专利检索 ap:("Carol Ensinger" OR "James Dowling" OR "Russell Petter" OR "Gnanasambandam Kumaravel") AND inv:"Gnanasambandam Kumaravel" 第 1 页

1.

发明申请
ADENOSINE RECEPTOR ANTAGONISTS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：腺苷受体拮抗剂及其制备和使用方法

公开(公告)号：US20080004293A1

公开(公告)日：2008-01-03

申请号：US11829269

申请日：2007-07-27

申请人： Carol Ensinger , James Dowling , Russell Petter , Gnanasambandam Kumaravel

发明人： Carol Ensinger , James Dowling , Russell Petter , Gnanasambandam Kumaravel

IPC分类号： A61K31/52 , A61P11/00 , A61P11/06 , A61P25/00 , A61P25/16 , A61P25/24 , A61P3/10 , A61P9/00 , C07D473/00

CPC分类号： C07D473/02 , C07D473/04 , C07D473/06

摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:

摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病适当。在一个实施方案中，本发明的特征在于式I的化合物：

2.

发明申请
Adenosine receptor antagonists and methods of making and using the same 审中-公开
标题翻译：腺苷受体拮抗剂及其制备和使用方法

公开(公告)号：US20070015732A1

公开(公告)日：2007-01-18

申请号：US11487764

申请日：2006-07-13

申请人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Chang , Ko Lin

发明人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Chang , Ko Lin

IPC分类号： A61K31/675 , A61K31/522 , C07F9/6512 , C07D473/02

CPC分类号： C07D473/06 , C07D473/22 , C07F9/65616

摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:

摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病适当。在一个实施方案中，本发明的特征在于式I的化合物：

3.

发明申请
Adenosine receptor antagonists and methods of making and using the same 失效
标题翻译：腺苷受体拮抗剂及其制备和使用方法

公开(公告)号：US20060252730A1

公开(公告)日：2006-11-09

申请号：US11484805

申请日：2006-07-10

申请人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Xi Chang , Ko Chung Lin

发明人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Xi Chang , Ko Chung Lin

IPC分类号： A61K31/675 , A61K31/522 , C07F9/6512 , C07D473/04

CPC分类号： C07D473/06 , C07D473/22 , C07F9/65616

摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:

摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病适当。在一个实施方案中，本发明的特征在于式I的化合物：

4.

发明申请
Adenosine receptor antagonists and methods of making and using the same 审中-公开
标题翻译：腺苷受体拮抗剂及其制备和使用方法

公开(公告)号：US20050222179A1

公开(公告)日：2005-10-06

申请号：US11128550

申请日：2005-05-13

申请人： Carol Ensinger , James Dowling , Russell Petter , Gnanasambandam Kumaravel

发明人： Carol Ensinger , James Dowling , Russell Petter , Gnanasambandam Kumaravel

IPC分类号： A61K31/52 , A61K31/522 , A61P1/00 , A61P3/10 , A61P7/10 , A61P7/12 , A61P9/00 , A61P9/04 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00 , C07D473/00 , C07D473/02 , C07D473/04 , C07D473/06 , C07D519/00

CPC分类号： C07D473/02 , C07D473/04 , C07D473/06

摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:

摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病适当。在一个实施方案中，本发明的特征在于式I的化合物：

5.

发明申请
Triazolopyrazines and methods of making and using the same 失效
标题翻译：三唑并吡嗪及其制备和使用方法

公开(公告)号：US20070010520A1

公开(公告)日：2007-01-11

申请号：US10552305

申请日：2004-04-09

申请人： James Dowling , Gang Yao , Hexi Chang , Hairuo Peng , Jeffrey Vessels , Russell Petter , Gnanasambandam Kumaravel

发明人： James Dowling , Gang Yao , Hexi Chang , Hairuo Peng , Jeffrey Vessels , Russell Petter , Gnanasambandam Kumaravel

IPC分类号： A61K31/498 , C07D487/04

CPC分类号： C07D241/20 , C07D487/04

摘要： The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula I (See formula on paper copy)

摘要翻译： 本发明基于以下发现：式（I）化合物对A2a腺苷受体具有意想不到的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括帕金森病在内的许多疾病。在一个实施方案中，本发明的特征在于式I的化合物（参见纸上的公式）

6.

发明申请
A2a adenosine receptor antagonists 失效
标题翻译： A2a腺苷受体拮抗剂

公开(公告)号：US20070173505A1

公开(公告)日：2007-07-26

申请号：US10552304

申请日：2004-04-09

申请人： Hairuo Peng , Gang Yao , Russell Petter , Gnanasambandam Kumaravel

发明人： Hairuo Peng , Gang Yao , Russell Petter , Gnanasambandam Kumaravel

IPC分类号： A61K31/53 , A61K31/519 , C07D487/04

CPC分类号： C07D519/00

摘要： The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula (I).

摘要翻译： 本发明基于以下发现：式（I）化合物对Aβ2α腺苷受体具有意想不到的高亲和力，并且可用作其用于预防和/或治疗多种疾病的拮抗剂，包括帕金森病疾病。在一个实施方案中，本发明的特征在于式（I）的化合物。

7.

发明申请
Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists 审中-公开
标题翻译：可用作a2a腺苷受体拮抗剂的三唑并[1,5-c]嘧啶和吡唑并[1,5-c]嘧啶

公开(公告)号：US20070010522A1

公开(公告)日：2007-01-11

申请号：US10552302

申请日：2004-04-09

申请人： Chi Vu , Russell Petter , Gnanasambandam Kumaravel

发明人： Chi Vu , Russell Petter , Gnanasambandam Kumaravel

IPC分类号： A61K31/519 , C07D487/04

CPC分类号： C07D487/04

摘要： The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula (I).

摘要翻译： 本发明基于以下发现：式（I）化合物对A2a腺苷受体具有意想不到的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括帕金森病在内的许多疾病。在一个实施方案中，本发明的特征在于式（I）的化合物。