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1.发明申请Combinations comprising HCV protease inhibitor(s) and HCV polymerase inhibitor(s), and methods of treatment related thereto 审中-公开包含HCV蛋白酶抑制剂和HCV聚合酶抑制剂的组合以及与之相关的治疗方法公开(公告)号：US20070274951A1
公开(公告)日：2007-11-29
申请号：US11705087
申请日：2007-02-09
申请人： Xiao Tong , Bruce Malcolm , Hsueh-Cheng Huang
发明人： Xiao Tong , Bruce Malcolm , Hsueh-Cheng Huang
IPC分类号： A61K38/21 , A61K31/16 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/47 , A61P31/12 , A61K31/535 , A61K31/54 , A61K31/555 , A61K31/70
CPC分类号： A61K38/07 , A61K38/06 , A61K38/08 , A61K45/06 , A61K2300/00
摘要： Disclosed are medicaments, pharmaceutical compositions, pharmaceutical kits, and methods based on combinations of at least one HCV protease inhibitor and at least one HCV polymerase inhibitor but not HCV-796; for concurrent or consecutive administration in treating or ameliorating one or more symptoms of HCV, or disorders associated with HCV in a subject in need thereof.
摘要翻译： 公开了基于至少一种HCV蛋白酶抑制剂和至少一种HCV聚合酶抑制剂但不是HCV-796的组合的药物，药物组合物，药物试剂盒和方法; 用于同时或连续给药以治疗或改善HCV的一种或多种症状或与有需要的受试者中与HCV相关的病症。
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公开(公告)号：US20070224167A1
公开(公告)日：2007-09-27
申请号：US11704505
申请日：2007-02-09
申请人： Emillo Emini , Michael Flint , Anita Howe , Bruce Malcolm , Stanley Mullen , Robert Ralston , Xiao Tong
发明人： Emillo Emini , Michael Flint , Anita Howe , Bruce Malcolm , Stanley Mullen , Robert Ralston , Xiao Tong
IPC分类号： A61K38/21 , A61K31/7056 , A61K31/407 , A61K31/343
CPC分类号： A61K31/343 , A61K31/407 , A61K31/7056 , A61K38/06 , A61K38/21 , A61K2300/00
摘要： Novel hepatitis C virus (“HCV”) inhibitor combinations comprising an HCV protease inhibitor and HCV polymerase inhibitor, and optionally one or more biologically active agents, as well as uses of these combinations as HCV inhibitors and for treating hepatitis C and related disorders are disclosed.
摘要翻译： 公开了包含HCV蛋白酶抑制剂和HCV聚合酶抑制剂以及任选的一种或多种生物活性剂的新型丙型肝炎病毒（“HCV”）抑制剂组合以及这些组合作为HCV抑制剂和治疗丙型肝炎及相关疾病的用途 。
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公开(公告)号：US20060198824A1
公开(公告)日：2006-09-07
申请号：US11365008
申请日：2006-03-01
申请人： Bruce Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
发明人： Bruce Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
IPC分类号： A61K31/7072 , A61K38/21
CPC分类号： A61K31/7072 , A61K38/212 , A61K2300/00
摘要： The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
摘要翻译： 本发明提供了在宿主中通过属于黄病毒科的病毒如HCV的感染的方法，其包括向宿主施用Ara-C同源物。
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公开(公告)号：US20090209483A1
公开(公告)日：2009-08-20
申请号：US12412967
申请日：2009-03-27
申请人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
发明人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
IPC分类号： A61K31/7068
CPC分类号： A61K31/7072 , A61K38/212 , A61K2300/00
摘要： The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
摘要翻译： 本发明提供了在宿主中通过属于黄病毒科的病毒如HCV的感染的方法，其包括向宿主施用Ara-C同源物。
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公开(公告)号：US07816339B2
公开(公告)日：2010-10-19
申请号：US12412967
申请日：2009-03-27
申请人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
发明人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
CPC分类号： A61K31/7072 , A61K38/212 , A61K2300/00
摘要： The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
摘要翻译： 本发明提供了在宿主中通过属于黄病毒科的病毒如HCV的感染的方法，其包括向宿主施用Ara-C同源物。
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6.发明授权Methods and compositions for diagnosing and treating disorders involving angiogenesis 失效用于诊断和治疗涉及血管发生的疾病的方法和组合物公开(公告)号：US06803211B2
公开(公告)日：2004-10-12
申请号：US09938391
申请日：2001-08-24
申请人： Xiao Tong , Michael G. Sheppard
发明人： Xiao Tong , Michael G. Sheppard
IPC分类号： C12P2106
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/78 , G01N2333/78
摘要： The present invention relates to polynucleotides associated with angiogenesis-related disorders. The present invention also relates to canine endostatin genes, novel genes associated with angiogenesis-related disorders, such as cancer. The invention encompasses endostatin nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, endostatin gene products and antibodies directed against such gene products, cloning vectors containing mammalian endostatin gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of endostatin genes and gene products and to using such compounds as therapeutic agents in the treatment of angiogenesis-related disorders, e.g., cancer. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of angiogenesis-related disorders, e.g., cancer, and to methods and compositions for the treatment these disorders.
摘要翻译： 本发明涉及与血管发生相关疾病相关的多核苷酸。 本发明还涉及犬内皮抑素基因，与血管生成相关疾病如癌症相关的新基因。 本发明包括内皮抑素核酸，重组DNA分子，克隆基因或其简并变体，针对此类基因产物的内皮抑素基因产物和抗体，含有哺乳动物内皮抑素基因分子的克隆载体，以及已被遗传工程化以表达该分子的宿主。 本发明还涉及用于鉴定调节内皮抑素基因和基因产物的表达的化合物的方法，并且使用这些化合物作为治疗剂来治疗血管生成相关病症例如癌症。 本发明还涉及用于诊断评估，基因测试和血管发生相关疾病例如癌症的预后的方法以及用于治疗这些疾病的方法和组合物。
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公开(公告)号：US20110033422A1
公开(公告)日：2011-02-10
申请号：US12906651
申请日：2010-10-18
申请人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
发明人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
IPC分类号： A61K38/21 , A61K31/7068 , A61P31/12
CPC分类号： A61K31/7072 , A61K38/212 , A61K2300/00
摘要： The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
摘要翻译： 本发明提供了在宿主中通过属于黄病毒科的病毒如HCV的感染的方法，其包括向宿主施用Ara-C同源物。
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8.发明申请Methods and compositions for diagnosing and treating disorders involving angiogenesis 审中-公开用于诊断和治疗涉及血管发生的疾病的方法和组合物公开(公告)号：US20050032163A1
公开(公告)日：2005-02-10
申请号：US10849650
申请日：2004-05-20
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to polynucleotides associated with angiogenesis-related disorders. The present invention also relates to feline endostatin genes, novel genes associated with angiogenesis-related disorders, such as cancer. The invention encompasses endostatin nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, endostatin gene products and antibodies directed against such gene products, cloning vectors containing mammalian endostatin gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of endostatin genes and gene products and to using such compounds as therapeutic agents in the treatment of angiogenesis-related disorders, e.g., cancer. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of angiogenesis-related disorders, e.g., cancer, and to methods and compositions for the treatment these disorders.
摘要翻译： 本发明涉及与血管发生相关疾病相关的多核苷酸。 本发明还涉及猫内皮抑素基因，与血管生成相关病症如癌症相关的新基因。 本发明包括内皮抑素核酸，重组DNA分子，克隆基因或其简并变体，针对此类基因产物的内皮抑素基因产物和抗体，含有哺乳动物内皮抑素基因分子的克隆载体，以及已被遗传工程化以表达该分子的宿主。 本发明还涉及用于鉴定调节内皮抑素基因和基因产物的表达的化合物的方法，并且使用这些化合物作为治疗剂来治疗血管生成相关病症例如癌症。 本发明还涉及用于诊断评估，基因测试和血管发生相关疾病例如癌症的预后的方法以及用于治疗这些疾病的方法和组合物。
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9.发明申请Methods and compositions for diagnosing and treating disorders involving angiogenesis 审中-公开用于诊断和治疗涉及血管发生的疾病的方法和组合物公开(公告)号：US20050009144A1
公开(公告)日：2005-01-13
申请号：US10920820
申请日：2004-08-17
申请人： Xiao Tong , Michael Sheppard
发明人： Xiao Tong , Michael Sheppard
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/00 , A61P9/10 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P25/00 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/78 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , G01N33/15 , G01N33/50 , A01K67/00 , A61K38/17 , C07H21/04 , C12N9/64
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/78 , G01N2333/78
摘要： The present invention relates to polynucleotides associated with angiogenesis-related disorders. The present invention also relates to canine endostatin genes, novel genes associated with angiogenesis-related disorders, such as cancer. The invention encompasses endostatin nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, endostatin gene products and antibodies directed against such gene products, cloning vectors containing mammalian endostatin gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of endostatin genes and gene products and to using such compounds as therapeutic agents in the treatment of angiogenesis-related disorders, e.g., cancer. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of angiogenesis-related disorders, e.g., cancer, and to methods and compositions for the treatment these disorders.
摘要翻译： 本发明涉及与血管发生相关疾病相关的多核苷酸。 本发明还涉及犬内皮抑素基因，与血管生成相关疾病如癌症相关的新基因。 本发明包括内皮抑素核酸，重组DNA分子，克隆基因或其简并变体，针对此类基因产物的内皮抑素基因产物和抗体，含有哺乳动物内皮抑素基因分子的克隆载体，以及已被遗传工程化以表达该分子的宿主。 本发明还涉及用于鉴定调节内皮抑素基因和基因产物的表达的化合物的方法，并且使用这些化合物作为治疗剂来治疗血管生成相关病症例如癌症。 本发明还涉及用于诊断评估，基因测试和血管发生相关疾病例如癌症的预后的方法以及用于治疗这些疾病的方法和组合物。
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公开(公告)号：US07524831B2
公开(公告)日：2009-04-28
申请号：US11365008
申请日：2006-03-01
申请人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
发明人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
CPC分类号： A61K31/7072 , A61K38/212 , A61K2300/00
摘要： The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
摘要翻译： 本发明提供了在宿主中通过属于黄病毒科的病毒如HCV的感染的方法，其包括向宿主施用Ara-C同源物。
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