公开(公告)号：US07925343B1

公开(公告)日：2011-04-12

申请号：US11539576

申请日：2006-10-06

申请人： Xiaoyi Min ,  Scott Salys ,  Yougandh Chitre ,  Eric Falkenberg ,  Gene A. Bornzin

发明人： Xiaoyi Min ,  Scott Salys ,  Yougandh Chitre ,  Eric Falkenberg ,  Gene A. Bornzin

IPC分类号： A61N1/39

CPC分类号： A61N1/3956 ,  A61B5/04014 ,  A61B5/046 ,  A61B5/7203 ,  A61N1/0563 ,  A61N1/37288

摘要： A subcutaneous implantable cardiac device system applies defibrillation currents in pathways aligned with the heart's own electrical system to decrease defibrillation thresholds. In one implementation, one or more subcutaneous sensors detect ventricular fibrillation. Positioning of subcutaneous sensors and filtering result in improved sensing with reduced noise. A subcutaneous patch component of the system that is in communication with a subcutaneous pacemaker or cardioverter-defibrillator may perform the sensing and apply the defibrillation. The subcutaneous patch may include one or more electrodes that perform both sensing and defibrillation. Variations of the subcutaneous patch may include battery and capacitor for generating onboard defibrillation current and may also include a microprocessor for advanced programmable operation.

摘要翻译： 皮下植入式心脏装置系统在与心脏自身的电气系统对准的途径中应用除颤电流以降低除颤阈值。 在一个实施方案中，一个或多个皮下传感器检测心室颤动。 皮下传感器的定位和过滤导致改进的感测，噪音降低。 与皮下起搏器或心律转复除颤器连通的系统的皮下补片部件可以执行感测并施加除颤。 皮下补片可以包括执行感测和除颤的一个或多个电极。 皮下贴片的变化可以包括用于产生板上除颤电流的电池和电容器，并且还可以包括用于高级可编程操作的微处理器。

公开(公告)号：US07881810B1

公开(公告)日：2011-02-01

申请号：US11753484

申请日：2007-05-24

申请人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

发明人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

IPC分类号： A61N1/05

CPC分类号： A61F2/2478 ,  A61B17/00 ,  A61B17/0057 ,  A61N1/0587

摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.

摘要翻译： 可以通过心脏的心包空间访问心脏的腔室或脉管系统。 最初，心包空间可以通过心肌的方法或亚型的方法进行。 因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。 铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

公开(公告)号：US08538555B1

公开(公告)日：2013-09-17

申请号：US12973810

申请日：2010-12-20

申请人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

发明人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

IPC分类号： A61N1/00

CPC分类号： A61F2/2478 ,  A61B17/00 ,  A61B17/0057 ,  A61N1/0587

摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.

摘要翻译： 可以通过心脏的心包空间访问心脏的腔室或脉管系统。 最初，心包空间可以通过心肌的方法或亚型的方法进行。 因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。 铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

公开(公告)号：US08311648B1

公开(公告)日：2012-11-13

申请号：US12973800

申请日：2010-12-20

申请人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

发明人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

IPC分类号： A61N1/05

CPC分类号： A61F2/2478 ,  A61B17/00 ,  A61B17/0057 ,  A61N1/0587

摘要： A delivery apparatus for accessing the pericardial space of a heart including an elongated body defining a lumen and a piercing member that extends from a distal portion of the elongated body for piercing tissue of the heart. A spring expands from a distal end of the piercing member in response to the distal end of the piercing member passing through the tissue and into the pericardial space. An electrode located on the spring in order to sense signals indicative of a distal end of the spring passing through the tissue and into the pericardial space.

摘要翻译： 一种用于进入心脏的心包空间的输送装置，包括限定内腔的细长主体和从细长主体的远端部分延伸以刺穿心脏的组织的穿刺构件。 响应于刺穿构件的远端穿过组织并进入心包空间，弹簧从穿刺构件的远端膨胀。 位于弹簧上的电极，用于感测指示穿过组织并进入心包空间的弹簧的远端的信号。

公开(公告)号：US08702616B2

公开(公告)日：2014-04-22

申请号：US12943653

申请日：2010-11-10

申请人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin ,  Eric Falkenberg

发明人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin ,  Eric Falkenberg

IPC分类号： A61B5/0205

CPC分类号： A61B5/0215 ,  A61B5/042 ,  A61B5/0464 ,  A61B5/053 ,  A61B7/00 ,  A61N1/36578

摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于 至少部分地基于时间差，决定是否存在舒张异常。 还公开了其它示例性方法，装置，系统等。

公开(公告)号：US20110060230A1

公开(公告)日：2011-03-10

申请号：US12943653

申请日：2010-11-10

申请人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin ,  Eric Falkenberg

发明人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin ,  Eric Falkenberg

IPC分类号： A61B5/0215 ,  A61B5/02

CPC分类号： A61B5/0215 ,  A61B5/042 ,  A61B5/0464 ,  A61B5/053 ,  A61B7/00 ,  A61N1/36578

摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于 至少部分地基于时间差，决定是否存在舒张异常。 还公开了其它示例性方法，装置，系统等。

公开(公告)号：US07386342B1

公开(公告)日：2008-06-10

申请号：US10937756

申请日：2004-09-08

申请人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

发明人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

IPC分类号： A61N1/368

CPC分类号： A61N1/0504 ,  A61N1/3622 ,  A61N1/37252

摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

公开(公告)号：US06904317B2

公开(公告)日：2005-06-07

申请号：US10043472

申请日：2002-01-09

申请人： Joseph J. Florio ,  Gene A. Bornzin ,  Peter Boileau ,  Eric Falkenberg ,  Janice Barstad

发明人： Joseph J. Florio ,  Gene A. Bornzin ,  Peter Boileau ,  Eric Falkenberg ,  Janice Barstad

IPC分类号： A61N1/362 ,  A61N1/36

CPC分类号： A61N1/3621

摘要： Dynamic overdrive pacing adjustment techniques are described for use in implantable cardiac stimulation devices. In a first technique, an overdrive pacing unit of a microcontroller of the implantable device operates to optimize various control parameters that affect overdrive pacing so as to achieve a desired degree of overdrive pacing for the particular patient in which the stimulation device is implanted. Parameters to be optimized include the number of overdrive beats paced once overdrive pacing is trigged, the overdrive pacing response function, the recovery rate, and various base rates. The control parameters are adjusted in a hierarchical order of priority until the desired degree of overdrive pacing is achieved. Adjustment of the number of overdrive beats, the recovery rate, and various base rates is iteratively performed by using incremental numerical adjustments. Adjustment of the overdrive pacing response function may be performed by selecting among a set of fixed predetermined linear response functions. In a second technique, the overdrive pacing unit operates to optimize the shape of a single non-linear dynamic overdrive pacing response function so as to achieve the desired degree of overdrive pacing for the patient. The second technique may either be employed alone or in combination with the first, hierarchical optimization technique.

摘要翻译： 动态超速起搏调节技术被描述用于可植入心脏刺激装置。 在第一技术中，可植入装置的微控制器的过驱动起搏单元操作以优化影响过驱动起搏的各种控制参数，以便为其中植入刺激装置的特定患者达到期望程度的过速起搏。 要优化的参数包括一旦超速起搏起搏起搏，超速起搏响应功能，恢复速率和各种基准速率起搏的过载跳动次数。 控制参数以优先级的等级顺序进行调整，直到达到期望的过速起搏程度。 通过使用增量数值调整迭代地执行过载跳动次数的调整，恢复率和各种基本速率。 可以通过在一组固定的预定线性响应函数中进行选择来执行过速起搏响应功能的调整。 在第二种技术中，超速起搏单元操作以优化单个非线性动态超速起搏响应功能的形状，以便达到病人期望程度的超速起搏起搏。 第二种技术可以单独使用，也可以与第一层级优化技术结合使用。

公开(公告)号：US07277755B1

公开(公告)日：2007-10-02

申请号：US10937623

申请日：2004-09-08

申请人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

发明人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

IPC分类号： A61N1/04 ,  A61N1/39 ,  A61N1/38

CPC分类号： A61N1/05 ,  A61N1/36071 ,  A61N1/36114 ,  A61N1/3622 ,  A61N1/3962

摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

公开(公告)号：US07194304B1

公开(公告)日：2007-03-20

申请号：US10702562

申请日：2003-11-05

申请人： Gene A. Bornzin ,  Eric Falkenberg ,  Mark W. Kroll ,  Gabriel A. Mouchawar

发明人： Gene A. Bornzin ,  Eric Falkenberg ,  Mark W. Kroll ,  Gabriel A. Mouchawar

IPC分类号： A61N1/365

CPC分类号： A61N1/3943

摘要： An implantable cardiac defibrillation assembly includes at least one implantable lead having a defibrillation electrode adapted for placement in a chamber of the heart. The lead includes a connector. The assembly further includes an implantable defibrillation device having a pulse generator that provides defibrillation pulses and that is configured to receive the connector to couple the defibrillation electrode to the pulse generator. The device further includes a system that evaluates and conditions the assembly to provide defibrillation therapy to the heart without requiring arrhythmia induction of the heart. The system may condition the device for defibrillation therapy by reforming the defibrillation output capacitor and evaluate defibrillation lead DC resistance, and R wave sensing and detection. In addition, the system may estimate defibrillation thresholds and electrical fields and condition the device by setting the device to provide an output voltage above the estimated threshold. All of the foregoing may be accomplished without inducing ventricular fibrillation.

摘要翻译： 植入式心脏除颤组件包括至少一个可植入引线，其具有适于放置在心脏腔室中的除颤电极。 引线包括一个连接器。 组件还包括具有脉冲发生器的可植入除颤装置，该脉冲发生器提供除颤脉冲，并且被配置为接收连接器以将除颤电极耦合到脉冲发生器。 该装置还包括一个系统，该系统评估和调节组件以向心脏提供除颤疗法，而不需要心律的心律失常诱导。 该系统可以通过重整除颤输出电容器并评估去纤颤引导直流电阻和R波感测和检测来调节器件进行除颤治疗。 此外，系统可以通过设置设备来提供高于估计阈值的输出电压来估计除颤阈值和电场并调节设备。 所有上述可以在不引起心室颤动的情况下完成。