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    Nanoparticle complexes having a defined number of ligands
    1.
    发明授权
    Nanoparticle complexes having a defined number of ligands 失效
    具有规定数目的配体的纳米颗粒复合物

    公开(公告)号：US07507530B2

    公开(公告)日：2009-03-24

    申请号：US10630613

    申请日：2003-07-30

    申请人： Xueying Huang ,  Zheng Ming

    发明人： Xueying Huang ,  Zheng Ming

    IPC分类号： C12Q1/68 ,  C12M1/36 ,  G01N15/06 ,  C07H21/04

    CPC分类号： B82Y30/00 ,  A61K47/6923 ,  B82Y5/00 ,  C12Q1/6834 ,  Y10S977/924 ,  C12Q2563/155

    摘要： A rapid method for the separation of nanoparticles having as few as one ligand attached thereto has been developed. The method relies on the size exclusion separation of a population of nanoparticle-ligand complexes having a narrow uniform size distribution. Ligands are typically biopolymers, functionalized to bind to other nanoparticles for the construction of geometric nanostructures.

    摘要翻译： 已经开发了用于分离具有少至一个配体的纳米颗粒的快速方法。 该方法依赖于具有窄均匀尺寸分布的纳米粒子 - 配体配合物群体的大小排阻分离。 配体通常是生物聚合物，官能化以结合其他纳米颗粒以构建几何纳米结构。

    Peptide-based conditioners and colorants for hair, skin, and nails
    2.
    发明申请
    Peptide-based conditioners and colorants for hair, skin, and nails 有权
    基于肽的调理剂和头发，皮肤和指甲的着色剂

    公开(公告)号：US20050050656A1

    公开(公告)日：2005-03-10

    申请号：US10935642

    申请日：2004-09-07

    申请人： Xueying Huang ,  Ying Wu ,  Hong Wang

    发明人： Xueying Huang ,  Ying Wu ,  Hong Wang

    IPC分类号： A61K8/64 ,  A61Q3/00 ,  A61Q3/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/04 ,  A61K7/06 ,  A61K7/11 ,  A61K7/13

    CPC分类号： C07K7/08 ,  A61K8/64 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q3/00 ,  A61Q5/065 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/04 ,  C07K7/06

    摘要： Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants based are described. The peptide-based hair conditioners and hair colorants consist of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants consist of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants consist of a nail-binding peptide coupled to a coloring agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based conditioners and colorants are also described.

    摘要翻译： 已经鉴定出以高亲和力结合头发，皮肤和指甲的肽。 描述了基于肽的护发素，头发着色剂，皮肤调理剂，皮肤着色剂和指甲着色剂。 基于肽的头发调理剂和毛发着色剂分别由与头发调理剂或着色剂偶联的毛发结合肽组成。 基于肽的皮肤调理剂和皮肤着色剂分别由与皮肤调理剂或着色剂偶联的皮肤结合肽组成。 基于肽的指甲着色剂由与着色剂偶联的指甲结合肽组成。 在所有这些组合物中，肽可以直接与活性剂偶联，或者偶联可以经由间隔物。 还描述了含有这些基于肽的调理剂和着色剂的个人护理组合物。

    Pepetide-based body surface reagents for personal care
    6.
    发明申请
    Pepetide-based body surface reagents for personal care 审中-公开
    用于个人护理的基于Pepetide的身体表面试剂

    公开(公告)号：US20050226839A1

    公开(公告)日：2005-10-13

    申请号：US11074473

    申请日：2005-03-08

    申请人： Xueying Huang ,  Ying Wu ,  Hong Wang ,  John O'Brien

    发明人： Xueying Huang ,  Ying Wu ,  Hong Wang ,  John O'Brien

    IPC分类号： A61K8/29 ,  A61K8/64 ,  A61Q1/10 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  C07K14/47 ,  A61K7/06 ,  A61K7/11

    CPC分类号： A61K8/64 ,  A61K8/29 ,  A61K2800/413 ,  A61K2800/42 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q1/02 ,  A61Q1/10 ,  A61Q3/00 ,  A61Q5/065 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  B82Y5/00 ,  C07K7/06 ,  C07K7/08

    摘要： Peptides have been identified that bind with high affinity to body surfaces, such as, hair, skin, nails, teeth, gums, corneal tissue, and oral cavity surfaces. Peptide-based body surface reagents formed by coupling a body surface binding peptide to a benefit agent are described. The peptide-based body surface reagents include peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, nail colorants, and oral care reagents. The peptide-based hair conditioners and hair colorants are comprised of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants are comprised of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants are comprised of a nail-binding peptide coupled to a coloring agent. The peptide-based oral care reagents are comprised of an oral cavity surface-binding peptide coupled to an oral care benefit agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based body surface reagents are also described.

    摘要翻译： 已经鉴定出已经以高亲和力结合身体表面，例如头发，皮肤，指甲，牙齿，牙龈，角膜组织和口腔表面的肽。 描述了通过将身体表面结合肽偶联到有益剂形成的基于肽的体表试剂。 基于肽的体表试剂包括基于肽的头发调理剂，毛发着色剂，皮肤调理剂，皮肤着色剂，指甲着色剂和口腔护理试剂。 基于肽的护发素和毛发着色剂分别由与头发调理剂或着色剂偶联的毛发结合肽组成。 基于肽的皮肤调理剂和皮肤着色剂分别由与皮肤调理剂或着色剂偶联的皮肤结合肽组成。 基于肽的指甲着色剂由与着色剂偶联的指甲结合肽组成。 基于肽的口腔护理试剂由与口腔护理有益剂偶联的口腔表面结合肽组成。 在所有这些组合物中，肽可以直接与活性剂偶联，或者偶联可以经由间隔物。 还描述了含有这些基于肽的体表试剂的个人护理组合物。

    Thin nanometer-controlled polymer film gradient
    8.
    发明授权
    Thin nanometer-controlled polymer film gradient 失效
    薄纳米控制聚合物膜梯度

    公开(公告)号：US06946164B2

    公开(公告)日：2005-09-20

    申请号：US10800271

    申请日：2004-03-12

    申请人： Xueying Huang

    发明人： Xueying Huang

    IPC分类号： B05D1/18 ,  B05D1/20 ,  B05D7/00 ,  B05D1/36

    CPC分类号： B82Y30/00 ,  B05D1/185 ,  B05D1/20 ,  B05D7/52 ,  B82Y40/00 ,  Y10T442/20

    摘要： This invention relates to a process that uses Surface Atom Transfer Radical Polymerization (SATRP) to grow thin polyethylene glycol alkyl acrylate (PEGAA) polymer film gradients on the moiety accepting surface of a substrate. This invention also relates to a method for producing thin PEGAA polymer film gradients having specific surface functionalities, a thickness ranging from about 0.5 nm to about 5000 nm, and a polymer chain density ranging from 0.1 to 100% surface coverage.

    摘要翻译： 本发明涉及使用表面原子转移自由基聚合（SATRP）在衬底的部分接受表面上生长薄聚乙二醇丙烯酸烷基酯（PEGAA）聚合物膜梯度的方法。 本发明还涉及一种用于生产具有比表面官能度，厚度范围为约0.5nm至约5000nm，聚合物链密度为0.1至100％表面覆盖度的薄PEGAA聚合物膜梯度的方法。

    Peptide-based conditioners and colorants for hair, skin, and nails
    10.
    发明申请
    Peptide-based conditioners and colorants for hair, skin, and nails 失效
    基于肽的调理剂和头发，皮肤和指甲的着色剂

    公开(公告)号：US20080152612A1

    公开(公告)日：2008-06-26

    申请号：US11716161

    申请日：2007-03-09

    申请人： Xueying Huang ,  Ying Wu ,  Hong Wang

    发明人： Xueying Huang ,  Ying Wu ,  Hong Wang

    IPC分类号： A61K8/64 ,  A61Q5/12

    CPC分类号： C07K7/08 ,  A61K8/64 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q3/00 ,  A61Q5/065 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/04 ,  C07K7/06

    摘要： Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants are described. The peptide-based hair conditioners and hair colorants consist of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants consist of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants consist of a nail-binding peptide coupled to a coloring agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based conditioners and colorants are also described.

    摘要翻译： 已经鉴定出以高亲和力结合头发，皮肤和指甲的肽。 描述了基于肽的护发素，头发着色剂，皮肤调理剂，皮肤着色剂和指甲着色剂。 基于肽的头发调理剂和毛发着色剂分别由与头发调理剂或着色剂偶联的毛发结合肽组成。 基于肽的皮肤调理剂和皮肤着色剂分别由与皮肤调理剂或着色剂偶联的皮肤结合肽组成。 基于肽的指甲着色剂由与着色剂偶联的指甲结合肽组成。 在所有这些组合物中，肽可以直接偶联到活性剂上，或者偶联可以通过间隔物。 还描述了含有这些基于肽的调理剂和着色剂的个人护理组合物。