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    Methods for the protection of memory and cognition
    3.
    发明申请
    Methods for the protection of memory and cognition 审中-公开
    保护记忆和认知的方法

    公开(公告)号：US20050004104A1

    公开(公告)日：2005-01-06

    申请号：US10859335

    申请日：2004-06-01

    申请人： Brian Cali ,  Yueh-Tyng Chien ,  Mark Currie ,  John Talley ,  Craig Zimmerman

    发明人： Brian Cali ,  Yueh-Tyng Chien ,  Mark Currie ,  John Talley ,  Craig Zimmerman

    IPC分类号： A01N43/36 ,  A01N43/38 ,  A61K20060101 ,  A61K31/40 ,  A61K31/405 ,  A61K31/454 ,  A61K31/55 ,  C07D209/02 ,  C07D405/00 ,  C07D409/00 ,  C07D411/00

    CPC分类号： A61K31/40 ,  A61K31/405 ,  C07D209/32

    摘要： The invention features certain compounds useful in the treatment of memory disorders, i.e., they reduce or delay memory loss or they enhance memory retention. Because certain of the compounds do not substantially inhibit either COX-1 or COX-2 at therapeutically relevant doses, these compounds are far less likely to cause gastrointestinal ulceration than is indomethacin, which is known to inhibit both COX-1 and COX-2. Certain of the compounds inhibit the activity of DAO at therapeutically relevant doses. Among the memory disorders that can be treated are AD, mild cognitive impairment (MCI; a common precursor to AD), and memory loss or cognitive impairment associated with vascular dementias, amnesia, dementia, AIDS dementia, Huntington's Disease, hydrocephalus, depression, Pick's Disease, Creutzfeldt-Jakob Syndrome, electroconvulsive therapy, or Parkinson's Disease.

    摘要翻译： 本发明的特征在于可用于治疗记忆障碍的某些化合物，即它们减少或延缓记忆丧失或增强记忆保留。 因为某些化合物在治疗相关剂量下基本上不抑制COX-1或COX-2，所以与已知抑制COX-1和COX-2的吲哚美辛相比，这些化合物不太可能引起胃肠溃疡。 某些化合物在治疗相关剂量下抑制DAO的活性。 在可以治疗的记忆障碍中，AD，轻度认知障碍（MCI，AD的共同前兆）以及与血管性痴呆，遗忘症，痴呆，艾滋病痴呆，亨廷顿舞蹈病，脑积水，抑郁症，Pick's 疾病，Creutzfeldt-Jakob综合征，电惊厥治疗或帕金森病。

    Staphylococcal GTPase obg nucleotide sequence encoding Staphylococcal GTP-binding protein
    4.
    发明授权
    Staphylococcal GTPase obg nucleotide sequence encoding Staphylococcal GTP-binding protein 失效
    葡萄球菌GTP酶obg核苷酸序列编码葡萄球菌GTP结合蛋白

    公开(公告)号：US06706495B2

    公开(公告)日：2004-03-16

    申请号：US09792420

    申请日：2001-02-23

    申请人： Yueh-tyng Chien ,  Jason A. Thresher ,  C. Richard Wobbe ,  Judith M. Healy

    发明人： Yueh-tyng Chien ,  Jason A. Thresher ,  C. Richard Wobbe ,  Judith M. Healy

    IPC分类号： C12P2106

    CPC分类号： C12N9/14 ,  A61K38/00 ,  C07K14/31

    摘要： The present invention provides an isolated Staphylococcal GTPase obg gene and a Staphylococcal GTP-binding protein encoded thereby. A recombinant expression vector and an engineered host cell are also provided that include a polynucleotide encoding a Staphylococcal GTP-binding protein. The present invention further relates to a method of producing Staphylococcal GTP-binding protein and a method for high throughput screening to identify potential antimicrobial compounds useful against Staphylococcal bacterial strains.

    摘要翻译： 本发明提供了分离的葡萄球菌GTP酶obg基因和由其编码的葡萄球菌GTP结合蛋白。 还提供重组表达载体和工程化宿主细胞，其包括编码葡萄球菌GTP结合蛋白的多核苷酸。 本发明还涉及葡萄球菌GTP结合蛋白的生产方法和用于高通量筛选以识别可用于葡萄球菌菌株的抗微生物化合物的方法。