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公开(公告)号:US20130039926A1
公开(公告)日:2013-02-14
申请号:US13553564
申请日:2012-07-19
申请人: William D. Thomas, JR. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
发明人: William D. Thomas, JR. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
CPC分类号: C07K14/005 , A61K39/12 , A61K39/205 , A61K39/42 , A61K2039/507 , C07K16/10 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C12N2760/20222 , C12N2760/20234
摘要: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
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公开(公告)号:US07727532B2
公开(公告)日:2010-06-01
申请号:US11890317
申请日:2007-08-02
申请人: William D. Thomas, Jr. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
发明人: William D. Thomas, Jr. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
IPC分类号: A61K39/42 , A61K39/205
CPC分类号: C07K14/005 , A61K39/12 , A61K39/205 , A61K39/42 , A61K2039/507 , C07K16/10 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C12N2760/20222 , C12N2760/20234
摘要: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
摘要翻译: 本文提供了特异性结合狂犬病病毒,其抗原结合部分的人单克隆抗体,以及制备和使用此类抗体及其抗原结合部分用于治疗受试者中狂犬病病毒的方法。
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公开(公告)号:US08226952B2
公开(公告)日:2012-07-24
申请号:US12767182
申请日:2010-04-26
申请人: William D. Thomas, Jr. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
发明人: William D. Thomas, Jr. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
IPC分类号: A61K39/42 , A61K39/205
CPC分类号: C07K14/005 , A61K39/12 , A61K39/205 , A61K39/42 , A61K2039/507 , C07K16/10 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C12N2760/20222 , C12N2760/20234
摘要: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
摘要翻译: 本文提供了特异性结合狂犬病病毒,其抗原结合部分的人单克隆抗体,以及制备和使用此类抗体及其抗原结合部分用于治疗受试者中狂犬病病毒的方法。
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公开(公告)号:US20090041777A1
公开(公告)日:2009-02-12
申请号:US11890317
申请日:2007-08-02
申请人: William D. Thomas, JR. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
发明人: William D. Thomas, JR. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
IPC分类号: A61K31/395 , C07K16/08 , C07H21/04 , C12N15/63 , C12N5/00 , A61K39/205 , C12Q1/70 , G01N33/566
CPC分类号: C07K14/005 , A61K39/12 , A61K39/205 , A61K39/42 , A61K2039/507 , C07K16/10 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C12N2760/20222 , C12N2760/20234
摘要: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
摘要翻译: 本文提供了特异性结合狂犬病病毒的人单克隆抗体,其抗原结合部分,以及制备和使用此类抗体及其抗原结合部分用于治疗受试者中狂犬病病毒的方法。
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公开(公告)号:US08609111B2
公开(公告)日:2013-12-17
申请号:US13490757
申请日:2012-06-07
申请人: Donna M. Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
发明人: Donna M. Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
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公开(公告)号:US08257709B2
公开(公告)日:2012-09-04
申请号:US12533552
申请日:2009-07-31
申请人: Donna M. Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
发明人: Donna M. Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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公开(公告)号:US08236311B2
公开(公告)日:2012-08-07
申请号:US12533501
申请日:2009-07-31
申请人: Donna M. Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
发明人: Donna M. Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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公开(公告)号:US07625559B2
公开(公告)日:2009-12-01
申请号:US11051453
申请日:2005-02-04
申请人: Donna Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
发明人: Donna Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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公开(公告)号:US20050068490A1
公开(公告)日:2005-03-31
申请号:US10675510
申请日:2003-09-29
申请人: Robert Mandell , Charles Campbell
发明人: Robert Mandell , Charles Campbell
IPC分类号: G02C7/04
摘要: A monocentric bifocal contact lens with upper and lower optical power zones is connected by a transition comprising a family of sigmoidal curves. The sigmoidal curve begins with a common tangent at the boundary of the near zone and, with a reversal of sign from the near zone curve, climbs with increasing positive slope to an inflection point, whereupon it continues to climb with decreasing positive slope until reaching the distance zone curve, with which it has a common tangent. There is no discontinuity in the first derivative of the curve throughout its length. A sigmoidal curve can be constructed from numerous mathematical functions, examples of which include polynomial, conic, transendental, or cumulative distribution curves.
摘要翻译: 具有上光功率区和下光功率区的单中心双焦隐形眼镜通过包括一系列S形曲线的转变来连接。 S形曲线从近区边界处的普通切线开始,并且随着近区曲线的符号反转,随着正斜率增加到拐点,随后以正斜率下降,直到达到 距离区曲线,它具有共同的切线。 曲线的一阶导数在整个长度上没有不连续性。 可以从许多数学函数构建S形曲线,其示例包括多项式,圆锥,Transendental或累积分布曲线。
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公开(公告)号:US20050287150A1
公开(公告)日:2005-12-29
申请号:US11051453
申请日:2005-02-04
申请人: Donna Ambrosino , Gregory Babcock , Teresa Broering , Robert Graziano , Hector Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William Thomas , Hui-Fen Zhang
发明人: Donna Ambrosino , Gregory Babcock , Teresa Broering , Robert Graziano , Hector Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William Thomas , Hui-Fen Zhang
IPC分类号: A61K39/40 , A61K47/64 , C07H21/04 , C07K16/12 , C12N5/06 , G01N33/554 , G01N33/569
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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