公开(公告)号：US09854804B2

公开(公告)日：2018-01-02

申请号：US13978488

申请日：2012-01-04

申请人： Won Gon Kim ,  Yun Ju Kwon ,  Mi Jin Sohn

发明人： Won Gon Kim ,  Yun Ju Kwon ,  Mi Jin Sohn

IPC分类号： A01N43/90 ,  C07K7/06 ,  C07K7/54 ,  A61K31/404

CPC分类号： A01N43/90 ,  A61K31/404 ,  C07K7/06

摘要： Disclosed are a novel strain with antibacterial activity, identified as Streptomyces sp. AN1542 strain (Accession No.: KCTC 12113BP), an antibacterial composition comprising a compound represented by Chemical Formula 1 or 2, or a strain producing the same as an active ingredient, and a method for producing the same. Exhibiting potent antibacterial activity against pathogenic microbes and antibiotic-resistant microbes, particularly, MRSA, QRSA, VRSA and VRE, the compound or the strain of the present invention can be applied to the treatment of infectious diseases caused by superbacteria.

公开(公告)号：US20140030242A1

公开(公告)日：2014-01-30

申请号：US13978488

申请日：2012-01-04

申请人： Won Gon Kim ,  Yun Ju Kwon ,  Mi Jin Sohn

发明人： Won Gon Kim ,  Yun Ju Kwon ,  Mi Jin Sohn

IPC分类号： A01N43/90 ,  C07K7/06

CPC分类号： A01N43/90 ,  A61K31/404 ,  C07K7/06

摘要： Disclosed are a novel strain with antibacterial activity, identified as Streptomyces sp. AN1542 strain (Accession No.: KCTC 12113BP), an antibacterial composition comprising a compound represented by Chemical Formula 1 or 2, or a strain producing the same as an active ingredient, and a method for producing the same. Exhibiting potent antibacterial activity against pathogenic microbes and antibiotic-resistant microbes, particularly, MRSA, QRSA, VRSA and VRE, the compound or the strain of the present invention can be applied to the treatment of infectious diseases caused by superbacteria.

摘要翻译： 公开了具有抗菌活性的新型菌株，被鉴定为链霉菌属（Streptomyces sp。）。 AN1542菌株（登录号：KCTC 12113BP），包含由化学式1或2表示的化合物的抗菌组合物或其生产与活性成分相同的菌株及其制备方法。 本发明的化合物或菌株对于致病微生物和抗生素抗性微生物，特别是MRSA，QRSA，VRSA和VRE具有有效的抗菌活性，可用于治疗由超细菌引起的感染性疾病。

公开(公告)号：US09034916B2

公开(公告)日：2015-05-19

申请号：US14009526

申请日：2011-11-28

申请人： Won Gon Kim ,  Baek Soo Han ,  Kyoung Shim Kim ,  Kwang Soo Kim ,  Young Mi Kang ,  Yu Jin Kim ,  Chun Hyung Kim ,  Mi Jin Sohn ,  Hoe Yune Jung

发明人： Won Gon Kim ,  Baek Soo Han ,  Kyoung Shim Kim ,  Kwang Soo Kim ,  Young Mi Kang ,  Yu Jin Kim ,  Chun Hyung Kim ,  Mi Jin Sohn ,  Hoe Yune Jung

IPC分类号： A01N43/02 ,  A61K31/335 ,  A01N43/08 ,  A61K31/34 ,  A01N37/00 ,  A61K31/21 ,  A01N31/14 ,  A61K31/075 ,  A01N31/00 ,  A61K31/045 ,  A61K31/357 ,  A61K36/83

CPC分类号： A61K31/357 ,  A61K36/83

摘要： The present invention relates to: a pharmaceutical composition or a Nurr1 activating composition for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the composition comprises an active ingredient in the form of genkwanin N or yuanhuacine, a Daphne genkwa extract comprising one or more of the above compounds, or a fraction thereof; or a functional food additive for preventing or alleviating a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the additive comprises genkwanin N or yuanhuacine, a Daphne genkwa extract comprising one or more of the above compounds, or a fraction thereof; and a method for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the method comprises the step of administering the pharmaceutical composition.

摘要翻译： 本发明涉及：用于预防或治疗神经退行性疾病或由Nurr1功能受损引起的疾病的药物组合物或Nurr1活化组合物，其中所述组合物包含以genkwanin N或元花胺形式的活性成分，达芙妮 genkwa提取物包含一种或多种上述化合物或其一部分; 或用于预防或减轻神经退行性疾病或由Nurr1功能受损引起的疾病的功能性食品添加剂，其中所述添加剂包括genkwanin N或元华辛，包含一种或多种上述化合物的Daphne genkwa提取物或其一部分; 以及用于预防或治疗由Nurr1功能受损引起的神经变性疾病或疾病的方法，其中所述方法包括施用所述药物组合物的步骤。

公开(公告)号：US09114155B2

公开(公告)日：2015-08-25

申请号：US14009596

申请日：2012-04-06

申请人： Won Gon Kim ,  Baek Soo Han ,  Kyoung Shim Kim ,  Kwang Soo Kim ,  Young Mi Kang ,  Chun Hyung Kim ,  Mi Jin Sohn ,  Hoe Yune Jung

发明人： Won Gon Kim ,  Baek Soo Han ,  Kyoung Shim Kim ,  Kwang Soo Kim ,  Young Mi Kang ,  Chun Hyung Kim ,  Mi Jin Sohn ,  Hoe Yune Jung

IPC分类号： A61K36/73 ,  A61K36/738

CPC分类号： A61K36/73 ,  A61K36/738

摘要： The present invention relates to a pharmaceutical composition for preventing or treating Parkinson's disease, which comprises, as an active ingredient, a Rhodotypos scandens extract obtained by extracting the stem of Rhodotypos scandens with an organic solvent, and a food additive showing the effect of preventing or treating Parkinson's disease, the food additive comprising Rhodotypos scandens extract as an active ingredient. The Rhodotypos scandens extracts of the present invention may prevent or treat Parkinson's disease without producing any particular side effects, and therefore can be widely used for more safely treating Parkinson's disease.

摘要翻译： 本发明涉及一种用于预防或治疗帕金森病的药物组合物，其包含作为活性成分的通过用有机溶剂提取红景天甙茎的获得的红景霉素提取物，以及显示出预防或 治疗帕金森病，食品添加剂包含红景天提取物作为活性成分。 本发明的红景天提取物可以预防或治疗帕金森氏病，而不产生任何特定的副作用，因此可广泛用于更安全地治疗帕金森病。

公开(公告)号：US20140370132A1

公开(公告)日：2014-12-18

申请号：US14009596

申请日：2012-04-06

申请人： Won Gon Kim ,  Baek Soo Han ,  Kyoung Shim Kim ,  Kwang Soo Kim ,  Young Mi Kang ,  Chun Hyung Kim ,  Mi Jin Sohn ,  Hoe Yune Jung

发明人： Won Gon Kim ,  Baek Soo Han ,  Kyoung Shim Kim ,  Kwang Soo Kim ,  Young Mi Kang ,  Chun Hyung Kim ,  Mi Jin Sohn ,  Hoe Yune Jung

IPC分类号： A61K36/73

CPC分类号： A61K36/73 ,  A61K36/738

摘要： The present invention relates to a pharmaceutical composition for preventing or treating Parkinson's disease, which comprises, as an active ingredient, a Rhodotypos scandens extract obtained by extracting the stem of Rhodotypos scandens with an organic solvent, and a food additive showing the effect of preventing or treating Parkinson's disease, the food additive comprising Rhodotypos scandens extract as an active ingredient. The Rhodotypos scandens extracts of the present invention may prevent or treat Parkinson's disease without producing any particular side effects, and therefore can be widely used for more safely treating Parkinson's disease.

摘要翻译： 本发明涉及一种用于预防或治疗帕金森病的药物组合物，其包含作为活性成分的通过用有机溶剂提取红景天甙茎的获得的红景霉素提取物，以及显示出预防或 治疗帕金森病，食品添加剂包含红景天提取物作为活性成分。 本发明的红景天提取物可以预防或治疗帕金森氏病，而不产生任何特定的副作用，因此可广泛用于更安全地治疗帕金森病。

公开(公告)号：US08574556B2

公开(公告)日：2013-11-05

申请号：US13129087

申请日：2008-11-12

申请人： Won Gon Kim ,  Chang Ji Zheng ,  Ki Young Kim ,  Mi Jin Sohn

发明人： Won Gon Kim ,  Chang Ji Zheng ,  Ki Young Kim ,  Mi Jin Sohn

IPC分类号： A61K8/365 ,  A61K8/00 ,  A61K8/18

CPC分类号： A61K36/185 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/2018 ,  A61K9/4866 ,  A61K31/19

摘要： The present invention relates to an antibacterial pharmaceutical composition comprising an Aceriphyllum rossii extract, and aceriphyllic acid A and 3-oxo-12-oleanen-27-oic acid isolated therefrom. The Aceriphyllum rossii extract of the present invention, and aceriphyllic acid A and 3-oxo-12-oleanen-27-oic acid isolated therefrom have strong antibacterial activities against Staphylococcus aureus, methicillin-resistant S. aureus, quinolone-resistant S. aureus, Acinetobacter calcoaceticus, Micrococcus luteus, Bacillus subtilis or Streptococcus mutans, Propionibacterium acnes, thereby being used for the prevention or treatment of pathogenic bacterial and resistant bacterial infections, cariogenic bacterial and acne bacterial infections.

摘要翻译： 本发明涉及一种抗菌药物组合物，其包含Aceriphyllum rossii提取物和从其中分离的Aceriphyllic A和3-氧代-12-油烯-27-酸。 本发明的Aceriphyllum rossii提取物和从其中分离出的Aceriphyllic A和3-氧代-12-油烯-27-酸，对金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌，抗喹诺酮类金黄色葡萄球菌， 醋酸不动杆菌，藤黄微球菌，枯草芽孢杆菌或变形链球菌，痤疮丙酸杆菌，因此用于预防或治疗致病细菌和抗性细菌感染，致龋细菌和痤疮细菌感染。

公开(公告)号：US20110223118A1

公开(公告)日：2011-09-15

申请号：US13129087

申请日：2008-11-12

申请人： Won Gon Kim ,  Chang Ji Zheng ,  Ki Young Kim ,  Mi Jin Sohn

发明人： Won Gon Kim ,  Chang Ji Zheng ,  Ki Young Kim ,  Mi Jin Sohn

IPC分类号： A61K8/37 ,  A61K36/18 ,  A61K31/215 ,  A61K8/97 ,  A61P17/10 ,  A61Q11/00

CPC分类号： A61K36/185 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/2018 ,  A61K9/4866 ,  A61K31/19

摘要： The present invention relates to an antibacterial pharmaceutical composition comprising an Aceriphyllum rossii extract, and aceriphyllic acid A and 3-oxo-12-oleanen-27-oic acid isolated therefrom. The Aceriphyllum rossii extract of the present invention, and aceriphyllic acid A and 3-oxo-12-oleanen-27-oic acid isolated therefrom have strong antibacterial activities against Staphylococcus aureus, methicillin-resistant S. aureus, quinolone-resistant S. aureus, Acinetobacter calcoaceticus, Micrococcus luteus, Bacillus subtilis or Streptococcus mutans, Propionibacterium acnes, thereby being used for the prevention or treatment of pathogenic bacterial and resistant bacterial infections, cariogenic bacterial and acne bacterial infections.

摘要翻译： 本发明涉及一种抗菌药物组合物，其包含Aceriphyllum rossii提取物和从其中分离的Aceriphyllic A和3-氧代-12-油烯-27-酸。 本发明的Aceriphyllum rossii提取物和从其中分离出的Aceriphyllic A和3-氧代-12-油烯-27-酸，对金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌，抗喹诺酮类金黄色葡萄球菌， 醋酸不动杆菌，藤黄微球菌，枯草芽孢杆菌或变形链球菌，痤疮丙酸杆菌，因此用于预防或治疗致病细菌和抗性细菌感染，致龋细菌和痤疮细菌感染。

公开(公告)号：US20090197347A1

公开(公告)日：2009-08-06

申请号：US11571335

申请日：2005-06-28

申请人： Mi Jin Sohn ,  Seung Bum Yoo ,  Yeon Chul Kim ,  Jae Hoon Oh ,  Eunkyung Kim ,  Seung Ho Choo

发明人： Mi Jin Sohn ,  Seung Bum Yoo ,  Yeon Chul Kim ,  Jae Hoon Oh ,  Eunkyung Kim ,  Seung Ho Choo

IPC分类号： G01N33/569 ,  G01N33/566

CPC分类号： G01N33/56905 ,  G01N33/543 ,  G01N2333/445 ,  Y02A50/58

摘要： Disclosed are an immunoassay of Plasmodium falciparum for determining the presence/absence of a specific and/or antibody thereof via label in conjugates bound to the specific antigen and/or antibody present in a sample, comprising immobilizing the specific antigen and antibody of Plasmodium falciparum on a solid phase, adding a sample obtained from a subject of interest to the solid phase so as to induce specific antibody-antigen reaction, adding a conjugate of the antigen and a label and a conjugate of the antibody and a label, separately prepared, so as to induce binding of at least one of the conjugates; and an assay device comprising the above-mentioned solid phase and conjugates.The present invention can effect specific detection of antigens and/or antibodies in patients with manifested malaria-symptoms as well as malaria carriers and can also be efficiently employed in samples at the early stage of malaria infection that is difficult to detect via conventional arts. Further, due to the capacity to utilize sera and blood plasma rather than whole blood, the present invention is well suited to large-scale examination such as blood screening.

摘要翻译： 公开了恶性疟原虫的免疫测定法，用于通过与样品中存在的特异性抗原和/或抗体结合的缀合物中的标记物来确定其特异性和/或抗体的存在/不存在，包括将恶性疟原虫的特异性抗原和抗体固定在 固相，将从感兴趣的受试者获得的样品加入到固相中，以诱导特异性抗体 - 抗原反应，加入分别制备的抗原和抗体的标记物和缀合物和标记的缀合物， 以诱导至少一种缀合物的结合; 以及包含上述固相和缀合物的测定装置。 本发明可以在具有表现的疟疾症状的患者以及疟疾携带者中实现抗原和/或抗体的特异性检测，并且还可以有效地用于通过常规技术难以检测的疟疾感染早期的样品中。 此外，由于能够利用血清和血浆而不是全血，本发明非常适合于大规模检查，如血液筛查。