Composition and method for the protection of proteins, cell components and cells during temperature stress

    公开(公告)号:US11110176B2

    公开(公告)日:2021-09-07

    申请号:US15821671

    申请日:2017-11-22

    Applicant: Xin Wen

    Inventor: Xin Wen

    Abstract: Embodiments of the disclosure pertain to compositions containing (i) one or more non-antifreeze proteins or cell components or cells and (ii) one or more antifreeze proteins (AFPs), mimetics thereof, and/or analogs thereof, and a method of stabilizing a biologic (e.g., a protein, microbe, cell component or cell) against temperature stress and aggregation. The AFP may be selected from known antifreeze polypeptides and antifreeze peptides, analogs and mimetics of antifreeze proteins, active fragments of such antifreeze proteins, polypeptide and peptide mimetics, antifreeze peptoids and polymers, and combinations thereof. The non-antifreeze protein, cell component or cell comprises a known protein, cell component or cell used in the pharmaceutical, medical, agricultural, veterinary and/or food industry(ies). The AFP protects the function of the non-antifreeze protein, microbe(s), cell component(s) or cell(s) under temperature stress (e.g., a temperature of −20-60° C.).

    Automated manufacturing system
    2.
    发明授权
    Automated manufacturing system 有权
    自动化制造系统

    公开(公告)号:US08082053B2

    公开(公告)日:2011-12-20

    申请号:US11935320

    申请日:2007-11-05

    Abstract: An automated manufacturing system comprises a computer processing system and a plurality of consolidation systems. The computer processing system receives information on product subbatches and product packages and consolidation status information to produce consolidation assignment information, each product package comprising one or more product subbatches. The consolidation systems receive the product subbatches in accordance to the consolidation assignment information and consolidate the product subbatches into product packages, wherein the status of the consolidation systems are tracked and the consolidation status information is sent to the computer processing system.

    Abstract translation: 自动化制造系统包括计算机处理系统和多个合并系统。 计算机处理系统接收关于产品子批和产品包和合并状态信息的信息以产生合并分配信息,每个产品包包括一个或多个产品子批。 整合系统根据合并分配信息接收产品子批次,并将产品子批次合并到产品包中,其中跟踪合并系统的状态,并将合并状态信息发送到计算机处理系统。

    Therapeutic Agents Useful for Treating Pain
    3.
    发明申请
    Therapeutic Agents Useful for Treating Pain 有权
    用于治疗疼痛的治疗剂

    公开(公告)号:US20100331369A1

    公开(公告)日:2010-12-30

    申请号:US12817773

    申请日:2010-06-17

    Applicant: Qun Sun Xin Wen

    Inventor: Qun Sun Xin Wen

    Abstract: A compound of formula: where Ar1, Ar2, X, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Cycloheteroalkenyl Compound”); compositions comprising an effective amount of a Cycloheteroalkenyl Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cycloheteroalkenyl Compound are disclosed herein.

    Abstract translation: 式中的化合物:其中Ar1,Ar2,X,R3和m如本文所公开或其药学上可接受的盐(“环烯基烯基化合物”); 包含有效量的环烯基烯基化合物的组合物; 以及用于治疗或预防疼痛,UI,溃疡,IBD,IBS,成瘾性障碍,帕金森病,帕金森综合征,焦虑,癫痫,中风,癫痫发作,瘙痒症状,精神病,认知障碍,记忆缺陷,受限制 脑功能,亨廷顿舞蹈病,肌萎缩性侧索硬化,痴呆,视网膜病变,肌肉痉挛,偏头痛,呕吐,运动障碍或抑郁症,包括向有需要的动物施用有效量的环烯基烯基化合物。

    AUTOMATED MANUFACTURING SYSTEM
    5.
    发明申请
    AUTOMATED MANUFACTURING SYSTEM 有权
    自动化制造系统

    公开(公告)号:US20080288521A1

    公开(公告)日:2008-11-20

    申请号:US11935320

    申请日:2007-11-05

    Abstract: An automated manufacturing system comprises a computer processing system and a plurality of consolidation systems. The computer processing system receives information on product subbatches and product packages and consolidation status information to produce consolidation assignment information, each product package comprising one or more product subbatches. The consolidation systems receive the product subbatches in accordance to the consolidation assignment information and consolidate the product subbatches into product packages, wherein the status of the consolidation systems are tracked and the consolidation status information is sent to the computer processing system.

    Abstract translation: 自动化制造系统包括计算机处理系统和多个合并系统。 计算机处理系统接收关于产品子批和产品包和合并状态信息的信息以产生合并分配信息,每个产品包包括一个或多个产品子批。 整合系统根据合并分配信息接收产品子批次,并将产品子批次合并到产品包中,其中跟踪合并系统的状态,并将合并状态信息发送到计算机处理系统。

    Producing printing images having personalized features
    6.
    发明授权
    Producing printing images having personalized features 有权
    制作具有个性化功能的打印图像

    公开(公告)号:US07437024B2

    公开(公告)日:2008-10-14

    申请号:US10962933

    申请日:2004-10-12

    CPC classification number: G06Q30/0641 G03D15/005 H04N1/60 H04N1/6086

    Abstract: A method for personalizing an image-based physical manifestation to conform with user preferences for image processing. In one implementation, the method includes identifying an image for processing, identifying user preferences for image processing and processing the image including manipulating image data for the image in accordance with the user preferences.

    Abstract translation: 一种用于个性化基于图像的物理表现以符合图像处理的用户偏好的方法。 在一个实现中,该方法包括识别用于处理的图像,识别用于图像处理的用户偏好并且处理该图像,包括根据用户偏好来操纵图像的图像数据。

    Automated manufacturing system
    7.
    发明授权
    Automated manufacturing system 有权
    自动化制造系统

    公开(公告)号:US07242993B2

    公开(公告)日:2007-07-10

    申请号:US10784488

    申请日:2004-02-23

    Abstract: An automated manufacturing system comprises a computer processing system and a plurality of consolidation systems. The computer processing system receives information on product subbatches and product packages and consolidation status information to produce consolidation assignment information, each product package comprising one or more product subbatches. The consolidation systems receive the product subbatches in accordance to the consolidation assignment information and consolidate the product subbatches into product packages, wherein the status of the consolidation systems are tracked and the consolidation status information is sent to the computer processing system.

    Abstract translation: 自动化制造系统包括计算机处理系统和多个合并系统。 计算机处理系统接收关于产品子批和产品包和合并状态信息的信息以产生合并分配信息,每个产品包包括一个或多个产品子批。 整合系统根据合并分配信息接收产品子批次,并将产品子批次合并到产品包中,其中跟踪合并系统的状态,并将合并状态信息发送到计算机处理系统。

    Digital ink jet printing apparatus and method
    8.
    发明授权
    Digital ink jet printing apparatus and method 失效
    数字喷墨打印设备及方法

    公开(公告)号:US06352328B1

    公开(公告)日:2002-03-05

    申请号:US08899574

    申请日:1997-07-24

    Abstract: Digital ink jet printing apparatus and method. The apparatus receives an input image file having a plurality of pixels, each pixel described by at least one pixel value respectively associated with an optical density. The apparatus comprises a printhead and at least one nozzle integrally attached to the printhead, the nozzle being capable of ejecting an ink droplet therefrom to define an associated one of the optical densities. A waveform generator is connected to the nozzle for generating an electronic waveform to be supplied to the nozzle. In this manner, the nozzle ejects the ink droplet in response to the waveform supplied thereto. The waveform is defined by a plurality of pulses. A look-up table stores a plurality of waveform serial numbers assigned to respective waveforms, each waveform being defined by at least one predetermined parameter, such as number of pulses, pulse amplitude, pulse width and/or time delay between pulses. A calibrator receiving the input image converts the pixel values of the input image to waveform index number associated with the waveform serial number.

    Abstract translation: 数字喷墨打印设备及方法。 该装置接收具有多个像素的输入图像文件,每个像素由分别与光密度相关联的至少一个像素值描述。 该设备包括打印头和与打印头整体连接的至少一个喷嘴,喷嘴能够从其喷射墨滴以限定相关联的一个光密度。 波形发生器连接到喷嘴,用于产生要供应到喷嘴的电子波形。 以这种方式,喷嘴响应于供给的波形喷射墨滴。 波形由多个脉冲定义。 查找表存储分配给各个波形的多个波形序列号,每个波形由至少一个预定参数(例如脉冲数,脉冲幅度,脉冲宽度和/或脉冲之间的时间延迟)来定义。 接收输入图像的校准器将输入图像的像素值转换成与波形序列号相关联的波形索引号。

    Format flexible ink jet printing having efficient receiver usage
    9.
    发明授权
    Format flexible ink jet printing having efficient receiver usage 失效
    格式化灵活的喷墨打印,具有高效的接收器使用

    公开(公告)号:US06334677B1

    公开(公告)日:2002-01-01

    申请号:US09210182

    申请日:1998-12-11

    CPC classification number: B41J11/008 B41J2/04 B41J15/22

    Abstract: Ink jet printing apparatus for forming a plurality of ink images on receivers in response to one or more digital image file(s) each including at least one or more digital images and information indicating the number of ink images to be made. The ink jet printing apparatus includes at least one ink jet print head adapted to deliver ink to the receiver and at least two receiver webs. The ink jet printing apparatus selectively moves one or more receiver webs along a receiver path past the ink jet print head. A control circuitry responsive to the digital image file(s) determines the locations of the ink images to be formed on the two receiver webs in such a manner that minimizes receiver waste. The ink jet printing apparatus actuates the ink jet print head(s) to form ink images on the receiver webs, whereby receiver waste is minimized.

    Abstract translation: 一种喷墨打印设备,用于响应于一个或多个数字图像文件形成多个墨水图像,每个数字图像文件包括至少一个或多个数字图像,以及指示要制作的墨水图像数量的信息。 喷墨打印设备包括至少一个喷墨打印头,其适于将墨水输送到接收器和至少两个接收器网。 喷墨打印设备沿着接收器路径选择性地移动经过喷墨打印头的一个或多个接收器纸幅。 响应于数字图像文件的控制电路以使接收器浪费最小化的方式确定要形成在两个接收器幅面上的油墨图像的位置。 喷墨打印设备致动喷墨打印头以在接收器网上形成墨图像,从而使接收器废物最小化。

    Printer and print head capable of printing in a plurality of dynamic ranges of ink droplet volumes and method of assembling same
    10.
    发明授权
    Printer and print head capable of printing in a plurality of dynamic ranges of ink droplet volumes and method of assembling same 失效
    能够在墨滴体积的多个动态范围内进行打印的打印机和打印头及其组装方法

    公开(公告)号:US06328399B1

    公开(公告)日:2001-12-11

    申请号:US09081984

    申请日:1998-05-20

    Applicant: Xin Wen

    Inventor: Xin Wen

    Abstract: Printer and print head capable of printing in a plurality of dynamic ranges of ink droplet volumes, and method of assembling same. A plurality of first nozzles are connected to a print head body, each first nozzle having a first orifice of a first size for ejecting an ink droplet having a first volume. The ink droplet volume is selected from a first dynamic range of volumes uniquely associated with each first nozzle. A plurality of second nozzles are also connected to the print head body, each second nozzle having a second orifice of a second size larger than the first size of the first nozzles for ejecting an ink droplet therethrough having a second volume larger than the first volume. The second volume is selected from a second dynamic range of volumes, which second dynamic range of volumes may be greater than the first dynamic range of volumes. In this manner, the printer and associated print head body are capable of printing in a plurality of dynamic ranges of volumes, so that a single printer can print either at low density levels or at high density levels with a minimum number of nozzles.

    Abstract translation: 能够在墨滴体积的多个动态范围内打印的打印机和打印头及其组装方法。 多个第一喷嘴连接到打印头主体,每个第一喷嘴具有用于喷射具有第一容积的墨滴的第一尺寸的第一孔。 墨滴体积选自与每个第一喷嘴唯一相关联的体积的第一动态范围。 多个第二喷嘴也连接到打印头本体,每个第二喷嘴具有第二尺寸的第二孔,其尺寸大于第一喷嘴的第一尺寸,用于喷射具有大于第一容积的第二容积的墨滴。 第二卷选自第二动态范围的卷,第二动态范围的卷可能大于卷的第一动态范围。 以这种方式,打印机和相关联的打印头主体能够以多个动态范围的卷打印,使得单个打印机可以以最小数量的喷嘴以低密度水平或高密度水平打印。

Patent Agency Ranking