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公开(公告)号：US06559119B1
公开(公告)日：2003-05-06
申请号：US08486048
申请日：1995-06-07
申请人： Willson H. Burgess , Howard P. Greisler , William N. Drohan , Thomas Maciag , Martin J. MacPhee
发明人： Willson H. Burgess , Howard P. Greisler , William N. Drohan , Thomas Maciag , Martin J. MacPhee
IPC分类号： A61K3836
CPC分类号： A61K38/37 , A61K31/513 , A61K31/65 , A61K33/06 , A61K33/14 , A61K35/19 , A61K38/00 , A61K38/1808 , A61K38/1841 , A61K38/363 , A61K38/39 , A61K38/4833 , A61K45/06 , A61K47/42 , A61L15/32 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/0085 , A61L27/34 , A61L27/507 , A61L2300/256 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/416 , A61L2300/418 , A61L2300/602 , C07K14/501 , C07K14/503 , C12N5/0062 , C12N5/069 , C12N2533/56 , C08L89/06 , C08L89/00 , C08L5/08 , A61K2300/00
摘要： This invention provides methods for the preparation of a tissue sealant-treated biomaterial, wherein the tissue sealant used in the method comprises at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are the biomaterial prepared therefrom, including vascular grafts.
摘要翻译： 本发明提供了用于制备组织密封剂处理的生物材料的方法，其中用于该方法的组织密封剂包含至少一种选自一种或多种抗体，止痛剂，抗凝剂，抗炎化合物，抗微生物组合物，抗增生剂 ，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡核苷酸聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。 还提供了由其制备的生物材料，包括血管移植物。
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公开(公告)号：US07229959B1
公开(公告)日：2007-06-12
申请号：US08479038
申请日：1995-06-07
申请人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Wilson H. Burgess , Thomas Maciag
发明人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Wilson H. Burgess , Thomas Maciag
IPC分类号： A61K38/36
CPC分类号： C12N5/069 , A61K31/25 , A61K31/337 , A61K31/4164 , A61K31/43 , A61K31/496 , A61K31/513 , A61K33/06 , A61K38/00 , A61K38/363 , A61K38/37 , A61K38/4833 , A61K45/06 , A61K47/42 , A61L15/32 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/0085 , A61L27/34 , A61L27/507 , A61L2300/256 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/416 , A61L2300/418 , A61L2300/602 , C07K14/501 , C07K14/503 , C12N5/0062 , C12N2533/56 , C08L89/06 , C08L89/00 , C08L5/08 , A61K2300/00
摘要： This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antibody. The composition may be further supplemented with, for example, one or more analgesics, antimicrobial compositions, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like.
摘要翻译： 本发明提供补充和未补充的组织密封剂及其生产和使用方法。 公开了补充有至少一种抗体的组织密封剂。 该组合物可进一步补充有例如一种或多种止痛剂，抗微生物组合物，抗凝剂，抗增殖剂，抗炎化合物，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，脱矿质骨或骨形态发生蛋白， 软骨诱导因子，寡核苷酸聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。
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3.发明授权Supplemented and unsupplemented tissue sealants, methods of their production and use 失效补充和未补充的组织密封剂，其生产和使用的方法公开(公告)号：US07189410B1
公开(公告)日：2007-03-13
申请号：US08474078
申请日：1995-06-07
申请人： William N. Drohan , Martin J. MacPhee , Wilson H. Burgess , Hernan Nunez , Manish Singh , Gene Liau , Thomas Maciag
发明人： William N. Drohan , Martin J. MacPhee , Wilson H. Burgess , Hernan Nunez , Manish Singh , Gene Liau , Thomas Maciag
CPC分类号： A61L15/32 , A61F13/0213 , A61F13/0253 , A61F13/0259 , A61F13/36 , A61F2013/00106 , A61F2013/00285 , A61F2013/00472 , A61F2013/0054 , A61F2013/00906 , A61F2013/00927 , A61F2013/00931 , A61K9/70
摘要： This invention provides a fibrin sealant bandage, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Also disclosed are methods of preparing and/or using the unsupplemented or supplemented fibrin sealant bandage.
摘要翻译： 本发明提供一种纤维蛋白密封胶绷带，其中所述纤维蛋白封闭剂可补充至少一种选自例如一种或多种调节化合物，抗体，抗微生物组合物，止痛剂，抗凝剂，抗增殖剂，抗炎化合物，细胞因子， 细胞毒素，药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡核苷酸聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。 还公开了制备和/或使用未补充或补充的纤维蛋白密封胶绷带的方法。
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4.再颁专利Supplemented and unsupplemented tissue sealants, methods of their production and use 有权补充和未补充的组织密封剂，其生产和使用的方法公开(公告)号：USRE39298E1
公开(公告)日：2006-09-19
申请号：US10465860
申请日：2003-06-20
申请人： Martin J. MacPhee , William N. Drohan , Gene Liau , Hernan Nunez , Wilson H. Burgess , Thomas Maciag , Manish Singh
发明人： Martin J. MacPhee , William N. Drohan , Gene Liau , Hernan Nunez , Wilson H. Burgess , Thomas Maciag , Manish Singh
CPC分类号： A61K38/363 , A61B17/00491 , A61B2017/00495 , A61F2002/2817 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0066 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2300/602 , C12N5/0062 , C12N5/069 , C12N2533/56 , A61K2300/00
摘要： This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are methods of using the site-specific supplemented tissue sealants, including preparation of a biomaterial.
摘要翻译： 本发明提供了补充组织密封剂的局部递送的方法，其中补充的组织密封剂包含至少一种选自一种或多种抗体，止痛剂，抗凝剂，抗炎化合物，抗微生物组合物，抗增殖剂，细胞因子，细胞毒素， 药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡聚体聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。 还提供了使用位点特异性补充组织密封剂的方法，包括制备生物材料。
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5.发明授权公开(公告)号：US07196054B1
公开(公告)日：2007-03-27
申请号：US08485883
申请日：1995-06-07
申请人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Thomas Maciag , Wilson H. Burgess
发明人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Thomas Maciag , Wilson H. Burgess
IPC分类号： A61K38/36
CPC分类号： C12N5/069 , A61K31/25 , A61K31/337 , A61K31/4164 , A61K31/43 , A61K31/496 , A61K31/513 , A61K33/06 , A61K38/00 , A61K38/363 , A61K38/37 , A61K38/4833 , A61K45/06 , A61K47/42 , A61L15/32 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/0085 , A61L27/34 , A61L27/507 , A61L2300/256 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/416 , A61L2300/418 , A61L2300/602 , C07K14/501 , C07K14/503 , C12N5/0062 , C12N2533/56 , C08L89/06 , C08L89/00 , C08L5/08 , A61K2300/00
摘要： This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antimicrobial composition. The composition may be further supplemented with, for example, one or more antibodies, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like.
摘要翻译： 本发明提供补充和未补充的组织密封剂及其生产和使用方法。 公开了补充有至少一种抗微生物组合物的组织密封剂。 该组合物可以进一步补充有例如一种或多种抗体，止痛剂，抗凝剂，抗增殖剂，抗炎化合物，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨 诱导因子，寡聚体聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。
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6.再颁专利Supplemented and unsupplemented tissue sealants, methods of their production and use 有权补充和未补充的组织密封剂，其生产和使用的方法公开(公告)号：USRE39321E1
公开(公告)日：2006-10-03
申请号：US10465853
申请日：2003-06-20
申请人： Martin J. MacPhee , William N. Drohan , Gene Liau , Hernan Nunez , Wilson H. Burgess , Jeffrey O. Hollinger , Thomas Maciag
发明人： Martin J. MacPhee , William N. Drohan , Gene Liau , Hernan Nunez , Wilson H. Burgess , Jeffrey O. Hollinger , Thomas Maciag
CPC分类号： A61K38/37 , A61K38/18 , A61K38/1825 , A61K38/1833 , A61K38/363 , A61K38/4833 , A61K45/06 , A61L24/0015 , A61L24/0036 , A61L24/106 , A61L2300/00 , A61K2300/00
摘要： This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, antiinflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Also disclosed are methods of preparing and/or using the unsupplemented or supplemented fibrin sealant dressing.
摘要翻译： 本发明提供一种纤维蛋白密封剂敷料，其中所述纤维蛋白封闭剂可补充至少一种选自例如一种或多种调节化合物，抗体，抗微生物组合物，止痛剂，抗凝剂，抗增殖剂，抗炎化合物，细胞因子，细胞毒素， 药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡聚体聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。 还公开了制备和/或使用未补充或补充的纤维蛋白密封剂敷料的方法。
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公开(公告)号：USRE37850E1
公开(公告)日：2002-09-17
申请号：US09538857
申请日：2000-03-28
IPC分类号： A61K3827
CPC分类号： C07K14/501 , A61K38/00 , Y10S930/12
摘要： Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering ECGF protein essentially free of other proteins of human origin. The product is useful for, among other purposes, diagnostic applications and as potential in the treatment of damaged blood vessels or other endothelial cell-lined structures.
摘要翻译： 内皮细胞生长因子通过应用重组DNA技术来制备编码ECGF蛋白质的克隆载体，公开了用于回收基本上不含人源蛋白质的ECGF蛋白质的方法。 该产品除了其它目的之外还可用于诊断应用，并且用于治疗损伤的血管或其它内皮细胞内衬结构的潜力。
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8.发明授权DNA encoding human endothelial cell growth factors and plasmids comprising said DNA 失效编码人内皮细胞生长因子的DNA和包含所述DNA的质粒
公开(公告)号：US5849538A
公开(公告)日：1998-12-15
申请号：US840088
申请日：1997-04-11
申请人： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
发明人： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
CPC分类号： C07K14/501 , A61K38/00 , Y10S930/12
摘要： The present invention is directed to DNA encoding human endothelial cell growth factors, and to plasmids comprising said DNA. In particular, the invention relates to DNA encoding a cleavable signal peptide and an endothelial cell growth factor, wherein removal of said signal peptide yields a mature form of the growth factor.
摘要翻译： 本发明涉及编码人内皮细胞生长因子的DNA和包含所述DNA的质粒。 特别地，本发明涉及编码可切割信号肽和内皮细胞生长因子的DNA，其中所述信号肽的去除产生成熟形式的生长因子。
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公开(公告)号：US5827826A
公开(公告)日：1998-10-27
申请号：US743261
申请日：1996-11-04
申请人： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
发明人： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
CPC分类号： C07K14/501 , A61K38/00 , Y10S930/12
摘要： The present invention is directed to compositions comprising endothelial cell growth factor, an acceptable carrier and, optionally, an extracellular matrix protein, a glycosaminoglycan or serum albumin. The compositions are useful for wound repair.
摘要翻译： 本发明涉及包含内皮细胞生长因子，可接受的载体和任选的细胞外基质蛋白，糖胺聚糖或血清白蛋白的组合物。 组合物可用于伤口修复。
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公开(公告)号：US5571790A
公开(公告)日：1996-11-05
申请号：US472964
申请日：1995-06-07
申请人： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
发明人： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
CPC分类号： C07K14/501 , A61K38/00 , Y10S930/12
摘要： Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering ECGF protein essentially free of other proteins of human origin. The product is useful for, among other purposes, diagnostic applications and as potential in the treatment of damaged blood vessels or other endothelial cell-lined structures.
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