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公开(公告)号:US07968681B2
公开(公告)日:2011-06-28
申请号:US12761346
申请日:2010-04-15
申请人: Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Lui , Joshua Silverman , Richard Smith , Candace Swimmer
发明人: Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Lui , Joshua Silverman , Richard Smith , Candace Swimmer
CPC分类号: C07K14/47 , A61K38/00 , C07K14/705 , G01N33/566 , G01N33/574 , G01N2333/4753 , G01N2333/82 , G01N2500/00
摘要: Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
摘要翻译: 提供了包含与c-MET结合的单体结构域的多肽或其部分。
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公开(公告)号:US07803907B2
公开(公告)日:2010-09-28
申请号:US11155989
申请日:2005-06-17
申请人: Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Richard Smith , Candace Swimmer
发明人: Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Richard Smith , Candace Swimmer
CPC分类号: C07K14/47 , A61K38/00 , C07K14/705 , G01N33/566 , G01N33/574 , G01N2333/4753 , G01N2333/82 , G01N2500/00
摘要: Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
摘要翻译: 提供了包含与c-MET结合的单体结构域的多肽或其部分。
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公开(公告)号:US07820790B2
公开(公告)日:2010-10-26
申请号:US11655776
申请日:2007-01-18
申请人: Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
发明人: Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
CPC分类号: C07K14/715
摘要: Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided.
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公开(公告)号:US07786262B2
公开(公告)日:2010-08-31
申请号:US11486246
申请日:2006-07-12
申请人: Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
发明人: Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
CPC分类号: C07K14/715
摘要: Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided.
摘要翻译: 提供了包含与IL-6结合的单体结构域的多肽或其部分。
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公开(公告)号:US20090305962A1
公开(公告)日:2009-12-10
申请号:US11655776
申请日:2007-01-18
申请人: Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
发明人: Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
IPC分类号: A61K38/16 , C07K14/435 , C07H21/04
CPC分类号: C07K14/715
摘要: Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided.
摘要翻译: 提供了包含与IL-6结合的单体结构域的多肽或其部分。
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公开(公告)号:US20080281076A1
公开(公告)日:2008-11-13
申请号:US11486246
申请日:2006-07-12
申请人: Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
发明人: Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
CPC分类号: C07K14/715
摘要: Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided.
摘要翻译: 提供了包含与IL-6结合的单体结构域的多肽或其部分。
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7.BINDING PROTEINS THAT BIND TO HUMAN FGFR1C, HUMAN BETA-KLOTHO AND BOTH HUMAN FGFR1C AND HUMAN BETA-KLOTHO 有权
标题翻译: 与人类FGFR1C,人类蛋白胆固醇和人类FGFR1C和人类蛋白胆碱受体结合的结合蛋白公开(公告)号:US20110150901A1
公开(公告)日:2011-06-23
申请号:US12958209
申请日:2010-12-01
申请人: Richard Smith , Alice Bakker , Amy N. Duguay , Peng Li , Yang Li
发明人: Richard Smith , Alice Bakker , Amy N. Duguay , Peng Li , Yang Li
IPC分类号: A61K39/395 , C07K14/00 , C07K16/00 , C07H21/00 , A61K38/18 , A61P3/00 , C12N15/63 , C12N5/10 , C12P21/06
CPC分类号: C07K14/001 , A61K38/00 , C07K14/50 , C07K14/705 , C07K2319/70 , C07K2319/75
摘要: Binding proteins that specifically bind to β-Klotho or portions thereof, FGFR1c or portions thereof, or both FGFR1c and β-Klotho, and optionally other proteins as well are provided. Coding sequences, methods of treatment and pharmaceutical compositions are also provided.
摘要翻译: 提供了特异性结合于其上的结合蛋白-Klotho或其部分,FGFR1c或其部分,或FGFR1c和&bgr; -Klotho以及任选的其它蛋白质的结合蛋白。 还提供编码序列,治疗方法和药物组合物。
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8.Binding proteins that bind to human FGFR1C, human β-klotho and both human FGFR1C and human β-klotho 有权
标题翻译: 结合人类FGFR1C,人类和人类klotho以及人类FGFR1C和人类bgr-klotho的结合蛋白公开(公告)号:US08372952B2
公开(公告)日:2013-02-12
申请号:US12958209
申请日:2010-12-01
申请人: Richard Smith , Alice Bakker , Amy N. Duguay , Peng Li , Yang Li
发明人: Richard Smith , Alice Bakker , Amy N. Duguay , Peng Li , Yang Li
CPC分类号: C07K14/001 , A61K38/00 , C07K14/50 , C07K14/705 , C07K2319/70 , C07K2319/75
摘要: Binding proteins that specifically bind to β-Klotho or portions thereof, FGFR1c or portions thereof, or both FGFR1c and β-Klotho, and optionally other proteins as well are provided. Coding sequences, methods of treatment and pharmaceutical compositions are also provided.
摘要翻译: 提供了特异性结合于其上的结合蛋白-Klotho或其部分,FGFR1c或其部分,或FGFR1c和&bgr; -Klotho以及任选的其它蛋白质的结合蛋白。 还提供编码序列,治疗方法和药物组合物。
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