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12 条记录 (耗时 0.036 秒)

    Process for production of delta-9- tetrahydrocannabinol
    2.
    发明申请
    Process for production of delta-9- tetrahydrocannabinol 失效
    制备δ-9-四氢大麻酚的方法

    公开(公告)号：US20070093665A1

    公开(公告)日：2007-04-26

    申请号：US11529147

    申请日：2006-09-28

    申请人： David Burdick ,  Steven Collier ,  Frederic Jos ,  Betina Biolatto ,  Bernhard Paul ,  Harold Meckler ,  Mark Helle ,  Alicia Habershaw

    发明人： David Burdick ,  Steven Collier ,  Frederic Jos ,  Betina Biolatto ,  Bernhard Paul ,  Harold Meckler ,  Mark Helle ,  Alicia Habershaw

    IPC分类号： C07D311/80

    CPC分类号： C07C29/00 ,  C07C37/16 ,  C07C67/343 ,  C07C2601/16 ,  C07C35/16 ,  C07C39/23 ,  C07C69/94

    摘要： The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: where R8, R9, and R10 are the same or different and independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or halo, with R1, R2, and R3 defined herein.

    摘要翻译： 本发明涉及一种制备δ-9-四氢大麻酚化合物或其衍生物的方法，包括在有效制备δ-9-四氢大麻酚化合物或其衍生物的条件下，用有机铝基路易斯酸催化剂处理第一中间体化合物 。 本发明的另一方面涉及制备大麻二醇或大麻二酸化合物的方法，包括在金属三氟甲磺酸酯催化剂存在下，在有效形成大麻二醇或大麻二醇化合物的条件下使第一起始化合物与第二起始化合物反应。 本发明还涉及下式的化合物：其中R 8，R 9和R 10是相同或不同的且独立地 选自H，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的杂芳基或卤素，R 1，R 2和R 2， 本文定义的SUB> 3 。

    Directly compressible formulations of azithromycin
    5.
    发明申请
    Directly compressible formulations of azithromycin 审中-公开

    公开(公告)号：US20060024364A1

    公开(公告)日：2006-02-02

    申请号：US11213022

    申请日：2005-08-26

    申请人： Brendan Murphy ,  Steven Collier ,  Ernest Quan ,  Barbara Johnson

    发明人： Brendan Murphy ,  Steven Collier ,  Ernest Quan ,  Barbara Johnson

    IPC分类号： A61K31/7052 ,  A61K9/20

    CPC分类号： A61K31/7052 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2095

    摘要： The present invention relates to a dry blend, used for forming azithromycin tablets by direct compression, comprising non-dihydrate azithromycin and at least one pharmaceutically acceptable excipient. This invention also relates to an azithromycin tablet comprising non-dihydrate azithromycin and at least one pharmaceutically acceptable excipient. Preferably, the azithromycin tablet is formed by directly compressing the dry blend, of the present invention, to form said azithromycin tablet. Preferably, the azithromycin tablet, of the present invention, contains a dosage of 250 mgA, 500 mgA or 600 mgA of azithromycin. This invention further relates to an azithromycin tablet which is produced by forming a dry blend of a non-granulated azithromycin form A and at least one pharmaceutically acceptable excipient. The azithromycin tablet is then formed by directly compressing the dry blend.

    Stable non-dihydrate azithromycin oral suspensions
    8.
    发明申请
    Stable non-dihydrate azithromycin oral suspensions 审中-公开
    稳定的非二水合阿奇霉素口服悬浮液

    公开(公告)号：US20050013835A1

    公开(公告)日：2005-01-20

    申请号：US10636013

    申请日：2003-08-06

    申请人： Steven Collier ,  William Curatolo ,  Barbara Johnson ,  Brendan Murphy

    发明人： Steven Collier ,  William Curatolo ,  Barbara Johnson ,  Brendan Murphy

    IPC分类号： A61K9/10 ,  A61K9/00 ,  A61K31/7042 ,  A61K31/7048 ,  A61K47/04 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61K47/46 ,  A61K9/14

    CPC分类号： A61K9/0095 ,  A61K31/7048

    摘要： This invention relates to a powder for oral suspension, and an oral suspension made therefrom, which comprises non-dihydrate azithromycin and an azithromycin conversion stabilizing excipient, wherein said excipient reduces the conversion of the form of azithromycin, when placed in suspension, to another form of azithromycin. This invention further relates to a method for reducing the conversion of a form of non-dihydrate azithromycin, in an oral suspension, by adding a surface tension reducing excipient that reduces the surface tension of the aqueous vehicle. Furthermore, this invention relates to a method for reducing the conversion of a non-dihydrate azithromycin, in an unflavored oral suspension, by raising the viscosity of the oral suspension, and in a flavored oral suspension by lowering the viscosity of the oral suspension.

    摘要翻译： 本发明涉及用于口服悬浮液的粉末和由其制备的口服悬浮液，其包含非二水合阿奇霉素和阿奇霉素转化稳定赋形剂，其中所述赋形剂将阿奇霉素的形式在悬浮液中降低至另一种形式 的阿奇霉素。 本发明还涉及通过添加降低水性载体的表面张力的降低表面张力的赋形剂来减少口服悬浮液中的非二水合阿奇霉素形式的转化的方法。 此外，本发明涉及通过提高口腔悬浮液的粘度和通过降低口服悬浮液的粘度而在调味的口服悬浮液中降低非风味口服悬浮液中的非二水合阿奇霉素的转化率的方法。