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1.发明申请Carboxyl-reduced derivatives of dermatan sulfate, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them 审中-公开硫酸皮肤素的羧基还原衍生物，其制备方法，作为药物的用途以及含有它们的药物组合物公开(公告)号：US20050164983A1
公开(公告)日：2005-07-28
申请号：US11016501
申请日：2004-12-17
IPC分类号： A61K31/737
CPC分类号： C08B37/0069
摘要： The present invention relates to the carboxyl-reduced derivatives of dermatan sulfate of formula (I): in which R1, R2, R3 or R4 represents H or SO3M, n is an integer of between 0 and 150, M is an alkali metal, isolated or as mixtures, to the diastereoisomers thereof, to the process for the preparation thereof, to the uses thereof as a medicinal product and to the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的硫酸皮肤素的羧基还原衍生物：其中R 1，R 2，R 3， 或R 4代表H或SO 3 M，n为0至150的整数，M为与其非对映异构体分离或作为混合物的碱金属， 其制备方法，其作为药用产品的用途和含有它们的药物组合物。
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2.发明申请Carboxyl-reduced derivatives of hyaluronic acid, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them 审中-公开透明质酸的羧基还原衍生物，其制备方法，作为药物的用途以及含有它们的药物组合物公开(公告)号：US20050203056A1
公开(公告)日：2005-09-15
申请号：US11015947
申请日：2004-12-17
IPC分类号： A61K31/728 , C08B37/00
CPC分类号： A61K31/728 , C08B37/00 , C08B37/0072
摘要： The present invention relates to the carboxyl-reduced derivatives of hyaluronic acid of formula (I): in which R or R1 represents H or SO3M, n is an integer of between 0 and 25 000, M is an alkali metal, isolated or as mixtures, to the diastereoisomers thereof, to the process for the preparation thereof, to the uses thereof as a medicinal product and to the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的透明质酸的羧基还原衍生物：其中R或R 1表示H或SO 3 M，n是整数 为0至25 000，M为与其非对映异构体，分离或混合的碱金属，其制备方法，作为药用产品的用途以及含有它们的药物组合物。
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3.发明申请Carboxyl-reduced derivatives of chondroitin sulfate, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them 审中-公开硫酸软骨素的羧基还原的衍生物，其制备，其作为药用产品的用途和含有它们的药物组合物公开(公告)号：US20050187187A1
公开(公告)日：2005-08-25
申请号：US11016175
申请日：2004-12-17
IPC分类号： A61K31/737 , C08B37/00
CPC分类号： C08B37/0069
摘要： The present invention relates to the carboxyl-reduced and chemoselectively O-sulfated derivatives of chondroitin sulfate of formula (I): in which R1, R2, R3 and R4 are H or SO3M, n is an integer of between 0 and 200, M is an alkali metal, isolated or as mixtures, to the diastereoisomers thereof, to the process for the preparation thereof, to the uses thereof as a medicinal product and to the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的硫酸软骨素的羧基还原和化学选择性O-硫酸化衍生物：其中R 1，R 2，R 2， 3和R 4是H或SO 3 M，n是0和200之间的整数，M是碱金属，分离的或作为混合物， 其非对映异构体，其制备方法，其作为药用产品的用途和含有它们的药物组合物。
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4.发明申请LOW MOLECULAR WEIGHT HEPARINS INCLUDING AT LEAST ONE COVALENT BOND WITH BIOTIN OR A BIOTIN DERIVATIVE, METHOD FOR MAKING SAME AND USE THEREOF 审中-公开低分子量重量包括至少一种与生物或生物素衍生物的共价键，其制备方法及其用途公开(公告)号：US20100081629A1
公开(公告)日：2010-04-01
申请号：US12539224
申请日：2009-08-11
IPC分类号： A61K31/727 , C07H1/00
CPC分类号： C08B37/0075 , A61K31/715
摘要： The invention relates to biotinylated low molecular weight heparins comprising constituent polysaccharides having at their reducing ends at least one covalent bond with biotin or a biotin derivative, and also to the process for preparing them, to pharmaceutical compositions containing them and to their therapeutic use.
摘要翻译： 本发明涉及生物素化的低分子量肝素，其包含在其还原端与生物素或生物素衍生物具有至少一个共价键的组成多糖，以及其制备方法，含有它们的药物组合物及其治疗用途。
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5.发明授权Method of screening a modulator of endothelial NO synthase comprising the use of heme binding protein 1 失效包括使用血红素结合蛋白1的内皮NO合成酶调节剂的筛选方法公开(公告)号：US08652785B2
公开(公告)日：2014-02-18
申请号：US13131914
申请日：2009-11-27
申请人： Alexandra Krog , Jochen Kruip , Paulus Wohlfart , Johann Gassenhuber , Kathrin Heermeier , Hartmut Strobel , Natalie Karst , Alexandra Ferrier , Christian Viskov
发明人： Alexandra Krog , Jochen Kruip , Paulus Wohlfart , Johann Gassenhuber , Kathrin Heermeier , Hartmut Strobel , Natalie Karst , Alexandra Ferrier , Christian Viskov
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893
摘要： The present invention relates to a method of screening for a modulator of endothelial NO synthase (eNOS) expression, a method of diagnosing a cardiovascular disease in a subject, the use of HEBP-1 for the identification of a medicament for preventing and/or treating a disease involving eNOS dysfunction, particularly a cardiovascular disease, the use of HEBP-1 for the detection of a component of eNOS signal transduction, and the use of HEBP1 for the regulation of eNOS promoter activity.
摘要翻译： 本发明涉及一种筛选内皮细胞合成酶（eNOS）表达调节剂的方法，一种诊断受试者心血管疾病的方法，使用HEBP-1鉴定用于预防和/或治疗的药物 涉及eNOS功能障碍，特别是心血管疾病的疾病，使用HEBP-1检测eNOS信号转导的成分，以及使用HEBP1来调节eNOS启动子活性。
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6.发明申请Oligosaccharides, preparation method and use thereof, and pharmaceutical compositions containing same 审中-公开寡糖，其制备方法和用途以及含有其的药物组合物公开(公告)号：US20070142323A1
公开(公告)日：2007-06-21
申请号：US11508800
申请日：2006-08-23
申请人： Christian Viskov , Pierre Mourier
发明人： Christian Viskov , Pierre Mourier
IPC分类号： A61K31/727 , C08B37/10 , C12P19/28
CPC分类号： A61K31/702 , C08B37/0078
摘要： The invention relates to oligosaccharides, the preparation method and use thereof, and pharmaceutical compositions containing same. More specifically, the invention relates to oligosaccharides which can be used for the treatment of cancer and, in particular, to prevent and inhibit the formation of metastases. The inventive oligosaccharides can be used, for example, during early breast, lung, prostate, colon or pancreatic cancer. The oligosaccharides can be administered subcutaneously, orally or intravenously. Moreover, said oligosaccharides can be used alone or together with other anticancer agents, e.g. cytotoxics such as docetaxel or paclitaxel.
摘要翻译： 本发明涉及寡糖，其制备方法和用途以及含有其的药物组合物。 更具体地，本发明涉及可用于治疗癌症，特别是预防和抑制转移形成的寡糖。 本发明的寡糖可以用于例如早期乳腺癌，肺癌，前列腺癌，结肠癌或胰腺癌。 寡糖可以皮下，口服或静脉内给药。 此外，所述寡糖可以单独使用或与其它抗癌剂一起使用。 细胞毒素如多西紫杉醇或紫杉醇。
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7.发明申请Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them 有权来自肝素的多糖的组合物，它们的制备和含有它们的药物组合物公开(公告)号：US20050171055A1
公开(公告)日：2005-08-04
申请号：US11096146
申请日：2005-04-01
IPC分类号： A61K31/727 , C08B37/00 , C08B37/10
CPC分类号： C08B37/0078 , A61K31/727 , C08B37/0075
摘要： Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.
摘要翻译： 由肝素衍生的多糖的碱金属和碱土金属盐，其制备方法和含有它们的药物组合物。
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公开(公告)号：US20110306553A1
公开(公告)日：2011-12-15
申请号：US13131914
申请日：2009-11-27
申请人： Alexandra Krog , Jochen Kruip , Paulus Wohlfart , Johann Gassenhuber , Kathrin Heermeier , Hartmut Strobel , Natalie Karst , Alexandra Ferrier , Christian Viskov
发明人： Alexandra Krog , Jochen Kruip , Paulus Wohlfart , Johann Gassenhuber , Kathrin Heermeier , Hartmut Strobel , Natalie Karst , Alexandra Ferrier , Christian Viskov
CPC分类号： G01N33/6893
摘要： The present invention relates to a method of screening for a modulator of endothelial NO synthase (eNOS) expression, a method of diagnosing a cardiovascular disease in a subject, the use of HEBP-1 for the identification of a medicament for preventing and/or treating a disease involving eNOS dysfunction, particularly a cardiovascular disease, the use of HEBP-1 for the detection of a component of eNOS signal transduction, and the use of HEBP1 for the regulation of eNOS promoter activity.
摘要翻译： 本发明涉及一种筛选内皮细胞合成酶（eNOS）表达调节剂的方法，一种诊断受试者心血管疾病的方法，使用HEBP-1鉴定用于预防和/或治疗的药物 涉及eNOS功能障碍，特别是心血管疾病的疾病，使用HEBP-1检测eNOS信号转导的成分，以及使用HEBP1来调节eNOS启动子活性。
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9.发明授权Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them 有权来自肝素的多糖的组合物，其制备方法和含有它们的药物组合物公开(公告)号：US07812007B2
公开(公告)日：2010-10-12
申请号：US11096146
申请日：2005-04-01
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： C08B37/0078 , A61K31/727 , C08B37/0075
摘要： Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.
摘要翻译： 由肝素衍生的多糖的碱金属和碱土金属盐，其制备方法和含有它们的药物组合物。
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10.发明授权Method for determining specific groups constituting heparins or low molecular weight heparins 有权确定构成肝素或低分子量肝素的特定组的方法公开(公告)号：US07687274B2
公开(公告)日：2010-03-30
申请号：US12007695
申请日：2008-01-14
申请人： Christian Viskov , Pierre Mourier
发明人： Christian Viskov , Pierre Mourier
CPC分类号： B01D15/366 , B01D15/363 , B01J2220/54 , C08B37/0078 , G01N2030/8813 , Y10T436/143333
摘要： The invention provides methods for analyzing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The methods of the invention may be used to analyze samples without pre-treatment or to analyze samples that have been partially or exhaustively depolymerised and, optionally, reduced. Specific saccharides can be detected.
摘要翻译： 本发明提供了通过高效液相色谱分析动态涂覆有季铵盐的固定相来分析肝素，低分子量肝素，超低分子量肝素和寡糖的方法。 本发明的方法可用于分析样品而无需预处理或分析已部分或全面解聚并任选还原的样品。 可以检测特异性糖。
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