Mammal-specific Growth-defective Arbovirus

    公开(公告)号:US20210222132A1

    公开(公告)日:2021-07-22

    申请号:US16645788

    申请日:2018-09-11

    申请人: Xiaowu Pang Xinbin Gu

    发明人: Xiaowu Pang Xinbin Gu

    IPC分类号: C12N7/00

    摘要: Arbovirus carries an altered furin cleavage site that results in enhanced cleavage of a precursor polyprotein, such as, prE2 or prM. Dengue virus particles can have an amino acid alteration within amino acids 80-130 of prM. Zika virus particles can have alterations at amino residues at and/or about the furin cleavage site. The virus can be produced in insect cells. The virus does not form progeny virus in mammal cells.

    Virus-like particle containing a Dengue virus recombinant replicon
    9.
    发明申请
    Virus-like particle containing a Dengue virus recombinant replicon 审中-公开
    含有登革病毒重组体复制子的病毒样颗粒

    公开(公告)号:US20090149405A1

    公开(公告)日:2009-06-11

    申请号:US12129908

    申请日:2008-05-30

    申请人: Xiaowu Pang

    发明人: Xiaowu Pang

    摘要: The present invention relates virus-like particle vaccine containing dengue virus recombinant replicon as its core and its preparation method. Such vaccine can efficiently express antigen in the infected tells. Because dengue virus can infect dendritic cells, it can efficiently present antigen and has immunity effects. Further, different dengue virus types can be used to repeatedly produce efficient immune response, which strengthen body's immune response against the pathogen containing such antigen. Such vaccine can prevent and cure cancer and viral diseases.

    摘要翻译: 本发明涉及含有登革热病毒重组复制子的核病毒样颗粒疫苗及其制备方法。 这种疫苗可以有效地表达抗原在受感染的病例中。 因为登革热病毒可以感染树突状细胞,因此能有效地呈递抗原并具有免疫作用。 此外,不同的登革热病毒类型可以用于反复产生有效的免疫应答,其加强了对含有这种抗原的病原体的机体的免疫应答。 这种疫苗可以预防和治愈癌症和病毒性疾病。

    Virus-like particle containing a dengue virus recombinant replicon
    10.
    发明申请
    Virus-like particle containing a dengue virus recombinant replicon 审中-公开
    病毒样颗粒含有登革热病毒重组体复制子

    公开(公告)号:US20060018928A1

    公开(公告)日:2006-01-26

    申请号:US11192923

    申请日:2005-07-29

    申请人: Xiaowu Pang

    发明人: Xiaowu Pang

    摘要: The present invention relates virus-like particle vaccine containing dengue virus recombinant replicon as its core and its preparation method. Such vaccine can efficiently express antigen in the infected tells. Because dengue virus can infect dendritic cells, it can efficiently present antigen and has immunity effects. Further, different dengue virus types can be used to repeatedly produce efficient immune response, which strengthen body's immune response against the pathogen containing such antigen. Such vaccine can prevent and cure cancer and viral diseases.

    摘要翻译: 本发明涉及含有登革热病毒重组复制子的核病毒样颗粒疫苗及其制备方法。 这种疫苗可以有效地表达抗原在受感染的病例中。 因为登革热病毒可以感染树突状细胞,因此能有效地呈递抗原并具有免疫作用。 此外,不同的登革热病毒类型可以用于反复产生有效的免疫应答,其加强了对含有这种抗原的病原体的机体的免疫应答。 这种疫苗可以预防和治愈癌症和病毒性疾病。