公开(公告)号：US20120185008A1

公开(公告)日：2012-07-19

申请号：US13353824

申请日：2012-01-19

申请人： Xiaohong Zhou ,  Robert Stadler ,  Richard Cornelussen ,  Lillian Kornet ,  Paul D. Ziegler ,  Karen J. Kleckner ,  Alberto Della Scala

发明人： Xiaohong Zhou ,  Robert Stadler ,  Richard Cornelussen ,  Lillian Kornet ,  Paul D. Ziegler ,  Karen J. Kleckner ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36114

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US20120185007A1

公开(公告)日：2012-07-19

申请号：US13353802

申请日：2012-01-19

申请人： Paul D. Ziegler ,  Lillian Kornet ,  Xiaohong Zhou ,  Richard Cornelussen ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Alberto Della Scala

发明人： Paul D. Ziegler ,  Lillian Kornet ,  Xiaohong Zhou ,  Richard Cornelussen ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36139 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3702 ,  A61N1/37235 ,  A61N1/3962

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

摘要翻译： 本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。 这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

公开(公告)号：US08718763B2

公开(公告)日：2014-05-06

申请号：US13353824

申请日：2012-01-19

申请人： Xiaohong Zhou ,  Robert Stadler ,  Richard N. M. Cornelussen ,  Lilian Kornet ,  Paul D. Ziegler ,  Karen J. Kleckner ,  Alberto Della Scala

发明人： Xiaohong Zhou ,  Robert Stadler ,  Richard N. M. Cornelussen ,  Lilian Kornet ,  Paul D. Ziegler ,  Karen J. Kleckner ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36114

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US08781582B2

公开(公告)日：2014-07-15

申请号：US13353802

申请日：2012-01-19

申请人： Paul D. Ziegler ,  Lilian Kornet ,  Xiaohong Zhou ,  Richard N. M. Cornelussen ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Alberto Della Scala

发明人： Paul D. Ziegler ,  Lilian Kornet ,  Xiaohong Zhou ,  Richard N. M. Cornelussen ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Alberto Della Scala

IPC分类号： A61N1/37

CPC分类号： A61N1/36139 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3702 ,  A61N1/37235 ,  A61N1/3962

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

摘要翻译： 本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。 这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

公开(公告)号：US08706223B2

公开(公告)日：2014-04-22

申请号：US13353891

申请日：2012-01-19

申请人： Xiaohong Zhou ,  Lilian Kornet ,  Richard N. M. Cornelussen ,  Paul D. Ziegler ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

发明人： Xiaohong Zhou ,  Lilian Kornet ,  Richard N. M. Cornelussen ,  Paul D. Ziegler ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

IPC分类号： A61N1/04

CPC分类号： A61N1/36139 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/368 ,  A61N1/37235

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

摘要翻译： 本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。 这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

公开(公告)号：US20120185010A1

公开(公告)日：2012-07-19

申请号：US13353891

申请日：2012-01-19

申请人： Xiaohong Zhou ,  Lilian Kornet ,  Richard N.M. Cornelussen ,  Paul D. Ziegler ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

发明人： Xiaohong Zhou ,  Lilian Kornet ,  Richard N.M. Cornelussen ,  Paul D. Ziegler ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36139 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/368 ,  A61N1/37235

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US20060116596A1

公开(公告)日：2006-06-01

申请号：US11000541

申请日：2004-12-01

申请人： Xiaohong Zhou ,  Thomas Mullen ,  Jeffrey Gillberg ,  Robert Stadler

发明人： Xiaohong Zhou ,  Thomas Mullen ,  Jeffrey Gillberg ,  Robert Stadler

IPC分类号： A61B5/04

CPC分类号： A61N1/3702 ,  A61B5/0422 ,  A61B5/0452

摘要： A system and method are provided for assessing T-wave alternans (TWA) using cardiac EGM signals received from implanted electrodes. A T-wave signal parameter is measured from signals received by an automatic gain control sense amplifier. A TWA measurement is computed from a beat-by-beat comparison of T-wave parameter measurements or using frequency spectrum techniques. The TWA measurement magnitude and measurement conditions are used in detecting a clinically important TWA. TWA assessment further includes discriminating concordant and discordant TWA in a multi-vector TWA assessment, and determining the association of a TWA measurement with QRS alternans, mechanical alternans, and other physiological events. A prediction of a pathological cardiac event is made in response to a TWA assessment. A response to a cardiac event prediction is provided.

摘要翻译： 提供了一种使用从植入电极接收的心脏EGM信号评估T波交替（TWA）的系统和方法。 从由自动增益控制读出放大器接收的信号测量T波信号参数。 通过T波参数测量或使用频谱技术的逐拍比较来计算TWA测量。 TWA测量值和测量条件用于检测临床重要的TWA。 TWA评估还包括在多向量TWA评估中区分一致和不一致的TWA，并确定TWA测量与QRS交替，机械交替和其他生理事件的关联。 病理性心脏事件的预测是针对TWA评估做出的。 提供对心脏事件预测的响应。

公开(公告)号：US20120109240A1

公开(公告)日：2012-05-03

申请号：US12915877

申请日：2010-10-29

申请人： Xiaohong Zhou ,  Robert Stadler ,  Bruce D. Gunderson ,  Walter H. Olson

发明人： Xiaohong Zhou ,  Robert Stadler ,  Bruce D. Gunderson ,  Walter H. Olson

IPC分类号： A61N1/39 ,  A61N1/365

CPC分类号： A61N1/3706 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61N1/3621

摘要： Methods and/or devices for initiating an automatic adjustment of arrhythmia detection parameters (e.g., upon delivery of cardiac therapy after detection of VT/VF).

摘要翻译： 用于启动心律失常检测参数的自动调整的方法和/或装置（例如，在检测到VT / VF之后递送心脏治疗）。

公开(公告)号：US20060116592A1

公开(公告)日：2006-06-01

申请号：US11186552

申请日：2005-07-21

申请人： Xiaohong Zhou ,  Thomas Mullen ,  Jeffrey Gillberg ,  Robert Stadler

发明人： Xiaohong Zhou ,  Thomas Mullen ,  Jeffrey Gillberg ,  Robert Stadler

IPC分类号： A61B5/04

CPC分类号： A61B5/0452 ,  A61B5/0422 ,  A61N1/365 ,  A61N1/3702 ,  A61N1/37258

摘要： A system and method are provided for assessing T-wave alternans (TWA) using cardiac EGM signals received from implanted electrodes. A T-wave signal parameter is measured from signals received by an automatic gain control sense amplifier. A TWA measurement is computed from a beat-by-beat comparison of T-wave parameter measurements or using frequency spectrum techniques. The TWA measurement magnitude and measurement conditions are used in detecting a clinically important TWA. TWA assessment further includes discriminating concordant and discordant TWA in a multi-vector TWA assessment, and determining the association of a TWA measurement with QRS alternans, mechanical alternans, and other physiological events. A prediction of a pathological cardiac event is made in response to a TWA assessment. A response to a cardiac event prediction is provided.

公开(公告)号：US08781583B2

公开(公告)日：2014-07-15

申请号：US13353919

申请日：2012-01-19

申请人： Richard N. M. Cornelussen ,  Xiaohong Zhou ,  Robert Stadler ,  Lilian Kornet

发明人： Richard N. M. Cornelussen ,  Xiaohong Zhou ,  Robert Stadler ,  Lilian Kornet

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/36585

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.