公开(公告)号：US07274459B2

公开(公告)日：2007-09-25

申请号：US10499632

申请日：2003-01-13

申请人： Wolfgang Schrof ,  Thorsten Müller ,  Alexander Centner ,  Stephan Lehmann ,  Joachim Hadeler

发明人： Wolfgang Schrof ,  Thorsten Müller ,  Alexander Centner ,  Stephan Lehmann ,  Joachim Hadeler

IPC分类号： G01N21/47

CPC分类号： G01N21/4738

摘要： A process for parallel and automated evaluation of the blushing of multiple samples of dispersion films, comprising: providing an illuminated array of spatially separated samples of dispersion films, imaging the array of samples by means of CCD camera at different times and digitizing the images, automatically determining multiple brightness for each sample at different times from the different digitized images for at least a portion of the samples, determining values of a parameter characteristic of the kinetics of the blushing from the different brightnesses, and comparing the values of the characteristic parameter for individual samples.

摘要翻译： 一种用于并行和自动评估多个分散膜样品的白化的方法，包括：提供分散膜的空间分离样品的照明阵列，通过CCD相机在不同时间对样品阵列成像并自动数字化图像 在至少一部分样本的不同数字化图像的不同时间确定每个样本的多个亮度，确定来自不同亮度的白化动力学参数特性的值，以及比较各个特征参数的值 样品。

公开(公告)号：US20050014282A1

公开(公告)日：2005-01-20

申请号：US10499632

申请日：2003-01-13

申请人： Wolfgang Schrof ,  Thorsten Muller ,  Alexander Centner ,  Stephan Lehmann ,  Joachim Hadeler

发明人： Wolfgang Schrof ,  Thorsten Muller ,  Alexander Centner ,  Stephan Lehmann ,  Joachim Hadeler

IPC分类号： G01N21/47 ,  G01N21/00

CPC分类号： G01N21/4738

摘要： The invention relates to a process for parallel and automated evaluation of the blushing of n samples of dispersion films, which comprises (a) providing an illuminated array of n spatially separated samples of the dispersion films, (b) imaging the array of n samples by means of a CCD camera at m+1 different times t0 to tm and digitizing the images, (c) automatically determining multiple brightnesses B(k, ti) for each sample at different times ti selected from t0 to tm from the m+1 different digitized images for at least a portion of the n samples, where B(k, ti) is the brightness of the kth of n samples at the respective time ti and is a measure for the blushing of this sample at this time, (d) determining values P(k) of a parameter characteristic of the kinetics of the blushing from the different brightnesses B(k, ti) for each sample for at least a portion of the n samples, where P(k) is the value of the characteristic parameter for the kth of the n samples.

摘要翻译： 本发明涉及用于并行和自动评估分散膜的n个样品的白化的方法，其包括（a）提供分散膜的n个空间分离的样品的照射阵列，（b）通过以下方式对n个样品的阵列进行成像： 在m + 1个不同时刻t0到tm的CCD照相机的手段，并对图像进行数字化;（c）在从m + 1不同的t0到tm的不同时刻ti自动确定每个样本的多个亮度B（k，ti） 对于n个样本的至少一部分的数字化图像，其中B（k，ti）是在相应时间ti的n个样本的第k个的亮度，并且是此时该样本的白化的量度，（d） 对于n个样本的至少一部分，针对每个样本的不同亮度B（k，ti）的脸红动力学参数特性的值P（k），其中P（k）是特征值 n个样本的第k个参数。

公开(公告)号：US07994227B2

公开(公告)日：2011-08-09

申请号：US10576921

申请日：2004-10-19

申请人： Sebastian Koltzenburg ,  Stephan Lehmann ,  Bernhard Steinmetz ,  Wolfgang Schrof ,  Joachim Hadeler ,  Winfried Mayer ,  Matthias Bratz ,  Werner Goedel

发明人： Sebastian Koltzenburg ,  Stephan Lehmann ,  Bernhard Steinmetz ,  Wolfgang Schrof ,  Joachim Hadeler ,  Winfried Mayer ,  Matthias Bratz ,  Werner Goedel

IPC分类号： A61K47/32 ,  A01N43/00 ,  A01N43/56

CPC分类号： C08F220/58 ,  A01N25/04 ,  A01N25/10 ,  A01N47/24 ,  C08F220/18 ,  C08F220/30 ,  A01N2300/00

摘要： The invention relates to nanoparticulate formulations comprising at least one active compound or compound with a special effect and at least one random radical copolymer. The copolymers are formed from monomers carrying sulfonic acid groups and additional olefinically unsaturated compounds.The formulations are dispersible as nanoparticles in an aqueous medium. The invention includes, in addition, processes for the preparation of the solid and liquid formulations, and their use.

摘要翻译： 本发明涉及包含至少一种具有特殊作用的活性化合物或化合物和至少一种无规自由基共聚物的纳米颗粒制剂。 共聚物由携带磺酸基团的单体和另外的烯属不饱和化合物形成。 制剂在水性介质中可作为纳米颗粒分散。 本发明还包括制备固体和液体制剂的方法及其用途。

公开(公告)号：US20050000274A1

公开(公告)日：2005-01-06

申请号：US10491423

申请日：2002-09-27

申请人： Wolfgang Schrof ,  Thorsten Muller ,  Sebastian Koltzenburg ,  Matthias Kroner ,  Stephan Lehmann ,  Joachim Hadeler

发明人： Wolfgang Schrof ,  Thorsten Muller ,  Sebastian Koltzenburg ,  Matthias Kroner ,  Stephan Lehmann ,  Joachim Hadeler

IPC分类号： G01N11/00 ,  G01N3/00 ,  G01N3/06 ,  G01N3/42 ,  G01N3/48

CPC分类号： G01N3/42 ,  G01N2203/0092 ,  G01N2203/0682

摘要： The invention relates to a process for the combinatorial investigation of the hardening of hardenable liquid or viscous formulations (a) in which n hardenable formulations are prepared in parallel in n containers, and (b) the degree of hardening is determined at least once on each of the n formulations by inserting a measurement tip into the formulation with a certain force and measuring the maximum penetration depth achieved as a measure of the degree of hardening of this formulation, and (c) for in each case one composition of the formulations, one or more parameters that are characteristic of the kinetics of hardening are determined from the measurement values for the penetration depth at various times after preparation of the formulations. Steps (a) to (c) are preferably carried out a number of times, and a dependence of the characteristic parameter(s) on the composition of the formulations is determined by analysis of the large number of individual values obtained in this way for the parameter(s) that is (are) characteristic of the kinetics of hardening, enabling the composition of the formulations to be optimized with respect to its hardening behavior.

摘要翻译： 本发明涉及用于组合研究可硬化液体或粘性制剂（a）的硬化的方法，其中在n个容器中并行制备n个可硬化制剂，和（b）硬化程度每个至少确定一次 通过以一定的力将测量尖端插入制剂中并测量作为该制剂的硬化程度的度量而获得的最大穿透深度，以及（c）在每种情况下，制剂的一种组合物，一种 或者从制剂配制后的不同时刻的穿透深度的测定值求出硬化动力学特征的更多的参数。 步骤（a）至（c）优选进行多次，并且通过分析以这种方式获得的大量个体值来确定特征参数对制剂组成的依赖性 硬化动力学特征的参数，使组合物能够根据其硬化行为进行优化。