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公开(公告)号：US4226871A
公开(公告)日：1980-10-07
申请号：US20147
申请日：1979-03-13
申请人： William A. Bolhofer , John D. Prugh
发明人： William A. Bolhofer , John D. Prugh
IPC分类号： C07D213/75 , C07D239/42 , A61K31/44 , C07D211/84
CPC分类号： C07D213/75 , C07D239/42 , Y10S514/925
摘要： Heterocyclic carbamates are disclosed which have potent gastric secretion inhibitory properties. The heterocyclic substituent is a pyridyl group or a 6-membered heterocycle with two nitrogen heteroatoms, which may be optionally substituted. Further substituents on the carbamate nitrogen and oxygen atoms are also disclosed. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
摘要翻译： 公开了具有有效的胃分泌抑制性质的杂环氨基甲酸酯。 杂环取代基是具有两个氮杂原子的吡啶基或6-元杂环，其可任选被取代。 还公开了氨基甲酸酯氮和氧原子上的其它取代基。 这些化合物对胃肠道胃分泌物的抑制具有深远的影响，并且还公开了用于这些用途的组合物。
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公开(公告)号：US4415575A
公开(公告)日：1983-11-15
申请号：US345957
申请日：1982-02-05
申请人： William A. Bolhofer , John D. Prugh
发明人： William A. Bolhofer , John D. Prugh
IPC分类号： C07D213/75 , C07D239/42 , A61K31/505
CPC分类号： C07D213/75 , C07D239/42 , Y10S514/926 , Y10S514/927
摘要： Heterocyclic carbamates are disclosed which have potent gastric secretion inhibitory properties. The heterocyclic substituent is a pyridyl group or a 6-membered heterocycle with two nitrogen heteroatoms, which may be optionally substituted. Further substituents on the carbamate nitrogen and oxygen atoms are also disclosed. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
摘要翻译： 公开了具有有效的胃分泌抑制性质的杂环氨基甲酸酯。 杂环取代基是具有两个氮杂原子的吡啶基或6-元杂环，其可任选被取代。 还公开了氨基甲酸酯氮和氧原子上的其它取代基。 这些化合物对胃肠道胃分泌物的抑制具有深远的影响，并且还公开了用于这些用途的组合物。
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公开(公告)号：US4220654A
公开(公告)日：1980-09-02
申请号：US45545
申请日：1979-06-04
IPC分类号： A61K31/415 , A61P1/04 , C07C45/63 , C07D233/54 , C07D233/64 , C07D233/90 , C07D333/42 , C07D403/06 , C07D409/04 , C07D409/06
CPC分类号： C07D233/64 , A61K31/415 , C07C205/45 , C07C45/63 , C07D233/90 , C07D333/42
摘要： There are disclosed novel compounds described as imidazole cyanoguanidines in which the imidazole moiety is connected to the cyanoguanidine moiety through a cyclic group which may optionally contain one or two alkylene linkages. The cyclic groups may be phenyl, cyclohexyl, thienyl and the like. Processes for the preparation of such compounds are also disclosed. The compounds are useful for the suppression of gastric acid secretion in mammals, and compositions for such uses are also disclosed.
摘要翻译： 公开了描述为咪唑氰基胍的新化合物，其中咪唑部分通过可任选地含有一个或两个亚烷基键的环状基团连接到氰基胍部分。 环状基团可以是苯基，环己基，噻吩基等。 还公开了制备这些化合物的方法。 该化合物可用于抑制哺乳动物中的胃酸分泌，并且还公开了用于这些用途的组合物。
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公开(公告)号：US4133885A
公开(公告)日：1979-01-09
申请号：US816617
申请日：1977-07-18
IPC分类号： A61K31/435 , A61P1/04 , C07D471/04 , A01N9/22 , C07D213/00
CPC分类号： C07D471/04 , Y10S514/819
摘要： Organic chemical compounds based upon the naphthyridine molecule are disclosed which have potent gastric secretion inhibitory properties. The naphthyridinone is substituted with a substituted amino alkyl group at the 1-position, and variously substituted at the remaining positions. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
摘要翻译： {PG，1]公开了基于萘啶分子的有机化合物，其具有有效的胃分泌抑制性质。 萘啶酮在1位被取代的氨基烷基取代，并在其余位置被不同地取代。 这些化合物对胃肠道胃分泌物的抑制具有深远的影响，并且还公开了用于这些用途的组合物。
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公开(公告)号：US4144338A
公开(公告)日：1979-03-13
申请号：US769475
申请日：1977-02-17
申请人： William A. Bolhofer
发明人： William A. Bolhofer
IPC分类号： C07D253/06 , A61K31/495 , A61P1/04 , C07D237/20 , C07D239/42 , C07D239/46 , C07D239/48 , C07D241/20 , C07D251/22 , A61K31/505
CPC分类号： C07D239/47 , C07D239/42 , C07D239/48 , C07D241/20 , C07D251/22 , Y10S514/819
摘要： Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a 6 membered heterocyclic substituent containing 2 or 3 heteroatoms, and also with a substituted amino alkyl group. Further substitution is also possible. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
摘要翻译： 公开了基于尿素分子的有机化合物，其具有有效的胃分泌抑制性质。 尿素被含有2或3个杂原子的6元杂环取代基，以及取代的氨基烷基取代。 进一步的替代也是可能的。 这些化合物对胃肠道胃分泌物的抑制具有深远的影响，并且还公开了用于这些用途的组合物。
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6.发明授权2-[.alpha.-(3-Trifluoromethylphenoxyl)-4-chlorobenzyl]oxazole and methods for preparing the same 失效2- {8 {6-（3-三氟甲基苯氧基）-4-氯苄基{9恶唑及其制备方法
公开(公告)号：US3953465A
公开(公告)日：1976-04-27
申请号：US410130
申请日：1973-10-26
申请人： William A. Bolhofer
发明人： William A. Bolhofer
IPC分类号： C07D263/32
摘要： [.alpha.-(3-Trifluoromethylphenoxy)-4-chlorobenzyl heterocycles which are prepared by the cyclization of an appropriately substituted [.alpha.(3-trifluoromethylphenoxy)-4-chlorobenzyl]compound. The products reduce the concentration of cholesterol, trigylcerides and other lipids in blood serum and are therefore useful in the treatment of atherosclerosis.
摘要翻译： 通过环化适当取代的[α-（3-三氟甲基苯氧基）-4-氯苄基]化合物制备的α-（3-三氟甲基苯氧基）-4-氯苄基杂环。 该产品降低血清中胆固醇，三倍体酯和其他脂质的浓度，因此可用于治疗动脉粥样硬化。
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7.发明授权
公开(公告)号：US4567191A
公开(公告)日：1986-01-28
申请号：US501943
申请日：1983-06-07
IPC分类号： C07D285/10 , C07D417/12 , A61K31/41
CPC分类号： C07D285/10 , C07D417/12
摘要： Novel amino-phenyl-thiadiazoledioxides and related compounds and processes for preparing such compounds are disclosed. The compounds are useful for suppressing gastric acid secretions in mammals.
摘要翻译： 公开了新的氨基 - 苯基 - 噻二唑二氧化物及相关化合物及其制备方法。 该化合物可用于抑制哺乳动物中的胃酸分泌。
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公开(公告)号：US4490533A
公开(公告)日：1984-12-25
申请号：US306441
申请日：1981-09-29
IPC分类号： C07D213/32 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/74 , C07D213/75 , C07D211/70 , C07D211/82 , C07D213/24 , C07D213/53
CPC分类号： C07D213/64 , C07D213/32 , C07D213/61 , C07D213/70 , C07D213/74 , C07D213/75
摘要： There are disclosed novel compounds described as aminoalkyl pyridine derivatives in which the aminoalkyl pyridine is connected to a guanidine moiety or a functional equivalent thereof, either directly or through a linear connecting group. Processes for the preparation of such compounds are also disclosed. The compounds are useful for the suppression of gastirc acid secretions in mammals and compositions for such uses are also disclosed.
摘要翻译： 公开了描述为氨基烷基吡啶衍生物的新化合物，其中氨基烷基吡啶直接或通过线性连接基团连接到胍部分或其功能等同物。 还公开了制备这些化合物的方法。 该化合物可用于抑制哺乳动物中的胃酸分泌物，并且还公开了用于这些用途的组合物。
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公开(公告)号：US4229456A
公开(公告)日：1980-10-21
申请号：US954388
申请日：1978-10-23
IPC分类号： C07D471/04 , C07D471/06 , C07D403/02 , A61K31/44
CPC分类号： C07D471/04 , C07D471/06
摘要： Organic chemical compounds based upon the naphthyridine molecule are disclosed which have potent gastric secretion inhibitory properties. The naphthyridinone is substituted with a substituted amino alkyl group at the 1-position, and variously substituted at the remaining positions. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
摘要翻译： 公开了基于萘啶分子的有机化合物，其具有有效的胃分泌抑制性质。 萘啶酮在1位被取代的氨基烷基取代，并在其余位置被不同地取代。 这些化合物对胃肠道胃分泌物的抑制具有深远的影响，并且还公开了用于这些用途的组合物。
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公开(公告)号：US4420615A
公开(公告)日：1983-12-13
申请号：US295930
申请日：1981-08-24
IPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D213/85 , C07D471/04 , C07D471/14 , A61K31/495
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D213/85 , C07D471/04
摘要： There are disclosed novel substituted pyridopyrimidine compounds and processes for preparing such compounds. These compounds are useful as gastric secretion inhibitors in mammals.
摘要翻译： 公开了新的取代的吡啶并嘧啶化合物及其制备方法。 这些化合物可用作哺乳动物中的胃分泌抑制剂。
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