公开(公告)号：US11110176B2

公开(公告)日：2021-09-07

申请号：US15821671

申请日：2017-11-22

Applicant: Xin Wen

Inventor： Xin Wen

IPC: A61K47/42 ,  C12N9/96 ,  C12N1/04 ,  A01N1/02 ,  A61K38/28

Abstract: Embodiments of the disclosure pertain to compositions containing (i) one or more non-antifreeze proteins or cell components or cells and (ii) one or more antifreeze proteins (AFPs), mimetics thereof, and/or analogs thereof, and a method of stabilizing a biologic (e.g., a protein, microbe, cell component or cell) against temperature stress and aggregation. The AFP may be selected from known antifreeze polypeptides and antifreeze peptides, analogs and mimetics of antifreeze proteins, active fragments of such antifreeze proteins, polypeptide and peptide mimetics, antifreeze peptoids and polymers, and combinations thereof. The non-antifreeze protein, cell component or cell comprises a known protein, cell component or cell used in the pharmaceutical, medical, agricultural, veterinary and/or food industry(ies). The AFP protects the function of the non-antifreeze protein, microbe(s), cell component(s) or cell(s) under temperature stress (e.g., a temperature of −20-60° C.).

公开(公告)号：US20200207808A1

公开(公告)日：2020-07-02

申请号：US16729025

申请日：2019-12-27

Applicant: Xin WEN

Inventor： Xin WEN

IPC: C07K1/36 ,  C07K1/02 ,  C07K14/195

Abstract: A method of purifying an antifreeze protein (AFP) and methods of producing AFPs are disclosed. The method of purifying an AFP includes heating a crude AFP in an aqueous medium to a temperature and for a length of time sufficient to precipitate at least some thermally unstable proteins in the crude AFP and form a precipitate and a supernatant; and removing the precipitate from the supernatant. One method of producing an AFP includes collecting a crude source of the AFP; and purifying the AFP by the purification method. Another method of producing an AFP includes growing or culturing a host configured to express a recombinant AFP in a growth medium, and collecting a crude AFP from the host and/or the growth medium. The growth medium comprises water, a protein hydrolysate or other source of amino acids, a yeast extract, a biologically metabolizable C3-C6 polyol, and one or more phosphate salts.

公开(公告)号：US20180133329A1

公开(公告)日：2018-05-17

申请号：US15807405

申请日：2017-11-08

Applicant: Xin WEN ,  Sen WANG

Inventor： Xin WEN ,  Sen WANG

IPC: A61K47/42 ,  A61K47/26 ,  A61K9/19

CPC classification number: A61K47/42 ,  A61K9/19 ,  A61K47/26

Abstract: The disclosure pertains to compositions to stabilize nutrient, food, pharmaceutical, and biological formulations by preventing the crystallization or precipitation of carbohydrates used in the formulations. The compositions contain (i) one or more carbohydrates, sugars, sugar alcohols, analogs thereof, and/or derivatives thereof and (ii) one or more antifreeze proteins (AFPs), mimetics thereof, and/or analogs thereof and methods of making and using the same. The AFP may be selected from antifreeze polypeptides and antifreeze peptides, analogs and mimetics of antifreeze proteins, active fragments of such antifreeze proteins, polypeptide and peptide mimetics, antifreeze peptoids and polymers, and combinations thereof. The carbohydrate, sugar or sugar alcohol has the formula CmHnOp, where m is an integer of 5 or 6, n is an integer of 2m or 2m+2, and p is equal to m, or the formula CaHbOc, where a is an integer of 10-12 or 15-18, b is 2a−2 when a is an integer of 10-12 or 2a−4 when a is an integer of 15-18, and c is a−1 when a is an integer of 10-12 or a−2 when a is an integer of 15-18. The AFP, AFP analog, or AFP mimetic inhibits or controls crystallization of the carbohydrate (e.g., during the storage of the solution of the carbohydrate or the analog or derivative thereof, during the freeze-drying of a formulation using the carbohydrate or the analog thereof) and stabilize the solution or the formulation using the carbohydrate or the carbohydrate analog or derivative.

公开(公告)号：US08082053B2

公开(公告)日：2011-12-20

申请号：US11935320

申请日：2007-11-05

Applicant: Xin Wen ,  Russ Ennio Muzzolini ,  Jeff D. Boone

Inventor： Xin Wen ,  Russ Ennio Muzzolini ,  Jeff D. Boone

IPC: G06F19/00

CPC classification number: G05B19/41865 ,  G05B2219/25182 ,  G05B2219/32263 ,  G06Q10/06 ,  Y02P90/20

Abstract: An automated manufacturing system comprises a computer processing system and a plurality of consolidation systems. The computer processing system receives information on product subbatches and product packages and consolidation status information to produce consolidation assignment information, each product package comprising one or more product subbatches. The consolidation systems receive the product subbatches in accordance to the consolidation assignment information and consolidate the product subbatches into product packages, wherein the status of the consolidation systems are tracked and the consolidation status information is sent to the computer processing system.

Abstract translation: 自动化制造系统包括计算机处理系统和多个合并系统。 计算机处理系统接收关于产品子批和产品包和合并状态信息的信息以产生合并分配信息，每个产品包包括一个或多个产品子批。 整合系统根据合并分配信息接收产品子批次，并将产品子批次合并到产品包中，其中跟踪合并系统的状态，并将合并状态信息发送到计算机处理系统。

公开(公告)号：US08033739B2

公开(公告)日：2011-10-11

申请号：US12291415

申请日：2008-11-10

Applicant: Xin-Wen Wang ,  Zhong-Hua Yao ,  Qi-Sheng Zheng

Inventor： Xin-Wen Wang ,  Zhong-Hua Yao ,  Qi-Sheng Zheng

IPC: G02B6/36 ,  G02B6/38

CPC classification number: G02B6/4201 ,  G02B6/4292 ,  G02B2006/4297 ,  H05K3/306 ,  H05K3/3447 ,  H05K2201/09781 ,  H05K2201/10121

Abstract: An optical connector (1) includes an housing (2) having a front wall, an upper wall, a bottom wall, a pair of side walls and a receiving cavity (215) formed therebetween for receiving a mating plug; and an optical member (3) having an optical portion (31) for receiving or emitting light and a number of contacts connected to the optical portion; an insulative cover member (25) attached to the housing and defining a first portion (251) covering an upper portion of the housing and a second portion (258) enclosing a rear portion of the housing, the first portion defining a cutout (252) extending therethrough along an up-to-down direction; a metal lock member (6) defining a lateral arm (61) being retained in the cutout and a locking portion (62) extending downward from the lateral arm and projecting through the housing to be soldered to a printed circuit board, the locking portion locks with the housing.

Abstract translation: 光学连接器（1）包括壳体（2），其具有前壁，上壁，底壁，一对侧壁和形成在其间的接收腔（215），用于接收配合插头; 以及具有用于接收或发射光的光学部分（31）和连接到所述光学部分的多个触点的光学部件（3） 绝缘覆盖件（25），其附接到所述壳体并且限定覆盖所述壳体的上部的第一部分（251）和封闭所述壳体的后部的第二部分（258），所述第一部分限定切口（252） 沿着上下方向延伸穿过其中; 限定横向臂（61）的金属锁定构件（6）保持在所述切口中;以及锁定部分（62），所述锁定部分（62）从所述横向臂向下延伸并且突出穿过所述壳体以被焊接到印刷电路板，所述锁定部分锁定 与房屋。

公开(公告)号：US20100331369A1

公开(公告)日：2010-12-30

申请号：US12817773

申请日：2010-06-17

Applicant: Qun Sun ,  Xin Wen

Inventor： Qun Sun ,  Xin Wen

IPC: A61K31/444 ,  A61P29/00

CPC classification number: A61K31/444 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: A compound of formula: where Ar1, Ar2, X, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Cycloheteroalkenyl Compound”); compositions comprising an effective amount of a Cycloheteroalkenyl Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cycloheteroalkenyl Compound are disclosed herein.

Abstract translation: 式中的化合物：其中Ar1，Ar2，X，R3和m如本文所公开或其药学上可接受的盐（“环烯基烯基化合物”）; 包含有效量的环烯基烯基化合物的组合物; 以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，受限制 脑功能，亨廷顿舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的环烯基烯基化合物。

公开(公告)号：USD621789S1

公开(公告)日：2010-08-17

申请号：US29352246

申请日：2009-12-18

Applicant: Xin-Wen Wang ,  Zhong-Hua Yao ,  Qi-Sheng Zheng

Designer： Xin-Wen Wang ,  Zhong-Hua Yao ,  Qi-Sheng Zheng

公开(公告)号：US20090327865A1

公开(公告)日：2009-12-31

申请号：US12484395

申请日：2009-06-15

Applicant: Juan Li ,  Xin Wen Qi ,  Fang Rui Shu ,  Mei Yang

Inventor： Juan Li ,  Xin Wen Qi ,  Fang Rui Shu ,  Mei Yang

IPC: G06F15/16 ,  G06F17/00

CPC classification number: G06F17/30 ,  G06F17/273 ,  G06F17/3089

Abstract: A method includes determining a location of erroneous content in a web page in response to a user's request for correcting the erroneous content in the web page; receiving the user's input of correction content for the erroneous content; and submitting correction information to a correction service provider including the location of the erroneous content and the correction content. An alternative method includes receiving correction information submitted by a user for erroneous content in a web page, the correction information including a location of the erroneous content and correction content; storing the received correction information; and retrieving the correction information and sending the correction information to the user in response to the user's request for visiting the web page.

Abstract translation: 一种方法包括响应于用户对网页中错误内容的修正请求来确定网页中错误内容的位置; 接收用户对错误内容的修正内容的输入; 以及将校正信息提交给校正服务提供者，包括错误内容的位置和校正内容。 一种替代方法包括：接收由用户在网页中错误内容提交的校正信息，所述校正信息包括错误内容和校正内容的位置; 存储所接收的校正信息; 以及检索所述校正信息，并且响应于所述用户访问所述网页的请求，向所述用户发送所述校正信息。

公开(公告)号：US20090287585A1

公开(公告)日：2009-11-19

申请号：US12476886

申请日：2009-06-02

Applicant: Peter Charles Elarde ,  Patrick C. Teo ,  Russ Ennio Muzzolini ,  Jeannine Marie Smith ,  Xin Wen

Inventor： Peter Charles Elarde ,  Patrick C. Teo ,  Russ Ennio Muzzolini ,  Jeannine Marie Smith ,  Xin Wen

IPC: G06Q30/00 ,  G06Q50/00

CPC classification number: B42D5/04 ,  B42D15/045 ,  G06Q30/0601

Abstract: A method for producing a gift card for a gift imaging product, comprises receiving an order of the gift imaging product from a user, producing the gift imaging product, producing the gift card by the user for the gift imaging product; and consolidating the gift card with the gift imaging product into one package.

Abstract translation: 一种用于制作礼物成像产品的礼品卡的方法，包括从用户接收礼品成像产品的订单，产生礼品成像产品，由用户为礼物成像产品生产礼品卡; 并将礼品卡与礼品成像产品整合成一个包装。

公开(公告)号：US20090123117A1

公开(公告)日：2009-05-14

申请号：US12291412

申请日：2008-11-10

Applicant: Xin-wen Wang ,  Zhong-Hua Yao ,  Qi-Sheng Zheng

Inventor： Xin-wen Wang ,  Zhong-Hua Yao ,  Qi-Sheng Zheng

IPC: G02B6/36

CPC classification number: G02B6/4292 ,  G02B2006/4297

Abstract: An optical fiber connector (100) includes an insulative housing (1) defining a receiving chamber (170), an optical fiber member (2) received in the receiving chamber (170) and a fastening member (5) fixed to the insulative housing (1). The insulative housing defines a receiving space (16) communicating with the receiving chamber (170) and a protrusion (173) protruding into the receiving space (16). The fastening member (5) includes a main portion (50) covering the optical fiber member (2), an extension (51) extending from the main portion (50) for being fastened to the insulative housing, and an elastic arm (53) located below the extension (51). The elastic arm (53) has a hook (530) on a distal end thereof to flexible abut against the protrusion (173).

Abstract translation: 光纤连接器（100）包括限定接收室（170）的绝缘壳体（1），容纳在容纳室（170）中的光纤部件（2）和固定到绝缘壳体上的紧固部件（5） 1）。 绝缘壳体限定与接收室（170）连通的容纳空间（16）和突出到容纳空间（16）中的突出部（173）。 紧固构件（5）包括覆盖光纤部件（2）的主体部（50），从主体部（50）延伸的用于固定在绝缘壳体上的延伸部（51）和弹性臂（53） 位于延伸部（51）的下方。 弹性臂（53）在其远端具有钩（530）以柔性地抵靠突起（173）。