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公开(公告)号：US20130012503A1
公开(公告)日：2013-01-10
申请号：US13528283
申请日：2012-06-20
IPC分类号： A01N43/713 , C07D417/06 , A01N43/78 , C07D401/06 , A01N43/42 , A01N43/88 , A01N43/54 , A01N43/60 , A01N43/58 , A01P3/00 , A01P1/00 , C07D409/06 , C07D403/06
CPC分类号： A61K45/06 , A01N37/50 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/78 , A01N43/88 , A01N47/24 , A61K31/41 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D257/04 , C07D401/06 , C07D403/06 , C07D409/06 , C07D417/06 , A61K2300/00
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US08940735B2
公开(公告)日：2015-01-27
申请号：US13528283
申请日：2012-06-20
IPC分类号： A01N43/713 , A01N43/78 , A01N43/42 , A01N43/88 , A01N43/54 , A01N43/60 , A01N43/58 , C07D417/06 , C07D401/06 , C07D409/06 , C07D403/06 , A61K31/497 , A61K45/06 , A61K31/41 , A61K31/428 , A61K31/498 , C07D257/04 , A61K31/427 , A61K31/4709 , A61K31/4439 , A61K31/506 , A61K31/4725 , A61K31/501
CPC分类号： A61K45/06 , A01N37/50 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/78 , A01N43/88 , A01N47/24 , A61K31/41 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D257/04 , C07D401/06 , C07D403/06 , C07D409/06 , C07D417/06 , A61K2300/00
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US08809378B2
公开(公告)日：2014-08-19
申请号：US13527387
申请日：2012-06-19
申请人： William J. Hoekstra , Stephen W. Rafferty , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Michael T. Sullenberger , Gary D. Gustafson
发明人： William J. Hoekstra , Stephen W. Rafferty , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Michael T. Sullenberger , Gary D. Gustafson
CPC分类号： C07D401/06 , A01N43/54 , A01N43/56 , A01N43/647 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/78 , A01N43/84 , C07D401/14 , C07D405/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US20120329788A1
公开(公告)日：2012-12-27
申请号：US13527426
申请日：2012-06-19
申请人： William J. Hoekstra , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Zachary A. Buchan , Michael T. Sullenberger , Gary D. Gustafson
发明人： William J. Hoekstra , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Zachary A. Buchan , Michael T. Sullenberger , Gary D. Gustafson
IPC分类号： A01N43/713 , C07D401/14 , C07D417/14 , C07D409/14 , A01N43/653 , A01N43/88 , A01N43/54 , A01P3/00 , C07D401/06 , A01N43/78
CPC分类号： A01N43/713 , A01N25/00 , A01N43/647 , A01N43/653 , A01N43/78 , C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US08748461B2
公开(公告)日：2014-06-10
申请号：US13527426
申请日：2012-06-19
申请人： William J. Hoekstra , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Zachary A. Buchan , Michael T. Sullenberger , Gary D. Gustafson
发明人： William J. Hoekstra , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Zachary A. Buchan , Michael T. Sullenberger , Gary D. Gustafson
CPC分类号： A01N43/713 , A01N25/00 , A01N43/647 , A01N43/653 , A01N43/78 , C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US20130005719A1
公开(公告)日：2013-01-03
申请号：US13527387
申请日：2012-06-19
申请人： William J. Hoekstra , Stephen W. Rafferty , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Michael T. Sullenberger , Gary D. Gustafson
发明人： William J. Hoekstra , Stephen W. Rafferty , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Michael T. Sullenberger , Gary D. Gustafson
IPC分类号： A01N43/40 , C07D401/14 , A01N43/54 , A01N43/88 , A01N43/84 , A01P1/00 , A01P3/00 , C07D401/06 , C07D413/14
CPC分类号： C07D401/06 , A01N43/54 , A01N43/56 , A01N43/647 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/78 , A01N43/84 , C07D401/14 , C07D405/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US20130005776A1
公开(公告)日：2013-01-03
申请号：US13561586
申请日：2012-07-30
IPC分类号： C12N9/99 , A61P31/10 , A61K31/4439
CPC分类号： C07D401/06
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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8.发明申请公开(公告)号：US20100305078A1
公开(公告)日：2010-12-02
申请号：US12515676
申请日：2007-11-21
IPC分类号： A61K31/56 , C07D405/12 , C07D239/72 , C07D239/00 , C07D401/02 , C07D257/12 , C07D253/06 , C07D251/02 , C07J1/00 , A61K31/497 , A61K31/517 , A61K31/53 , A61K31/395 , A61P43/00
CPC分类号： A61K31/506 , Y02A50/411
摘要： The presently disclosed subject matter is directed to metallo-oxidoreductase inhibitors having metal binding moities linked to a targeting moiety through a linking group or a direct bond, methods for screening for metallo-oxidoreductase inhibitors, and methods of treating an oxidoreductase related disorder by administering a metallo-oxidoreductase inhibitor to a subject in need of treatment thereof.
摘要翻译： 目前公开的主题涉及具有通过连接基团或直接键连接至靶向部分的金属结合力的金属氧化还原酶抑制剂，筛选金属氧化还原酶抑制剂的方法，以及通过施用治疗氧化还原酶相关病症的方法 金属氧化还原酶抑制剂加工成需要治疗的对象。
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公开(公告)号：US09150527B2
公开(公告)日：2015-10-06
申请号：US14342323
申请日：2012-08-27
IPC分类号： C07D277/32 , C07D277/22 , C07D277/24 , A61K45/06 , A61K31/427 , A61K31/542 , C07D417/12 , C07D513/04 , A01N43/78 , A01N43/84 , A01N43/90 , C07D277/28 , C07D277/56 , C07D417/06 , C07D417/14
CPC分类号： C07D277/24 , A01N43/78 , A01N43/84 , A01N43/90 , A61K31/427 , A61K31/542 , A61K45/06 , C07D277/22 , C07D277/28 , C07D277/32 , C07D277/56 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , A61K2300/00
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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10.发明授权Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties 有权使用金属结合部分与靶向部分组合的金属氧化还原酶抑制剂公开(公告)号：US08680270B2
公开(公告)日：2014-03-25
申请号：US12515676
申请日：2007-11-21
IPC分类号： C07D403/10 , A61K31/506 , A61K31/41 , A61P31/04
CPC分类号： A61K31/506 , Y02A50/411
摘要： The presently disclosed subject matter is directed to metallo-oxidoreductase inhibitors having metal binding moities linked to a targeting moiety through a linking group or a direct bond, methods for screening for metallo-oxidoreductase inhibitors, and methods of treating an oxidoreductase related disorder by administering a metallo-oxidoreductase inhibitor to a subject in need of treatment thereof.
摘要翻译： 目前公开的主题涉及具有通过连接基团或直接键连接至靶向部分的金属结合力的金属氧化还原酶抑制剂，筛选金属氧化还原酶抑制剂的方法，以及通过施用治疗氧化还原酶相关病症的方法 金属氧化还原酶抑制剂加工成需要治疗的对象。
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