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1.发明申请USE OF COMPOSITION COMPRISING AMLODIPINE IN PREPARING MEDICAMENTS FOR TREATING A LOWER URINARY TRACT DISORDER 审中-公开在制备药物用于治疗下尿路性疾病的过程中使用包含阿米膦酸的组合物公开(公告)号：US20100048644A1
公开(公告)日：2010-02-25
申请号：US12447438
申请日：2007-10-25
申请人： Xiping Xu , Houxun Xing , Xianhui Qin , Haipeng Liu , Mingxia Chen , Duo Yu , Yan Wang , Guangliang Chen
发明人： Xiping Xu , Houxun Xing , Xianhui Qin , Haipeng Liu , Mingxia Chen , Duo Yu , Yan Wang , Guangliang Chen
IPC分类号： A61K31/435 , A61P13/02
CPC分类号： A61K31/4422
摘要： Use of composition comprising amlodipine in preparing medicaments for treating a lower urinary tract disorder. The lower urinary tract disorder is selected from the group consisting of benign prostate hyperplasia, lower urinary tract syndrome or overactive bladder, especially the lower urinary tract disorder accompanying with hypertension. Amlodipine is any one selected from the group consisting of amlodipine, amlodipine active metabolite, levoamlodipine, pharmaceutically acceptable precursor of amlodipine, or pharmaceutically acceptable salts of amlodipine, amlodipine active metabolite, levoamlodipine, or pharmaceutically acceptable precursor of amlodipine. The pharmaceutical dose of amlodipine is in the range of 1-10 mg. The invention belongs to the field of pharmacy.
摘要翻译： 包含氨氯地平的组合物在制备用于治疗下尿路疾病的药物中的用途。 下尿路疾病选自良性前列腺增生，下尿路综合征或膀胱过度活动症，特别是伴有高血压的下尿路疾病。 氨氯地平是选自氨氯地平，氨氯地平活性代谢物，左旋氨氯地平，氨氯地平的药学上可接受的前体或氨氯地平的药学上可接受的盐，氨氯地平活性代谢物，左旋氨氯地平或其药学上可接受的氨氯地平前体的任何一种。 氨氯地平的药物剂量范围为1-10mg。 本发明属于药学领域。
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2.发明申请Usages of MTHFR gene polymorphisms in predicting homocysteine level, disease risk, and treatment effects and related methods and kit 审中-公开使用MTHFR基因多态性预测同型半胱氨酸水平，疾病风险和治疗效果及相关方法和试剂盒公开(公告)号：US20070134709A1
公开(公告)日：2007-06-14
申请号：US11638634
申请日：2006-12-13
申请人： Xiping Xu , Zhian Fang , Shanqun Jiang , Binyan Wang , Jianhua Yang , Shanchun Zhang , Guangyun Mao , Houxun Xing , Ping Liu , Yan Wang , Tonghua Zang , Mengde Wang , Yu Wang , Chengxiang Dai , Kerong Zhang
发明人： Xiping Xu , Zhian Fang , Shanqun Jiang , Binyan Wang , Jianhua Yang , Shanchun Zhang , Guangyun Mao , Houxun Xing , Ping Liu , Yan Wang , Tonghua Zang , Mengde Wang , Yu Wang , Chengxiang Dai , Kerong Zhang
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04 , A61K31/401 , C12M3/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： This invention features our discovery on usages of Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphisms in predicting homocysteine (Hcy) level and/or incidence and prognosis of diseases associated with increased Hcy level in a subject, as well as predicting treatment effects of medicines in the category of Angiotension Converting Enzyme Inhibihor (ACEI) with and without combination with B Vitamins. This invention also features our discovery on laboratory and analytical methods that are essential to the above described usages of MTHFR gene polymorphisms. In addition, this invention features a kit that has translated the above discoveries into a practical and reliable tool that can be applied to accomplish the above described usages of MTHFR gene polymorphisms. This invention represents an important step in realizing personalized medicine, with the goal to tailor diagnosis, prevention and treatment strategy to meet individual needs.
摘要翻译： 本发明的特征在于我们发现亚甲基四氢叶酸还原酶（MTHFR）基因多态性在预测同型半胱氨酸（Hcy）水平和/或与受试者中Hcy水平升高相关的疾病的发病率和预后以及预测该类药物的治疗效果 的血管紧张素转换酶抑制剂（ACEI）与B族维生素和/或B组合。 本发明还具有我们对实验室和分析方法的发现，其对于上述MTHFR基因多态性的用途是必需的。 此外，本发明的特征在于将上述发现翻译成可用于实现上述MTHFR基因多态性使用的实用且可靠的工具的试剂盒。 本发明是实现个性化医学的重要一步，目标是量身定制诊断，预防和治疗策略，以满足个人需求。
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公开(公告)号：US11952603B2
公开(公告)日：2024-04-09
申请号：US16108930
申请日：2018-08-22
申请人： Kenneth S. Manning , Yan Wang , Dustin Nielsen , Ryan Ruf , Colin Crowley , Jon Restivo , Dana Spangenberg , Karla Anhalt , Mark Romich , Anisha Akula , Carmen Fritz
发明人： Kenneth S. Manning , Yan Wang , Dustin Nielsen , Ryan Ruf , Colin Crowley , Jon Restivo , Dana Spangenberg , Karla Anhalt , Mark Romich , Anisha Akula , Carmen Fritz
CPC分类号： C12N9/94 , A61K9/00 , A61K31/327 , A61K35/39 , A61K38/46 , C12N7/00 , C12N2750/10063 , C12N2750/14363 , C12N2770/32263 , A61K35/39 , A61K2300/00 , A61K38/46 , A61K2300/00 , A61K31/327 , A61K2300/00
摘要： A pancreatin preparation having reduced viral infectivity includes one or more pancreatin enzymes and peracetic acid (PAA). At least one pancreatin enzyme may be derived from an animal source such as a porcine pancreas gland. In a particular embodiment, the one or more pancreatin enzymes are selected from the group consisting of lipases, proteases, and amylases.
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公开(公告)号：US11579086B2
公开(公告)日：2023-02-14
申请号：US17496262
申请日：2021-10-07
申请人： Yan Wang , Cory McCluskey
发明人： Yan Wang , Cory McCluskey
摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.
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公开(公告)号：US20220026363A1
公开(公告)日：2022-01-27
申请号：US17496285
申请日：2021-10-07
申请人： Yan Wang , Cory McCluskey
发明人： Yan Wang , Cory McCluskey
摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.
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公开(公告)号：US20220026362A1
公开(公告)日：2022-01-27
申请号：US17496262
申请日：2021-10-07
申请人： Yan Wang , Cory McCluskey
发明人： Yan Wang , Cory McCluskey
摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.
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公开(公告)号：US10993305B2
公开(公告)日：2021-04-27
申请号：US16722070
申请日：2019-12-20
申请人： Yan Wang
发明人： Yan Wang
摘要： A wireless receiving circuit and a wireless control device. The wireless receiving circuit includes a signal receiving module, a Bluetooth signal processing module, a voltage stabilization module, and an output control module. An output end of the signal receiving module is connected with an input end of the Bluetooth signal processing module, and a voltage end of the Bluetooth signal processing module is connected with an output end of the voltage stabilization module. An output end of the Bluetooth signal processing module is connected with an input end of the output control module. The signal receiving module is to receive an external Bluetooth signal and is to transmit the signal to the Bluetooth signal processing module. The Bluetooth signal processing module is to process the external Bluetooth signal and is to transmit a control signal to the output control module.
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公开(公告)号：US20200277654A1
公开(公告)日：2020-09-03
申请号：US16875381
申请日：2020-05-15
申请人： Yan Wang
发明人： Yan Wang
IPC分类号： C12Q1/686 , C12Q1/6827 , C12Q1/6876 , C12Q1/6848
摘要： Disclosed are methods for detecting DNA mutations of target genes in a DNA sample by combining single-molecule clonal amplification and mutant primer specific extension detection. In the method, thousands and millions of DNA molecules are locally amplified to form immobilized DNA clusters of identical sequences. Mutation specific primers are used to anneal to the mutant sequences in the DNA clusters and are extended by DNA polymerase to make labeled DNA strands. The labeled DNA clusters are detected to identify the DNA clusters of mutant sequences. This method enables detection of single mutation molecule and direct enumeration of mutation molecules in the sample. Once generated from a DNA sample, the immobilized DNA clusters can be reused many times for detection of different mutations or sequences of interest. Methods for determining differential gene expression and chromosome copy number variation are also disclosed.
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