公开(公告)号：US09387264B2

公开(公告)日：2016-07-12

申请号：US13856788

申请日：2013-04-04

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD ,  THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV

Inventor： Michal Neeman ,  Raz Zarivach ,  Marina Radoul ,  Batya Cohen ,  Moriel Vandsburger ,  Limor Lewin

IPC: A61K49/14 ,  C07K14/47 ,  C07K14/195

CPC classification number: A61K49/14 ,  C07K14/195 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/42

Abstract: The invention provides a fusion ferritin protein wherein a ferritin heavy chain polypeptide is fused to a peptide, wherein the peptide is fused to the C-terminal end of the ferritin heavy chain; and the peptide includes at least a portion of a Mms6 protein sequence and at least one heterologous amino acid at its N-terminal end. The invention further provides methods of use of the ferritin fusion protein for Magnetic Resonance Imaging.

Abstract translation: 本发明提供融合铁蛋白，其中铁蛋白重链多肽与肽融合，其中该肽融合到铁蛋白重链的C末端; 并且肽在其N-末端包括至少一部分Mms6蛋白序列和至少一个异源氨基酸。 本发明还提供了用于磁共振成像的铁蛋白融合蛋白的使用方法。

公开(公告)号：US09492100B2

公开(公告)日：2016-11-15

申请号：US14242965

申请日：2014-04-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Michal Neeman ,  Moriel Vandsburger

IPC: A61B5/055 ,  G01R33/56 ,  A61B5/00

CPC classification number: A61B5/055 ,  A61B5/0044 ,  A61B2576/023 ,  G01R33/5605

Abstract: The invention provides magnetic resonance imaging methods for detecting cardiac diseases including myocardial fibrosis. Specifically, the invention provides a magnetic resonance imaging (MRI) pulse sequence that could be used to perform magnetization transfer (MT) or chemical exchange saturation transfer (CEST) in the heart.

Abstract translation: 本发明提供用于检测包括心肌纤维化在内的心脏病的磁共振成像方法。 具体地，本发明提供可用于在心脏中进行磁化转移（MT）或化学交换饱和转移（CEST）的磁共振成像（MRI）脉冲序列。

公开(公告)号：US20140303479A1

公开(公告)日：2014-10-09

申请号：US14242965

申请日：2014-04-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Michal Neeman ,  Moriel Vandsburger

IPC: A61B5/055

CPC classification number: A61B5/055 ,  A61B5/0044 ,  A61B2576/023 ,  G01R33/5605

Abstract: The invention provides magnetic resonance imaging methods for detecting cardiac diseases including myocardial fibrosis. Specifically, the invention provides a magnetic resonance imaging (MRI) pulse sequence that could be used to perform magnetization transfer (MT) or chemical exchange saturation transfer (CEST) in the heart.

Abstract translation: 本发明提供用于检测包括心肌纤维化在内的心脏病的磁共振成像方法。 具体地，本发明提供可用于在心脏中进行磁化转移（MT）或化学交换饱和转移（CEST）的磁共振成像（MRI）脉冲序列。