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公开(公告)号：US5064840A
公开(公告)日：1991-11-12
申请号：US511893
申请日：1990-04-10
申请人： Albert A. Carr , Francis P. Miller , John M. Kane
发明人： Albert A. Carr , Francis P. Miller , John M. Kane
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： The present invention is directed to a new class of therapeutic agent which are useful as anti-psychotic agents and as analgesics.
摘要翻译： 本发明涉及可用作抗精神病药和镇痛剂的新类治疗剂。
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公开(公告)号：US5292752A
公开(公告)日：1994-03-08
申请号：US847971
申请日：1992-03-05
申请人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller , Thaddeus R. Nieduzak
发明人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller , Thaddeus R. Nieduzak
IPC分类号： C07D211/32 , A61K31/445
CPC分类号： C07D211/32 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813 , Y10S514/821 , Y10S514/822
摘要： The present invention is directed to a new class of piperidinyl medicinal agents which are useful as antithrombotic agents and as serotonin 5HT.sub.2 antagonists.
摘要翻译： 本发明涉及可用作抗血栓形成剂和5-羟色胺5HT 2拮抗剂的新一类哌啶基药物。
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3.发明授权1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants 失效可用作镇痛药和肌肉松弛剂的1,4-二取代哌啶基化合物
公开(公告)号：US4870083A
公开(公告)日：1989-09-26
申请号：US254208
申请日：1988-10-11
IPC分类号： A61K31/445 , A61K31/4465 , A61P25/04 , C07D211/22
CPC分类号： C07D211/22
摘要： The present invention relates to 1,4-disubstituted-piperidinyl compounds and their use as analgesic agents and as muscle relaxants.
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4.发明授权Use of 1,4-disubstituted-piperidinyl compounds for analgesia and muscle relaxation 失效用于麻醉和松弛放松的1,4-二异丁基哌啶化合物的应用
公开(公告)号：US5162342A
公开(公告)日：1992-11-10
申请号：US725704
申请日：1991-07-03
IPC分类号： C07D211/22 , C07D211/32
CPC分类号： C07D211/22 , C07D211/32 , Y10S514/906
摘要： The present invention relates to 1,4-disubstituted-piperidinyl compounds that have utility as analgesics and as muscle relaxants.
摘要翻译： 本发明涉及作为止痛剂和肌肉松弛剂有用的1,4-二取代哌啶基化合物。
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公开(公告)号：US5064838A
公开(公告)日：1991-11-12
申请号：US279900
申请日：1988-12-07
IPC分类号： A61K20060101 , A61K31/00 , A61K31/445 , A61K31/451 , A61P21/00 , A61P21/02 , A61P25/04 , C07D20060101 , C07D211/18 , C07D211/22 , C07D211/32
CPC分类号： C07D211/22 , C07D211/32
摘要： The present invention relates to 1,4-disubstituted-piperidinyl compounds that have utility as analgesics and as muscle relaxants.
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公开(公告)号：US5500433A
公开(公告)日：1996-03-19
申请号：US371063
申请日：1995-01-10
申请人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller , Thaddeus R. Nieduzak , Mark W. Dudley , . Christopher J. Schmidt , Robert A. Frank
发明人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller , Thaddeus R. Nieduzak , Mark W. Dudley , . Christopher J. Schmidt , Robert A. Frank
IPC分类号： C07D211/32 , A61K31/445
CPC分类号： C07D211/32 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813 , Y10S514/821 , Y10S514/822
摘要： The present invention is directed to a new class of piperidinyl medicinal agents which are useful for treating drug abuse.
摘要翻译： 本发明涉及可用于治疗药物滥用的新一类哌啶基药物。
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7.发明授权Method of using 1,4-disubstituted piperidinyl compounds in the treatment of coronary vasospasons and variant angina 失效使用1,4-二取代哌啶基化合物治疗冠状动脉血管痉挛和变异型心绞痛的方法
公开(公告)号：US5166211A
公开(公告)日：1992-11-24
申请号：US797643
申请日：1991-12-16
申请人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller
发明人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller
IPC分类号： C07D211/22 , C07D211/28 , C07D211/32
CPC分类号： C07D211/28 , C07D211/22 , C07D211/32 , Y10S514/929
摘要： The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT.sub.2 antagonists.
摘要翻译： 本发明涉及一类新的化合物，其可以表征为用作抗心律失常药，止痛剂和5-羟色胺5HT2拮抗剂的1,4-二取代哌啶基化合物。
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公开(公告)号：US5093341A
公开(公告)日：1992-03-03
申请号：US237600
申请日：1988-08-26
申请人： Albert A. Carr , John E. Koerner , Richard C. Dage , Tung Li , Francis P. Miller
发明人： Albert A. Carr , John E. Koerner , Richard C. Dage , Tung Li , Francis P. Miller
IPC分类号： C07C62/38 , A61K31/445 , A61K31/451 , A61P9/00 , C07C51/00 , C07C51/353 , C07C67/00 , C07C69/757 , C07C69/94 , C07C69/95 , C07C201/00 , C07C205/37 , C07C205/59 , C07C205/61 , C07D20060101 , C07D211/22 , C07D211/26 , C07D211/28 , C07D211/32 , C07D307/00 , C07D307/70 , C07D307/92 , C07D317/44 , C07D317/48 , C07D317/70 , C07D493/04 , C07D493/06 , C07D493/08 , C07F7/18
CPC分类号： C07D211/22 , C07D211/28 , C07D211/32 , C07D317/70 , C07D493/04 , C07D493/08 , C07F7/1856
摘要： The present invention is directed to a new class of compounds useful as antiarrhythmics, analgesics and serotonin 5HT.sub.2 antagonists, which compounds have the following formula: ##STR1## wherein; Y is represented by H, CO(CH.sub.2).sub.n CH.sub.3 in which n is an integer from 0-3, or SO.sub.2 (CH.sub.2).sub.n CH.sub.3 in which n is an integer from 0--3; X is represented CO, CHOH, or C.dbd.N--O--A, wherein A is represented by hydrogen or a C.sub.1-4 alkyl; R is either selected from the group consisting of halogens, lower alkyl groups, lower alkoxy groups, and hydrogen or R is a divalent substituent and is represented by a 3,4-methylenedioxy or a 3,4-ethylenedioxy substituent; m is an integer from 1-5; and the pharmaceutically acceptable acid addition salts thereof.
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9.发明授权5-heterocyclic-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants 失效5-杂环-2,4-二烷基-3H-1,2,4-三唑-3-硫酮及其作为抗抑郁药的用途
公开(公告)号：US4952593A
公开(公告)日：1990-08-28
申请号：US76588
申请日：1987-07-23
申请人： John M. Kane , Francis P. Miller
发明人： John M. Kane , Francis P. Miller
IPC分类号： A61K31/41 , A61K31/44 , A61K31/4409 , A61K31/4427 , A61P25/24 , A61P25/26 , C07D213/81 , C07D249/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
CPC分类号： C07D401/04
摘要： This invention relates to novel 5-R.sub.n -(Het)-2,4-di alkyl-3H-1,2,4-triazole-3-thiones, to the intermediates and processes for their preparation, and to their use as antidepressants.
摘要翻译： 本发明涉及新的5-Rn-（Het）-2,4-二烷基-3H-1,2,4-三唑-3-噻吩并对其制备方法及其作为抗抑郁药的用途。
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10.发明授权5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders 失效5-芳基-3H-1,2,4-三唑-3-酮及其在治疗神经变性疾病中的用途
公开(公告)号：US5436252A
公开(公告)日：1995-07-25
申请号：US494049
申请日：1990-03-15
IPC分类号： A61K31/41 , A61K31/44 , A61K31/47 , C07D249/12 , C07D401/04
CPC分类号： C07D401/04 , A61K31/41 , A61K31/44 , A61K31/47 , C07D249/12
摘要： This invention relates to neuroprotective 5-aryl-3H-1,2,4-triazol-3-ones and to their use in the treatment of neurodegenerative disorders such as cerebral ischemia, stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease.
摘要翻译： 本发明涉及神经保护性5-芳基-3H-1,2,4-三唑-3-酮及其在治疗神经变性疾病如脑缺血，中风，阿尔茨海默病，帕金森病和亨廷顿病中的用途。
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