公开(公告)号：US20210347767A1

公开(公告)日：2021-11-11

申请号：US16871354

申请日：2020-05-11

申请人： Xingke JU ,  Chengyuan LIANG ,  Yuzhi LIU ,  Bin TIAN ,  Lei TIAN ,  Gennian MAO ,  Limei WANG ,  Yuanyuan HE ,  Yongbo WANG ,  Jingwen XU ,  Dan YANG ,  Liang QI ,  Wenbo YAO ,  Qianqian ZHAO ,  Han LI

发明人： Xingke JU ,  Chengyuan LIANG ,  Yuzhi LIU ,  Bin TIAN ,  Lei TIAN ,  Gennian MAO ,  Limei WANG ,  Yuanyuan HE ,  Yongbo WANG ,  Jingwen XU ,  Dan YANG ,  Liang QI ,  Wenbo YAO ,  Qianqian ZHAO ,  Han LI

IPC分类号： C07D409/14 ,  B01J27/24

摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US20220089518A1

公开(公告)日：2022-03-24

申请号：US17026224

申请日：2020-09-19

申请人： Han LI ,  Nan HUI ,  Guaiping QIAO ,  Juan LI ,  Wenbo YAO ,  Yongbo WANG ,  Gennian MAO ,  Bin TIAN ,  Yanjun LI ,  Qiaoqiao ZHAO ,  Jingwen XU ,  Dan YANG ,  Chengyuan LIANG

发明人： Han LI ,  Nan HUI ,  Guaiping QIAO ,  Juan LI ,  Wenbo YAO ,  Yongbo WANG ,  Gennian MAO ,  Bin TIAN ,  Yanjun LI ,  Qiaoqiao ZHAO ,  Jingwen XU ,  Dan YANG ,  Chengyuan LIANG

IPC分类号： C07C67/40 ,  A01N37/00

摘要： A method of preparing a compound of formula (I): is disclosed. The compound of formula (I) can be used as an antioxidant agent. The compound can also be used as an antibacterial agent to inhibit Staphylococcus aureus MRSA 18-222 and Pseudomonas aeruginosa MDR-PA 18-1774.

公开(公告)号：US20220348540A1

公开(公告)日：2022-11-03

申请号：US17239582

申请日：2021-04-24

申请人： Dan YANG ,  Jingyi LI ,  Liang XIN ,  Ruina BIAN ,  Jie ZHANG ,  Qianqian ZHAO ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

发明人： Dan YANG ,  Jingyi LI ,  Liang XIN ,  Ruina BIAN ,  Jie ZHANG ,  Qianqian ZHAO ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

IPC分类号： C07C323/52 ,  A61P31/04 ,  C07C319/28

摘要： A compound with anti-drug resistant bacteria activity having the formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20220354826A1

公开(公告)日：2022-11-10

申请号：US17239583

申请日：2021-04-24

申请人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Dan YANG ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

发明人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Dan YANG ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

IPC分类号： A61K31/4164 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20220194918A1

公开(公告)日：2022-06-23

申请号：US17128103

申请日：2020-12-19

申请人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Dan YANG ,  Nan HUI ,  Guaiping QIAO ,  Han LI ,  Yanjun LI ,  Liang QI ,  Wenbo YAO ,  Gennian MAO ,  Chengyuan LIANG

发明人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Dan YANG ,  Nan HUI ,  Guaiping QIAO ,  Han LI ,  Yanjun LI ,  Liang QI ,  Wenbo YAO ,  Gennian MAO ,  Chengyuan LIANG

IPC分类号： C07D339/04 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US20190389876A1

公开(公告)日：2019-12-26

申请号：US16120403

申请日：2018-09-03

申请人： Bin TIAN ,  Xingke JU ,  Lei TIAN ,  Jie LI ,  Songsong RUAN ,  Minyi JIA ,  Danni TIAN ,  Han LI ,  Qianqian ZHAO ,  Xuechuan WANG ,  Chengyuan LIANG

发明人： Bin TIAN ,  Xingke JU ,  Lei TIAN ,  Jie LI ,  Songsong RUAN ,  Minyi JIA ,  Danni TIAN ,  Han LI ,  Qianqian ZHAO ,  Xuechuan WANG ,  Chengyuan LIANG

IPC分类号： C07D493/04

摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US20220235008A1

公开(公告)日：2022-07-28

申请号：US17157916

申请日：2021-01-25

申请人： Wenbo YAO ,  Guaiping QIAO ,  Nan HUI ,  Juan LI ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Han LI ,  Gennian MAO ,  Bin TIAN ,  Dan YANG ,  Chengyuan LIANG

发明人： Wenbo YAO ,  Guaiping QIAO ,  Nan HUI ,  Juan LI ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Han LI ,  Gennian MAO ,  Bin TIAN ,  Dan YANG ,  Chengyuan LIANG

IPC分类号： C07D215/233 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20220348539A1

公开(公告)日：2022-11-03

申请号：US17239575

申请日：2021-04-24

申请人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Dan YANG ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG

发明人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Dan YANG ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG

IPC分类号： C07C323/52 ,  C07C319/20

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20200147042A1

公开(公告)日：2020-05-14

申请号：US16270567

申请日：2019-02-07

申请人： Chengyuan LIANG ,  Lei TIAN ,  Shunjun DING ,  Xingke JU ,  Yuzhi LIU ,  Xiaolin XIE ,  Dezhu ZHANG

发明人： Chengyuan LIANG ,  Lei TIAN ,  Shunjun DING ,  Xingke JU ,  Yuzhi LIU ,  Xiaolin XIE ,  Dezhu ZHANG

IPC分类号： A61K31/404 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US20230172889A1

公开(公告)日：2023-06-08

申请号：US17695741

申请日：2022-03-15

申请人： Chengyuan LIANG ,  Liang XIN ,  Juan XIA ,  Yuqing ZHAO ,  Jie ZHANG ,  Lei TIAN ,  Jingyi LI ,  Shaojun ZHANG ,  Qianqian ZHAO

发明人： Chengyuan LIANG ,  Liang XIN ,  Juan XIA ,  Yuqing ZHAO ,  Jie ZHANG ,  Lei TIAN ,  Jingyi LI ,  Shaojun ZHANG ,  Qianqian ZHAO

IPC分类号： A61K31/216 ,  A61P31/04

CPC分类号： A61K31/216 ,  A61P31/04

摘要： A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I)




R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.