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公开(公告)号:US12098393B2
公开(公告)日:2024-09-24
申请号:US16645788
申请日:2018-09-11
申请人: Xiaowu Pang , Xinbin Gu
发明人: Xiaowu Pang , Xinbin Gu
IPC分类号: C12N7/00
CPC分类号: C12N7/00 , C12N2710/12034 , C12N2770/24122 , C12N2770/24134 , C12N2770/24151 , C12N2770/36134
摘要: Arbovirus carries an altered furin cleavage site that results in enhanced cleavage of a precursor polyprotein, such as, prE2 or prM. Dengue virus particles can have an amino acid alteration within amino acids 80-130 of prM. Zika virus particles can have alterations at amino residues at and/or about the furin cleavage site. The virus can be produced in insect cells. The virus does not form progeny virus in mammal cells.
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公开(公告)号:US10040824B2
公开(公告)日:2018-08-07
申请号:US11622233
申请日:2007-01-11
申请人: Xiaowu Pang , Xinbin Gu
发明人: Xiaowu Pang , Xinbin Gu
IPC分类号: C07K14/005 , C12N7/00 , C12N15/86 , A61K39/00
摘要: Replicon virus-like particles can be used as flavivirus vaccines.
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公开(公告)号:US20210222132A1
公开(公告)日:2021-07-22
申请号:US16645788
申请日:2018-09-11
申请人: Xiaowu Pang , Xinbin Gu
发明人: Xiaowu Pang , Xinbin Gu
IPC分类号: C12N7/00
摘要: Arbovirus carries an altered furin cleavage site that results in enhanced cleavage of a precursor polyprotein, such as, prE2 or prM. Dengue virus particles can have an amino acid alteration within amino acids 80-130 of prM. Zika virus particles can have alterations at amino residues at and/or about the furin cleavage site. The virus can be produced in insect cells. The virus does not form progeny virus in mammal cells.
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公开(公告)号:US20070249032A1
公开(公告)日:2007-10-25
申请号:US11622233
申请日:2007-01-11
申请人: Xiaowu Pang , Xinbin Gu
发明人: Xiaowu Pang , Xinbin Gu
CPC分类号: C07K14/005 , A61K2039/5254 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N2770/24123 , C12N2770/24134 , C12N2770/24143 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要: Replicon virus-like particles can be used as flavivirus vaccines.
摘要翻译: 复制子病毒样颗粒可用作黄病毒疫苗。
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公开(公告)号:US08048427B2
公开(公告)日:2011-11-01
申请号:US12394822
申请日:2009-02-27
申请人: Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
发明人: Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
CPC分类号: A61K39/21 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2770/24123 , C12N2770/24143 , C12N2770/24161 , C12N2770/24162 , C12N2840/203 , Y02A50/386
摘要: The present invention discloses the construction of dengue virus subgenomic replicons containing large deletions in the structural region (C-preM-E) of the genome, which replicons are useful as vaccines to protect against dengue virus infection.
摘要翻译: 本发明公开了在基因组结构域(C-preM-E)中含有大缺失的登革热病毒亚基因组复制子的构建,该复制子可用作防止登革热病毒感染的疫苗。
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公开(公告)号:US20120107358A1
公开(公告)日:2012-05-03
申请号:US13242036
申请日:2011-09-23
申请人: Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
发明人: Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
CPC分类号: A61K39/21 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2770/24123 , C12N2770/24143 , C12N2770/24161 , C12N2770/24162 , C12N2840/203 , Y02A50/386
摘要: The present invention discloses the construction of dengue virus subgenomic replicons containing large deletions in the structural region (C-preM-E) of the genome, which replicons are useful as vaccines to protect against dengue virus infection.
摘要翻译: 本发明公开了在基因组结构域(C-preM-E)中含有大缺失的登革热病毒亚基因组复制子的构建,该复制子可用作防止登革热病毒感染的疫苗。
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公开(公告)号:US07524508B2
公开(公告)日:2009-04-28
申请号:US10656721
申请日:2003-09-05
申请人: Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
发明人: Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
CPC分类号: A61K39/21 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2770/24123 , C12N2770/24143 , C12N2770/24161 , C12N2770/24162 , C12N2840/203 , Y02A50/386
摘要: The present invention discloses the construction of dengue virus subgenomic replicons containing large deletions in the structural region (C-preM-E) of the genome, which replicons are useful as vaccines to protect against dengue virus infection.
摘要翻译: 本发明公开了在基因组结构域(C-preM-E)中含有大缺失的登革热病毒亚基因组复制子的构建,该复制子可用作防止登革热病毒感染的疫苗。
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公开(公告)号:US20100233210A1
公开(公告)日:2010-09-16
申请号:US12394822
申请日:2009-02-27
申请人: Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
发明人: Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
CPC分类号: A61K39/21 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2770/24123 , C12N2770/24143 , C12N2770/24161 , C12N2770/24162 , C12N2840/203 , Y02A50/386
摘要: The present invention discloses the construction of dengue virus subgenomic replicons containing large deletions in the structural region (C-preM-E) of the genome, which replicons are useful as vaccines to protect against dengue virus infection.
摘要翻译: 本发明公开了在基因组结构域(C-preM-E)中含有大缺失的登革热病毒亚基因组复制子的构建,该复制子可用作防止登革热病毒感染的疫苗。
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9.
公开(公告)号:US20090149405A1
公开(公告)日:2009-06-11
申请号:US12129908
申请日:2008-05-30
申请人: Xiaowu Pang
发明人: Xiaowu Pang
IPC分类号: A61K31/711 , C12N15/11 , C12P19/34
CPC分类号: C07K14/005 , A61K39/12 , A61K2039/5154 , A61K2039/5256 , A61K2039/5258 , A61K2039/585 , C12N15/86 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2770/32122 , C12N2810/6009 , Y02A50/386
摘要: The present invention relates virus-like particle vaccine containing dengue virus recombinant replicon as its core and its preparation method. Such vaccine can efficiently express antigen in the infected tells. Because dengue virus can infect dendritic cells, it can efficiently present antigen and has immunity effects. Further, different dengue virus types can be used to repeatedly produce efficient immune response, which strengthen body's immune response against the pathogen containing such antigen. Such vaccine can prevent and cure cancer and viral diseases.
摘要翻译: 本发明涉及含有登革热病毒重组复制子的核病毒样颗粒疫苗及其制备方法。 这种疫苗可以有效地表达抗原在受感染的病例中。 因为登革热病毒可以感染树突状细胞,因此能有效地呈递抗原并具有免疫作用。 此外,不同的登革热病毒类型可以用于反复产生有效的免疫应答,其加强了对含有这种抗原的病原体的机体的免疫应答。 这种疫苗可以预防和治愈癌症和病毒性疾病。
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10.
公开(公告)号:US20060018928A1
公开(公告)日:2006-01-26
申请号:US11192923
申请日:2005-07-29
申请人: Xiaowu Pang
发明人: Xiaowu Pang
IPC分类号: A61K39/12 , C12N15/86 , A61K39/193
CPC分类号: C07K14/005 , A61K39/12 , A61K2039/5154 , A61K2039/5256 , A61K2039/5258 , A61K2039/585 , C12N15/86 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2770/32122 , C12N2810/6009 , Y02A50/386
摘要: The present invention relates virus-like particle vaccine containing dengue virus recombinant replicon as its core and its preparation method. Such vaccine can efficiently express antigen in the infected tells. Because dengue virus can infect dendritic cells, it can efficiently present antigen and has immunity effects. Further, different dengue virus types can be used to repeatedly produce efficient immune response, which strengthen body's immune response against the pathogen containing such antigen. Such vaccine can prevent and cure cancer and viral diseases.
摘要翻译: 本发明涉及含有登革热病毒重组复制子的核病毒样颗粒疫苗及其制备方法。 这种疫苗可以有效地表达抗原在受感染的病例中。 因为登革热病毒可以感染树突状细胞,因此能有效地呈递抗原并具有免疫作用。 此外,不同的登革热病毒类型可以用于反复产生有效的免疫应答,其加强了对含有这种抗原的病原体的机体的免疫应答。 这种疫苗可以预防和治愈癌症和病毒性疾病。
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