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1.发明申请公开(公告)号：US20090280153A1
公开(公告)日：2009-11-12
申请号：US11919274
申请日：2006-03-31
申请人： William L. Hunter , Philip M. Toleikis , David M. Gravett , Arpita Maiti , Richard T. Liggins , Aniko Takacs-Cox , Rui Avelar , Pierre E. Signore , Troy A. E. Loss , Anne Hutchinson , Gaye McDonald-Jones , Fara Lakhani
发明人： William L. Hunter , Philip M. Toleikis , David M. Gravett , Arpita Maiti , Richard T. Liggins , Aniko Takacs-Cox , Rui Avelar , Pierre E. Signore , Troy A. E. Loss , Anne Hutchinson , Gaye McDonald-Jones , Fara Lakhani
IPC分类号： A61F2/00 , A61K31/335 , A61N1/00
CPC分类号： A61N1/3605 , A61L27/54 , A61L31/16 , A61L2300/40 , A61N1/362 , A61N1/37 , A61N1/3956
摘要： Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the devices are implanted within an animal.
摘要翻译： 用于与组织接触的电子装置（例如，心律管理和神经刺激装置）与抗瘢痕形成剂组合使用，以便抑制当装置植入动物体内时可能发生的瘢痕形成。
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公开(公告)号：US20090203632A1
公开(公告)日：2009-08-13
申请号：US12247840
申请日：2008-10-08
申请人： Rui Avelar , Richard T. Liggins , Philip M. Toleikis , Troy A. E. Loss , David M. Gravett , Arpita Maiti
发明人： Rui Avelar , Richard T. Liggins , Philip M. Toleikis , Troy A. E. Loss , David M. Gravett , Arpita Maiti
IPC分类号： A61K31/7048 , A61K31/337 , A61K31/4745 , A61K31/505 , A61K31/519 , A61K31/407 , A61K31/136 , A61P19/00
CPC分类号： A61K31/335 , A61K9/0024 , A61K9/06 , A61K9/1075 , A61K9/1652 , A61K9/1658 , A61K47/10 , A61K47/34 , A61K47/36
摘要： A method for treating contracture is provided that includes administering to a patient in need thereof a composition that includes a therapeutic agent effective in treating contracture. Compositions, devices, and kits for use in treating contracture are also described.
摘要翻译： 提供了一种治疗挛缩的方法，其包括向有需要的患者施用包含有效治疗挛缩的治疗剂的组合物。 也描述了用于治疗挛缩的组合物，装置和试剂盒。
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公开(公告)号：US20120052040A1
公开(公告)日：2012-03-01
申请号：US13069258
申请日：2011-03-22
申请人： William L. Hunter , Philip M. Toleikis , David M. Gravelt , Arpita Maiti , Richard T. Liggins , Aniko Takacs-Cox , Rui Avelar , Troy A.E. Loss , Dechi Guan , Kaiyue Wang
发明人： William L. Hunter , Philip M. Toleikis , David M. Gravelt , Arpita Maiti , Richard T. Liggins , Aniko Takacs-Cox , Rui Avelar , Troy A.E. Loss , Dechi Guan , Kaiyue Wang
IPC分类号： A61K31/77 , A61K31/513 , A61K31/436 , A61P31/00 , C07D239/553 , C07D498/16 , C08G81/00 , A61P35/00 , A61K31/337 , C07D205/12
CPC分类号： A61K45/06 , A61L27/54 , A61L31/16 , A61L2300/404 , A61L2300/416 , A61L2300/432
摘要： Compositions comprising anti-fibrotic agent(s) and/or polymeric compositions can be used in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.
摘要翻译： 包含抗纤维化剂和/或聚合物组合物的组合物可用于各种医学应用，包括预防手术粘连，治疗炎性关节炎，治疗瘢痕和瘢痕疙瘩，治疗血管疾病和预防软骨 失利。
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公开(公告)号：US07166570B2
公开(公告)日：2007-01-23
申请号：US11006893
申请日：2004-12-07
申请人： William L. Hunter , David M. Gravett , Philip M. Toleikis , Arpita Maiti , Pierre E. Signore , Richard T. Liggins , Dechi Guan
发明人： William L. Hunter , David M. Gravett , Philip M. Toleikis , Arpita Maiti , Pierre E. Signore , Richard T. Liggins , Dechi Guan
CPC分类号： A61L27/54 , A61B17/11 , A61B17/12022 , A61B17/12099 , A61B17/12109 , A61B17/1214 , A61B17/12168 , A61B17/12186 , A61B17/1219 , A61B17/68 , A61F2250/0067 , A61K38/363 , A61K38/38 , A61K38/39 , A61K38/4833 , A61K45/06 , A61L31/16 , A61L2300/00 , A61L2300/412 , A61L2430/38 , A61K2300/00
摘要： Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue.
摘要翻译： 植入物与纤维化诱导剂组合使用以诱导纤维化，否则当植入物置于动物内时可能不发生，或增加植入物和宿主组织之间的纤维化。
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公开(公告)号：US09326934B2
公开(公告)日：2016-05-03
申请号：US13461424
申请日：2012-05-01
IPC分类号： A61K9/14 , A61K9/00 , A61K9/06 , A61K9/16 , A61K31/337 , A61K31/365 , A61K31/54 , A61K47/34 , A61L31/04 , A61L31/14 , A61L31/16 , A61K47/48 , A61K51/12
CPC分类号： A61K9/0024 , A61K9/06 , A61K9/1647 , A61K31/337 , A61K31/365 , A61K31/54 , A61K47/34 , A61K47/6903 , A61K51/1213 , A61L31/041 , A61L31/145 , A61L31/16 , A61L2300/434 , C08L71/02 , C08L89/06
摘要： Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.
摘要翻译： 公开了组合物，其从混合在一起的快速形成共价键的两部分聚合物组合物提供药物递送。 当期望与组织和凝胶形成的快速粘合以及药物递送时，这种组合物特别适用于各种组织相关应用。 例如，组合物可用作组织密封剂，促进止血，实现组织粘连，提供组织增大和预防手术粘连。
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公开(公告)号：US20090192214A1
公开(公告)日：2009-07-30
申请号：US12259916
申请日：2008-10-28
IPC分类号： A61K31/337 , A61P35/00
CPC分类号： A61K9/0024 , A61K9/06 , A61K9/1647 , A61K31/337 , A61K31/365 , A61K31/54 , A61K47/34 , A61K47/6903 , A61K51/1213 , A61L31/041 , A61L31/145 , A61L31/16 , A61L2300/434 , C08L71/02 , C08L89/06
摘要： Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.
摘要翻译： 公开了组合物，其从混合在一起的快速形成共价键的两部分聚合物组合物提供药物递送。 当期望与组织和凝胶形成的快速粘合以及药物递送时，这种组合物特别适用于各种组织相关应用。 例如，组合物可用作组织密封剂，促进止血，实现组织粘连，提供组织增大和预防手术粘连。
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公开(公告)号：US20120252905A1
公开(公告)日：2012-10-04
申请号：US13461424
申请日：2012-05-01
CPC分类号： A61K9/0024 , A61K9/06 , A61K9/1647 , A61K31/337 , A61K31/365 , A61K31/54 , A61K47/34 , A61K47/6903 , A61K51/1213 , A61L31/041 , A61L31/145 , A61L31/16 , A61L2300/434 , C08L71/02 , C08L89/06
摘要： Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.
摘要翻译： 公开了组合物，其从混合在一起的快速形成共价键的两部分聚合物组合物提供药物递送。 当期望与组织和凝胶形成的快速粘合以及药物递送时，这种组合物特别适用于各种组织相关应用。 例如，组合物可用作组织密封剂，促进止血，实现组织粘连，提供组织增大和预防手术粘连。
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公开(公告)号：US20100222863A1
公开(公告)日：2010-09-02
申请号：US12750947
申请日：2010-03-31
申请人： David M. Gravett , Pierre E. Signore , Kaiyue Wang , Philip M. Toleikis , Dechi Guan , Zengxuan Hu , Arpita Maiti
发明人： David M. Gravett , Pierre E. Signore , Kaiyue Wang , Philip M. Toleikis , Dechi Guan , Zengxuan Hu , Arpita Maiti
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61L31/005 , A61L31/14 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/432 , A61L2300/434 , A61L2300/602
摘要： Silk-containing stent grafts are provided comprising an endoluminal stent and a graft, wherein the silk induces the in vivo adhesion of the stent graft to vessel walls, or, otherwise induces or accelerates an in vivo fibrotic reaction causing said stent graft to adhere to vessel wall. Also provided are methods for making and using such stent grafts.
摘要翻译： 提供的含有丝素的支架移植物包括腔内支架和移植物，其中所述丝诱导所述支架移植物体内粘附于血管壁，或以其它方式诱导或加速体内纤维化反应，导致所述支架移植物附着于血管 壁。 还提供了制造和使用这种支架移植物的方法。
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公开(公告)号：US20090226500A1
公开(公告)日：2009-09-10
申请号：US12162572
申请日：2007-01-31
IPC分类号： A61F2/04 , A61K31/135 , A61K31/553 , A61K31/496 , A61K31/4164 , A61K31/395 , A61K31/426
CPC分类号： A61L31/16 , A61K9/0024 , A61L17/005 , A61L2300/404 , A61L2300/41 , A61L2300/432
摘要： Sutures are used in combination with anti-scarring agents to inhibit fibrosis between the sutures and the host tissues into which the sutures are inserted. Compositions and methods are described for use in reducing excessive scarring, surgical adhesion, and other disorders.
摘要翻译： 缝线与抗瘢痕形成剂组合使用以抑制缝合线和插入缝线的主体组织之间的纤维化。 描述了组合物和方法用于减少过度的瘢痕形成，手术粘连和其它障碍。
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公开(公告)号：US20110264139A1
公开(公告)日：2011-10-27
申请号：US13085140
申请日：2011-04-12
CPC分类号： A61L17/005 , A61K9/0024 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61L31/16 , A61L2300/30 , A61L2300/40 , A61L2300/45 , Y10T29/49826
摘要： Sutures are used in combination with fibrosing agents to induce or stimulate fibrosis that between the sutures and the host tissues into which the sutures are inserted. Compositions and methods are described for use in lifting tissue, closing wound, and other applications.
摘要翻译： 缝线与纤维化剂组合使用以诱导或刺激缝合线和插入缝线的主体组织之间的纤维化。 描述组合物和方法用于提升组织，闭合伤口和其它应用。
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