公开(公告)号：US20100289509A1

公开(公告)日：2010-11-18

申请号：US11939969

申请日：2007-11-14

申请人： Won Seok CHUNG ,  Kyu Tae YOO ,  Jeo Young SHIM ,  Junghoon LEE ,  Misun CHA ,  Junglm HAN ,  Seungwon JUNG

发明人： Won Seok CHUNG ,  Kyu Tae YOO ,  Jeo Young SHIM ,  Junghoon LEE ,  Misun CHA ,  Junglm HAN ,  Seungwon JUNG

IPC分类号： G01R27/08

CPC分类号： G01N33/551 ,  G01N27/127 ,  G01N33/5438 ,  Y10S977/852

摘要： A device and method are disclosed for detecting biomolecules. More specifically, by measuring the change in the electrical properties of a complex between a probe and carbon nanotubes, a non-label detection is achieved, capable of a rapid, sensitive and electrical detection of the presence and concentration of biomolecules in a sample solution.

摘要翻译： 公开了用于检测生物分子的装置和方法。 更具体地，通过测量探针和碳纳米管之间的络合物的电学性质的变化，实现了非标记检测，能够快速，灵敏和电检测样品溶液中生物分子的存在和浓度。

公开(公告)号：US20080315861A1

公开(公告)日：2008-12-25

申请号：US12019765

申请日：2008-01-25

申请人： Won Seok CHUNG ,  Kyu Tae YOO ,  Jeo Young SHIM ,  Jung Im HAN

发明人： Won Seok CHUNG ,  Kyu Tae YOO ,  Jeo Young SHIM ,  Jung Im HAN

IPC分类号： G01N33/68

CPC分类号： B01L3/502761 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2400/0415 ,  G01N27/4145

摘要： A biomolecule detector and a method thereof are provided to detect the biomolecules in a liquid sample using a field effect transistor (FET) array. The FET array is characterized in that the transistor used has no gate electrode layer, a reference electrode is provided in the space between the transistors in the array instead of the gate electrode layer. Using the FET array, the existence of the biomolecules in the sample can be detected electrically and effectively under the circumstance where an external voltage is applied to flow the biomolecules. Using the FET array to detect the biomolecules, the deviation for each transistor is reduced and the multiplex processing is also possible to measure the plurality of analyzing samples at the same time.

摘要翻译： 提供生物分子检测器及其方法以使用场效应晶体管（FET）阵列检测液体样品中的生物分子。 FET阵列的特征在于所使用的晶体管不具有栅电极层，参考电极设置在阵列中的晶体管之间的空间中，而不是栅极电极层。 使用FET阵列，可以在施加外部电压以使生物分子流动的情况下电性和有效地检测样品中的生物分子的存在。 使用FET阵列来检测生物分子，每个晶体管的偏差减小，并且多路复用处理也可以同时测量多个分析样本。

公开(公告)号：US20080308846A1

公开(公告)日：2008-12-18

申请号：US12125506

申请日：2008-05-22

申请人： Jeo Young SHIM ,  Kyu Tae YOO ,  Won Seok CHUNG ,  Jung Im HAN

发明人： Jeo Young SHIM ,  Kyu Tae YOO ,  Won Seok CHUNG ,  Jung Im HAN

IPC分类号： G01N27/414 ,  H01L21/00

CPC分类号： G01N27/4145

摘要： A device for detecting biomolecules includes: a semiconductor substrate; a source region and a drain region separately provided at the substrate; a chamber formed at the substrate including a region between the source region and the drain region, the chamber configured to contain a sample including the biomolecules; and an electrode which applies a voltage to the sample in the chamber. The biomolecules are mobile with respect to the electrode and sample. Methods for detecting biomolecules are also disclosed.

摘要翻译： 用于检测生物分子的装置包括：半导体衬底; 分别设置在所述基板上的源极区域和漏极区域; 在所述基板上形成的室，所述室包括所述源极区域和所述漏极区域之间的区域，所述室被配置为容纳包含所述生物分子的样品; 以及向室中的样品施加电压的电极。 生物分子相对于电极和样品是可移动的。 还公开了检测生物分子的方法。

公开(公告)号：US20090122828A1

公开(公告)日：2009-05-14

申请号：US12108686

申请日：2008-04-24

申请人： Jung Im HAN ,  Jeo Young SHIM ,  Won Seok CHUNG ,  Kak NAMKOONG

发明人： Jung Im HAN ,  Jeo Young SHIM ,  Won Seok CHUNG ,  Kak NAMKOONG

IPC分类号： G01N25/02

CPC分类号： G01N27/4145

摘要： A method for identifying a biomolecule using a biomolecule detector having a field effect transistor (FET) is provided. The method comprises the steps of (a) heating a sample containing a biomolecule loaded in the detector to thereby elevate the temperature of the sample; (b) measuring electric current flowing through a channel formed between a source region and a drain region in the FET while raising the temperature in the step (a); (c) obtaining a transition temperature that is the temperature at maximum point of current variation from data measured in the step (b); and (d) identifying the biomolecule using the transition temperature obtained in the step (c).

摘要翻译： 提供了使用具有场效应晶体管（FET）的生物分子检测器来鉴定生物分子的方法。 该方法包括以下步骤：（a）加热装载在检测器中的生物分子的样品，从而提高样品的温度; （b）测量在步骤（a）中提高温度的同时流过形成在FET中的源极区域和漏极区域之间的沟道的电流; （c）获得作为在步骤（b）中测量的数据的电流变化的最大点处的温度的转变温度; 和（d）使用在步骤（c）中获得的转变温度鉴定生物分子。

公开(公告)号：US20090090175A1

公开(公告)日：2009-04-09

申请号：US12141448

申请日：2008-06-18

申请人： Jeo Young SHIM ,  Jung Im HAN ,  Won Seok CHUNG

发明人： Jeo Young SHIM ,  Jung Im HAN ,  Won Seok CHUNG

IPC分类号： G01N33/49

CPC分类号： C12Q1/6825 ,  C12Q2539/101 ,  C12Q2531/113 ,  C12Q2527/107

摘要： A method and a device for detecting nucleic acid are disclosed, wherein impurities in a sample can be easily removed.. The method comprises injecting a sample containing an adsorption medium with nucleic adsorbed thereon into a chamber; washing the sample; heating the sample to denature the nucleic acid; cooling down; and detecting nucleic acid by using the biomolecule detection device. The device includes: a source and a drain region; a gate electrode layer; a chamber formed over the semiconductor substrate including the gate electrode layer; and a heating means, wherein a gate adsorption layer to which a nucleic acid is adsorbed is formed on the gate electrode layer. A single-stranded nucleic acid is adsorbed to the gate adsorption layer, and a channel is formed between the source and the drain region. The current in the channel provides a basis to detect a gene.

摘要翻译： 公开了一种用于检测核酸的方法和装置，其中样品中的杂质可以容易地去除。该方法包括将含有其上吸附有核酸的吸附介质的样品注入室中; 洗样 加热样品使核酸变性; 冷却下来; 并通过使用生物分子检测装置检测核酸。 该器件包括：源极和漏极区域; 栅极电极层; 形成在包括栅电极层的半导体衬底上的腔室; 以及加热装置，其中在所述栅极电极层上形成有吸附有核酸的栅极吸附层。 单链核酸被吸附到栅极吸附层，并且在源区和漏区之间形成沟道。 通道中的电流为检测基因提供了依据。

公开(公告)号：US20090280509A1

公开(公告)日：2009-11-12

申请号：US12265129

申请日：2008-11-05

申请人： Hun Joo LEE ,  Sung Ouk JUNG ,  Jeo Young SHIM

发明人： Hun Joo LEE ,  Sung Ouk JUNG ,  Jeo Young SHIM

IPC分类号： G01N33/543 ,  C12M1/00 ,  B01J19/00

CPC分类号： G01N33/54373 ,  G01N29/022 ,  G01N29/036 ,  G01N33/6854 ,  G01N2291/012 ,  G01N2291/015 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0423 ,  G01N2800/24

摘要： A surface acoustic wave (SAW) immunosensor for diagnosing allergy disease includes one or more SAW devices on each of which allergens derived from one allergy-causing substance are fixed and an allergen derived from another allergy-causing substance is not included, that is, allergens derived from different allergy-causing substances being fixed on different SAW devices; and a signal detector which detects an output signal from the SAW device. Also a method for diagnosing allergy disease is capable of measuring levels of allergen-specific IgE and total IgE in blood or another sample taken from a subject of diagnosis using a SAW immunosensor, the allergens being derived from various allergy-causing substances, thereby capable of effectively diagnosing allergy disease for various allergy-causing substances.

摘要翻译： 用于诊断过敏疾病的表面声波（SAW）免疫传感器包括一个或多个SAW器件，其中每一个SAW器件，其中每一个来自一种过敏原物质的过敏原是固定的，并且不包括衍生自另一种过敏原物质的变应原，即变应原 衍生自不同的过敏原物质固定在不同的SAW器件上; 以及信号检测器，其检测来自SAW器件的输出信号。 用于诊断变态反应疾病的方法还能够测量使用SAW免疫传感器从血液或取自诊断对象的另一个样品中的变应原特异性IgE和总IgE的水平，所述过敏原来源于各种过敏原物质，从而能够 有效诊断各种过敏性疾病的各种过敏原物质。