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公开(公告)号：US20090326432A1
公开(公告)日：2009-12-31
申请号：US12524719
申请日：2008-01-25
IPC分类号： A61M5/00
CPC分类号： A61F9/00781
摘要： The present invention relates to an ocular implant, particularly a glaucoma stent.It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis.In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).
摘要翻译： 本发明涉及眼部植入物，特别是青光眼支架。 本发明的目的是设计一种允许眼睛压力被调节，即保持在期望水平的眼部植入物，同时防止流动阻力随时间增加，例如由于纤维化。 为了实现该目的，根据本发明的眼部植入物包括小管（5），其壁表面（3）围绕中空管道，中空管道在中空管道的纵向两侧敞开，其中 提供允许眼睛流入的第一开口（1）和允许眼睛被排出的第二开口（2），并且其中壁表面（3）由液体密封材料形成，并且其中至少 一个压力控制阀（4）设置在壁表面（3）的区域中。
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公开(公告)号：US08206333B2
公开(公告)日：2012-06-26
申请号：US12524719
申请日：2008-01-25
IPC分类号： A61M5/00
CPC分类号： A61F9/00781
摘要： The present invention relates to an ocular implant, particularly a glaucoma stent.It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis.In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).
摘要翻译： 本发明涉及眼部植入物，特别是青光眼支架。 本发明的目的是设计一种允许眼睛压力被调节，即保持在期望水平的眼部植入物，同时防止流动阻力随时间增加，例如由于纤维化。 为了实现该目的，根据本发明的眼部植入物包括小管（5），其壁表面（3）围绕中空管道，中空管道在中空管道的纵向两侧敞开，其中 提供允许眼睛流入的第一开口（1）和允许眼睛被排出的第二开口（2），并且其中壁表面（3）由液体密封材料形成，并且其中至少 一个压力控制阀（4）设置在壁表面（3）的区域中。
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3.发明授权Electrode configuration and measuring device for measuring the electrical activity in electrically active tissue 有权用于测量电活动组织中的电活动的电极配置和测量装置公开(公告)号：US08774892B2
公开(公告)日：2014-07-08
申请号：US12763374
申请日：2010-04-20
IPC分类号： A61B5/0492
CPC分类号： A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6817 , A61B5/6838 , A61B5/6848 , A61B5/6849 , A61B2562/125
摘要： An electrode arrangement for sensing electrical activity in target tissue is described. A support electrode has an elongate electrode body with a base end and a penetrating end for insertion into the target tissue. A fixation electrode has an elongate electrode body with a base end and a penetrating end at an angle to the electrode body. The electrodes are joined together with their electrode bodies in parallel so that the penetrating end of the fixation electrode penetrates a fixed distance into the target tissue so that at least one of the electrodes senses electrical activity in the target tissue.
摘要翻译： 描述了用于感测靶组织中的电活动的电极装置。 支撑电极具有细长电极体，其具有基端和用于插入目标组织的穿透端。 固定电极具有细长电极体，其具有基端和与电极体成角度的贯通端。 电极与其电极体平行连接在一起，使得固定电极的穿透端穿过目标组织的固定距离，使得至少一个电极感测目标组织中的电活动。
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4.发明申请公开(公告)号：US20110282177A1
公开(公告)日：2011-11-17
申请号：US12601156
申请日：2008-06-04
IPC分类号： A61B5/0492
CPC分类号： A61B5/6817 , A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6838 , A61B5/6848 , A61N1/0541 , A61N1/36036
摘要： The invention relates to an electrode arrangement and a measuring device for measuring the action flow and/or the action potential of an electrically active tissue. The aim of the invention is to provide a simple and economically producible electrode for measuring action flows and/or action potentials in electrically active tissues (preferably the stapedius muscle tissue), ensuring that the electrode is fixed securely, but reversibly, in the muscle tissue and that the muscle tissue is disturbed as little as possible. The electrode arrangement according to the invention comprises a first electrode (2) and a fixing element (3), the first electrode (2) being connected to a first, long electrical line (4) and consisting of a long base body (6) comprising a first end (7) and a second end (8). The first electrical line (4) is connected to the base body (6) in the region of the second end (8) thereof, and means are provided for reversibly fixing the fixing element (3) to the first electrode (2).
摘要翻译： 本发明涉及一种用于测量电活性组织的作用流和/或动作电位的电极装置和测量装置。 本发明的目的是提供一种用于测量电活动组织（优选吻合肌肉组织）中的作用流动和/或动作电位的简单且经济地生产的电极，确保电极在肌肉组织中可靠地可逆地固定 并且尽可能少地扰乱肌肉组织。 根据本发明的电极装置包括第一电极（2）和固定元件（3），所述第一电极（2）连接到第一长电线（4）并由长基体（6）组成， 包括第一端（7）和第二端（8）。 第一电线（4）在其第二端（8）的区域中连接到基体（6），并且设置用于将固定元件（3）可逆地固定到第一电极（2）的装置。
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5.发明授权公开(公告)号：US08725227B2
公开(公告)日：2014-05-13
申请号：US12601156
申请日：2008-06-04
IPC分类号： A61B5/0492 , A61F11/00
CPC分类号： A61B5/6817 , A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6838 , A61B5/6848 , A61N1/0541 , A61N1/36036
摘要： The invention relates to an electrode arrangement and a measuring device for measuring the action flow and/or the action potential of an electrically active tissue. The aim of the invention is to provide a simple and economically producible electrode for measuring action flows and/or action potentials in electrically active tissues (preferably the stapedius muscle tissue), ensuring that the electrode is fixed securely, but reversibly, in the muscle tissue and that the muscle tissue is disturbed as little as possible. The electrode arrangement according to the invention comprises a first electrode (2) and a fixing element (3), the first electrode (2) being connected to a first, long electrical line (4) and consisting of a long base body (6) comprising a first end (7) and a second end (8). The first electrical line (4) is connected to the base body (6) in the region of the second end (8) thereof, and means are provided for reversibly fixing the fixing element (3) to the first electrode (2).
摘要翻译： 本发明涉及一种用于测量电活性组织的作用流和/或动作电位的电极装置和测量装置。 本发明的目的是提供一种用于测量电活动组织（优选吻合肌肉组织）中的作用流动和/或动作电位的简单且经济地生产的电极，确保电极在肌肉组织中可靠地可逆地固定 并且尽可能少地扰乱肌肉组织。 根据本发明的电极装置包括第一电极（2）和固定元件（3），所述第一电极（2）连接到第一长电线（4）并由长基体（6）组成， 包括第一端（7）和第二端（8）。 第一电线（4）在其第二端（8）的区域中连接到基体（6），并且设置用于将固定元件（3）可逆地固定到第一电极（2）的装置。
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6.发明申请公开(公告)号：US20100268054A1
公开(公告)日：2010-10-21
申请号：US12763374
申请日：2010-04-20
IPC分类号： A61B5/0492
CPC分类号： A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6817 , A61B5/6838 , A61B5/6848 , A61B5/6849 , A61B2562/125
摘要： An electrode arrangement for sensing electrical activity in target tissue is described. A support electrode has an elongate electrode body with a base end and a penetrating end for insertion into the target tissue. A fixation electrode has an elongate electrode body with a base end and a penetrating end at an angle to the electrode body. The electrodes are joined together with their electrode bodies in parallel so that the penetrating end of the fixation electrode penetrates a fixed distance into the target tissue so that at least one of the electrodes senses electrical activity in the target tissue.
摘要翻译： 描述了用于感测靶组织中的电活动的电极装置。 支撑电极具有细长电极体，其具有基端和用于插入目标组织的穿透端。 固定电极具有细长电极体，其具有基端和与电极体成角度的贯通端。 电极与其电极体平行连接在一起，使得固定电极的穿透端穿过目标组织的固定距离，使得至少一个电极感测目标组织中的电活动。
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公开(公告)号：US20110190866A1
公开(公告)日：2011-08-04
申请号：US13057974
申请日：2009-07-17
申请人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David P. Martin , Simon F. Williams
发明人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David P. Martin , Simon F. Williams
CPC分类号： A61L31/18 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/606 , C08L67/04
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.
摘要翻译： 可吸收支架和可吸收支架涂层已经开发出具有改进的性能。 这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。 这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。 衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或脱胶的情况下扩展，并且可以用作药物掺入的涂层基质。
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公开(公告)号：US09162010B2
公开(公告)日：2015-10-20
申请号：US13284287
申请日：2011-10-28
申请人： Thomas Lenarz , Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Simon Williams , David Martin
发明人： Thomas Lenarz , Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Simon Williams , David Martin
CPC分类号： A61L27/34 , A61K9/0024 , A61L27/54 , A61L31/08 , A61L31/10 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61M31/002 , A61N1/36036 , C08L67/04
摘要： Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.
摘要翻译： 已经开发了用于植入式刺激装置如耳蜗植入物的药物递送系统和生物相容性涂层。 这些药物递送系统和涂层包含聚羟基链烷酸酯（PHA）聚合物和共聚物。 药物递送系统可以用于将药理活性物质例如直接从耳蜗植入物递送到内耳。 涂层可以赋予耳蜗装置润滑性，便于插入电极。 在优选的实施方案中，药物递送系统包含聚羟基链烷酸酯聚合物，并且在最优选的实施方案中，PHA聚合物包含聚（4-羟基丁酸酯）（P（4HB））或其共聚物。 一个特别优选的实施方案是其中耳蜗植入电极的硅氧烷鞘被表面改性并且涂覆有P（4HB），并且P（4HB）含有药理学活性物质或已被这种物质包被。
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公开(公告)号：US20120283666A1
公开(公告)日：2012-11-08
申请号：US13284287
申请日：2011-10-28
申请人： Thomas Lenarz , Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Simon Williams , David Martin
发明人： Thomas Lenarz , Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Simon Williams , David Martin
CPC分类号： A61L27/34 , A61K9/0024 , A61L27/54 , A61L31/08 , A61L31/10 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61M31/002 , A61N1/36036 , C08L67/04
摘要： Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.
摘要翻译： 已经开发了用于植入式刺激装置如耳蜗植入物的药物递送系统和生物相容性涂层。 这些药物递送系统和涂层包含聚羟基链烷酸酯（PHA）聚合物和共聚物。 药物递送系统可以用于将药理活性物质例如直接从耳蜗植入物递送到内耳。 涂层可以赋予耳蜗装置润滑性，便于插入电极。 在优选的实施方案中，药物递送系统包含聚羟基链烷酸酯聚合物，并且在最优选的实施方案中，PHA聚合物包含聚（4-羟基丁酸酯）（P（4HB））或其共聚物。 一个特别优选的实施方案是其中耳蜗植入电极的硅氧烷鞘被表面改性并且涂覆有P（4HB），并且P（4HB）含有药理学活性物质或已被这种物质包被。
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公开(公告)号：US20110027381A1
公开(公告)日：2011-02-03
申请号：US12445635
申请日：2007-10-16
申请人： Georg Gradl , Detlef Behrend , Klaus-Peter Schmitz , Katrin Sternberg , Kathleen Schmohl , Sven Kramer
发明人： Georg Gradl , Detlef Behrend , Klaus-Peter Schmitz , Katrin Sternberg , Kathleen Schmohl , Sven Kramer
CPC分类号： A61K38/44 , A61K33/06 , A61K38/39 , A61K45/06 , A61L24/0084 , A61L27/46 , A61L2430/02 , C12Y110/03002 , C08L89/06 , A61K2300/00
摘要： The present invention relates to a combination for the treatment of osteoporosis and/or the prophylaxis and treatment of bone fractures, said combination comprising collagen, an additional peptide, a calcium-containing substance and a wetting agent with a terminally functionalized oligolactone. The invention also relates to artificial bones and implants produced by the combination and to the use of said combination for fixing implants and treating osteoporosis and/or the prophylaxis and treatment of bone fractures. The invention further relates to a method for producing artificial bones and implants.
摘要翻译： 本发明涉及用于治疗骨质疏松症和/或预防和治疗骨折的组合，所述组合包括胶原，附加肽，含钙物质和具有末端官能化寡聚内酯的润湿剂。 本发明还涉及通过组合产生的人造骨和植入物，以及用于固定植入物和治疗骨质疏松症和/或骨折的预防和治疗的所述组合的使用。 本发明还涉及一种用于生产人造骨和植入物的方法。
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