公开(公告)号：US07925343B1

公开(公告)日：2011-04-12

申请号：US11539576

申请日：2006-10-06

申请人： Xiaoyi Min ,  Scott Salys ,  Yougandh Chitre ,  Eric Falkenberg ,  Gene A. Bornzin

发明人： Xiaoyi Min ,  Scott Salys ,  Yougandh Chitre ,  Eric Falkenberg ,  Gene A. Bornzin

IPC分类号： A61N1/39

CPC分类号： A61N1/3956 ,  A61B5/04014 ,  A61B5/046 ,  A61B5/7203 ,  A61N1/0563 ,  A61N1/37288

摘要： A subcutaneous implantable cardiac device system applies defibrillation currents in pathways aligned with the heart's own electrical system to decrease defibrillation thresholds. In one implementation, one or more subcutaneous sensors detect ventricular fibrillation. Positioning of subcutaneous sensors and filtering result in improved sensing with reduced noise. A subcutaneous patch component of the system that is in communication with a subcutaneous pacemaker or cardioverter-defibrillator may perform the sensing and apply the defibrillation. The subcutaneous patch may include one or more electrodes that perform both sensing and defibrillation. Variations of the subcutaneous patch may include battery and capacitor for generating onboard defibrillation current and may also include a microprocessor for advanced programmable operation.

摘要翻译： 皮下植入式心脏装置系统在与心脏自身的电气系统对准的途径中应用除颤电流以降低除颤阈值。 在一个实施方案中，一个或多个皮下传感器检测心室颤动。 皮下传感器的定位和过滤导致改进的感测，噪音降低。 与皮下起搏器或心律转复除颤器连通的系统的皮下补片部件可以执行感测并施加除颤。 皮下补片可以包括执行感测和除颤的一个或多个电极。 皮下贴片的变化可以包括用于产生板上除颤电流的电池和电容器，并且还可以包括用于高级可编程操作的微处理器。

公开(公告)号：US07881810B1

公开(公告)日：2011-02-01

申请号：US11753484

申请日：2007-05-24

申请人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

发明人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

IPC分类号： A61N1/05

CPC分类号： A61F2/2478 ,  A61B17/00 ,  A61B17/0057 ,  A61N1/0587

摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.

摘要翻译： 可以通过心脏的心包空间访问心脏的腔室或脉管系统。 最初，心包空间可以通过心肌的方法或亚型的方法进行。 因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。 铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

公开(公告)号：US20080215127A1

公开(公告)日：2008-09-04

申请号：US12122458

申请日：2008-05-16

申请人： Yougandh Chitre ,  Xiaoyi Min ,  Gene A. Bornzin

发明人： Yougandh Chitre ,  Xiaoyi Min ,  Gene A. Bornzin

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0573

摘要： A bipolar pacing and sensing lead incorporates a range of active surface areas for each of the anode and cathode electrodes, and a range of inter-electrode spacings between the anode and cathode electrodes which, in combination, provide acceptable near-field signal amplitudes and attenuate the amplitudes of unwanted signals, such as far-field R-waves, far-field P-waves, and T-waves.

摘要翻译： 双极起搏和感测引线包括用于阳极和阴极电极中的每一个的一系列活性表面积，以及阳极和阴极电极之间的一系列电极间间隔，其组合提供可接受的近场信号幅度并衰减 不想要的信号的幅度，例如远场R波，远场P波和T波。

公开(公告)号：US07218960B1

公开(公告)日：2007-05-15

申请号：US10606299

申请日：2003-06-24

申请人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

发明人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/0031 ,  A61B5/7242 ,  A61N1/3702

摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

摘要翻译： 提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。 由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发病的方法。 简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。 如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。 本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

公开(公告)号：US07643872B2

公开(公告)日：2010-01-05

申请号：US11686784

申请日：2007-03-15

申请人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

发明人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

IPC分类号： A61B5/0452 ,  A61N1/36

CPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7242 ,  A61N1/3627 ,  A61N1/3702

摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

摘要翻译： 提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。 由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发作的方法。 简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。 如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。 本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

公开(公告)号：US08538555B1

公开(公告)日：2013-09-17

申请号：US12973810

申请日：2010-12-20

申请人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

发明人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

IPC分类号： A61N1/00

CPC分类号： A61F2/2478 ,  A61B17/00 ,  A61B17/0057 ,  A61N1/0587

摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.

摘要翻译： 可以通过心脏的心包空间访问心脏的腔室或脉管系统。 最初，心包空间可以通过心肌的方法或亚型的方法进行。 因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。 铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

公开(公告)号：US08311648B1

公开(公告)日：2012-11-13

申请号：US12973800

申请日：2010-12-20

申请人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

发明人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

IPC分类号： A61N1/05

CPC分类号： A61F2/2478 ,  A61B17/00 ,  A61B17/0057 ,  A61N1/0587

摘要： A delivery apparatus for accessing the pericardial space of a heart including an elongated body defining a lumen and a piercing member that extends from a distal portion of the elongated body for piercing tissue of the heart. A spring expands from a distal end of the piercing member in response to the distal end of the piercing member passing through the tissue and into the pericardial space. An electrode located on the spring in order to sense signals indicative of a distal end of the spring passing through the tissue and into the pericardial space.

摘要翻译： 一种用于进入心脏的心包空间的输送装置，包括限定内腔的细长主体和从细长主体的远端部分延伸以刺穿心脏的组织的穿刺构件。 响应于刺穿构件的远端穿过组织并进入心包空间，弹簧从穿刺构件的远端膨胀。 位于弹簧上的电极，用于感测指示穿过组织并进入心包空间的弹簧的远端的信号。

公开(公告)号：US07383091B1

公开(公告)日：2008-06-03

申请号：US10656649

申请日：2003-09-04

申请人： Yougandh Chitre ,  Xiaoyi Min ,  Gene A. Bornzin

发明人： Yougandh Chitre ,  Xiaoyi Min ,  Gene A. Bornzin

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0573

摘要： A bipolar pacing and sensing lead incorporates a range of active surface areas for each of the anode and cathode electrodes, and a range of inter-electrode spacings between the anode and cathode electrodes which, in combination, provide acceptable near-field signal amplitudes and attenuate the amplitudes of unwanted signals, such as far-field R-waves, far-field P-waves, and T-waves.

摘要翻译： 双极起搏和感测引线包括用于阳极和阴极电极中的每一个的一系列活性表面积，以及阳极和阴极电极之间的一系列电极间间隔，其组合提供可接受的近场信号幅度并衰减 不想要的信号的幅度，例如远场R波，远场P波和T波。

公开(公告)号：US07225015B1

公开(公告)日：2007-05-29

申请号：US10603398

申请日：2003-06-24

申请人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

发明人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

IPC分类号： A61B5/0468

CPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7242 ,  A61N1/3627 ,  A61N1/3702

摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

公开(公告)号：US08702616B2

公开(公告)日：2014-04-22

申请号：US12943653

申请日：2010-11-10

申请人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin ,  Eric Falkenberg

发明人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin ,  Eric Falkenberg

IPC分类号： A61B5/0205

CPC分类号： A61B5/0215 ,  A61B5/042 ,  A61B5/0464 ,  A61B5/053 ,  A61B7/00 ,  A61N1/36578

摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于 至少部分地基于时间差，决定是否存在舒张异常。 还公开了其它示例性方法，装置，系统等。