公开(公告)号：US20050075573A1

公开(公告)日：2005-04-07

申请号：US10800950

申请日：2004-03-15

申请人： William Park ,  Vaughn Marian ,  David Petersen ,  Todor Sheljaskow ,  Mirsaid Bolorforosh ,  Worth Walters ,  Sevig Ayter

发明人： William Park ,  Vaughn Marian ,  David Petersen ,  Todor Sheljaskow ,  Mirsaid Bolorforosh ,  Worth Walters ,  Sevig Ayter

IPC分类号： A61B8/00 ,  A61B8/12 ,  B06B1/06 ,  G10K11/00 ,  H04R17/00 ,  H05K7/20 ,  A61B8/14

CPC分类号： A61B8/546 ,  A61B8/00 ,  A61B8/12 ,  A61B8/445 ,  B06B1/06 ,  G10K11/004

摘要： An ultrasound transducer assembly is disclosed having a housing, a transducer array mounted in the housing and an electronics assembly mounted in the housing, the electronics assembly including one or more sub-assemblies having heat generating components disposed thereon. The electronics sub-assemblies further include thermal conducting features which conduct heat generated by the heat generating components out of the electronics assembly where it can be further removed by other thermal management techniques. These other thermal management techniques may include techniques utilized to cool the transducer array.

摘要翻译： 公开了一种超声换能器组件，其具有壳体，安装在壳体中的换能器阵列和安装在壳体中的电子组件，电子组件包括一个或多个具有设置在其上的发热部件的子组件。 电子组件还包括导热特征，其将由发热组件产生的热量传导出电子组件，在那里可以通过其它热管理技术进一步去除热。 这些其他热管理技术可以包括用于冷却换能器阵列的技术。

公开(公告)号：US20060173344A1

公开(公告)日：2006-08-03

申请号：US11039588

申请日：2005-01-19

申请人： Vaughn Marian ,  William Park ,  Timothy Petersen

发明人： Vaughn Marian ,  William Park ,  Timothy Petersen

IPC分类号： A61B8/14

CPC分类号： F28D15/00 ,  A61B8/00 ,  A61B8/546 ,  F25B1/00 ,  F25B21/02 ,  F25B25/005 ,  F25B2321/0251 ,  F25D19/006 ,  F28D15/0266 ,  F28D15/0275 ,  F28D2021/0029 ,  F28F13/00 ,  F28F2250/08 ,  H04R9/022

摘要： Methods and systems are provided for cooling an ultrasound transducer using a refrigeration system located within the imaging system. A closed loop of recirculating coolant located in the transducer assembly transports waste heat from the remotely located heat producing acoustic components or active electronics components to a thermally conductive shoe, located within the transducer connector. Thermally conductive materials in each connector, the ultrasound system connector and the transducer assembly connector, are positioned in contact to thermally conduct heat from the transducer assembly to a refrigeration system, located in the imaging system, free of fluid transfer.

摘要翻译： 提供了用于使用位于成像系统内的制冷系统来冷却超声换能器的方法和系统。 位于换能器组件中的再循环冷却剂的闭环将来自远程位于发热的声学组件或有源电子部件的废热传送到位于换能器连接器内的导热靴。 每个连接器中的导热材料，超声系统连接器和换能器组件连接器被定位成接触，以将来自换能器组件的热量传导到位于成像系统中的没有流体转移的制冷系统。

公开(公告)号：US20080287479A1

公开(公告)日：2008-11-20

申请号：US11945452

申请日：2007-11-27

申请人： Richard Hutchings ,  William Park ,  Gary Bolton ,  Chad Van Huis ,  Jeff Kohrt

发明人： Richard Hutchings ,  William Park ,  Gary Bolton ,  Chad Van Huis ,  Jeff Kohrt

IPC分类号： A61K31/438 ,  C07D401/14 ,  A61K31/454 ,  A61K31/439

CPC分类号： C07D401/04 ,  C07D401/14

摘要： This invention provides compounds of the formula: useful in the inhibition or modulation of serine palmitoyl transferase and their use in methods of treatment or amelioration of type 2 diabetes, type 1 diabetes, insulin resistance, the effects of obesity, metabolic syndrome (sometimes referred to as Syndrome X), impaired glucose tolerance, Cushing's disease, cardiovascular disease, prothrombotic conditions, myocardial infarction, hypertension, congestive heart failure, cardiomyopathy, atherosclerosis, dyslipidemia, sepsis, liver damage, retinal degenerative disorders, cachexia, emphysema, hepatitis C infections, HIV infections and inflammatory disorders and useful in methods for raising HDL plasma levels in a mammal. The compounds of this invention can also be used to prevent damage or loss of pancreatic islet beta cells (such as in the case of pancreatic beta cell apoptosis, including those related to insulin-dependent diabetes mellitus).

摘要翻译： 本发明提供下式的化合物：可用于抑制或调节丝氨酸棕榈酰转移酶及其在治疗或改善2型糖尿病，1型糖尿病，胰岛素抵抗，肥胖症，代谢综合征（有时称为 作为综合征X），葡萄糖耐量减低，库欣氏病，心血管疾病，血栓形成状况，心肌梗死，高血压，充血性心力衰竭，心肌病，动脉粥样硬化，血脂异常，败血症，肝损伤，视网膜退行性疾病，恶病质，肺气肿，丙型肝炎感染， HIV感染和炎症性疾病，并且可用于在哺乳动物中提高HDL血浆水平的方法。 本发明的化合物也可用于防止胰岛β细胞的损伤或损失（例如在胰腺β细胞凋亡的情况下，包括与胰岛素依赖性糖尿病相关的细胞凋亡）。

公开(公告)号：US20070088069A1

公开(公告)日：2007-04-19

申请号：US11546168

申请日：2006-10-11

申请人： Xue-Min Cheng ,  Richard Hutchings ,  Walter Howard ,  Robert Kennedy ,  William Park ,  Yuntao Song ,  Bharat Trivedi

发明人： Xue-Min Cheng ,  Richard Hutchings ,  Walter Howard ,  Robert Kennedy ,  William Park ,  Yuntao Song ,  Bharat Trivedi

IPC分类号： A61K31/4164 ,  C07D233/66

CPC分类号： C07D233/90

摘要： Novel imidazole compounds and pharmaceutical compositions are described, as are methods of using such compounds, alone or in combination with another pharmaceutically active agent, to treat subjects, including humans, suffering from hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and atherosclerosis.

摘要翻译： 还描述了新的咪唑化合物和药物组合物，以及使用这些化合物单独或与另一种药物活性剂组合来治疗患有高脂血症，高胆固醇血症，高甘油三酯血症和动脉粥样硬化的受试者，包括人的方法。

公开(公告)号：US20070000937A1

公开(公告)日：2007-01-04

申请号：US11492676

申请日：2006-07-24

申请人： Steven Hunter ,  David Browning ,  Dennis Fuhrman ,  William Park

发明人： Steven Hunter ,  David Browning ,  Dennis Fuhrman ,  William Park

IPC分类号： G07F11/00

CPC分类号： G07F17/0092 ,  B65G1/0435 ,  B65G1/1373 ,  B65G1/1378 ,  B65G25/02 ,  G07F11/24 ,  G07F11/26 ,  G07F11/44 ,  G07F11/54 ,  G07F11/58 ,  G07F11/62

摘要： The system includes a bin hopper which temporarily stores a plurality of small elements, such as medications. The elements are moved out of the bin and singulated into a one-by-one sequence by a series of singulating conveyors. The resulting sequence of elements is moved onto a main system conveyor where the element is identified and then moved to a loading mechanism which arranges the item so it is ready to be gripped and stored. The system includes a mass storage apparatus comprising a series of four upstanding cylindrical drums, each having a plurality of individually accessible and addressable cell storage locations for the elements. A gripping apparatus removes the elements from the loading mechanism and transfers them to a selected location in a cylindrical drum. When an article is to be dispensed, the drum is rotated so that an ejection arm comes adjacent the desired location in the drum. The ejector arm is actuated, pushing the small element out of its slot, into the center of the drum, where it falls onto a conveyor which moves the dispensed item from the system.

公开(公告)号：US08340251B2

公开(公告)日：2012-12-25

申请号：US13158851

申请日：2011-06-13

申请人： William Bertozzi ,  Michael Donovan ,  Alexei Klimenko ,  Stephen E. Korbly ,  William Park

发明人： William Bertozzi ,  Michael Donovan ,  Alexei Klimenko ,  Stephen E. Korbly ,  William Park

IPC分类号： H01J35/18 ,  H01J35/10

CPC分类号： H05G2/00 ,  H01J35/12 ,  H01J2235/08 ,  H01J2235/1204 ,  H05H6/00

摘要： Methods and systems for generating bremsstrahlung with enhanced photon flux in a narrow cone at forward angles utilize a thin target of a high-Z material such as gold as radiator, supported on a tube of a low-Z material such as titanium, which tube contains a circulating fluid such as water which acts as a coolant and also may absorb the incident electron beam.

摘要翻译： 用于产生具有在前方角度的窄锥体中增强的光子通量的bre致辐射的方法和系统利用诸如金的高Z材料的薄靶作为散热器，其支撑在诸如钛的低Z材料的管上，该管包含 诸如水的循环流体，其作为冷却剂并且还可以吸收入射的电子束。

公开(公告)号：US07983396B2

公开(公告)日：2011-07-19

申请号：US12121515

申请日：2008-05-15

申请人： William Bertozzi ,  Michael Donovan ,  Alexei Klimenko ,  Stephen E. Korbly ,  William Park

发明人： William Bertozzi ,  Michael Donovan ,  Alexei Klimenko ,  Stephen E. Korbly ,  William Park

IPC分类号： H01J35/18 ,  H01J35/10

CPC分类号： H05G2/00 ,  H01J35/12 ,  H01J2235/08 ,  H01J2235/1204 ,  H05H6/00

摘要： Methods and systems for generating bremsstrahlung with enhanced photon flux in a narrow cone at forward angles utilize a thin target of a high-Z material such as gold as radiator, supported on a tube of a low-Z material such as titanium, which tube contains a circulating fluid such as water which acts as a coolant and also may absorb the incident electron beam.

摘要翻译： 用于产生具有在前方角度的窄锥体中增强的光子通量的bre致辐射的方法和系统利用诸如金的高Z材料的薄靶作为散热器，其支撑在诸如钛的低Z材料的管上，该管包含 诸如水的循环流体，其作为冷却剂并且还可以吸收入射的电子束。

公开(公告)号：US20090311318A1

公开(公告)日：2009-12-17

申请号：US12484119

申请日：2009-06-12

申请人： Daniel Holsworth ,  William Park

发明人： Daniel Holsworth ,  William Park

IPC分类号： A61K31/538 ,  C07D413/10 ,  A61K9/22 ,  A61K9/52

CPC分类号： A61K31/538 ,  C07D413/10

摘要： The present invention provides enantiomerically pure substituted (S)-benzoxazinone compounds and an extended release formulation of the compounds. The compounds exhibit potent renin inhibition activities and improved bioavailability.

摘要翻译： 本发明提供对映体纯的取代的（S） - 苯并恶嗪酮化合物和化合物的延长释放制剂。 该化合物显示出有效的肾素抑制活性和改善的生物利用度。

公开(公告)号：US20090215763A1

公开(公告)日：2009-08-27

申请号：US12392992

申请日：2009-02-25

申请人： Daniel Holsworth ,  William Park

发明人： Daniel Holsworth ,  William Park

IPC分类号： A61K31/5365 ,  C07D498/04 ,  A61P9/12

CPC分类号： C07D498/04 ,  C07D413/04

摘要： The present invention provides substituted oxazinone compounds, such as substituted benzoxazinones, which exhibit potent renin inhibition activities.

摘要翻译： 本发明提供了取代的恶嗪酮化合物，例如取代的苯并恶嗪酮，其显示出有效的肾素抑制活性。

公开(公告)号：US20060287378A1

公开(公告)日：2006-12-21

申请号：US11389664

申请日：2006-03-24

申请人： Gary Bolton ,  Daniel Bowles ,  David Boyles ,  Walter Howard ,  Richard Hutchings ,  Robert Kennedy ,  William Park ,  Yuntao Song ,  Bharat Trivedi

发明人： Gary Bolton ,  Daniel Bowles ,  David Boyles ,  Walter Howard ,  Richard Hutchings ,  Robert Kennedy ,  William Park ,  Yuntao Song ,  Bharat Trivedi

IPC分类号： A61K31/4178 ,  A61K31/4172 ,  C07D405/02 ,  C07D233/54

CPC分类号： C07D413/14 ,  A61K31/4172 ,  A61K31/4178 ,  A61K45/06 ,  C07D207/34 ,  C07D207/36 ,  C07D233/64 ,  C07D233/66 ,  C07D233/84 ,  C07D233/90 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D413/12 ,  A61K2300/00

摘要： Novel imidazoles and novel pyrroles are provided. Also provided are pharmaceutical compositions, methods of making and methods of using the compounds.

摘要翻译： 提供了新颖的咪唑和新颖的吡咯。 还提供了药物组合物，制备方法和使用该化合物的方法。