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    Composite organic-inorganic nanoparticles and methods for use thereof
    1.
    发明申请
    Composite organic-inorganic nanoparticles and methods for use thereof 审中-公开
    复合有机 - 无机纳米颗粒及其使用方法

    公开(公告)号：US20050147963A1

    公开(公告)日：2005-07-07

    申请号：US10748336

    申请日：2003-12-29

    申请人： Xing Su ,  Jingwu Zhang ,  Lei Sun ,  Andrew Berlin

    发明人： Xing Su ,  Jingwu Zhang ,  Lei Sun ,  Andrew Berlin

    IPC分类号： G01N21/65 ,  G01N33/543 ,  C12Q1/70 ,  C12M1/34 ,  C12Q1/68

    CPC分类号： G01N33/54346 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/658 ,  G01N2021/6482 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656

    摘要： Composite organic-inorganic nanoparticles (COIN) are provided that produce surface-enhanced Raman signals when excited by a laser. The nanoparticles include metallic colloids and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanoparticle, and a wide variety of Raman-active organic compounds can be incorporated into the particle. Indeed, a large number of unique Raman signatures can be created by employing nanoparticles containing Raman-active organic compounds of different structures, mixtures, and ratios. Thus, nanoparticles and methods described herein are useful for the simultaneous detection of many analytes in a mixture, resulting in rapid qualitative analysis of a mixture. In addition, since many Raman-active organic compounds can be incorporated into a single nanoparticle, the SERS signal from a single COIN particle is strong relative to SERS signals obtained from Raman-active materials that do not contain the nanoparticles described herein.

    摘要翻译： 提供了复合有机 - 无机纳米粒子（COIN），当激光激发时产生表面增强的拉曼信号。 纳米颗粒包括金属胶体和拉曼活性有机化合物。 实现合适的SERS信号所需的金属在纳米颗粒中是固有的，并且可以将多种拉曼活性有机化合物掺入颗粒中。 实际上，通过使用含有不同结构，混合物和比例的拉曼活性有机化合物的纳米颗粒，可以产生大量独特的拉曼特征。 因此，本文所述的纳米颗粒和方法可用于同时检测混合物中的许多分析物，导致混合物的快速定性分析。 另外，由于许多拉曼活性有机化合物可以并入单个纳米颗粒中，所以来自单个COIN颗粒的SERS信号相对于不含本文所述纳米颗粒的拉曼活性材料获得的SERS信号是强的。

    Composite organic-inorganic nanoclusters
    2.
    发明申请
    Composite organic-inorganic nanoclusters 审中-公开
    复合有机 - 无机纳米团簇

    公开(公告)号：US20050191665A1

    公开(公告)日：2005-09-01

    申请号：US11021682

    申请日：2004-12-23

    申请人： Xing Su ,  Jingwu Zhang ,  Lei Sun ,  Andrew Berlin

    发明人： Xing Su ,  Jingwu Zhang ,  Lei Sun ,  Andrew Berlin

    IPC分类号： G01N21/65 ,  G01N33/543 ,  C12Q1/68 ,  G01J3/44 ,  G01N33/553

    CPC分类号： G01N33/54346 ,  G01N21/658

    摘要： Composite organic-inorganic nanoclusters (COINs) are provided that produce surface-enhanced Raman signals (SERS) when excited by a laser. The nanoclusters include metal particles and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanocluster and a wide variety of Raman-active organic compounds and combinations thereof can be incorporated into the nanocluster. In addition, polymeric microspheres containing the nanoclusters and methods of making them are also provided. The nanoclusters and microspheres can be used, for example, in assays for multiplex detection of biological molecules.

    摘要翻译： 提供了复合有机 - 无机纳米团簇（COINs），当激光激发时产生表面增强拉曼信号（SERS）。 纳米团簇包括金属颗粒和拉曼活性有机化合物。 实现合适的SERS信号所需的金属在纳米簇中是固有的，并且可以将多种拉曼活性有机化合物及其组合掺入纳米团簇中。 此外，还提供了含有纳米簇的聚合物微球及其制备方法。 纳米团簇和微球可用于例如用于多重检测生物分子的测定中。

    Composite organic-inorganic nanoparticles and methods for use thereof
    3.
    发明申请
    Composite organic-inorganic nanoparticles and methods for use thereof 审中-公开
    复合有机 - 无机纳米颗粒及其使用方法

    公开(公告)号：US20050142567A1

    公开(公告)日：2005-06-30

    申请号：US10830422

    申请日：2004-04-21

    申请人： Xing Su ,  Jingwu Zhang ,  Lei Sun ,  Andrew Berlin

    发明人： Xing Su ,  Jingwu Zhang ,  Lei Sun ,  Andrew Berlin

    IPC分类号： G01N21/65 ,  G01N33/543 ,  C12Q1/68 ,  G01N33/553

    CPC分类号： G01N33/54346 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/658 ,  G01N2021/6482 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656

    摘要： Composite organic-inorganic nanoparticles (COIN) and clusters of such nanoparticles are provided that produce surface-enhanced Raman signals when excited by a laser. The nanoparticles include metallic colloids and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanoparticle, and a wide variety of Raman-active organic compounds can be incorporated into the particle. Methods for producing the nanoparticles and clusters of nanoparticles are also provided. In addition, polymeric microspheres containing the nanoparticles and clusters of nanoparticles and methods of making them are also provided. Methods for using the nanoparticles, clusters, and microspheres in assays for multiplex detection of biological molecules do not require signal amplification techniques.

    摘要翻译： 提供复合有机 - 无机纳米颗粒（COIN）和这种纳米颗粒的簇，当激光激发时产生表面增强的拉曼信号。 纳米颗粒包括金属胶体和拉曼活性有机化合物。 实现合适的SERS信号所需的金属在纳米颗粒中是固有的，并且可以将多种拉曼活性有机化合物掺入颗粒中。 还提供了制备纳米颗粒和纳米颗粒簇的方法。 此外，还提供了包含纳米颗粒和纳米颗粒簇的聚合物微球及其制备方法。 在用于多重检测生物分子的测定中使用纳米颗粒，簇和微球的方法不需要信号放大技术。

    External modification of composite organic inorganic nanoclusters
    4.
    发明授权
    External modification of composite organic inorganic nanoclusters 有权
    复合有机无机纳米团簇的外部改性

    公开(公告)号：US07790286B2

    公开(公告)日：2010-09-07

    申请号：US12036869

    申请日：2008-02-25

    申请人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    发明人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    IPC分类号： B32B5/16

    CPC分类号： G01N21/658 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/783 ,  Y10T428/12049 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 提供了能够提供来自结合在其中的有机拉曼活性分子的增强拉曼信号的改性和官能化的金属纳米团簇。 例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    EXTERNAL MODIFICATION OF COMPOSITE ORGANIC INORGANIC NANOCLUSTERS
    5.
    发明申请
    EXTERNAL MODIFICATION OF COMPOSITE ORGANIC INORGANIC NANOCLUSTERS 有权
    复合有机无机纳米粒子的外部修饰

    公开(公告)号：US20090069481A1

    公开(公告)日：2009-03-12

    申请号：US12036869

    申请日：2008-02-25

    申请人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    发明人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    IPC分类号： C08K3/10

    CPC分类号： G01N21/658 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/783 ,  Y10T428/12049 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 提供了能够提供来自结合在其中的有机拉曼活性分子的增强拉曼信号的改性和官能化的金属纳米团簇。 例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    Self-assembling raman-active nanoclusters
    8.
    发明申请
    Self-assembling raman-active nanoclusters 审中-公开
    自组装拉曼活性纳米团簇

    公开(公告)号：US20080152534A1

    公开(公告)日：2008-06-26

    申请号：US11643426

    申请日：2006-12-21

    申请人： Jingwu Zhang ,  Xing Su ,  Lei Sun ,  Haovu Qin

    发明人： Jingwu Zhang ,  Xing Su ,  Lei Sun ,  Haovu Qin

    IPC分类号： C01B35/04 ,  C22C21/00 ,  C22C5/02 ,  C22C5/04 ,  C22C5/06 ,  C22C9/00

    CPC分类号： C22C21/00 ,  C22C5/02 ,  C22C5/04

    摘要： Raman-active nanoclusters comprised of a metal and a Raman-active organic molecule incorporated therein that are capable of self-assembly are described. The Raman-active nanoclusters are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 描述了由能够自组装的金属和拉曼活性有机分子组成的拉曼活性纳米团簇。 拉曼活性纳米团簇能够作为分析物检测的敏感报告者。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    External modification of composite organic inorganic nanoclusters comprising raman active organic compound
    9.
    发明授权
    External modification of composite organic inorganic nanoclusters comprising raman active organic compound 有权
    包含拉曼活性有机化合物的复合有机无机纳米团簇的外部改性

    公开(公告)号：US07361410B2

    公开(公告)日：2008-04-22

    申请号：US10940698

    申请日：2004-09-13

    申请人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    发明人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    IPC分类号： B32B5/16 ,  B05D3/02

    CPC分类号： G01N21/658 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/783 ,  Y10T428/12049 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 提供了能够提供来自结合在其中的有机拉曼活性分子的增强拉曼信号的改性和官能化的金属纳米团簇。 例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。