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公开(公告)号：US20240092759A1
公开(公告)日：2024-03-21
申请号：US18260744
申请日：2022-01-07
申请人： YALE UNIVERSITY
发明人： William L. Jorgensen
IPC分类号： C07D401/14 , A61K45/06 , A61P31/14 , C07D401/04 , C07D401/10 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/14 , A61K45/06 , A61P31/14 , C07D401/04 , C07D401/10 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Provided herein are compounds of formula (I) or (I-A), which act as non-covalent inhibitors of SARS-CoV2 main protease (Mpro). The compounds of formula (I) or (I-A) are useful in treating COVID-19 infections, as well as reducing or ameliorating symptoms associated with COVID-19 infection.
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公开(公告)号：US20210002264A1
公开(公告)日：2021-01-07
申请号：US16979306
申请日：2019-03-15
申请人： YALE UNIVERSITY
IPC分类号： C07D405/12 , C07D231/12 , C07D231/16
摘要： In one aspect, the invention comprises compounds that bind and inhibit macrophage migration inhibitory factor. In another aspect, the invention provides methods of treating inflammatory disease, neurological disorders and cancer using the compounds of the invention.
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公开(公告)号：US20200377457A1
公开(公告)日：2020-12-03
申请号：US16999015
申请日：2020-08-20
申请人： YALE UNIVERSITY
IPC分类号： C07D209/18 , C07D235/12 , C07D235/24 , C07D249/06 , C07D263/58 , C07D275/04 , C07D307/80 , C07D307/83 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/06 , C07D413/04 , C07D417/04
摘要： The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression.
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公开(公告)号：US20220112166A1
公开(公告)日：2022-04-14
申请号：US17500622
申请日：2021-10-13
申请人： YALE UNIVERSITY
IPC分类号： C07D249/14 , A61K31/4196 , A61K45/06 , C07D401/12 , A61K31/4439 , C07D405/12 , C07D413/12 , A61K31/4245
摘要： The compounds of Formula I described herein regulate activity of JAK2 by specifically binding to the JAK2 pseudokinase domain, JH2, and are useful as therapeutic agents in the treatment or amelioration of myeloproliferative disorders. Also provided herein are methods of treating myeloproliferative disorders, and methods of making compounds of Formula I.
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公开(公告)号：US10336721B2
公开(公告)日：2019-07-02
申请号：US15550573
申请日：2016-02-12
申请人： YALE UNIVERSITY
IPC分类号： C07D401/04 , C07D403/04 , C07D471/04
摘要： The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory diseases and cancer.
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公开(公告)号：US11584717B2
公开(公告)日：2023-02-21
申请号：US16229069
申请日：2018-12-21
申请人： YALE UNIVERSITY
IPC分类号： C07D209/18 , C07D235/12 , C07D235/24 , C07D249/06 , C07D263/58 , C07D275/04 , C07D307/80 , C07D307/83 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/06 , C07D413/04 , C07D417/04
摘要： The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression.
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公开(公告)号：US11465991B2
公开(公告)日：2022-10-11
申请号：US16979306
申请日：2019-03-15
申请人： YALE UNIVERSITY
IPC分类号： C07D405/12 , C07D231/12 , C07D231/16
摘要： In one aspect, the invention comprises compounds that bind and inhibit macrophage migration inhibitory factor. In another aspect, the invention provides methods of treating inflammatory disease, neurological disorders and cancer using the compounds of the invention.
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公开(公告)号：US20190276425A1
公开(公告)日：2019-09-12
申请号：US16419834
申请日：2019-05-22
申请人： YALE UNIVERSITY
IPC分类号： C07D401/04 , C07D403/04 , C07D471/04
摘要： The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory diseases and cancer.
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公开(公告)号：US09382245B2
公开(公告)日：2016-07-05
申请号：US14509301
申请日：2014-10-08
申请人： YALE UNIVERSITY
IPC分类号： C07D471/04 , C07D239/54 , A61K31/513 , A61K45/06 , C07D403/12 , C07D407/12
CPC分类号： C07D471/04 , A61K31/513 , A61K45/06 , C07D239/54 , C07D403/12 , C07D407/12 , A61K2300/00
摘要： The present invention is directed to novel nanomolar and picomolar inhibitors of HIV reverse transcriptase, pharmaceutical compositions therefrom and methods for inhibiting reverse transcriptase and treating HIV infections, especially included drug resistant strains of HIV-1 and HIV-2 and/or secondary disease states and/or conditions which occur as a consequence of HIV infection.
摘要翻译： 本发明涉及HIV逆转录酶的新型纳摩尔和皮摩尔抑制剂，其药物组合物及其抑制逆转录酶和治疗HIV感染的方法，特别包括HIV-1和HIV-2和/或继发性疾病状态的耐药菌株，以及 /或由于HIV感染而发生的病症。
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公开(公告)号：US20140288017A1
公开(公告)日：2014-09-25
申请号：US14348952
申请日：2012-10-12
申请人： YALE UNIVERSITY
IPC分类号： C07C255/54 , A61K31/4409 , A61K45/06 , C07D239/54 , A61K31/513 , C07D239/553 , A61K31/5377 , A61K31/277 , A61K31/536 , A61K31/505 , C07D251/42 , A61K31/53 , C07D213/69 , A61K31/4412 , C07D487/04 , A61K31/5025 , C07D213/57
CPC分类号： C07C255/54 , A61K31/277 , A61K31/4409 , A61K31/4412 , A61K31/5025 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/536 , A61K31/5377 , A61K45/06 , C07D213/57 , C07D213/69 , C07D239/10 , C07D239/54 , C07D239/553 , C07D251/42 , C07D405/12 , C07D471/04 , C07D487/04
摘要： The present invention is directed to novel catechol diether compounds, pharmaceutical compositions therefrom and methods for inhibiting reverse transcriptase and treating HIV infections, especially included drug resistant strains of HIV 1 and 2 and/or secondary disease states and/or conditions which occur as a consequence of HIV infection.
摘要翻译： 本发明涉及新颖的儿茶酚二醚化合物，其药物组合物及其抑制逆转录酶和治疗HIV感染的方法，特别是包括HIV 1和2的耐药菌株和/或随后发生的继发性疾病状态和/或病症 的艾滋病毒感染。
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