公开(公告)号：US10132306B2

公开(公告)日：2018-11-20

申请号：US14612542

申请日：2015-02-03

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith

IPC: F04B49/06 ,  F04B13/02 ,  F04B23/06 ,  F04B49/12 ,  F04B49/20 ,  G01N30/34

Abstract: Described is a method of generating a flow having a composition gradient. A plurality of pump strokes is generated for each pump in a plurality of pumps. Each pump stroke has an initiation time and provides a volume contribution of a liquid to be mixed in the flow according to the composition gradient for the flow. The pump strokes of the pumps are controlled so that a sum of the volume contributions of the liquids that occurs between consecutive initiations of one of the pumps is maintained at a constant value throughout the duration of the flow. For each pump, the flow rates and the times between stroke initiations can change as long as the sum of all volumes contributed between the consecutive initiations of one of the pumps is held constant. Advantageously, the method achieves a constant compositional noise characteristic throughout the duration of the flow.

公开(公告)号：US20150219091A1

公开(公告)日：2015-08-06

申请号：US14612542

申请日：2015-02-03

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith

IPC: F04B49/06 ,  F04B13/02 ,  F04B23/06 ,  F04B49/20 ,  F04B49/12

CPC classification number: F04B49/065 ,  F04B13/02 ,  F04B23/06 ,  F04B49/06 ,  F04B49/12 ,  F04B49/20 ,  G01N30/34

Abstract: Described is a method of generating a flow having a composition gradient. A plurality of pump strokes is generated for each pump in a plurality of pumps. Each pump stroke has an initiation time and provides a volume contribution of a liquid to be mixed in the flow according to the composition gradient for the flow. The pump strokes of the pumps are controlled so that a sum of the volume contributions of the liquids that occurs between consecutive initiations of one of the pumps is maintained at a constant value throughout the duration of the flow. For each pump, the flow rates and the times between stroke initiations can change as long as the sum of all volumes contributed between the consecutive initiations of one of the pumps is held constant. Advantageously, the method achieves a constant compositional noise characteristic throughout the duration of the flow.

Abstract translation: 描述了产生具有组成梯度的流的方法。 在多个泵中为每个泵产生多个泵冲程。 每个泵冲程具有起始时间，并且根据流动的组成梯度提供要在流中混合的液体的体积贡献。 控制泵的泵冲程，使得在整个持续时间期间，在一个泵的连续启动之间发生的液体的体积贡献的总和保持在恒定值。 对于每个泵，只要在一个泵的连续启动之间贡献的所有体积的总和保持恒定，则流速和冲程启动之间的时间可以改变。 有利地，该方法在整个流程的持续时间内实现了恒定的组成噪声特性。

公开(公告)号：US10060886B2

公开(公告)日：2018-08-28

申请号：US14612532

申请日：2015-02-03

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Joshua A. Shreve

IPC: G01N30/34 ,  F04B23/04 ,  F04B49/06

CPC classification number: G01N30/34 ,  F04B23/04 ,  F04B49/065

Abstract: Described is a method of generating a flow having a composition gradient such as a mobile phase gradient for liquid chromatography. A pair of pumps is operated such that the initiations of pump strokes for one pump are controlled to occur between the initiations of pump strokes for the other pump so that the sequences of pump strokes fort the two pumps are interspersed in time. Initiations of the pump strokes of the second pump are offset in time relative to initiations of the pump strokes of the first pump such that variations in the flow rates of the first and second pumps due to initiation do not overlap in time. The volume of liquid contributed by a pump stroke is controlled according to the relative contribution of the respective pump to the composition gradient.

公开(公告)号：US20150336026A1

公开(公告)日：2015-11-26

申请号：US14696572

申请日：2015-04-27

Applicant: Waters Technologies Corporation

Inventor： Neal B. Almeida ,  Christopher Seith ,  Michael R. Jackson ,  John Angelosanto ,  Joseph A. Jarrell

IPC: B01D15/18 ,  G01N30/26

CPC classification number: B01D15/18 ,  G01N30/26 ,  G01N30/34 ,  Y10T137/0424 ,  Y10T137/4259

Abstract: Described is a method for purging a fluid channel is a low pressure gradient formation liquid flow system. Control of the fluid channels for multiple solvents allows for one or more static volumes of solvents not intended for use in an isocratic flow to be purged from their fluid channels to avoid contamination of the isocratic solvent. Advantageously, the method avoids the need to modify equipment or to reconfigure a pumping system so that the inlet is directly coupled to a single solvent source. Thus there is no need to bypass existing valves and liquid coupling components where solvents are combined during conventional gradient operation.

Abstract translation: 描述了一种清洗流体通道的方法是低压梯度形成液体流动系统。 用于多种溶剂的流体通道的控制允许一个或多个静态体积的溶剂不用于从其流体通道中清除等度流，以避免污染等度溶剂。 有利地，该方法避免了修改设备或重新配置泵送系统的需要，使得入口直接耦合到单个溶剂源。 因此，在常规梯度操作期间，不需要绕过现有的阀和液体耦合部件，其中溶剂被组合。

公开(公告)号：US20190264670A1

公开(公告)日：2019-08-29

申请号：US16263013

申请日：2019-01-31

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  Christopher Seith

IPC: F04B15/08 ,  B01D15/40 ,  G01N30/32

Abstract: Described is an apparatus for providing a fluid at an increased pressure. The apparatus has a range of applications including use with carbon dioxide-based chromatography systems to achieve accurate flow rate control for a carbon dioxide pump. The apparatus includes a thermally-controlled chamber, chamber inlet and outlet check valves, and a temperature controller to control a temperature of fluid inside the chamber. The apparatus also includes a capacitance chamber in fluidic communication with the outlet check valve. A flow of gas passes into the chamber through the inlet check valve when a fluid pressure inside the chamber is less than an inlet fluid pressure and out from the chamber through the outlet check valve when the fluid pressure inside the chamber is greater than an outlet fluid pressure. Thermal control of the chamber allows accurate control of the gas flow into and out from the chamber.

公开(公告)号：US20180313585A1

公开(公告)日：2018-11-01

申请号：US15565324

申请日：2016-04-07

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Nathan Barrett ,  Kara O'Donnell ,  Neal B. Almeida ,  Wen Lu ,  James E. Usowicz ,  Maruth Sok ,  Kurt D. Joudrey ,  Joshua A. Shreve

IPC: F25B25/00 ,  B01D15/40 ,  B01D15/18 ,  G01N30/30

CPC classification number: F25B25/005 ,  B01D15/40 ,  G01N30/30

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling pump heads and providing balanced cooling and heat transfer between multiple pump heads. Multi-pump systems that are used to pump fluids that vary greatly in density with minor changes in temperature, such as the mobile phase of a C02-based chromatography system, require highly stable temperature conditions. In order to achieve a substantially equal average heat transfer between multiple pump heads and a coolant fluid, coolant fluid may be flowed through coolant passageways within the pump heads in a recursive and/or parallel coolant flow patterns. Such recursive and/or parallel coolant fluid flow patterns provide increased stability in temperature, compressibility, and density of the fluids passing through a multi-pump system.

公开(公告)号：US09770678B2

公开(公告)日：2017-09-26

申请号：US14687290

申请日：2015-04-15

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Steven J. Ciavarini ,  Kara O'Donnell ,  John Angelosanto ,  John Leason

IPC: B01D19/00 ,  B01D15/08 ,  B01D15/16 ,  G01N30/26 ,  G01N30/14 ,  G01N30/34

CPC classification number: B01D19/0073 ,  B01D15/08 ,  B01D15/16 ,  B01D19/0036 ,  B01D19/0063 ,  B01D19/0068 ,  G01N30/14 ,  G01N30/26 ,  G01N30/34

Abstract: Described is a method for vacuum degassing of a liquid such as a solvent for a liquid chromatography system. The method includes modulating application of a vacuum to a fluid channel of a degasser so that each volume of a liquid drawn from the degasser experiences a residence time that is equal to the residence times of the other volumes. The residence time is determined as a time that the volume resides in the fluid channel under application of the vacuum and to a magnitude of the applied vacuum. The method is advantageous for use with liquid chromatography systems where differences in the diffusion rates of solvents into the degasser vacuum can otherwise introduce error into the composition gradient of a mobile phase.

公开(公告)号：US10585077B2

公开(公告)日：2020-03-10

申请号：US15565347

申请日：2016-04-07

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette

IPC: B01D53/02 ,  G01N30/84 ,  G01N30/32 ,  B01D15/24 ,  G01N30/30 ,  G01N30/62 ,  G01N30/80 ,  B01D15/40 ,  G01N30/82

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as CO2, and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.

公开(公告)号：US09744477B2

公开(公告)日：2017-08-29

申请号：US14696572

申请日：2015-04-27

Applicant: Waters Technologies Corporation

Inventor： Neal B. Almeida ,  Christopher Seith ,  Michael R. Jackson ,  John Angelosanto ,  Joseph A. Jarrell

IPC: F16K11/22 ,  B01D15/18 ,  G01N30/26 ,  G01N30/34

CPC classification number: B01D15/18 ,  G01N30/26 ,  G01N30/34 ,  Y10T137/0424 ,  Y10T137/4259

Abstract: Described is a method for purging a fluid channel is a low pressure gradient formation liquid flow system. Control of the fluid channels for multiple solvents allows for one or more static volumes of solvents not intended for use in an isocratic flow to be purged from their fluid channels to avoid contamination of the isocratic solvent. Advantageously, the method avoids the need to modify equipment or to reconfigure a pumping system so that the inlet is directly coupled to a single solvent source. Thus there is no need to bypass existing valves and liquid coupling components where solvents are combined during conventional gradient operation.

公开(公告)号：US20170113171A1

公开(公告)日：2017-04-27

申请号：US15333902

申请日：2016-10-25

Applicant: Waters Technologies Corporation

Inventor： Senthil Bala ,  Colin Fredette ,  Christopher Seith

IPC: B01D45/04 ,  B01D53/02 ,  G01N30/02 ,  B01D45/12

CPC classification number: B01D53/025 ,  B01D11/00 ,  B01D15/24 ,  B01D15/40 ,  B01D19/0052 ,  B01D2011/007 ,  G01N30/84

Abstract: The present technology relates to methodologies, systems and apparatus for separating a liquid and a gas from a multi-phase flow stream. In particular, a gas-liquid separator having a curvilinear flow path sized is described. The flow path is designed to create a shift in the axial velocity of the primary flow field through the gas-liquid separator and generate a secondary flow field effect perpendicular to the primary flow field. The curvilinear flow path can minimize additional dispersion and provide improved efficiencies in fraction collection.