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    Retina implant for stimulating a retina as a function of incident light
    1.
    发明申请
    Retina implant for stimulating a retina as a function of incident light 审中-公开
    用于刺激视网膜作为入射光的函数的视网膜植入物

    公开(公告)号：US20060069416A1

    公开(公告)日：2006-03-30

    申请号：US11194017

    申请日：2005-07-29

    申请人： Wilfried Nisch ,  Martin Stelzle ,  Heinz-Gerhard Graf ,  Eberhart Zrenner ,  Markus Schubert ,  Hugo Haemmerle

    发明人： Wilfried Nisch ,  Martin Stelzle ,  Heinz-Gerhard Graf ,  Eberhart Zrenner ,  Markus Schubert ,  Hugo Haemmerle

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36046

    摘要： The present invention relates to a retina implant for the functional electrostimulation of a retina as a function of incident light. The retina implant has a stimulation chip that is designed to be implanted in the area of the retina of an eye. It further includes a radiation receiver that provides energy for the stimulation chip as a function of invisible radiation that occurs. In accordance with one aspect of the present invention, the radiation receiver is designed so as to be implanted in the area of the eye in a fashion spatially separated from the stimulation chip. The stimulation chip also has decoupling means in order to separate invisible scattered radiation from impinging visible light.

    摘要翻译： 本发明涉及视网膜植入物，用于根据入射光的功能性电刺激视网膜。 视网膜植入物具有被设计成植入眼睛视网膜区域的刺激芯片。 它还包括辐射接收器，其作为发生的不可见辐射的函数为刺激芯片提供能量。 根据本发明的一个方面，辐射接收器设计成以与刺激芯片空间分离的方式植入眼睛区域。 刺激芯片还具有去耦装置，以便将不可见的散射辐射与入射的可见光分开。

    Active retina implant with a multiplicity of pixel elements
    2.
    发明申请
    Active retina implant with a multiplicity of pixel elements 有权
    活性视网膜植入物具有多个像素元素

    公开(公告)号：US20060184245A1

    公开(公告)日：2006-08-17

    申请号：US11305920

    申请日：2005-12-19

    申请人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    发明人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    IPC分类号： A61F2/14

    CPC分类号： A61N1/36046

    摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

    摘要翻译： 活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。 每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极， 刺激信号。 还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。 图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。 刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

    Active retina implant with a multiplicity of pixel elements
    3.
    发明授权
    Active retina implant with a multiplicity of pixel elements 有权
    活性视网膜植入物具有多个像素元素

    公开(公告)号：US07751896B2

    公开(公告)日：2010-07-06

    申请号：US11305920

    申请日：2005-12-19

    申请人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    发明人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    IPC分类号： A61F2/14

    CPC分类号： A61N1/36046

    摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

    摘要翻译： 活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。 每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极， 刺激信号。 还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。 图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。 刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

    Method and kit for performing functional tests on biological cells
    5.
    发明申请
    Method and kit for performing functional tests on biological cells 审中-公开
    用于对生物细胞进行功能测试的方法和试剂盒

    公开(公告)号：US20050214832A1

    公开(公告)日：2005-09-29

    申请号：US11051315

    申请日：2005-02-04

    申请人： Hugo Haemmerle ,  Thomas Joos ,  Markus Templin ,  Hansjurgen Volkmer ,  Kerstin Ragnitz ,  Susanne Stumpf ,  Cornelia Kuschel

    发明人： Hugo Haemmerle ,  Thomas Joos ,  Markus Templin ,  Hansjurgen Volkmer ,  Kerstin Ragnitz ,  Susanne Stumpf ,  Cornelia Kuschel

    IPC分类号： C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/567

    CPC分类号： G01N33/5005

    摘要： A process for carrying out functional assays on test cells is described comprising the following steps: a) providing an array of measuring points which are separate from each other and to which in each case capture molecules to which said test cells can bind are immobilized, b) generating a mixture of said test cells and of reference particles which are capable of binding to said capture molecules and which are distinguishable from said test cells, c) contacting the mixture of step b) with the array so that test cells and reference particles can bind to each measuring point, and d) determining the ratio of bound test cells of interest to bound reference particles for at least some of the measuring points. In a further process, at least one measuring point with its assigned capture molecules is distributed between a plurality of measuring areas in the array, which are arranged at various sites in said array. In another process, the array is agitated, after contacting with the test cells and, where appropriate, the reference particles.

    摘要翻译： 描述了用于在测试细胞上进行功能测定的方法，其包括以下步骤：a）提供彼此分离的测量点阵列，并且在每种情况下捕获所述测试细胞可以结合的分子被固定化，b ）产生所述测试细胞和能够结合所述捕获分子并且可与所述测试细胞区分的参考颗粒的混合物，c）使步骤b）的混合物与阵列接触，使得测试细胞和参考颗粒可以 结合到每个测量点，以及d）确定至少一些测量点的目标结合测试细胞与结合参考颗粒的比例。 在另一个过程中，具有其分配的捕获分子的至少一个测量点分布在阵列中的多个测量区域之间，其被布置在所述阵列中的各个位置。 在另一个方法中，在与测试电池接触并且在适当的时候搅拌参考颗粒。