公开(公告)号：US20140128421A1

公开(公告)日：2014-05-08

申请号：US14112583

申请日：2012-04-13

申请人： Wei Lv ,  Shanbao Yu ,  Yu Luo ,  Yi Chen ,  Jian Ding

发明人： Wei Lv ,  Shanbao Yu ,  Yu Luo ,  Yi Chen ,  Jian Ding

IPC分类号： C07D491/22

CPC分类号： C07D491/22

摘要： Provided are a camptothecin compound containing 7-membered lactone ring, as shown in general formula I, and pharmaceutically acceptable salt thereof, as well as the preparation method and use thereof. In general formula I, R1 is H, a C1˜C3 alkyl, acetyl or propionyl; R2 is H, a C1˜C6 alkyl, a C3˜C6 cycloalkyl, piperidyl; or a C1˜C6 alkyl substituted by an amino; R3 is H, a C1˜C3 alkyl, or a C1˜C6 alkyl substituted by an amino; R4 is H, a hydroxyl, or a C1˜C6 alkoxy; R5 is H, or a C1˜C6 alkoxyl; or R4 and R5 are linked to each other to form —OCH2O— or —OCH2CH2O—. The compound has good anti-tumor activity, and can be clinically used via oral administration, intravenous injection, and intramuscular injection, among others.

摘要翻译： 提供了如通式I所示的含有7-元内酯环的喜树碱化合物及其药学上可接受的盐以及其制备方法和用途。 在通式Ⅰ中，R 1是H，C 1 -C 3烷基，乙酰基或丙酰基; R2是H，C1〜C6烷基，C3〜C6环烷基，哌啶基; 或被氨基取代的C 1-6烷基; R3是H，C1〜C3烷基或被氨基取代的C1〜C6烷基; R4是H，羟基或C1〜C6烷氧基; R5是H或C1〜C6烷氧基; 或R 4和R 5彼此连接形成-OCH 2 O-或-OCH 2 CH 2 O-。 该化合物具有良好的抗肿瘤活性，可以通过口服给药，静脉内注射和肌内注射等临床使用。

公开(公告)号：US09115150B2

公开(公告)日：2015-08-25

申请号：US14112583

申请日：2012-04-13

申请人： Wei Lv ,  Shanbao Yu ,  Yu Luo ,  Yi Chen ,  Jian Ding

发明人： Wei Lv ,  Shanbao Yu ,  Yu Luo ,  Yi Chen ,  Jian Ding

IPC分类号： C07D491/22

CPC分类号： C07D491/22

摘要： Provided are a camptothecin compound containing 7-membered lactone ring, as shown in general formula I, and pharmaceutically acceptable salt thereof, as well as the preparation method and use thereof. In general formula I, R1 is H, a C1˜C3 alkyl, acetyl or propionyl; R2 is H, a C1˜C6 alkyl, a C3˜C6 cycloalkyl, piperidyl; or a C1˜C6 alkyl substituted by an amino; R3 is H, a C1˜C3 alkyl, or a C1˜C6 alkyl substituted by an amino; R4 is H, a hydroxyl, or a C1˜C6 alkoxy; R5 is H, or a C1˜C6 alkoxyl; or R4 and R5 are linked to each other to form —OCH2O— or —OCH2CH2O—. The compound has good anti-tumor activity, and can be clinically used via oral administration, intravenous injection, and intramuscular injection, among others.

摘要翻译： 提供了如通式I所示的含有7-元内酯环的喜树碱化合物及其药学上可接受的盐以及其制备方法和用途。 在通式I中，R 1是H，C 1 -C 3烷基，乙酰基或丙酰基; R2是H，C1〜C6烷基，C3〜C6环烷基，哌啶基; 或被氨基取代的C 1-6烷基; R3是H，C1〜C3烷基或被氨基取代的C1〜C6烷基; R4是H，羟基或C1〜C6烷氧基; R5是H或C1〜C6烷氧基; 或R 4和R 5彼此连接形成-OCH 2 O-或-OCH 2 CH 2 O-。 该化合物具有良好的抗肿瘤活性，可以通过口服给药，静脉内注射和肌内注射等临床使用。

公开(公告)号：USD861923S1

公开(公告)日：2019-10-01

申请号：US29641469

申请日：2018-03-22

申请人： Yu Luo

设计人： Yu Luo

公开(公告)号：US08920623B2

公开(公告)日：2014-12-30

申请号：US12589302

申请日：2009-10-21

申请人： Yu Luo ,  Neil D. Brown ,  Michael P. Toben

发明人： Yu Luo ,  Neil D. Brown ,  Michael P. Toben

IPC分类号： C25D21/18 ,  C25D3/30 ,  C25D3/60

CPC分类号： C25D3/30 ,  C25D3/60 ,  C25D21/18

摘要： Methods are disclosed for replenishing tin and its alloying metals in an aqueous electrolytic plating bath using an acidic solution containing stannous oxide. During electroplating of tin or tin alloys the stannous ions and alloying metal ions are depleted. To maintain continuous and efficient electroplating processes predetermined amounts of the plating bath containing tin and its alloying metals are bailed out. The bail out is then mixed with a predetermined amount of acidic solution containing stannous oxide and any alloying metals. The mixture is then retuned to the plating bath to return the stannous ions and alloying metal ions to their steady state concentrations.

摘要翻译： 公开了使用含有氧化亚锡的酸性溶液在水性电解电镀槽中补充锡及其合金金属的方法。 在锡或锡合金电镀期间，亚锡离子和合金金属离子耗尽。 为了保持连续而有效的电镀工艺，预先规定量的含有锡及其合金金属的镀浴被调出。 然后将保释与预定量的含有氧化亚锡和任何合金金属的酸性溶液混合。 然后将混合物回到电镀浴中，以将亚锡离子和合金化金属离子返回到其稳态浓度。

公开(公告)号：US08888984B2

公开(公告)日：2014-11-18

申请号：US13370181

申请日：2012-02-09

申请人： Inho Lee ,  Elissei Iagodkine ,  Yi Qin ,  Yu Luo

发明人： Inho Lee ,  Elissei Iagodkine ,  Yi Qin ,  Yu Luo

IPC分类号： C25D3/60 ,  C25D7/12 ,  C25D3/56 ,  C25D3/64

CPC分类号： C25D3/60 ,  C25D3/56 ,  C25D3/64 ,  C25D7/00 ,  C25D7/12 ,  C25D7/123

摘要： Tin-silver alloy electroplating baths having certain amine-oxide surfactants and methods of electrodepositing a tin-silver-containing layer using these baths are disclosed. Such electroplating baths are useful to provide tin-silver solder deposits having reduced void formation and improved within-die uniformity.

摘要翻译： 公开了具有某些氧化胺表面活性剂的锡 - 银合金电镀浴和使用这些浴电沉积含锡银层的方法。 这种电镀浴可用于提供具有减小的空隙形成和改进的管芯内均匀性的锡 - 银焊料沉积物。

公开(公告)号：US08858243B2

公开(公告)日：2014-10-14

申请号：US13713004

申请日：2012-12-13

申请人： Yu Luo ,  Hong-Jing Luo ,  Xing-Liang Liu

发明人： Yu Luo ,  Hong-Jing Luo ,  Xing-Liang Liu

IPC分类号： H01R13/648 ,  H01R13/652 ,  H01R13/6471 ,  H01R31/08

CPC分类号： H01R13/652 ,  H01R13/6471 ,  H01R31/08

摘要： An electrical connector includes a housing including a base portion and a tongue portion and contacts. The contacts include contacting plate at the tongue portion, leg portion extending from the rear and retaining portions retained in the base portion. The contacts includes a first group and second group, each group including ground contacts and signal contacts. The contacting plates of the first group are located along a first side face of the tongue portion, the contacting plate of the second group are located along an opposite second side face, the retaining portions of the first and second groups being spaced from each other. A one-piece grounding bar is retained in the base portion, the ground bar includes a beam portion hidden in the base portion and between said retaining portions of the first group and second groups, and fingers touch with corresponding retaining portions of ground contacts.

摘要翻译： 电连接器包括壳体，其包括基部和舌部以及接触。 触点包括在舌部处的接触板，从后部延伸的腿部和保持在基部中的保持部。 触点包括第一组和第二组，每组包括接地触点和信号触点。 第一组的接触板沿着舌部的第一侧面定位，第二组的接触板沿着相对的第二侧面定位，第一组和第二组的保持部彼此间隔开。 一体式接地棒保持在基部中，接地棒包括隐藏在基部中的梁部分和第一组和第二组的所述保持部分之间的手指部分，并且手指与相应的接地保持部分接触。

公开(公告)号：US08702451B2

公开(公告)日：2014-04-22

申请号：US13459084

申请日：2012-04-28

申请人： Yu Luo ,  Xing-Liang Liu

发明人： Yu Luo ,  Xing-Liang Liu

IPC分类号： H01R13/648

CPC分类号： H01R12/725 ,  H01R13/6471

摘要： sa An electrical connector includes an insulating housing defining an uninterrupted tongue portion with opposite first surface and second surface and a plurality of contacts loaded in the tongue portion. The contacts includes a first group of contacts with first contacting portions loaded in the first surface, a second group of contacts with second contacting portions loaded in the second surface. Each of the first and second group of contacts is composed of signal contacts and grounding contacts and a connecting bar is assembled to electrically connect at least one first grounding contact and one second grounding contact.

摘要翻译： sa电连接器包括绝缘壳体，其限定具有相对的第一表面和第二表面的不间断的舌部分以及装载在舌部中的多个触点。 触头包括第一组触点，其中第一接触部分装载在第一表面中，第二组触点具有装载在第二表面中的第二接触部分。 第一和第二组触点中的每一个由信号触点和接地触点组成，并且连接杆被组装以电连接至少一个第一接地触点和一个第二接地触点。

公开(公告)号：US08523615B2

公开(公告)日：2013-09-03

申请号：US13313018

申请日：2011-12-07

申请人： Yu Luo ,  Xing-Liang Liu

发明人： Yu Luo ,  Xing-Liang Liu

IPC分类号： H01R12/00

CPC分类号： H01R13/2435 ,  H01R12/7082 ,  H01R12/714 ,  H01R12/73

摘要： A compression connector for mounting to a print circuit board includes an insulative housing and a plurality of terminals received in the housing. The housing includes a first mating surface and a second mating surface opposite to the first mating surface. A number of terminal passageways are disposed between and running through the first and second mating faces. Each terminal includes a retaining section. Each of terminal passageway defines a retaining slot along a height direction orienting from the first mating surface to the second mating surface to receive the retaining section of the terminal and two limited portions at two ends of the retaining slot in the height direction so as to allow the retaining section to move in the height direction without dropping out.

摘要翻译： 用于安装到印刷电路板的压缩连接器包括绝缘壳体和容纳在壳体中的多个端子。 壳体包括第一配合表面和与第一配合表面相对的第二配合表面。 多个端子通道设置在第一和第二配合面之间并且穿过第一和第二配合面。 每个终端包括保持部分。 每个终端通道沿着从第一配合表面定向到第二配合表面的高度方向限定一个保持狭槽，以便在高度方向上容纳端子的保持部分和两个限制部分在保持槽的两端，以便允许 保持部分在高度方向上移动而不脱落。

公开(公告)号：USD651177S1

公开(公告)日：2011-12-27

申请号：US29378636

申请日：2010-11-08

申请人： Yu Luo

设计人： Yu Luo

公开(公告)号：US20100116674A1

公开(公告)日：2010-05-13

申请号：US12589302

申请日：2009-10-21

申请人： Yu Luo ,  Neil D. Brown ,  Michael P. Toben

发明人： Yu Luo ,  Neil D. Brown ,  Michael P. Toben

IPC分类号： C25D21/18

CPC分类号： C25D3/30 ,  C25D3/60 ,  C25D21/18

摘要： Methods are disclosed for replenishing tin and its alloying metals in an aqueous electrolytic plating bath using an acidic solution containing stannous oxide. During electroplating of tin or tin alloys the stannous ions and alloying metal ions are depleted. To maintain continuous and efficient electroplating processes predetermined amounts of the plating bath containing tin and its alloying metals are bailed out. The bail out is then mixed with a predetermined amount of acidic solution containing stannous oxide and any alloying metals. The mixture is then retuned to the plating bath to return the stannous ions and alloying metal ions to their steady state concentrations.

摘要翻译： 公开了使用含有氧化亚锡的酸性溶液在水性电解电镀槽中补充锡及其合金金属的方法。 在锡或锡合金电镀期间，亚锡离子和合金金属离子耗尽。 为了保持连续而有效的电镀工艺，预先规定量的含有锡及其合金金属的镀浴被调出。 然后将保释与预定量的含有氧化亚锡和任何合金金属的酸性溶液混合。 然后将混合物回到电镀浴中，以将亚锡离子和合金化金属离子返回到其稳态浓度。