请号:US15303321

    申请日:2015-04-10

    CPC classification number: G01N30/30 G01N1/44 G01N2030/3007

    Abstract: A passive pre-heater assembly includes a thermally conductive heat-spreading block and a plurality of passive pre-heaters in thermally conductive communication with the heat-spreading block. The plurality of the pre-heaters exchanges heat with the thermally conductive heat-spreading block. Each pre-heater includes a thermally conductive base in thermal communication with the heat-spreading block, and a plurality of thermally conductive fins is in thermal communication with the thermally conductive base. The plurality of fins of each pre-heater exchanges heat convectively with ambient air and conductively with the thermally conductive base of that pre-heater. A given one of the passive pre-heaters further comprises a tube in thermally conductive contact with the thermally conductive base of the given passive pre-heater. The thermally conductive heat-spreading block exchanges heat with a fluid passing through the tube of the given passive pre-heater.

    Abstract translation: 无源预热器组件包括导热散热块和与热扩散块导热连通的多个无源预热器。 多个预热器与导热散热块交换热量。 每个预热器包括与热扩散块热连通的导热基座,并且多个导热翅片与导热基底热连通。 每个预热器的多个散热片与环境空气对流交换热量,并与该预热器的导热底座导电地交换。 被动预热器中的给定的一个还包括与给定的无源预热器的导热底座导热接触的管。 导热散热块与通过给定无源预热器的管的流体进行热交换。

    Phase Detection in Multi-Phase Fluids
    10.
    发明申请
    Phase Detection in Multi-Phase Fluids 有权
    多相流相检测

    公开(公告)号:US20150101419A1

    公开(公告)日:2015-04-16

    申请号:US14511636

    申请日:2014-10-10

    CPC classification number: G01F1/74 G01N21/41 G01N30/74

    Abstract: The present disclosure relates to phase detection in multi-phase fluids where two fluid phases can be present in the fluid. Phase detection apparatus and methods are disclosed for determining the phase(s) (e.g., supercritical, liquid, and/or gas) of a fluid in a multi-phase fluid system, such as carbon dioxide based separation and chromatography system.

    Abstract translation: 本公开涉及在流体中可以存在两个流体相的多相流体中的相位检测。 公开了用于确定多相流体系统中的流体(例如基于二氧化碳的分离和色谱系统)的相(例如超临界,液体和/或气体)的相位检测装置和方法。

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