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14 条记录 (耗时 0.033 秒)

    INHIBITORS OF ION CHANNELS
    8.
    发明申请
    INHIBITORS OF ION CHANNELS 失效
    离子通道的抑制剂

    公开(公告)号：US20100234343A1

    公开(公告)日：2010-09-16

    申请号：US12729193

    申请日：2010-03-22

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： A61K31/397 ,  C07D417/12 ,  A61K31/427 ,  A61K31/4439 ,  A61P25/00

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    Inhibitors of ion channels
    9.
    发明授权
    Inhibitors of ion channels 失效
    离子通道抑制剂

    公开(公告)号：US08338608B2

    公开(公告)日：2012-12-25

    申请号：US12729193

    申请日：2010-03-22

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： C07D417/12 ,  A61K31/4436

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    INHIBITORS OF ION CHANNELS
    10.
    发明申请
    INHIBITORS OF ION CHANNELS 失效
    离子通道的抑制剂

    公开(公告)号：US20070135493A1

    公开(公告)日：2007-06-14

    申请号：US11555977

    申请日：2006-11-02

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： A61K31/513 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/426 ,  C07D417/02

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与发作相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。