公开(公告)号：US20090024181A1

公开(公告)日：2009-01-22

申请号：US12116765

申请日：2008-05-07

申请人： Raghu Raghavan ,  Stuart A. Grossman

发明人： Raghu Raghavan ,  Stuart A. Grossman

IPC分类号： A61N1/00 ,  A61B19/00 ,  A61B5/05 ,  G06G7/48

CPC分类号： A61B34/10 ,  A61B6/461 ,  A61B6/481 ,  A61B6/501 ,  A61B90/00 ,  A61B2034/101 ,  A61B2034/252 ,  A61N2005/1021 ,  G06F19/00 ,  G06F19/321 ,  G06T7/0012 ,  G06T2207/30016 ,  G16H50/50 ,  Y02A90/24 ,  Y02A90/26

摘要： A treatment simulator for providing information on physiological states and effects of treatment of neurological disease, comprising a computer, and an application configured to operate with the computer. The application is capable of: obtaining radiological imaging from the brain; obtaining anatomical information from the radiological imaging within a region of interest within the brain; constructing a physiological states model which assesses physiological states of the region of interest; locating sources of interstitial flow of particulate matter and obtaining fluid conductivities of paths of the interstitial flow utilizing the anatomical information and the physiological states model; and creating a flow model of the particulate matter which assesses velocities of flow and interstitial pressure variations utilizing the sources of interstitial flow and the fluid conductivities.

摘要翻译： 一种用于提供关于神经系统疾病的治疗的生理状况和效果的信息的治疗模拟器，包括计算机以及被配置为与所述计算机一起操作的应用。 该应用能够：从脑获得放射成像; 从大脑内感兴趣的区域内的放射成像获得解剖信息; 构建评估感兴趣区域的生理状态的生理状态模型; 利用解剖信息和生理状态模型确定颗粒物质的间质流的来源并获得间质流的路径的流体电导率; 并创建颗粒物质的流动模型，其使用间隙流和流体电导率来评估流动速率和间隙压力变化。

公开(公告)号：US09265577B2

公开(公告)日：2016-02-23

申请号：US12116765

申请日：2008-05-07

申请人： Raghu Raghavan ,  Stuart A. Grossman

发明人： Raghu Raghavan ,  Stuart A. Grossman

IPC分类号： A61B19/00 ,  G06T7/00 ,  G06F19/00

CPC分类号： A61B34/10 ,  A61B6/461 ,  A61B6/481 ,  A61B6/501 ,  A61B90/00 ,  A61B2034/101 ,  A61B2034/252 ,  A61N2005/1021 ,  G06F19/00 ,  G06F19/321 ,  G06T7/0012 ,  G06T2207/30016 ,  G16H50/50 ,  Y02A90/24 ,  Y02A90/26

摘要： Methods and systems for providing planning and dispensation of research and/or treatment for brain disease. Radiological information is generated in a region of interest in an area of the a brain of an individual using a radiological imaging system. A physiological states model is constructed which assesses physiological states of the region of interest. Locations of sources of interstitial fluid flow, fluid conductivities of paths, and anatomical information in the region of interest are obtained using the radiological imaging information. Velocities of the interstitial fluid flow in the region of interest are computed using the physiological states model, the locations of sources of interstitial flow, the fluid conductivities, and the anatomic information. A model of the area of the brain is created, the model including the region of interest.

摘要翻译： 提供脑部疾病的研究和/或治疗的规划和分配的方法和系统。 使用放射线成像系统在个体的大脑的区域中的感兴趣区域中产生放射线信息。 构建了一个生理状态模型，评估感兴趣区域的生理状态。 使用放射成像信息获得组织液流的来源的位置，路径的流体电导率和感兴趣区域中的解剖信息。 使用生理状态模型，间质流源，流体电导率和解剖信息来计算感兴趣区域中的间质液流的速度。 创建大脑区域的模型，该模型包括感兴趣的区域。

公开(公告)号：US20120215157A1

公开(公告)日：2012-08-23

申请号：US13208756

申请日：2011-08-12

申请人： James G. Berryman ,  Raghu Raghavan

发明人： James G. Berryman ,  Raghu Raghavan

IPC分类号： A61M37/00 ,  F17D3/01

CPC分类号： A61B8/481 ,  A61B5/4839 ,  A61B8/0816 ,  A61B8/0833 ,  A61B34/73 ,  A61N7/00 ,  G01N29/0654 ,  G01N2291/02836 ,  Y10T137/0391 ,  Y10T137/206

摘要： The present invention provides for a method of controlling mass movement of fluid material within a field of interest comprising using time reversal acoustic focusing. The time reversal acoustic focusing can be is used for simultaneous spatial and temporal focusing of acoustic energy to control the duration of localization and/or direction of movement of material within tissue or liquid within tissue. Both delivery of material and persistence with respect to target locations can be enhanced by focusing of sonic waveforms or transmissions towards targeted areas in a field of interest, such as within a patient.

摘要翻译： 本发明提供一种在感兴趣的领域内控制流体材料的质量移动的方法，包括使用时间反转声聚焦。 时间反转声聚焦可以用于声能的同时空间和时间聚焦以控制在组织内的组织或液体内的材料的定位和/或运动方向的持续时间。 可以通过将声波形或发射集中在感兴趣的领域（例如患者体内）中的目标区域来增强相对于目标位置的物质输送和持久性。

公开(公告)号：US20100030102A1

公开(公告)日：2010-02-04

申请号：US12226579

申请日：2007-05-14

申请人： David Poston ,  Raghu Raghavan ,  Martin L. Brady

发明人： David Poston ,  Raghu Raghavan ,  Martin L. Brady

IPC分类号： A61B5/03 ,  A61M25/00 ,  A61M25/10 ,  G06F15/18 ,  G06N5/04

CPC分类号： A61B17/3401 ,  A61B17/3421 ,  A61B17/3478 ,  A61B2017/3407 ,  A61B2017/3419 ,  A61F2/82 ,  A61M25/0021 ,  A61M25/0029 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/0074 ,  A61M2025/0036 ,  A61M2025/0042 ,  A61M2025/0096 ,  A61M2025/0681

摘要： A medical device and method for planning or performing a method for delivering material through tissue into a defined area of a patient may comprise: a material delivery element through which the material may flow out of a delivery end; and observing the migration, flow and persistence of material delivered and developing an plan or optimizing a plan for the delivery of material into the defined area. Novel catheter devices are provided to support these methods.

摘要翻译： 用于规划或执行将材料通过组织递送到患者的限定区域中的方法的医疗装置和方法可以包括：材料递送元件，材料可以通过该材料输送元件从输送端流出; 并观察所交付材料的迁移，流动和持久性，制定计划或优化将材料运送到规定区域的计划。 提供新颖的导管装置来支持这些方法。

公开(公告)号：US20050265589A1

公开(公告)日：2005-12-01

申请号：US11063662

申请日：2005-02-23

申请人： Raghu Raghavan ,  Timothy Poston ,  John Kucharczyk

发明人： Raghu Raghavan ,  Timothy Poston ,  John Kucharczyk

IPC分类号： A61B5/055 ,  A61B6/03 ,  G06F19/00 ,  G06K9/00 ,  G06K9/34 ,  A61B5/05

CPC分类号： G06F19/3481 ,  A61B5/055 ,  A61B6/03 ,  G06F19/00 ,  G06F19/3456 ,  G16H50/50

摘要： A method supplies a dynamic vector map of properties within a region or a unified suite of quantification functionality for property functions, such as density functions, conduction functions (e.g., thermal conduction, electrical conduction, atomic or subatomic mass conduction, macromolecular mass conduction), defined on, defined in or defining a three-dimensional space, which functions may optionally vary in time. At least two services assisting in the definition of the map or suite, even in a dynamic modality, are selected from: (a) computation of the volume of the region where the density lies above or below a specified threshold, or between two specified values; (b) computation of the integral of the density; (c) estimation of the rate of change of the density with respect to time, optionally restricted to a specified region; (d) estimation of the local or global failure of conservation represented by changes with time in the density; (e) estimation of the local or global rate at which material with a changing density is passing through a specified surface (e.g., boundary); and (f) separation of the density of a material with a changing density, given an implemented transport model, into “free” and “bound” densities.

摘要翻译： 一种方法提供属性功能范围内的属性的动态向量图或属性函数的统一的量化功能，例如密度函数，传导函数（例如，热传导，导电，原子或亚原子质量传导，大分子质量传导） 定义在，定义或定义三维空间，哪些功能可以可选地在时间上变化。 即使在动态模式中，帮助定义地图或套件的至少两个服务可从以下选项中选择：（a）计算密度高于或低于指定阈值或两个指定值之间的区域的体积 ; （b）密度积分的计算; （c）可选地限制在特定区域内的密度相对于时间的变化率的估计; （d）以密度随时间变化而表示的地方或全球保护失效的估计; （e）估计具有变化密度的材料通过指定表面（例如边界）的局部或全局速率; （f）将已实施的运输模式，以密度变化的材料密度分离为“自由”和“限制”密度。

公开(公告)号：US20050186544A1

公开(公告)日：2005-08-25

申请号：US10771545

申请日：2004-02-05

申请人： Raghu Raghavan ,  Timothy Poston

发明人： Raghu Raghavan ,  Timothy Poston

IPC分类号： G09B23/28 ,  G09B23/30

CPC分类号： G09B23/30 ,  G06F17/5018

摘要： A method and system for mapping anatomical connection and signaling across a multiplicity of channels, channel contents, and channel speed. In particular, the anatomical connection and signaling is mapped in relation to the human brain. Constructs a three-dimensional, dynamically structured, active model, for general or individual patterns. Uses for the present invention include: risk reduction in surgery to significant channels; planning cell insertion at sites where they can be expected to migrate to a less reachable target site; guiding searches for metastatic tumors; indirectly localizing brain structures; constructing models of disease in which multiple sites are involved in the deficit and any proposed repair; and building simulation of normal processes which require the sequential interaction of multiple sites.

摘要翻译： 用于在多个信道，信道内容和信道速度上映射解剖连接和信令的方法和系统。 特别地，解剖学连接和信号被映射到与人的大脑相关联。 构建一个三维，动态结构化的活动模型，用于一般或单个模式。 本发明的用途包括：手术对重要通道的风险降低; 在可以预期迁移到较少可达目标站点的地点规划单元插入; 指导性搜索转移性肿瘤; 间接定位脑结构; 构建多个地点涉及赤字和任何拟议修复的疾病模式; 并构建需要多个站点顺序交互的正常进程的模拟。

公开(公告)号：US09757543B2

公开(公告)日：2017-09-12

申请号：US14229876

申请日：2014-03-29

申请人： Raghu Raghavan ,  Martin Brady

发明人： Raghu Raghavan ,  Martin Brady

IPC分类号： A61M31/00 ,  A61M37/00 ,  A61M25/10

CPC分类号： A61M25/10 ,  A61M2025/105 ,  A61M2025/1086

摘要： Surgery is performed on a patient with a novel device by: excising tissue from tissue mass within a patient to create a cavity within the tissue mass; inserting a novel device of this invention into the cavity; shaping a flexible expandable component of the device to adjust dimensions on the flexible expandable component; providing a liquid into the component through the liquid input port; and controlling pressure or flow rate of the liquid in the component to move the liquid through the multiple openings and into the cavity. The device has a liquid inlet port, an exterior surface having length, width and depth, and multiple openings in the surface distributed throughout the length, width and depth to act as liquid delivery ports; the exterior surface of the liquid delivery device being shapeable by internal pneumatic pressure or hydraulic pressure to better fit inside dimensions of a surgical cavity; the multiple openings deliver the liquid through the multiple openings.

公开(公告)号：US09101282B2

公开(公告)日：2015-08-11

申请号：US11534383

申请日：2006-09-22

申请人： Andreas Hartlep ,  Christoph Pedain ,  Martin Brady ,  Raghu Raghavan

发明人： Andreas Hartlep ,  Christoph Pedain ,  Martin Brady ,  Raghu Raghavan

IPC分类号： A61B5/055 ,  G01R33/56 ,  A61B5/00 ,  G06T7/00

CPC分类号： A61B5/055 ,  A61B5/0042 ,  A61B5/4064 ,  A61B5/7264 ,  A61B2576/026 ,  G01R33/5608 ,  G06T7/12 ,  G06T2207/10088 ,  G06T2207/30016

摘要： A medical imaging processing method includes: using an imaging method to acquire at least first and second data sets of a region of interest of a patient's body, with at least one image acquisition parameter being changed so that first and second data sets yield different contrast levels relating to different substance and/or tissue types, and wherein the at least one acquisition parameter used to obtain the first data set is selected to enhance the contrast between one of the substance and/or tissue types relative to other substance and/or tissue types, and the at least one acquisition parameter used to obtain the second data set is selected to enhance the contrast between a different one of the substance and/or tissue types relative other substance and/or tissue types, thereby to optimize the contrast between at least three different substance and/or tissue types; and processing the two data sets to identify the different tissue types and/or boundaries therebetween.

摘要翻译： 医疗成像处理方法包括：使用成像方法来获取患者身体的至少一个感兴趣区域的数据集，其中至少一个图像获取参数被改变，使得第一和第二数据组产生不同的对比度 涉及不同的物质和/或组织类型，并且其中用于获得第一数据集的至少一个采集参数被选择以增强物质和/或组织类型之一相对于其他物质和/或组织类型之间的对比度 ，并且选择用于获得第二数据集的至少一个采集参数以增强物质和/或组织类型之间的不同物质与其他物质和/或组织类型之间的对比度，从而优化至少 三种不同的物质和/或组织类型; 并且处理两个数据集以识别其间的不同组织类型和/或边界。

公开(公告)号：US20150173715A1

公开(公告)日：2015-06-25

申请号：US14568138

申请日：2014-12-12

申请人： Raghu Raghavan ,  Timothy Poston

发明人： Raghu Raghavan ,  Timothy Poston

IPC分类号： A61B8/00 ,  G09B23/28 ,  A61B8/08 ,  A61B8/14 ,  A61B8/02

CPC分类号： A61B8/46 ,  A61B8/4245 ,  A61B8/4254 ,  A61B8/52 ,  A61B8/5207 ,  A61B8/5223 ,  A61B8/565 ,  G06F19/00 ,  G06F19/321 ,  G06T7/0012 ,  G09B23/286 ,  G16H30/00 ,  G16H30/20 ,  G16H30/40 ,  G16H40/00 ,  G16H40/67

摘要： A local user obtains data on the response of internal tissues of a subject to a non-invasive imaging system, choosing sensor positions according to a geometric display. The data obtained are evaluated with respect to predefined quantitative values. The process of obtaining and processing the internal tissue response data is repeated until an image meeting predetermined image quality characteristics is obtained. Specific or general content of the image may be restricted by the local processor, with a distal processor receiving the obtained image data, so as to limit specific or general types of image information from being viewed by the local user, such as image data that can be used to identify the sex of a fetus within the subject.

摘要翻译： 本地用户获取关于受试者的内部组织对非侵入性成像系统的响应的数据，根据几何显示来选择传感器位置。 所获得的数据相对于预定义的定量值进行评估。 重复获取和处理内部组织响应数据的过程，直到获得满足预定图像质量特性的图像。 图像的特定或一般内容可能受到本地处理器的限制，远端处理器接收所获得的图像数据，以便限制本地用户观看的特定或一般类型的图像信息，诸如可以 用于确定受试者内胎儿的性别。

公开(公告)号：US08582397B2

公开(公告)日：2013-11-12

申请号：US12945048

申请日：2010-11-12

申请人： Raghu Raghavan ,  Timothy Poston

发明人： Raghu Raghavan ,  Timothy Poston

IPC分类号： G10K11/34

CPC分类号： G10K11/346 ,  A61M37/00 ,  Y10T137/206

摘要： Known time reversal methods consist of three steps which may be listed as (i) the recording of signals and (ii) the time reversing of the recorded signals, and (iii) the transmission of the time-reversed signals. The first and third steps of the above process are retained, but the second step is modified. The empirical signal is transformed to fit mathematical forms taught by the mathematics of singularity and catastrophe theory that ensure a structural stability to the waveforms that will be received, when the time reversed signals are transmitted again. This structural stability ensures robustness of the waveform and the predominant direction of the flux of energy of the waveform, and improves controllability of the location of the high magnitude regions of the energy flux despite limited knowledge of the exact properties of the medium. Applications to drug delivery in the brain, and geophysical applications are envisaged.

摘要翻译： 已知的时间反转方法由三个步骤组成，可以列为：（i）信号的记录和（ii）记录信号的时间反转，以及（iii）时间反转信号的传输。 上述过程的第一和第三步骤被保留，但第二步被修改。 经验信号被转换为适合数学形式教授的奇点和灾难理论的数学，确保结构稳定的波形将被接收，当时间反转信号被再次传输。 这种结构稳定性确保波形的鲁棒性和波形能量通量的主要方向，并且尽管对介质的确切性质有所了解，但是提高了能量通量的高幅度区域的位置的可控性。 应用于大脑中的药物递送以及地球物理应用。