公开(公告)号：US20230072222A1

公开(公告)日：2023-03-09

申请号：US17583378

申请日：2022-01-25

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD

发明人： Helena SHOMAR MONGES ,  Rotem SOREK ,  Lianet NODA GARCIA ,  Arthur MACHLENKIN ,  David SPERANDIO

IPC分类号： C07H19/20 ,  C07H19/10 ,  A61P31/14

摘要： Disclosed herein are 3, 4-didehydro- and 3′-deoxy-3, 4-didehydro-compounds and pharmaceutical compositions thereof. Methods of use of these pharmaceutical compositions include those for treating diseases including virus-induced diseases, cancer, autoimmune diseases, immune disorders, and bacterial-associated diseases or infections, or combinations thereof. Examples of viral-induced diseases include viral infections by RNA or DNA viruses, for example SAR-CoV-2, EBV, BKV, JCV and HCMV.

公开(公告)号：US20240228521A1

公开(公告)日：2024-07-11

申请号：US18554795

申请日：2022-04-14

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.

发明人： David SPERANDIO ,  Helena SHOMAR MONNGES ,  Eugene J. EISENBERG ,  Arthur MACHLENKIN

IPC分类号： C07F9/6561 ,  A61K31/675

CPC分类号： C07F9/6561 ,  A61K31/675

摘要： Disclosed herein are 3, 4-didehydro- and 3′-deoxy-3, 4-didehydro-compounds, and pharmaceutical compositions thereof. The 3, 4-didehydro- and 3′-deoxy-3, 4-didehydro-compounds, and pharmaceutical compositions thereof may be used in methods of treating diseases including virus-induced diseases, cancer, autoimmune diseases, immune disorders, and bacterial-associated diseases or infections, or combinations thereof. Examples of viral-induced diseases include viral infections by RNA or DNA viruses, for example SARS-CoV-2, EBV, and BKV.