利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

33 条记录 (耗时 0.044 秒)

    Methods for the protection of memory and cognition
    7.
    发明申请
    Methods for the protection of memory and cognition 审中-公开
    保护记忆和认知的方法

    公开(公告)号：US20050004104A1

    公开(公告)日：2005-01-06

    申请号：US10859335

    申请日：2004-06-01

    申请人： Brian Cali ,  Yueh-Tyng Chien ,  Mark Currie ,  John Talley ,  Craig Zimmerman

    发明人： Brian Cali ,  Yueh-Tyng Chien ,  Mark Currie ,  John Talley ,  Craig Zimmerman

    IPC分类号： A01N43/36 ,  A01N43/38 ,  A61K20060101 ,  A61K31/40 ,  A61K31/405 ,  A61K31/454 ,  A61K31/55 ,  C07D209/02 ,  C07D405/00 ,  C07D409/00 ,  C07D411/00

    CPC分类号： A61K31/40 ,  A61K31/405 ,  C07D209/32

    摘要： The invention features certain compounds useful in the treatment of memory disorders, i.e., they reduce or delay memory loss or they enhance memory retention. Because certain of the compounds do not substantially inhibit either COX-1 or COX-2 at therapeutically relevant doses, these compounds are far less likely to cause gastrointestinal ulceration than is indomethacin, which is known to inhibit both COX-1 and COX-2. Certain of the compounds inhibit the activity of DAO at therapeutically relevant doses. Among the memory disorders that can be treated are AD, mild cognitive impairment (MCI; a common precursor to AD), and memory loss or cognitive impairment associated with vascular dementias, amnesia, dementia, AIDS dementia, Huntington's Disease, hydrocephalus, depression, Pick's Disease, Creutzfeldt-Jakob Syndrome, electroconvulsive therapy, or Parkinson's Disease.

    摘要翻译： 本发明的特征在于可用于治疗记忆障碍的某些化合物，即它们减少或延缓记忆丧失或增强记忆保留。 因为某些化合物在治疗相关剂量下基本上不抑制COX-1或COX-2，所以与已知抑制COX-1和COX-2的吲哚美辛相比，这些化合物不太可能引起胃肠溃疡。 某些化合物在治疗相关剂量下抑制DAO的活性。 在可以治疗的记忆障碍中，AD，轻度认知障碍（MCI，AD的共同前兆）以及与血管性痴呆，遗忘症，痴呆，艾滋病痴呆，亨廷顿舞蹈病，脑积水，抑郁症，Pick's 疾病，Creutzfeldt-Jakob综合征，电惊厥治疗或帕金森病。

    Modulators of FAAH
    9.
    发明申请
    Modulators of FAAH 审中-公开
    FAAH调制器

    公开(公告)号：US20060167075A1

    公开(公告)日：2006-07-27

    申请号：US11340232

    申请日：2006-01-25

    申请人： James Pearson ,  G. Milne ,  Mark Currie ,  Brian Cali ,  John Talley

    发明人： James Pearson ,  G. Milne ,  Mark Currie ,  Brian Cali ,  John Talley

    IPC分类号： A61K31/415 ,  A61K31/365

    CPC分类号： A61K31/365 ,  A61K31/415

    摘要： Methods for inhibiting the activity of FAAH and methods for preventing and/or treating certain disorders, e.g., anxiety disorders, sleep disorders and weight disorders, by administering celecoxib, valdecoxib or certain structurally related compounds at a dosage that is sufficient to treat and/or prevent the disorder are described.

    摘要翻译： 通过以足以治疗和/或治疗的剂量施用塞来考昔，伐地考昔或某些结构相关的化合物来抑制FAAH的活性的方法和预防和/或治疗某些疾病，例如焦虑症，睡眠障碍和体重障碍的方法 防止这种疾病的描述。