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公开(公告)号:US20130066283A1
公开(公告)日:2013-03-14
申请号:US13503841
申请日:2010-10-22
申请人: Yair Alster , Hanson S. Gifford , Cary J. Reich , Eugene de Juan, JR. , John A. Scholl , Jose D. Alejandro , Douglas Sutton , Omer Rafaeli
发明人: Yair Alster , Hanson S. Gifford , Cary J. Reich , Eugene de Juan, JR. , John A. Scholl , Jose D. Alejandro , Douglas Sutton , Omer Rafaeli
IPC分类号: A61F9/01
CPC分类号: A61F9/008 , A61B18/02 , A61F9/0079 , A61F9/00804 , A61F9/009 , A61F2009/00872 , A61F2009/00893 , A61N1/36021 , A61N1/36046 , A61N1/40 , A61N7/02
摘要: Methods and apparatus for the treatment of the eye to reduce pain can treat at least an outer region of the tissue so as to denervate nerves extending into the inner region and reduce the pain. For example, the cornea of the eye may comprise an inner region having an epithelial defect, and an outer portion of the cornea can be treated to reduce pain of the epithelial defect. The outer portion of the cornea can be treated to denervate nerves extending from the outer portion to the inner portion. The outer portion can be treated in many ways to denervate the nerve, for example with one or more of heat, cold or a denervating noxious substance such as capsaicin. The denervation of the nerve can be reversible, such that corneal innervation can return following treatment.
摘要翻译: 用于治疗眼睛以减轻疼痛的方法和装置可以治疗组织的至少外部区域,以便使延伸到内部区域的神经衰老,并减轻疼痛。 例如,眼睛的角膜可以包括具有上皮缺损的内部区域,并且可以治疗角膜的外部部分以减少上皮缺损的疼痛。 角膜的外部可以被处理以将从外部延伸到内部部分的神经去激活。 外部部分可以以许多方式被治疗以使神经变性,例如用一种或多种热,冷或去神经感染的有害物质如辣椒素。 神经的去神经可以是可逆的,使得角膜神经支配可以在治疗后返回。
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公开(公告)号:US09943401B2
公开(公告)日:2018-04-17
申请号:US12384659
申请日:2009-04-06
申请人: Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfarlane , Douglas Sutton , John Anthony Scholl
发明人: Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfarlane , Douglas Sutton , John Anthony Scholl
CPC分类号: A61F2/142 , A61F2/14 , A61F9/00 , A61F2250/0067 , G02C7/047
摘要: A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.
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公开(公告)号:US20100036488A1
公开(公告)日:2010-02-11
申请号:US12384659
申请日:2009-04-06
申请人: Eugene de Juan, JR. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfariane , Douglas Sutton , John Anthony
发明人: Eugene de Juan, JR. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfariane , Douglas Sutton , John Anthony
IPC分类号: A61F2/14
CPC分类号: A61F2/142 , A61F2/14 , A61F9/00 , A61F2250/0067 , G02C7/047
摘要: A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.
摘要翻译: 用于治疗上皮缺损的治疗镜片包括设置在基质和/或Bowman膜上的治疗材料层,以抑制从泪液到基质和/或Bowman膜的水流,使得可以恢复角膜deturgescence 减少角膜肿胀和光散射。 该层可以覆盖并保护神经纤维以减轻疼痛。 该层可以包括折射率以抑制从基质和/或Bowman膜的前表面的光散射。 透镜可以包括弯曲的前表面,当上皮再生时,该前表面为患者提供功能视觉。 治疗材料层可以以许多方式定位在眼睛上,例如通过固化以将该层粘附到基质和/或Bowman膜的暴露表面上的喷雾。
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公开(公告)号:US20100255061A1
公开(公告)日:2010-10-07
申请号:US12696678
申请日:2010-01-29
申请人: Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
发明人: Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
IPC分类号: A61F9/00 , A61K39/395 , A61P27/02 , A61K31/5575 , A61K31/58 , A61F2/14 , B23P17/04
CPC分类号: G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译: 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小,当耦合到多孔结构并且植入患者体内时,释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧,以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口,使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ,例如当器件长时间植入时,可以使用颗粒,细胞,细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器,使得该装置可以从输送装置的内腔输送,并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。
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公开(公告)号:US08277830B2
公开(公告)日:2012-10-02
申请号:US13252998
申请日:2011-10-04
申请人: Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
发明人: Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
CPC分类号: G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
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公开(公告)号:US08399006B2
公开(公告)日:2013-03-19
申请号:US12696678
申请日:2010-01-29
申请人: Eugene de Juan, Jr. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
发明人: Eugene de Juan, Jr. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
CPC分类号: G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译: 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小,当耦合到多孔结构并且植入患者体内时,释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧,以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口,使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ,例如当器件长时间植入时,可以使用颗粒,细胞,细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器,使得该装置可以从输送装置的内腔输送,并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。
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公开(公告)号:US20120029470A1
公开(公告)日:2012-02-02
申请号:US13252942
申请日:2011-10-04
申请人: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
发明人: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
IPC分类号: A61F9/00
CPC分类号: G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
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公开(公告)号:US20130204209A1
公开(公告)日:2013-08-08
申请号:US13831695
申请日:2013-03-15
申请人: Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
发明人: Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
IPC分类号: A61F9/00
CPC分类号: G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
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公开(公告)号:US08298578B2
公开(公告)日:2012-10-30
申请号:US13252942
申请日:2011-10-04
申请人: Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
发明人: Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
CPC分类号: G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
摘要翻译: 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小,当耦合到多孔结构并且植入患者体内时,释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧,以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。
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公开(公告)号:US20120029445A1
公开(公告)日:2012-02-02
申请号:US13252998
申请日:2011-10-04
申请人: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
发明人: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
CPC分类号: G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
摘要翻译: 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小,当耦合到多孔结构并且植入患者体内时,释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧,以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。
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