-
1.发明授权Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals 有权取代的2-（苯并二氢吡喃-6-基氧基） - 噻唑及其作为药物的用途公开(公告)号：US08912224B2
公开(公告)日：2014-12-16
申请号：US13230357
申请日：2011-09-12
申请人： Werngard Czechtizky , John Weston , Nils Rackelmann , Michael Podeschwa , Petra Arndt , Klaus Wirth , Heinz Goegelein , Olaf Ritzeler , Volker Kraft , Patrice Bellevergue , Gary McCort
发明人： Werngard Czechtizky , John Weston , Nils Rackelmann , Michael Podeschwa , Petra Arndt , Klaus Wirth , Heinz Goegelein , Olaf Ritzeler , Volker Kraft , Patrice Bellevergue , Gary McCort
IPC分类号： A61K31/425 , C07D471/10 , C07F9/6558 , C07D417/12 , C07D513/04 , C07D487/04 , C07D417/14
CPC分类号： C07D417/14 , A61K9/0019 , A61K47/10 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , C07F9/65586
摘要： The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式I的取代的2-（色满-6-基氧基） - 噻唑，其中Ar，R 2，R 3和R 4如权利要求中所定义。 式I的化合物是钠 - 钙交换剂（NCX）的抑制剂，特别是亚型1型（NCX1）的钠 - 钙交换剂的抑制剂，并且适用于治疗细胞内钙稳态受干扰的多种疾病，例如 作为心律失常，心力衰竭和中风。 本发明还涉及式I化合物的制备方法，它们作为药物的用途，以及包含它们的药物组合物。
-
2.发明申请Combination of phenylcarboxamides with blockers of the IKr channel and their use for the treatment of atrial arrhythmias 有权苯卡巴胺与IKr通道阻滞剂的组合及其用于治疗房性心律失常的用途公开(公告)号：US20050038083A1
公开(公告)日：2005-02-17
申请号：US10796894
申请日：2004-03-09
申请人： Joachim Brendel , Klaus Wirth , Heinz Goegelein , Maurits Allessie , Yuri Blaauw
发明人： Joachim Brendel , Klaus Wirth , Heinz Goegelein , Maurits Allessie , Yuri Blaauw
IPC分类号： A61K31/165 , A61K31/18 , A61K31/44 , A61K45/06
CPC分类号： A61K45/06 , A61K31/165 , A61K31/18 , A61K31/44 , A61K2300/00
摘要： The invention relates to the combination of one or more IKr channel blockers and of one or more Kv1.5 blockers, in particular phenyl-carboxamides of the formula Ia or Ib or pharmaceutically tolerable salts thereof, and the use of the combination for the treatment of atrial arrhythmias.
摘要翻译： 本发明涉及一种或多种IKr通道阻滞剂和一种或多种Kv1.5阻断剂，特别是式Ia或Ib的苯基 - 甲酰胺或其药学上可耐受的盐的组合，以及该组合用于治疗 房性心律失常。
-
3.发明授权Combination of phenylcarboxamides with blockers of the IKr channel and their use for the treatment of atrial arrhythmias 有权苯卡巴胺与IKr通道阻滞剂的组合及其用于治疗房性心律失常的用途公开(公告)号：US08106099B2
公开(公告)日：2012-01-31
申请号：US10796894
申请日：2004-03-09
申请人： Joachim Brendel , Klaus Wirth , Heinz Goegelein , Maurits Allessie , Yuri Blaauw
发明人： Joachim Brendel , Klaus Wirth , Heinz Goegelein , Maurits Allessie , Yuri Blaauw
CPC分类号： A61K45/06 , A61K31/165 , A61K31/18 , A61K31/44 , A61K2300/00
摘要： The invention relates to the combination of one or more IKr channel blockers and of one or more Kv1.5 blockers, in particular phenyl-carboxamides of the formula Ia or Ib or pharmaceutically tolerable salts thereof, and the use of the combination for the treatment of atrial arrhythmias.
摘要翻译： 本发明涉及一种或多种IKr通道阻滞剂和一种或多种Kv1.5阻断剂，特别是式Ia或Ib的苯基 - 甲酰胺或其药学上可耐受的盐的组合，以及该组合用于治疗 房性心律失常。
-
![2-(Butyl-1-sulfonylamino)-N-[1(R)-(6-methoxypyridin-3-yl)propyl] benzamide, its use as a medicament, and pharmaceutical preparations comprising it](/abs-image/US/2006/06/29/US20060142350A1/abs.jpg.150x150.jpg)
4.发明申请2-(Butyl-1-sulfonylamino)-N-[1(R)-(6-methoxypyridin-3-yl)propyl] benzamide, its use as a medicament, and pharmaceutical preparations comprising it 审中-公开2-（丁基-1-磺酰基氨基）-N- [1（R） - （6-甲氧基吡啶-3-基）丙基]苯甲酰胺，其作为药物的用途，以及包含它的药物制剂公开(公告)号：US20060142350A1
公开(公告)日：2006-06-29
申请号：US11355303
申请日：2006-02-15
申请人： Joachim Brendel , Heinz Goegelein , Klaus Wirth , Gert Kuerzel
发明人： Joachim Brendel , Heinz Goegelein , Klaus Wirth , Gert Kuerzel
IPC分类号： A61K31/44 , C07D213/63
CPC分类号： C07C311/08 , C07D213/64
摘要： The invention relates to 2-(butyl-1-sulfonylamino)-N-[1(R)-(6-methoxy-pyridin-3-yl)propyl]benzamide of the formula I and to its pharmaceutically acceptable salts, their preparation and use, in particular for the treatment and prophylaxis of atrial arrhythmias, for example atrial fibrillation or atrial flutters.
摘要翻译： 本发明涉及式I的2-（丁基-1-磺酰基氨基）-N- [1（R） - （6-甲氧基 - 吡啶-3-基）丙基]苯甲酰胺及其药学上可接受的盐，其制备和 特别用于治疗和预防房性心律失常，例如房颤或心房扑动。
-
5.发明申请Combination of phenylcarboxylic acid amides with beta-adrenoreceptor blockers and their use for the treatment of atrial arrhythmias 审中-公开苯甲酰胺与β-肾上腺素受体阻滞剂的组合及其用于治疗房性心律失常公开(公告)号：US20050054673A1
公开(公告)日：2005-03-10
申请号：US10932431
申请日：2004-09-01
申请人： Klaus Wirth , Joachim Brendel , Heinz Goegelein
发明人： Klaus Wirth , Joachim Brendel , Heinz Goegelein
IPC分类号： A61K31/00 , A61K31/138 , A61K31/165 , A61K31/18 , A61K31/44 , A61K31/47 , A61K45/06 , A01N37/18
CPC分类号： A61K31/18 , A61K31/00 , A61K31/138 , A61K31/165 , A61K31/44 , A61K31/47 , A61K45/06 , A61K2300/00
摘要： The invention relates to the combination of one or more beta-blockers and of one or more Kv1.5 blockers, in particular phenylcarboxamides of the formula la and/or lb and/or physiologically tolerable salts thereof, and the use of the combination for the treatment or prophylaxis of atrial arrhythmias.
摘要翻译： 本发明涉及一种或多种β-阻滞剂和一种或多种Kv1.5阻断剂，特别是式Ia和/或1b的苯基甲酰胺和/或其生理上可耐受的盐的组合，以及该组合用于 治疗或预防房性心律失常。
-
6.发明授权Piperidinesulfonylureas and -thioureas, their preparation, their use and pharmaceutical compositions comprising them 有权哌啶磺酰脲和硫脲，它们的制备，它们的用途和包含它们的药物组合物公开(公告)号：US08586612B2
公开(公告)日：2013-11-19
申请号：US11761565
申请日：2007-06-12
申请人： Stephanie Hachtel , Heinrich Christian Englert , Uwe Gerlach , Heinz Goegelein , Holger Heitsch , Karl-Heinz Lehr , Stefania Pfeiffer-Marek
发明人： Stephanie Hachtel , Heinrich Christian Englert , Uwe Gerlach , Heinz Goegelein , Holger Heitsch , Karl-Heinz Lehr , Stefania Pfeiffer-Marek
IPC分类号： A61K31/445
CPC分类号： C07D211/96
摘要： The present invention relates to piperidinesulfonylureas and piperidinesulfonylthioureas of formula I, in which A, X, R(1), R(2) and R(3) have the meanings indicated in the claims. The compounds of formula I are valuable active pharmaceutical ingredients which show in particular an inhibiting effect on ATP-sensitive potassium channels of the cardiac muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies or reduced contractility of the heart or for the prevention of sudden cardiac death. The invention further relates to processes for preparing the compounds of formula I, their use and pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式I的哌啶磺酰脲和哌啶磺酰硫脲，其中A，X，R（1），R（2）和R（3）具有权利要求中所示的含义。 式I的化合物是有价值的活性药物成分，其特别表现出对心肌的ATP敏感性钾通道的抑制作用，并且适用于例如治疗心血管系统疾病如冠心病，心律失常 ，心脏功能不全，心肌病或心脏收缩力降低或预防心源性猝死。 本发明还涉及制备式I化合物的方法，其用途和包含它们的药物组合物。
-
公开(公告)号：US20070292859A1
公开(公告)日：2007-12-20
申请号：US11574839
申请日：2005-08-27
申请人： Detlef Kozian , Heinz Goegelein , Karl-Ernst Siegler , Martina Jacobs , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Heinz Goegelein , Karl-Ernst Siegler , Martina Jacobs , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention concerns methods of identifying an increase in risk for coronary heart disease in an individual, wherein the presence of another amino acid than Glutaminic Acid at position 23 and/or the presence of another amino acid than Valine at position 337 in the Kir6.2 protein is determined in a sample. Moreover, probes, primers, polypeptides or polynucleotides suitable for said methods are claimed.
摘要翻译： 本发明涉及鉴定个体中冠状动脉心脏病风险增加的方法，其中在Kir6.2中存在另一个氨基酸比谷氨酸在第23位和/或存在另外一个氨基酸比缬氨酸337位置存在 在样品中测定蛋白质。 此外，要求适用于所述方法的探针，引物，多肽或多核苷酸。
-
8.发明申请METHOD FOR IDENTIFYING A COMPOUND HAVING AN ANTIARRHYTHMIC EFFECT AS WELL AS USES RELATING THERETO 审中-公开用于鉴定具有抗相关作用的化合物的方法公开(公告)号：US20130123143A1
公开(公告)日：2013-05-16
申请号：US13812792
申请日：2011-07-25
申请人： Aimo Kannt , Dieter Kadereit , Heinz Goegelein
发明人： Aimo Kannt , Dieter Kadereit , Heinz Goegelein
CPC分类号： C12Q1/527 , C12Q1/025 , G01N2800/326
摘要： The present invention relates to a method of identifying a compound having an antiarrhythmic effect and to a use of adenosine-diphospho-ribose cyclase (cardiac ADPRC) for the identification of a compound having said effect.
摘要翻译： 本发明涉及鉴定具有抗心律失常作用的化合物的方法以及使用腺苷 - 二磷酸 - 核糖环化酶（心脏ADPRC）来鉴定具有所述作用的化合物。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.039 秒)
