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    Intracorporeal gas exchange devices, systems and methods
    6.
    发明授权
    Intracorporeal gas exchange devices, systems and methods 有权
    体内气体交换装置，系统和方法

    公开(公告)号：US08734382B2

    公开(公告)日：2014-05-27

    申请号：US12865958

    申请日：2009-02-06

    申请人： Brian J. Frankowski ,  William J. Federspiel ,  Kevin M. Mihelc ,  Samuel C. Lieber

    发明人： Brian J. Frankowski ,  William J. Federspiel ,  Kevin M. Mihelc ,  Samuel C. Lieber

    IPC分类号： A61M37/00 ,  A61M1/00

    CPC分类号： A61M37/00 ,  A61M1/1678 ,  A61M1/26 ,  A61M1/262 ,  A61M5/14 ,  A61M2005/006 ,  A61M2005/1403 ,  A61M2025/0031 ,  A61M2025/0057 ,  B01D63/02 ,  B01D2313/025 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/20

    摘要： A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of a gas between an intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood contacting medical system includes at least one seal, and a purge system via which a flushing fluid is introduced under pressure over a blood-side face of the at least one seal and caused to flow through a space on the blood-side face of the at least one seal. The system can further include a rotatable member. The space on the blood-side face of the at least one seal can be in fluid connection with an annular space adjacent to a rotating element operatively connected to the rotatable member.

    摘要翻译： 用于体内气体交换的系统包括柔性可旋转的轴; 多个轴向间隔开的搅拌机构，其位于可旋转的轴上，使得可旋转的轴可在轴向间隔开的搅拌机构之间弯曲; 多个中空透气纤维，其适于允许气体在体内流体和中空纤维的内部之间扩散。 多个中空纤维从搅拌机构径向向外定位。 血液接触医疗系统包括至少一个密封件和净化系统，通过该清洗系统，冲洗流体在压力下被引导到至少一个密封件的血液侧面上并且流过血液侧面上的空间 所述至少一个密封件。 该系统还可包括可旋转构件。 所述至少一个密封件的血液侧面上的空间可以与与可旋转构件可操作地连接的旋转元件相邻的环形空间流体连接。

    Paracorporeal respiratory assist lung
    7.
    发明授权
    Paracorporeal respiratory assist lung 有权
    体外呼吸辅助肺

    公开(公告)号：US07927544B2

    公开(公告)日：2011-04-19

    申请号：US11408650

    申请日：2006-04-21

    申请人： William J. Federspiel ,  Brian J. Frankowski ,  Brendan C. Mack ,  Scott W. Morley ,  Meir Rosenberg ,  Robert G. Svitek

    发明人： William J. Federspiel ,  Brian J. Frankowski ,  Brendan C. Mack ,  Scott W. Morley ,  Meir Rosenberg ,  Robert G. Svitek

    IPC分类号： A61M1/00 ,  A61M37/00 ,  B01D63/00 ,  C02F1/44

    CPC分类号： A61M1/1698 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1086 ,  A61M1/265 ,  A61M1/267 ,  A61M2205/3334 ,  B01D63/02 ,  B01D63/16 ,  B01D2313/10

    摘要： A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is introduced to the center of the device and is passed radially through the fiber bundle. The bundle is rotated at rapidly changing velocities with a rotational actuator (for example, a motor or magnetic coupling). The rotation of the fiber bundle provides centrifugal kinetic energy to the fluid giving the device pumping capabilities and may create Taylor vortexes to increase mass transfer. Rotation of the fiber bundle increases the relative velocity between the fluid and the hollow fibers and increases the mass transfer. The porosity of the fiber bundle may be varied to enhance gas exchange with the blood. Alternatively, a rotating core may be used with a stationary fiber bundle.

    摘要翻译： 体外呼吸辅助肺配置有以快速变化的速度旋转的环形圆柱形中空纤维膜（纤维束）。 流体（例如血液）被引入装置的中心并且径向通过纤维束。 使用旋转致动器（例如，电动机或磁耦合）以快速变化的速度旋转束。 纤维束的旋转为流体提供离心动能，给予装置泵送能力，并且可以产生泰勒涡流以增加传质。 纤维束的旋转增加了流体和中空纤维之间的相对速度，并增加了传质。 可以改变纤维束的孔隙率以增强与血液的气体交换。 或者，旋转芯可以与固定纤维束一起使用。

    INTRACORPOREAL GAS EXCHANGE DEVICES, SYSTEMS AND METHODS
    8.
    发明申请
    INTRACORPOREAL GAS EXCHANGE DEVICES, SYSTEMS AND METHODS 有权
    内部气体交换装置，系统和方法

    公开(公告)号：US20100331767A1

    公开(公告)日：2010-12-30

    申请号：US12865958

    申请日：2009-02-06

    申请人： Brian J. Frankowski ,  William J. Federspiel ,  Kevin M. Mihelc ,  Samuel C. Lieber

    发明人： Brian J. Frankowski ,  William J. Federspiel ,  Kevin M. Mihelc ,  Samuel C. Lieber

    IPC分类号： A61M37/00

    CPC分类号： A61M37/00 ,  A61M1/1678 ,  A61M1/26 ,  A61M1/262 ,  A61M5/14 ,  A61M2005/006 ,  A61M2005/1403 ,  A61M2025/0031 ,  A61M2025/0057 ,  B01D63/02 ,  B01D2313/025 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/20

    摘要： A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood contacting medical system includes at least one seal, and a purge system via which a flushing fluid is introduced under pressure over a blood-side face of the seal and caused to flow through a space on the blood side of the seal. The system can further include a rotatable member. The space on the blood side of the seal can be in fluid connection with an annular space adjacent to a rotating element operatively connected to the rotatable member.

    摘要翻译： 用于体内气体交换的系统包括柔性可旋转的轴; 多个轴向间隔开的搅拌机构，其位于可旋转的轴上，使得可旋转的轴可在轴向间隔开的搅拌机构之间弯曲; 多个中空透气纤维，其适于允许气体在体内流体和中空纤维内部之间扩散。 多个中空纤维从搅拌机构径向向外定位。 血液接触医疗系统包括至少一个密封件和清洗系统，通过该清洗系统，冲洗流体在压力下在密封件的血液侧面上被引入并且流过密封件的血液侧上的空间。 该系统还可包括可旋转构件。 密封件的血液侧的空间可以与与可旋转构件可操作地连接的旋转元件相邻的环形空间流体连接。

    Paracorporeal respiratory assist lung
    9.
    发明授权
    Paracorporeal respiratory assist lung 有权
    体外呼吸辅助肺

    公开(公告)号：US08647569B1

    公开(公告)日：2014-02-11

    申请号：US13084100

    申请日：2011-04-11

    申请人： William J. Federspiel ,  Brian J. Frankowski ,  Brendan C. Mack ,  Scott W. Morley ,  Meir Rosenberg ,  Robert G. Svitek

    发明人： William J. Federspiel ,  Brian J. Frankowski ,  Brendan C. Mack ,  Scott W. Morley ,  Meir Rosenberg ,  Robert G. Svitek

    IPC分类号： A61M1/00 ,  A61M37/00 ,  B01D63/00 ,  C02F1/44

    CPC分类号： A61M1/1698 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1086 ,  A61M1/265 ,  A61M1/267 ,  A61M2205/3334 ,  B01D63/02 ,  B01D63/16 ,  B01D2313/10

    摘要： A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is introduced to the center of the device and is passed radially through the fiber bundle. The bundle is rotated at rapidly changing velocities with a rotational actuator (for example, a motor or magnetic coupling). The rotation of the fiber bundle provides centrifugal kinetic energy to the fluid giving the device pumping capabilities and may create Taylor vortexes to increase mass transfer. Rotation of the fiber bundle increases the relative velocity between the fluid and the hollow fibers and increases the mass transfer. The porosity of the fiber bundle may be varied to enhance gas exchange with the blood. Alternatively, a rotating core may be used with a stationary fiber bundle.

    摘要翻译： 体外呼吸辅助肺配置有以快速变化的速度旋转的环形圆柱形中空纤维膜（纤维束）。 流体（例如血液）被引入装置的中心并且径向通过纤维束。 使用旋转致动器（例如，电动机或磁耦合）以快速变化的速度旋转束。 纤维束的旋转为流体提供离心动能，给予装置泵送能力，并且可以产生泰勒涡流以增加传质。 纤维束的旋转增加了流体和中空纤维之间的相对速度，并增加了传质。 可以改变纤维束的孔隙率以增强与血液的气体交换。 或者，旋转芯可以与固定纤维束一起使用。