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    Protective Coatings For Acidic Active Ingredients
    5.
    发明申请
    Protective Coatings For Acidic Active Ingredients 有权
    酸性活性成分保护涂料

    公开(公告)号：US20120076834A1

    公开(公告)日：2012-03-29

    申请号：US13246324

    申请日：2011-09-27

    申请人： Karl Kolter ,  Maximilian Angel

    发明人： Karl Kolter ,  Maximilian Angel

    IPC分类号： A61K9/00 ,  A61K31/192 ,  A61K31/616

    CPC分类号： A61K31/192 ,  A61K9/5073 ,  A61K31/616

    摘要： Dosage forms provided with protective coatings in which a core comprising at least one acidic active ingredient is provided with at least one inner and one outer coating layer, where the outer layer comprises, as component A, a cationic polymer which is an emulsion polymer of N,N-diethylaminoethyl methacrylate and further monomers.

    摘要翻译： 提供有保护性涂层的剂型，其中包含至少一种酸性活性成分的核心设置有至少一个内部和一个外部涂层，其中外层包含作为组分A的阳离子聚合物，其为N ，甲基丙烯酸N-二乙基氨基乙酯和其它单体。

    METHOD FOR COATING TABLETS
    6.
    发明申请
    METHOD FOR COATING TABLETS 审中-公开
    涂布片的方法

    公开(公告)号：US20110117142A1

    公开(公告)日：2011-05-19

    申请号：US13002179

    申请日：2009-07-01

    申请人： Karl Kolter ,  Nils Rottmann ,  Maximilian Angel

    发明人： Karl Kolter ,  Nils Rottmann ,  Maximilian Angel

    IPC分类号： A61K9/00 ,  A61K47/32 ,  A61K8/02 ,  C09D139/06 ,  A01C1/06 ,  B05D3/02 ,  A23P1/08 ,  A23P1/00 ,  A23L1/00 ,  A23L1/29

    CPC分类号： A61K9/284 ,  A61K9/2853

    摘要： The present invention relates to a polymeric composition for coating solid substrates (S) consisting of: a) 0.5-90% by weight of polyethylene glycol with a weight-average molecular weight in the range from 1500 to 20 000 g/mol (component A), b) 0.5-20% by weight of a water-soluble polyvinylpyrrolidone with a Fikentscher K value in the range from 12 to 90 (component B), c) 0-95% by weight of a solvent (L), and d) 0-70% by weight of one or more non-polymeric aids (component C).

    摘要翻译： 本发明涉及一种用于涂布固体基质（S）的聚合物组合物，其由以下组成：a）0.5-90重量％的重均分子量为1500至200000g / mol的聚乙二醇（组分A ），b）0.5-20重量％的Fikentscher K值在12至90（组分B）范围内的水溶性聚乙烯吡咯烷酮，c）0-95重量％的溶剂（L），d ）0-70重量％的一种或多种非聚合助剂（组分C）。

    CATALYTIC PROCESS FOR PREPARING (METH)ACRYLIC ESTERS OF N-HYDROXYALKYLATED LACTAMS
    8.
    发明申请
    CATALYTIC PROCESS FOR PREPARING (METH)ACRYLIC ESTERS OF N-HYDROXYALKYLATED LACTAMS 失效

    公开(公告)号：US20100010236A1

    公开(公告)日：2010-01-14

    申请号：US12525826

    申请日：2008-02-11

    申请人： Hermann Bergmann ,  Frank Hoefer ,  Maximilian Angel

    发明人： Hermann Bergmann ,  Frank Hoefer ,  Maximilian Angel

    IPC分类号： C07D201/08

    CPC分类号： C07D207/12

    摘要： A process for preparing (meth)acrylic esters (F) of N-hydroxyalkylated lactams, in which cyclic N-hydroxyalkylated lactams (L) in whichR1 is C1-C5-alkylene, or C2-C20-alkylene interrupted by one or more oxygen and/or sulfur atoms and/or one or more substituted or unsubstituted imino groups and/or by one or more cycloalkyl, —(CO)—, —O(CO)O—, —(NH)(CO)O—, —O(CO)(NH)—, —O(CO)— or —(CO)O— groups, where the radicals mentioned may each be substituted by aryl, alkyl, aryloxy, alkyloxy, heteroatoms and/or heterocycles,with the proviso that R1 must not have any atom other than a carbon atom directly adjacent to the lactam carbonyl group,R2 is C1-C20-alkylene, C5-C12-cycloalkylene, C6-C12-arylene, or C2-C20-alkylene interrupted by one or more oxygen and/or sulfur atoms and/or one or more substituted or unsubstituted imino groups and/or by one or more cycloalkyl, —(CO)—, —O(CO)O—, —(NH)(CO)O—, —O(CO)(NH)—, —O(CO)— or —(CO)O— groups, where the radicals mentioned may each be substituted by aryl, alkyl, aryloxy, alkyloxy, heteroatoms and/or heterocycles, orR2—OH is a group of the formula —[Xi]k—H,k is from 1 to 50 andXi, for each i=1 to k, may each independently be selected from the group of —CH2—CH2—O—, —CH2—CH2—N(H)—, —CH2—CH2—CH2—N(H)—, —CH2—CH(NH2)—, —CH2—CH(NHCHO)—, —CH2—CH(CH3)—O—, —CH(CH3)—CH2—O—, —CH2—C(CH3)2—O—, —C(CH3)2—CH2—O—, —CH2—CH2—CH2—O—, —CH2—CH2—CH2—CH2—O—, —CH2—CHVin—O—, —CHVin—CH2—O—, —CH2—CHPh—O— and —CHPh—CH2—O—, in which Ph is phenyl and Vin is vinyl,in the presence of at least one metal salt of C1-C10-alkoxides (A), is esterified with (meth)acrylic acid (S) or transesterified with at least one (meth)acrylic ester (D), in which the metal salt of C1-C10-alkoxides (A) used as a catalyst is added in the absence of solvents and completely at the start of the reaction.

    Water-soluble or water-dispersible (co) polymers of hydroxyalkyl (meth) acrylates, a process for their preparation, and their use as coating agent, binder and/or film-forming excipient pharmaceutical dosage forms
    9.
    发明授权
    Water-soluble or water-dispersible (co) polymers of hydroxyalkyl (meth) acrylates, a process for their preparation, and their use as coating agent, binder and/or film-forming excipient pharmaceutical dosage forms 失效
    （甲基）丙烯酸羟烷基酯的水溶性或水分散性（共）聚合物，其制备方法及其作为包衣剂，粘合剂和/或成膜赋形剂药物剂型的用途

    公开(公告)号：US07049360B2

    公开(公告)日：2006-05-23

    申请号：US09964796

    申请日：2001-09-28

    申请人： Maximilian Angel ,  Axel Sanner ,  Karl Kolter

    发明人： Maximilian Angel ,  Axel Sanner ,  Karl Kolter

    IPC分类号： C08K3/20

    CPC分类号： A61K9/2846 ,  A61K9/2027 ,  C08F261/04

    摘要： The present invention relates to water-soluble or water-dispersible copolymers obtainable by free-radical polymerization of a) 80 to 20% by weight of hydroxy-C1–C6-alkyl (meth)acrylate and, where appropriate, one or more compounds of the formula (A) or (B) with R1=H, C1–C6-alkyl, R2=H, CH3 R3=C1–C24-alkyl or mixtures thereof in the presence of b) 20 to 80% by weight of polyvinyl alcohol (PVA) and c) where appropriate 0 to 20% by weight of other polymerizable compounds (C), a process for their preparation, and their use as coating agent, binder and/or film-forming excipient in pharmaceutical dosage forms.

    摘要翻译： 本发明涉及通过自由基聚合得到的水溶性或水分散性共聚物，该共聚物是a）80-20％（重量）的羟基-C 1 -C 6 - - （甲基）丙烯酸烷基酯和（如果合适的话）一种或多种式（A）或（B）的化合物，其中R 1 = H，C 1 -C C 1 -C 6烷基，R 2 = H，CH 3 3 R 3 = C 1〜 -C 24 - - - 烷基或其混合物，b）20-80％（重量）的聚乙烯醇（PVA）和c）适当时0-20％重量的其它可聚合化合物（C ），其制备方法，以及它们作为药物剂型中的包衣剂，粘合剂和/或成膜赋形剂的用途。

    Rapidly soluble film covering based on polyvinylalcohol-polyether graft copolymers combined with components containing hydroxyl, amide, or ester functions
    10.
    发明申请
    Rapidly soluble film covering based on polyvinylalcohol-polyether graft copolymers combined with components containing hydroxyl, amide, or ester functions 审中-公开
    基于聚乙烯醇 - 聚醚接枝共聚物与含有羟基，酰胺或酯官能团的组分组合的快速溶解膜覆盖

    公开(公告)号：US20050107498A1

    公开(公告)日：2005-05-19

    申请号：US10501773

    申请日：2003-02-04

    申请人： Karl Kolter ,  Maximilian Angel

    发明人： Karl Kolter ,  Maximilian Angel

    IPC分类号： A61K9/28 ,  C08K5/15 ,  C08K3/00 ,  C08K3/34

    CPC分类号： A61K9/2853

    摘要： A quick dissolving film coating composition for coating solid substrates is composed of a) 10-90% by weight of a polyvinyl alcohol-polyether graft copolymer (component A), b) 5-80% by weight of at least one further component containing at least one functional group selected from the group consisting of hydroxyl, amide and ester functions (component B), and c) 0-70% by weight of further customary coating constituents (components C).

    摘要翻译： 用于涂布固体基材的快速溶解膜涂料组合物由a）10-90重量％的聚乙烯醇 - 聚醚接枝共聚物（组分A）组成，b）5-80重量％的至少一种另外的组分，其含有 至少一个选自羟基，酰胺和酯官能团的官能团（组分B），和c）0-70重量％的进一步常规涂料组分（组分C）。