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16 条记录 (耗时 0.031 秒)

    Inhibitors of ion channels
    5.
    发明授权
    Inhibitors of ion channels 失效
    离子通道抑制剂

    公开(公告)号：US08338608B2

    公开(公告)日：2012-12-25

    申请号：US12729193

    申请日：2010-03-22

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： C07D417/12 ,  A61K31/4436

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    INHIBITORS OF ION CHANNELS
    6.
    发明申请
    INHIBITORS OF ION CHANNELS 失效
    离子通道的抑制剂

    公开(公告)号：US20070135493A1

    公开(公告)日：2007-06-14

    申请号：US11555977

    申请日：2006-11-02

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： A61K31/513 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/426 ,  C07D417/02

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与发作相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    INHIBITORS OF ION CHANNELS
    7.
    发明申请
    INHIBITORS OF ION CHANNELS 失效
    离子通道的抑制剂

    公开(公告)号：US20100234343A1

    公开(公告)日：2010-09-16

    申请号：US12729193

    申请日：2010-03-22

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： A61K31/397 ,  C07D417/12 ,  A61K31/427 ,  A61K31/4439 ,  A61P25/00

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    Inhibitors of ion channels
    8.
    发明授权
    Inhibitors of ion channels 失效
    离子通道抑制剂

    公开(公告)号：US07705158B2

    公开(公告)日：2010-04-27

    申请号：US11555977

    申请日：2006-11-02

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： A61K31/427 ,  C07D277/46

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    Imines as ion channel modulators
    9.
    发明申请
    Imines as ion channel modulators 失效
    作为离子通道调节剂

    公开(公告)号：US20060178346A1

    公开(公告)日：2006-08-10

    申请号：US11346546

    申请日：2006-02-01

    申请人： Xiaodong Wang ,  Alan Fulp ,  Darrick Seconi

    发明人： Xiaodong Wang ,  Alan Fulp ,  Darrick Seconi

    IPC分类号： A61K31/675 ,  A61K31/506 ,  A61K31/501 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/444 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/422

    CPC分类号： C07D213/54 ,  C07C251/40 ,  C07C251/80 ,  C07C257/06 ,  C07C257/14 ,  C07C257/22 ,  C07C259/12 ,  C07C259/14 ,  C07D213/58 ,  C07D413/06 ,  C07F9/12

    摘要： The present invention provides a class of chemical compounds useful in the treatment of sickle cell disease, diseases characterized by unwanted or abnormal cell proliferation and for the treatment of ocular disorders such as glaucoma. The active compounds are tri-(aryl or heteroaryl) methane compounds or analogues thereof which further comprise an imine moiety and where the tertiary carbon atom can be replaced with a different atom such as Si, Ge, N or P. The compounds enhance resistance to degradation in a biological medium, inhibit potassium flux in a cell, reduce mammalian cell proliferation, reduce the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.

    摘要翻译： 本发明提供了一类用于治疗镰状细胞病，特征在于不想要的或异常细胞增殖的疾病和用于治疗眼部疾病如青光眼的化合物。 活性化合物是三（芳基或杂芳基）甲烷化合物或其类似物，其还包含亚胺部分，其中叔碳原子可被不同的原子如Si，Ge，N或P替代。化合物增强了对 在生物培养基中降解，抑制细胞内的钾通量，减少哺乳动物细胞增殖，减少红细胞的Gardos通道，减少镰状红细胞脱水和/或延缓红细胞镰状或变形的发生。