公开(公告)号：US09989459B2

公开(公告)日：2018-06-05

申请号：US14775752

申请日：2014-03-11

Applicant: Waters Technologies Corporation

Inventor： Anthony C. Jeannotte ,  Mark Basile ,  Senthil Bala ,  Colin Fredette

IPC: G01N21/05 ,  G01N30/74 ,  G01N21/41

CPC classification number: G01N21/4133 ,  G01N21/05 ,  G01N30/74 ,  G01N2021/4146

Abstract: The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.

公开(公告)号：US11268902B2

公开(公告)日：2022-03-08

申请号：US15953276

申请日：2018-04-13

Applicant: Waters Technologies Corporation

Inventor： Anthony C. Jeannotte ,  Mark Basile ,  Senthil Bala ,  Colin Fredette

IPC: G01N21/41 ,  G01N21/05 ,  G01N30/74

Abstract: The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.

公开(公告)号：US10585077B2

公开(公告)日：2020-03-10

申请号：US15565347

申请日：2016-04-07

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette

IPC: B01D53/02 ,  G01N30/84 ,  G01N30/32 ,  B01D15/24 ,  G01N30/30 ,  G01N30/62 ,  G01N30/80 ,  B01D15/40 ,  G01N30/82

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as CO2, and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.

公开(公告)号：US20170113171A1

公开(公告)日：2017-04-27

申请号：US15333902

申请日：2016-10-25

Applicant: Waters Technologies Corporation

Inventor： Senthil Bala ,  Colin Fredette ,  Christopher Seith

IPC: B01D45/04 ,  B01D53/02 ,  G01N30/02 ,  B01D45/12

CPC classification number: B01D53/025 ,  B01D11/00 ,  B01D15/24 ,  B01D15/40 ,  B01D19/0052 ,  B01D2011/007 ,  G01N30/84

Abstract: The present technology relates to methodologies, systems and apparatus for separating a liquid and a gas from a multi-phase flow stream. In particular, a gas-liquid separator having a curvilinear flow path sized is described. The flow path is designed to create a shift in the axial velocity of the primary flow field through the gas-liquid separator and generate a secondary flow field effect perpendicular to the primary flow field. The curvilinear flow path can minimize additional dispersion and provide improved efficiencies in fraction collection.

公开(公告)号：US10159913B2

公开(公告)日：2018-12-25

申请号：US15333876

申请日：2016-10-25

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette ,  Maruth Sok ,  Carlos Gomez ,  Joshua A. Shreve

IPC: B01D19/00 ,  B01D15/40 ,  G01N30/14 ,  G01N30/84

Abstract: Methods, systems and apparatus are provided for degassing a supersaturated solution. An example degasser is described having a continuous body of gas-permeable tubing to remove an amount of a gas from the supersaturated solution below the gas's saturation point in the supersaturated solution. The degasser can be connected to at least one of a fraction collector or a detector. The example degasser is sized and/or positioned to cause a change in pressure (ΔP) across the degasser to drive removal of a dissolved gas from a supersaturated solution passing through the degasser. As a result of the reduction of gas, efficiencies in system flow and fraction collection are achieved.

公开(公告)号：US20180231461A1

公开(公告)日：2018-08-16

申请号：US15953276

申请日：2018-04-13

Applicant: Waters Technologies Corporation

Inventor： Anthony C. Jeannotte ,  Mark Basile ,  Senthil Bala ,  Colin Fredette

IPC: G01N21/41 ,  G01N21/05 ,  G01N30/74

CPC classification number: G01N21/4133 ,  G01N21/05 ,  G01N30/74 ,  G01N2021/4146

Abstract: The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.

公开(公告)号：US20180106770A1

公开(公告)日：2018-04-19

申请号：US15565347

申请日：2016-04-07

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette

IPC: G01N30/84 ,  G01N30/80 ,  G01N30/62 ,  G01N30/32 ,  G01N30/30 ,  B01D15/24

CPC classification number: G01N30/84 ,  B01D15/24 ,  B01D15/40 ,  G01N30/30 ,  G01N30/32 ,  G01N30/62 ,  G01N30/80 ,  G01N30/82

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as CO2, and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.

公开(公告)号：US20170136389A1

公开(公告)日：2017-05-18

申请号：US15333876

申请日：2016-10-25

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette ,  Maruth Sok ,  Carlos Gomez ,  Joshua A. Shreve

IPC: B01D19/00 ,  G01N30/14 ,  B01D15/40

CPC classification number: B01D15/40 ,  B01D19/0031 ,  G01N30/84 ,  G01N2030/8423

Abstract: Methods, systems and apparatus are provided for degassing a supersaturated solution. An example degasser is described having a continuous body of gas-permeable tubing to remove an amount of a gas from the supersaturated solution below the gas's saturation point in the supersaturated solution. The degasser can be connected to at least one of a fraction collector or a detector. The example degasser is sized and/or positioned to cause a change in pressure (ΔP) across the degasser to drive removal of a dissolved gas from a supersaturated solution passing through the degasser. As a result of the reduction of gas, efficiencies in system flow and fraction collection are achieved.