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公开(公告)号：US5527819A
公开(公告)日：1996-06-18
申请号：US488957
申请日：1995-06-07
申请人： Theresa M. Williams , Terrence M. Ciccarone , Walfred S. Saari , John S. Wai , William J. Greenlee , Suresh K. Balani , Mark E. Goldman , Anthony D. Theoharides, deceased , Jacob M. Hoffman, Jr. , William C. Lumma, Jr. , Joel R. Huff , Clarence S. Rooney , Philip E. Sanderson
发明人： Theresa M. Williams , Terrence M. Ciccarone , Walfred S. Saari , John S. Wai , William J. Greenlee , Suresh K. Balani , Mark E. Goldman , Anthony D. Theoharides, deceased , Jacob M. Hoffman, Jr. , William C. Lumma, Jr. , Joel R. Huff , Clarence S. Rooney , Philip E. Sanderson
IPC分类号： C07D209/12 , C07D209/30 , C07D209/42 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/12 , C07D521/00 , A61K31/40
CPC分类号： C07D231/12 , C07D209/12 , C07D209/30 , C07D209/42 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/12
摘要： Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译： 新型吲哚化合物抑制HIV逆转录酶，可用于预防或治疗艾滋病毒和艾滋病感染，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒药物结合使用，抗感染药物 ，免疫调节剂，抗生素或疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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公开(公告)号：US5308854A
公开(公告)日：1994-05-03
申请号：US971691
申请日：1992-11-04
IPC分类号： C07D213/64 , C07D213/69 , C07D213/74 , C07D401/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , A61K31/44
CPC分类号： C07D213/64 , C07D213/69 , C07D213/74 , C07D401/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/10 , C07D417/12
摘要： Novel aminopyridones inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译： 新型氨基吡啶酮可抑制HIV逆转录酶，可用于预防或治疗艾滋病毒和艾滋病感染，作为化合物，药学上可接受的盐，药物组合物成分，不论是否与其他抗病毒药物，抗感染药物， 免疫调节剂，抗生素或疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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公开(公告)号：US4497810A
公开(公告)日：1985-02-05
申请号：US541834
申请日：1983-10-14
IPC分类号： C07D285/00 , A61K31/54 , A61P1/00 , A61P43/00 , C07D285/15 , C07D417/12 , C07D417/06
CPC分类号： C07D285/15 , C07D417/12
摘要： There are disclosed novel 1,2,4,6-thiatriazine-1,1-dioxides and related compounds which are connected to a substituted phenyl or heterocyclic group through a linear or cyclic connecting group. Processes are provided for the preparation of such compounds. The compounds are useful for the suppression of gastric acid secretions in mammals and compositions for such uses are also disclosed.
摘要翻译： 公开了通过线性或环状连接基团与取代的苯基或杂环基连接的新的1,2,4,6-三氮杂-1,1-二氧化物及相关化合物。 提供了制备这些化合物的方法。 该化合物可用于抑制哺乳动物中的胃酸分泌物，并且还公开了用于此类用途的组合物。
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4.发明授权Ethers of hydroxybenzothiazole-2-sulfonamide for the topical treatment of elevated intraocular pressure 失效用于局部治疗眼内压升高的羟基苯并噻唑-2-磺酰胺的醚
公开(公告)号：US4505923A
公开(公告)日：1985-03-19
申请号：US547189
申请日：1983-10-31
IPC分类号： C07D277/80 , A61K31/425
CPC分类号： C07D277/80 , Y10S514/912
摘要： Novel ethers of hydroxy-2-benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.
摘要翻译： 羟基-2-苯并噻唑磺酰胺的新型醚可用于局部治疗眼压升高。 眼科组合物包括滴剂和插入物。
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公开(公告)号：US4496737A
公开(公告)日：1985-01-29
申请号：US432219
申请日：1982-09-27
IPC分类号： C07D277/42 , C07D277/48 , C07D307/52
CPC分类号： C07D307/52 , C07D277/48
摘要： A process is disclosed for preparing intermediates which are useful for obtaining sulfamylamidine antisecretory agents.
摘要翻译： 公开了一种制备可用于获得氨磺酰脒抗分泌剂的中间体的方法。
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公开(公告)号：US4220654A
公开(公告)日：1980-09-02
申请号：US45545
申请日：1979-06-04
IPC分类号： A61K31/415 , A61P1/04 , C07C45/63 , C07D233/54 , C07D233/64 , C07D233/90 , C07D333/42 , C07D403/06 , C07D409/04 , C07D409/06
CPC分类号： C07D233/64 , A61K31/415 , C07C205/45 , C07C45/63 , C07D233/90 , C07D333/42
摘要： There are disclosed novel compounds described as imidazole cyanoguanidines in which the imidazole moiety is connected to the cyanoguanidine moiety through a cyclic group which may optionally contain one or two alkylene linkages. The cyclic groups may be phenyl, cyclohexyl, thienyl and the like. Processes for the preparation of such compounds are also disclosed. The compounds are useful for the suppression of gastric acid secretion in mammals, and compositions for such uses are also disclosed.
摘要翻译： 公开了描述为咪唑氰基胍的新化合物，其中咪唑部分通过可任选地含有一个或两个亚烷基键的环状基团连接到氰基胍部分。 环状基团可以是苯基，环己基，噻吩基等。 还公开了制备这些化合物的方法。 该化合物可用于抑制哺乳动物中的胃酸分泌，并且还公开了用于这些用途的组合物。
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公开(公告)号：US4133885A
公开(公告)日：1979-01-09
申请号：US816617
申请日：1977-07-18
IPC分类号： A61K31/435 , A61P1/04 , C07D471/04 , A01N9/22 , C07D213/00
CPC分类号： C07D471/04 , Y10S514/819
摘要： Organic chemical compounds based upon the naphthyridine molecule are disclosed which have potent gastric secretion inhibitory properties. The naphthyridinone is substituted with a substituted amino alkyl group at the 1-position, and variously substituted at the remaining positions. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
摘要翻译： {PG，1]公开了基于萘啶分子的有机化合物，其具有有效的胃分泌抑制性质。 萘啶酮在1位被取代的氨基烷基取代，并在其余位置被不同地取代。 这些化合物对胃肠道胃分泌物的抑制具有深远的影响，并且还公开了用于这些用途的组合物。
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8.发明授权4-(2-methyl-2-hydroxypropylamino)-5,6-dihydrot hieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide 失效4-（2-甲基-2-羟丙基氨基）-5,6-二氢噻吩并[2,3-b]噻喃-2-磺酰胺-7,7-二氧化物
公开(公告)号：US4946859A
公开(公告)日：1990-08-07
申请号：US387033
申请日：1989-07-31
IPC分类号： A61K31/38 , A61P25/02 , A61P27/02 , C07D495/04
CPC分类号： C07D495/04
摘要： 4-(2-Methyl-2-hydroxypropylamino)-5,6-dihydrothieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide is a major mammalian metabolite of 4-(2-methylpropylamino)-5,6-dihydrothieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide and is itself an active carbonic anhydrase inhibitor useful in the treatment of ocular hypertension by topical administration.
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公开(公告)号：US4229456A
公开(公告)日：1980-10-21
申请号：US954388
申请日：1978-10-23
IPC分类号： C07D471/04 , C07D471/06 , C07D403/02 , A61K31/44
CPC分类号： C07D471/04 , C07D471/06
摘要： Organic chemical compounds based upon the naphthyridine molecule are disclosed which have potent gastric secretion inhibitory properties. The naphthyridinone is substituted with a substituted amino alkyl group at the 1-position, and variously substituted at the remaining positions. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
摘要翻译： 公开了基于萘啶分子的有机化合物，其具有有效的胃分泌抑制性质。 萘啶酮在1位被取代的氨基烷基取代，并在其余位置被不同地取代。 这些化合物对胃肠道胃分泌物的抑制具有深远的影响，并且还公开了用于这些用途的组合物。
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公开(公告)号：US07115597B2
公开(公告)日：2006-10-03
申请号：US10677687
申请日：2003-10-02
申请人： Mark T. Bilodeau , George D. Hartman , Jacob M. Hoffman, Jr. , John T. Sisko , Peter J. Manley , Anthony M. Smith , Thomas J. Tucker , William C. Lumma, Jr. , Leonard Rodman
发明人： Mark T. Bilodeau , George D. Hartman , Jacob M. Hoffman, Jr. , John T. Sisko , Peter J. Manley , Anthony M. Smith , Thomas J. Tucker , William C. Lumma, Jr. , Leonard Rodman
IPC分类号： C07D417/12 , A61K31/427 , C07D241/04
CPC分类号： C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04 , C07D487/08 , C07D491/08
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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