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公开(公告)号：US20130012503A1
公开(公告)日：2013-01-10
申请号：US13528283
申请日：2012-06-20
IPC分类号： A01N43/713 , C07D417/06 , A01N43/78 , C07D401/06 , A01N43/42 , A01N43/88 , A01N43/54 , A01N43/60 , A01N43/58 , A01P3/00 , A01P1/00 , C07D409/06 , C07D403/06
CPC分类号： A61K45/06 , A01N37/50 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/78 , A01N43/88 , A01N47/24 , A61K31/41 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D257/04 , C07D401/06 , C07D403/06 , C07D409/06 , C07D417/06 , A61K2300/00
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US20130005776A1
公开(公告)日：2013-01-03
申请号：US13561586
申请日：2012-07-30
IPC分类号： C12N9/99 , A61P31/10 , A61K31/4439
CPC分类号： C07D401/06
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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3.发明申请公开(公告)号：US20100305078A1
公开(公告)日：2010-12-02
申请号：US12515676
申请日：2007-11-21
IPC分类号： A61K31/56 , C07D405/12 , C07D239/72 , C07D239/00 , C07D401/02 , C07D257/12 , C07D253/06 , C07D251/02 , C07J1/00 , A61K31/497 , A61K31/517 , A61K31/53 , A61K31/395 , A61P43/00
CPC分类号： A61K31/506 , Y02A50/411
摘要： The presently disclosed subject matter is directed to metallo-oxidoreductase inhibitors having metal binding moities linked to a targeting moiety through a linking group or a direct bond, methods for screening for metallo-oxidoreductase inhibitors, and methods of treating an oxidoreductase related disorder by administering a metallo-oxidoreductase inhibitor to a subject in need of treatment thereof.
摘要翻译： 目前公开的主题涉及具有通过连接基团或直接键连接至靶向部分的金属结合力的金属氧化还原酶抑制剂，筛选金属氧化还原酶抑制剂的方法，以及通过施用治疗氧化还原酶相关病症的方法 金属氧化还原酶抑制剂加工成需要治疗的对象。
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公开(公告)号：US09056855B2
公开(公告)日：2015-06-16
申请号：US13882443
申请日：2011-10-28
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , C07D401/06 , C07D409/14 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/26
CPC分类号： C07D401/06 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/26 , C07D409/14
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
摘要翻译： 本发明描述了具有金属酶调节活性的化合物，以及治疗由这些金属酶介导的疾病，病症或症状的方法。
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公开(公告)号：US08901121B2
公开(公告)日：2014-12-02
申请号：US13527402
申请日：2012-06-19
申请人： William J. Hoekstra , Stephen W. Rafferty , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Michael T. Sullenberger
发明人： William J. Hoekstra , Stephen W. Rafferty , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Michael T. Sullenberger
IPC分类号： A61K31/535 , A61K31/44 , C07D239/42 , C07D413/08 , C07D401/08 , C07D403/08 , A01N43/713 , A01N43/54 , C07D417/06 , A01N43/647 , A01N43/76 , C07D409/14 , C07D405/06 , C07D401/14 , C07D401/06 , C07D413/06 , A01N43/78 , A01N43/56
CPC分类号： C07D401/06 , A01N43/54 , A01N43/56 , A01N43/647 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/78 , A01N43/84 , C07D401/14 , C07D405/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US08796001B2
公开(公告)日：2014-08-05
申请号：US13527413
申请日：2012-06-19
申请人： William J. Hoekstra , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Zachary A. Buchan , Michael T. Sullenberger
发明人： William J. Hoekstra , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Zachary A. Buchan , Michael T. Sullenberger
IPC分类号： A61K31/505 , A61K31/44 , A61K31/655 , A61K31/47 , C12N9/99 , C07D239/02 , C07D401/08 , C07D215/12 , C07D417/08 , C07D413/08
CPC分类号： A01N43/713 , A01N25/00 , A01N43/647 , A01N43/653 , A01N43/78 , C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US20130005752A1
公开(公告)日：2013-01-03
申请号：US13527413
申请日：2012-06-19
申请人： William J. Hoekstra , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Zachary A. Buchan , Michael T. Sullenberger
发明人： William J. Hoekstra , Christopher M. Yates , Robert J. Schotzinger , Michael R. Loso , Zachary A. Buchan , Michael T. Sullenberger
IPC分类号： A61K31/4439 , C12N9/99 , C07D401/14 , A61K31/444 , C07D417/14 , A61K31/506 , A61K31/4709 , A61P31/10 , A61P1/00 , A61P29/00 , A61P15/00 , A61P27/02 , A61P9/00 , A61P35/00 , C07D401/06
CPC分类号： A01N43/713 , A01N25/00 , A01N43/647 , A01N43/653 , A01N43/78 , C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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8.发明申请METALLOENZYME INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES 审中-公开金属化合物抑制剂使用金属结合物与组织动物组合公开(公告)号：US20110015158A1
公开(公告)日：2011-01-20
申请号：US12747382
申请日：2008-12-03
IPC分类号： A61K31/675 , C07D493/14 , C07D209/04 , C07D285/12 , C07D471/04 , C07D241/04 , C07D243/14 , C07D291/08 , G01N33/573 , A61K31/357 , A61K31/404 , A61K31/433 , A61K31/437 , A61K31/495 , A61K31/5513 , A61K31/55
CPC分类号： A61K31/10 , A61K31/122 , A61K31/35 , A61K31/37 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/404 , A61K31/431 , A61K31/437 , A61K31/44 , A61K31/55 , A61K31/5513
摘要： The presently disclosed subject matter is described to metalloenzyme inhibitors having metal binding moieties linked to a targeting moiety through a linking group or a direct bond, method of screening for metalloenzyme inhibitors, and methods for treating a metalloenzyme related disorder by administering a metalloenzyme inhibitor to a subject in need of treatment thereof.
摘要翻译： 将目前公开的主题描述为具有通过连接基团或直接键连接至靶向部分的金属结合部分的金属酶抑制剂，筛选金属酶抑制剂的方法，以及通过向金属酶抑制剂施用金属酶抑制剂来治疗金属酶相关病症的方法 需要治疗。
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公开(公告)号：US09150527B2
公开(公告)日：2015-10-06
申请号：US14342323
申请日：2012-08-27
IPC分类号： C07D277/32 , C07D277/22 , C07D277/24 , A61K45/06 , A61K31/427 , A61K31/542 , C07D417/12 , C07D513/04 , A01N43/78 , A01N43/84 , A01N43/90 , C07D277/28 , C07D277/56 , C07D417/06 , C07D417/14
CPC分类号： C07D277/24 , A01N43/78 , A01N43/84 , A01N43/90 , A61K31/427 , A61K31/542 , A61K45/06 , C07D277/22 , C07D277/28 , C07D277/32 , C07D277/56 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , A61K2300/00
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US08940735B2
公开(公告)日：2015-01-27
申请号：US13528283
申请日：2012-06-20
IPC分类号： A01N43/713 , A01N43/78 , A01N43/42 , A01N43/88 , A01N43/54 , A01N43/60 , A01N43/58 , C07D417/06 , C07D401/06 , C07D409/06 , C07D403/06 , A61K31/497 , A61K45/06 , A61K31/41 , A61K31/428 , A61K31/498 , C07D257/04 , A61K31/427 , A61K31/4709 , A61K31/4439 , A61K31/506 , A61K31/4725 , A61K31/501
CPC分类号： A61K45/06 , A01N37/50 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/78 , A01N43/88 , A01N47/24 , A61K31/41 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D257/04 , C07D401/06 , C07D403/06 , C07D409/06 , C07D417/06 , A61K2300/00
摘要： The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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