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1.发明申请DEVICES, SYSTEMS AND METHODS FOR REDUCING THE CONCENTRATION OF A CHEMICAL ENTITY IN FLUIDS 有权减少流体中化学成分浓度的装置，系统和方法公开(公告)号：US20100258116A1
公开(公告)日：2010-10-14
申请号：US12816455
申请日：2010-06-16
IPC分类号： A62B7/00
CPC分类号： B01D69/144 , A61M1/1698 , A61M1/28 , A61M1/3679 , B01D19/0031 , B01D53/229 , B01D67/009 , B01D67/0093 , B01D69/08 , B01D69/145 , B01D71/26 , B01D71/70 , B01D2311/2653 , B01D2323/30 , B01D2325/10 , Y02C10/10
摘要： A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized carbonic anhydrase on or in the vicinity of a first surface of the membrane to be contacted with the fluid such that the immobilized carbonic anhydrase comes into contact with the fluid. The first surface exhibits carbonic anhydrase activity of at least 20% of maximum theoretical activity of the first surface of the membrane based on monolayer surface coverage of carbonic anhydrase in the case that the carbonic anhydrase is immobilize on the first surface.
摘要翻译： 用于从水性流体中去除至少一部分二氧化碳的装置包括至少一个膜，二氧化碳可以通过该膜从流体中除去，并将固定的碳酸酐酶固定在膜的第一表面上或其附近，至 与流体接触，使得固定的碳酸酐酶与流体接触。 在碳酸酐酶固定在第一表面的情况下，第一表面基于碳酸酐酶的单层表面覆盖，显示出膜的第一表面的最大理论活性的至少20％的碳酸酐酶活性。
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2.发明授权Devices, systems and methods for reducing the concentration of a chemical entity in fluids 有权减少流体中化学物质浓度的装置，系统和方法公开(公告)号：US07763097B2
公开(公告)日：2010-07-27
申请号：US11811265
申请日：2007-06-08
IPC分类号： B01D53/22
CPC分类号： B01D69/144 , A61M1/1698 , A61M1/28 , A61M1/3679 , B01D19/0031 , B01D53/229 , B01D67/009 , B01D67/0093 , B01D69/08 , B01D69/145 , B01D71/26 , B01D71/70 , B01D2311/2653 , B01D2323/30 , B01D2325/10 , Y02C10/10
摘要： A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized carbonic anhydrase on or in the vicinity of a first surface of the membrane to be contacted with the fluid such that the immobilized carbonic anhydrase comes into contact with the fluid. The first surface exhibits carbonic anhydrase activity of at least 20% of maximum theoretical activity of the first surface of the membrane based on monolayer surface coverage of carbonic anhydrase in the case that the carbonic anhydrase is immobilize on the first surface.
摘要翻译： 用于从水性流体中去除至少一部分二氧化碳的装置包括至少一个膜，二氧化碳可以通过该膜从流体中除去，并将固定的碳酸酐酶固定在膜的第一表面上或其附近，至 与流体接触，使得固定的碳酸酐酶与流体接触。 在碳酸酐酶固定在第一表面的情况下，第一表面基于碳酸酐酶的单层表面覆盖，显示出膜的第一表面的最大理论活性的至少20％的碳酸酐酶活性。
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3.发明授权Devices, systems and methods for reducing the concentration of a chemical entity in fluids 有权减少流体中化学物质浓度的装置，系统和方法公开(公告)号：US08323379B2
公开(公告)日：2012-12-04
申请号：US13280033
申请日：2011-10-24
申请人： William J. Federspiel , Alan J. Russell , Heung-Il Oh , Joel Kaar
发明人： William J. Federspiel , Alan J. Russell , Heung-Il Oh , Joel Kaar
CPC分类号： B01D69/144 , A61M1/1698 , A61M1/28 , A61M1/3679 , B01D19/0031 , B01D53/229 , B01D67/009 , B01D67/0093 , B01D69/08 , B01D69/145 , B01D71/26 , B01D71/70 , B01D2311/2653 , B01D2323/30 , B01D2325/10 , Y02C10/10
摘要： A method of improving the blood compatibility of a blood-contacting surface includes immobilizing carbonic anhydrase on the surface, wherein the surface exhibits carbonic anhydrase activity of at least 20% of maximum theoretical activity of the surface based on monolayer surface coverage of carbonic anhydrase.
摘要翻译： 改善血液接触表面的血液相容性的方法包括将碳酸酐酶固定在表面上，其中基于碳酸酐酶的单层表面覆盖，表面显示出碳酸酐酶活性至少为表面最大理论活性的20％。
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公开(公告)号：US20080293842A1
公开(公告)日：2008-11-27
申请号：US11596233
申请日：2005-05-13
CPC分类号： C07C233/38 , A61K9/1274 , A61K31/14 , A61K31/16 , B82Y5/00 , Y02A50/473 , Y10S977/712 , Y10S977/797 , Y10S977/882 , Y10T428/2982
摘要： The invention concerns the synthesis of nanotubes and nanocarpets by the spontaneous self-assembly of single chain achiral diacetylenes The monomer units may be cross-linked by UV irradiation to form stable supramolecular assemblies. The nanotubes of the invention, which are remarkably homogeneous in length and diameter, exhibit chromogenic and antibacterial properties.
摘要翻译： 本发明涉及通过单链非手性二乙炔的自发自组装纳米管和纳米胶的合成。单体单元可以通过UV照射交联以形成稳定的超分子组装。 在长度和直径上显着均匀的本发明的纳米管表现出显色和抗菌性能。
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公开(公告)号：US07335400B2
公开(公告)日：2008-02-26
申请号：US10850674
申请日：2004-05-21
IPC分类号： B05D3/00
CPC分类号： C12N11/08 , C08G18/0866 , C08G18/3278 , C08G18/42 , C08G18/6446 , C08G18/706 , C08G18/798 , C09D175/04 , C12N11/04
摘要： A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethanes in the presence of enzyme has enabled the irreversible attachment of the enzyme to the polymeric matrix. The distribution of immobilized enzyme as well as activity retention are homogeneous within the polyurethane. Decreasing ECC hydrophobicity, via the use of a less hydrophobic polyisocyanate prepolymer during polymerization, significantly enhanced the intrinsic activity of the ECC.
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公开(公告)号：US06759220B1
公开(公告)日：2004-07-06
申请号：US09441592
申请日：1999-11-17
申请人： Keith E. LeJeune , Alan J. Russell
发明人： Keith E. LeJeune , Alan J. Russell
IPC分类号： C12N1118
摘要： A method of increasing loading of active enzyme immobilized in a polyurethane polymer including the steps of: synthesizing the polyurethane polymer in a reaction mixture containing water and enzyme; and including a sufficient amount of a surfactant in the reaction mixture to increase enzyme activity at an enzyme loading.
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公开(公告)号：US08012278B2
公开(公告)日：2011-09-06
申请号：US11796492
申请日：2007-04-27
申请人： Alan J. Russell , Sang B. Lee
发明人： Alan J. Russell , Sang B. Lee
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/168 , C01B32/17 , C01P2004/03 , C01P2004/04 , C01P2004/13 , Y10S977/762 , Y10S977/788
摘要： A method for joining nanotubes end-to-end, includes contacting the nanotubes with a joining fluid. The joining fluid has at least one property that is different from at least one property associated with ends of the nanotubes. In one embodiment, the method further includes contacting the nanotubes with a first, treating fluid and removing the bulk first fluid before the nanotubes are contacted with the joining fluid. The joining fluid is immiscible in the treating fluid to effect end-to-end joining of the nanotubes.
摘要翻译： 一种用于将纳米管端对端连接的方法包括使纳米管与接合流体接触。 连接流体具有至少一种不同于与纳米管的端部相关联的至少一种性质的性质。 在一个实施方案中，该方法还包括在纳米管与接合流体接触之前使纳米管与第一处理流体接触并除去本体第一流体。 接合流体在处理流体中不混溶以实现纳米管的端到端连接。
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公开(公告)号：US20090136553A1
公开(公告)日：2009-05-28
申请号：US12237835
申请日：2008-09-25
申请人： Jorg C. Gerlach , Jianjun Guan , Steven R. Little , Alan J. Russell , Jillian Tengood , William R. Wagner
发明人： Jorg C. Gerlach , Jianjun Guan , Steven R. Little , Alan J. Russell , Jillian Tengood , William R. Wagner
CPC分类号： A61L27/38 , A61L27/50 , A61L27/54 , A61L2300/414 , A61L2300/45 , A61L2300/602 , D01D5/24
摘要： Provided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded within a cell growth scaffold. The tubular structures are useful in growing 3-dimensional tissue structures because nutrients, cytokines or other cell growth and/or differentiation compounds, as well as drugs, such as antibiotics and steroids, can be administered over time, and the tubular structures can be dissolved non-invasively.
摘要翻译： 提供了生物相容性，可触发性可溶解的材料的管状结构，例如在生理温度以下具有LCST的纤维素或共聚物。 结构可以嵌入细胞生长支架内。 管状结构可用于生长三维组织结构，因为营养物质，细胞因子或其它细胞生长和/或分化化合物以及药物如抗生素和类固醇可随时间施用，并且管状结构可溶解 非侵略性
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公开(公告)号：US20080139689A1
公开(公告)日：2008-06-12
申请号：US11894010
申请日：2007-08-17
IPC分类号： B29C71/04
CPC分类号： C08L33/14 , C08F120/34 , C08F255/02 , C08F265/06 , C08F291/00 , C08F293/005 , C08L53/00
摘要： A polymer formed by controlled radical polymerization includes groups that can be modified after controlled radical polymerization to form a radical. The polymer can be the reaction product of a controlled radical polymerization of radically polymerizable monomers, wherein at least one of the radically polymerizable monomers includes at least one group that can be modified after the controlled radical polymerization to form a radical. A compound includes a first group that is stimulated upon application of energy to the molecule to tether the molecule to a surface or to another polymer chain and a second group comprising a controlled radical polymerization initiator functionality. A block copolymer includes at least a first segment to impart a predetermined functionality to a target surface and at least a second segment including functional groups to interact with the targeted surface to attach the block copolymer to the surface. The first segment can free of functional groups that interact with the surface to attach the block copolymer to the surface.
摘要翻译： 通过受控自由基聚合形成的聚合物包括可以在受控自由基聚合反应形成基团之后进行改性的基团。 聚合物可以是可自由基聚合的单体的受控自由基聚合的反应产物，其中至少一种可自由基聚合的单体包括至少一个可在受控自由基聚合之后修饰以形成基团的基团。 化合物包括在向分子施加能量以将分子束缚至表面或另一聚合物链时被刺激的第一组和包含受控自由基聚合引发剂官能团的第二组。 嵌段共聚物包括至少一个赋予靶表面预定官能度的第一链段和至少一个包含官能团的第二链段以与目标表面相互作用以将该嵌段共聚物连接到该表面上。 第一段可以没有与表面相互作用的官能团，以将嵌段共聚物附着在表面上。
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公开(公告)号：US06905733B2
公开(公告)日：2005-06-14
申请号：US10202224
申请日：2002-07-24
IPC分类号： G01N27/327 , C12N11/04 , C12N11/08 , B05D3/00
摘要： This invention provides a method of irreversibly immobilizing an enzyme into polyurethane coatings. This invention also provides for an enzyme-containing coating having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethane coatings in the presence of enzyme has enabled the irreversible attachment of the enzyme to the polymeric matrix. The distribution of immobilized enzyme as well as activity retention are homogeneous within the coating. Decreasing ECC hydrophobicity, via the use of a less hydrophobic polyisocyanate prepolymer during polymerization, significantly enhanced the intrinsic activity of the ECC.
摘要翻译： 本发明提供了将酶不可逆地固定在聚氨酯涂层中的方法。 本发明还提供具有大约100％酶固定程度的含酶涂层。 在存在酶的情况下水性聚氨酯涂层的合成使酶能够与聚合物基质不可逆地连接。 固定化酶的分布以及活性保留在涂层内是均匀的。 通过在聚合过程中通过使用较少疏水性的多异氰酸酯预聚物来降低ECC疏水性，显着提高了ECC的内在活性。
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