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公开(公告)号：US20070010520A1
公开(公告)日：2007-01-11
申请号：US10552305
申请日：2004-04-09
申请人： James Dowling , Gang Yao , Hexi Chang , Hairuo Peng , Jeffrey Vessels , Russell Petter , Gnanasambandam Kumaravel
发明人： James Dowling , Gang Yao , Hexi Chang , Hairuo Peng , Jeffrey Vessels , Russell Petter , Gnanasambandam Kumaravel
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： C07D241/20 , C07D487/04
摘要： The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula I (See formula on paper copy)
摘要翻译： 本发明基于以下发现：式（I）化合物对A2a腺苷受体具有意想不到的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括帕金森病在内的许多疾病。 在一个实施方案中，本发明的特征在于式I的化合物（参见纸上的公式）
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公开(公告)号：US20070173505A1
公开(公告)日：2007-07-26
申请号：US10552304
申请日：2004-04-09
IPC分类号： A61K31/53 , A61K31/519 , C07D487/04
CPC分类号： C07D519/00
摘要： The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula (I).
摘要翻译： 本发明基于以下发现：式（I）化合物对Aβ2α腺苷受体具有意想不到的高亲和力，并且可用作其用于预防和/或治疗多种疾病的拮抗剂，包括帕金森病 疾病。 在一个实施方案中，本发明的特征在于式（I）的化合物。
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3.发明申请公开(公告)号：US20070015732A1
公开(公告)日：2007-01-18
申请号：US11487764
申请日：2006-07-13
申请人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Chang , Ko Lin
发明人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Chang , Ko Lin
IPC分类号： A61K31/675 , A61K31/522 , C07F9/6512 , C07D473/02
CPC分类号： C07D473/06 , C07D473/22 , C07F9/65616
摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。 腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病 适当。 在一个实施方案中，本发明的特征在于式I的化合物：
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公开(公告)号：US20060252730A1
公开(公告)日：2006-11-09
申请号：US11484805
申请日：2006-07-10
申请人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Xi Chang , Ko Chung Lin
发明人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Xi Chang , Ko Chung Lin
IPC分类号： A61K31/675 , A61K31/522 , C07F9/6512 , C07D473/04
CPC分类号： C07D473/06 , C07D473/22 , C07F9/65616
摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。 腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病 适当。 在一个实施方案中，本发明的特征在于式I的化合物：
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5.发明申请公开(公告)号：US20080004293A1
公开(公告)日：2008-01-03
申请号：US11829269
申请日：2007-07-27
IPC分类号： A61K31/52 , A61P11/00 , A61P11/06 , A61P25/00 , A61P25/16 , A61P25/24 , A61P3/10 , A61P9/00 , C07D473/00
CPC分类号： C07D473/02 , C07D473/04 , C07D473/06
摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。 腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病 适当。 在一个实施方案中，本发明的特征在于式I的化合物：
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6.发明申请公开(公告)号：US20050222179A1
公开(公告)日：2005-10-06
申请号：US11128550
申请日：2005-05-13
IPC分类号： A61K31/52 , A61K31/522 , A61P1/00 , A61P3/10 , A61P7/10 , A61P7/12 , A61P9/00 , A61P9/04 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00 , C07D473/00 , C07D473/02 , C07D473/04 , C07D473/06 , C07D519/00
CPC分类号： C07D473/02 , C07D473/04 , C07D473/06
摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。 腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病 适当。 在一个实施方案中，本发明的特征在于式I的化合物：
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![Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists](/abs-image/US/2007/01/11/US20070010522A1/abs.jpg.150x150.jpg)
7.发明申请Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists 审中-公开可用作a2a腺苷受体拮抗剂的三唑并[1,5-c]嘧啶和吡唑并[1,5-c]嘧啶公开(公告)号：US20070010522A1
公开(公告)日：2007-01-11
申请号：US10552302
申请日：2004-04-09
申请人： Chi Vu , Russell Petter , Gnanasambandam Kumaravel
发明人： Chi Vu , Russell Petter , Gnanasambandam Kumaravel
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula (I).
摘要翻译： 本发明基于以下发现：式（I）化合物对A2a腺苷受体具有意想不到的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括帕金森病在内的许多疾病。 在一个实施方案中，本发明的特征在于式（I）的化合物。
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公开(公告)号：US08450335B2
公开(公告)日：2013-05-28
申请号：US12492180
申请日：2009-06-26
申请人： Juswinder Singh , Russell Petter , Richland Wayne Tester , Arthur F. Kluge , Hormoz Mazdiyasni , William Frederick Westlin, III , Deqiang Niu , Lixin Qiao
发明人： Juswinder Singh , Russell Petter , Richland Wayne Tester , Arthur F. Kluge , Hormoz Mazdiyasni , William Frederick Westlin, III , Deqiang Niu , Lixin Qiao
IPC分类号： A61K31/505
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/18
摘要： The present invention provides 2,4-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same. In some embodiments, the present invention provides a compound of formula I-b: wherein each of Ring A, Ring B, W1, W2, Ry, Rv, Rx, m, p, and R1 is described herein.
摘要翻译： 本发明提供可用作激酶抑制剂的2,4-二取代嘧啶化合物，其药学上可接受的组合物及其使用方法。 在一些实施方案中，本发明提供式I-b的化合物：其中环A，环B，W1，W2，Ry，Rv，Rx，m，p和R1各自在本文中进行描述。
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公开(公告)号：US20100249092A1
公开(公告)日：2010-09-30
申请号：US12648693
申请日：2009-12-29
申请人： Juswinder Singh , Russell Petter , Richland Wayne Tester , Arthur F. Kluge , Hormoz Mazdiyasni , William Frederick Westlin, III , Deqiang Niu , Lixin Qiao
发明人： Juswinder Singh , Russell Petter , Richland Wayne Tester , Arthur F. Kluge , Hormoz Mazdiyasni , William Frederick Westlin, III , Deqiang Niu , Lixin Qiao
IPC分类号： A61K31/505 , C07D239/48 , C07D401/12 , A61K31/506 , C07D401/04 , C07D403/12 , C07D413/14 , A61K31/538 , C07D413/12 , C07D401/14 , A61K31/5377 , C07D417/14 , A61K31/541 , C07D405/14 , A61P3/10 , A61P37/06 , A61P29/00 , A61P35/00 , A61P17/00 , A61P1/00 , A61P11/00 , A61P19/00 , A61P7/02 , C12Q1/48 , G01N33/53
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K45/06 , C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/18 , C07D495/04
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
摘要翻译： 本发明提供化合物，其药学上可接受的组合物及其使用方法。
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10.发明申请Arylphenylamino-,Arylphenylamide-, and Arylphenylether-Sulfide Derivatives 审中-公开芳基苯基氨基 - ，芳基苯基酰胺 - 和芳基苯基醚 - 硫化物衍生物公开(公告)号：US20070259863A1
公开(公告)日：2007-11-08
申请号：US11587732
申请日：2005-04-28
申请人： Donovan Chin , Thomas Durand-Reville , Francine Farouz , Kerry Fowler , Kevin Guckian , Irina Jaconbson , Ramesh Kasar , Russell Petter , Daniel Scott , C. Gregory Sowell , Eugene Thorsett , Edward Yin-Shiang Lin
发明人： Donovan Chin , Thomas Durand-Reville , Francine Farouz , Kerry Fowler , Kevin Guckian , Irina Jaconbson , Ramesh Kasar , Russell Petter , Daniel Scott , C. Gregory Sowell , Eugene Thorsett , Edward Yin-Shiang Lin
IPC分类号： C07D307/54
CPC分类号： C07D233/64 , C07C323/62 , C07C2601/14 , C07C2602/44 , C07D207/14 , C07D207/26 , C07D211/56 , C07D211/58 , C07D213/34 , C07D213/56 , C07D231/40 , C07D257/04 , C07D261/08 , C07D261/10 , C07D295/185 , C07D307/54 , C07D309/14 , C07D333/34 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12 , C07D451/02 , C07D451/04
摘要： The present invention relates in part to compounds of formulas I and III: and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.
摘要翻译： 本发明部分地涉及式I和III的化合物及其药学上可接受的盐和前药。 这些化合物可用于治疗疾病如炎症和免疫疾病。 本发明还涉及包含这些化合物的药物组合物，以及抑制受试者的炎症或抑制免疫应答的方法。
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