公开(公告)号：US09632098B2

公开(公告)日：2017-04-25

申请号：US13878230

申请日：2011-10-08

申请人： Xiaofeng Zeng ,  Yue Zhang ,  Zhinan Shou ,  Hua Mao ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

发明人： Xiaofeng Zeng ,  Yue Zhang ,  Zhinan Shou ,  Hua Mao ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

IPC分类号： G01N33/68 ,  C07K14/705 ,  C07K14/52 ,  C07K16/18 ,  G01N33/564 ,  A61K38/19

CPC分类号： G01N33/6893 ,  A61K38/19 ,  C07K14/52 ,  C07K14/705 ,  C07K16/18 ,  G01N33/564 ,  G01N33/6854 ,  G01N2800/52

摘要： The present application provides compositions and methods useful for detecting and monitoring autoimmune diseases in a human subject. The methods comprise providing a moesin fragment for binding to an anti-moesin autoantibody and contacting the moesin fragment with a sample obtained from the human subject. The moesin fragment comprises the entire N-terminal FERM domain of a human moesin protein. The human subject has or is suspected of having an autoimmune disease such as connective tissue disease, systemic sclerosis, Sjogren's syndrome, or systemic lupus erythematosus.

公开(公告)号：US20130210678A1

公开(公告)日：2013-08-15

申请号：US13878230

申请日：2011-10-08

申请人： Xiaofeng Zeng ,  Yue Zhang ,  Zhinan Shou ,  Hua Mao ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

发明人： Xiaofeng Zeng ,  Yue Zhang ,  Zhinan Shou ,  Hua Mao ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

IPC分类号： G01N33/68 ,  C07K14/705

CPC分类号： G01N33/6893 ,  A61K38/19 ,  C07K14/52 ,  C07K14/705 ,  C07K16/18 ,  G01N33/564 ,  G01N33/6854 ,  G01N2800/52

摘要： The present invention provides compositions and methods useful for detecting and monitoring autoimmune diseases.

摘要翻译： 本发明提供了用于检测和监测自身免疫疾病的组合物和方法。

公开(公告)号：US09354241B2

公开(公告)日：2016-05-31

申请号：US13878235

申请日：2011-10-08

申请人： Yue Zhang ,  Jun Bao ,  Hua Mao ,  Fei Xiang ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

发明人： Yue Zhang ,  Jun Bao ,  Hua Mao ,  Fei Xiang ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

IPC分类号： G01N33/68 ,  A61K38/19 ,  C07K14/52 ,  G01N33/564

CPC分类号： G01N33/6893 ,  A61K38/19 ,  C07K14/52 ,  G01N33/564 ,  G01N2800/22

摘要： The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.

摘要翻译： 本申请提供了用于检测和监测获得性再生障碍性贫血的组合物和方法。

公开(公告)号：US20130203091A1

公开(公告)日：2013-08-08

申请号：US13878235

申请日：2011-10-08

申请人： Yue Zhang ,  Jun Bao ,  Hua Mao ,  Fei Xiang ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

发明人： Yue Zhang ,  Jun Bao ,  Hua Mao ,  Fei Xiang ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  A61K38/19 ,  C07K14/52 ,  G01N33/564 ,  G01N2800/22

摘要： The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.

摘要翻译： 本申请提供了用于检测和监测获得性再生障碍性贫血的组合物和方法。

公开(公告)号：US20130266537A1

公开(公告)日：2013-10-10

申请号：US13878232

申请日：2011-10-08

申请人： Yue Zhang ,  Jun Bao ,  Hua Mao ,  Zhinan Shou ,  Weina Situ

发明人： Yue Zhang ,  Jun Bao ,  Hua Mao ,  Zhinan Shou ,  Weina Situ

IPC分类号： C07K7/08 ,  A61K38/08 ,  A61K38/20 ,  A61K45/06 ,  A61K38/19 ,  C07K7/06 ,  A61K38/10

CPC分类号： A61K39/3955 ,  A61K38/08 ,  A61K38/10 ,  A61K38/191 ,  A61K38/2006 ,  A61K38/204 ,  A61K38/2086 ,  A61K45/06 ,  C07K7/06 ,  C07K7/08 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/73 ,  C07K2317/76 ,  A61K2300/00

摘要： The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.

公开(公告)号：US09345764B2

公开(公告)日：2016-05-24

申请号：US13878232

申请日：2011-10-08

申请人： Yue Zhang ,  Jun Bao ,  Hua Mao ,  Zhinan Shou ,  Weina Situ

发明人： Yue Zhang ,  Jun Bao ,  Hua Mao ,  Zhinan Shou ,  Weina Situ

IPC分类号： C07K7/08 ,  A61K38/08 ,  A61K38/20 ,  A61K45/06 ,  A61K38/19 ,  A61K38/10 ,  C07K7/06 ,  A61K39/395 ,  C07K16/18 ,  C07K16/28

CPC分类号： A61K39/3955 ,  A61K38/08 ,  A61K38/10 ,  A61K38/191 ,  A61K38/2006 ,  A61K38/204 ,  A61K38/2086 ,  A61K45/06 ,  C07K7/06 ,  C07K7/08 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/73 ,  C07K2317/76 ,  A61K2300/00

摘要： The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.

摘要翻译： 本申请提供了用于治疗和诊断与moesin活化相关的疾病和病症的组合物和方法。

公开(公告)号：US20230020152A1

公开(公告)日：2023-01-19

申请号：US17948116

申请日：2022-09-19

申请人： Yue Zhang

发明人： Yue Zhang

IPC分类号： F28D15/04

摘要： A plate vapor chamber array assembly with a plurality of plate vapor chambers joined in an array and each chamber having an evaporation area and an evacuated sealed chamber. The plate vapor chambers may be in direct contact with adjacent plate vapor chambers. A vapor chamber clamp surrounding the array has an inner surface engaging an outer edge of at least two of the plate vapor chambers of the array to press a surface of the plate vapor chamber array directly against the heat source.

公开(公告)号：US20180021448A9

公开(公告)日：2018-01-25

申请号：US14253881

申请日：2014-04-16

申请人： R. Yongxin Zhao ,  Yue Zhang ,  Yourang Ma ,  Hangzhou DAC Biotech Co., Ltd.

发明人： R. Yongxin Zhao ,  Yue Zhang ,  Yourang Ma

IPC分类号： A61K45/06

CPC分类号： C07D207/40 ,  A61K45/06 ,  A61K47/64 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6863 ,  A61K47/6867 ,  Y02A50/412 ,  Y02A50/416

摘要： A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

公开(公告)号：US09618418B2

公开(公告)日：2017-04-11

申请号：US14541353

申请日：2014-11-14

申请人： Yue Zhang ,  Hao Ming Chang

发明人： Yue Zhang ,  Hao Ming Chang

IPC分类号： G01M3/28 ,  F17D5/02 ,  G01F1/00

CPC分类号： G01M3/2807 ,  F17D5/02 ,  G01F1/00 ,  G01F25/0007

摘要： Disclosed is a leakage detection system (200) and a leakage detection method for detecting leakage in a gas supply system (10′) comprising a gas source (11; 12) connected to a gas delivery module (14) by a pipeline. The leakage detection system (200) comprises a flow meter (113) connectable along the pipeline remotely from an inlet of the gas delivery module (14); and a detection module (110) configured to receive signals representing a measured flow rate from the flow meter (113), and to compare the measured flow rate (115) to a stored leakage-free reference value (116) to detect an increase in flow rate in the presence of a leak. A flow resistance between the detection module (110) and an outlet of the gas delivery module (14) amplifies the increase in flow rate in the presence of a leak. The system (200) may comprise a flow rate elevation system (121) connectable between the gas source (11; 12) and the flow meter (113) for temporarily increasing the flow rate in the pipeline.

公开(公告)号：US09539246B2

公开(公告)日：2017-01-10

申请号：US14241720

申请日：2012-08-29

申请人： Bellamkonda K. Kishore ,  Noel G. Carlson ,  Yue Zhang

发明人： Bellamkonda K. Kishore ,  Noel G. Carlson ,  Yue Zhang

IPC分类号： A61K33/00 ,  A61K31/4365 ,  A61K31/519 ,  A61K45/06 ,  A61K31/64 ,  A61K31/7076

CPC分类号： A61K31/4365 ,  A61K31/519 ,  A61K31/64 ,  A61K31/7076 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed is a treatment of diabetes insipidus. Methods of treating diabetes insipidus disorders associated with P2Y receptors using the compounds and compositions are also disclosed.

摘要翻译： 披露了治疗尿崩症。 还公开了使用该化合物和组合物治疗与P2Y受体相关的尿崩症的方法。